Global Erbitux Market - 2021-2028

Global Erbitux Market - 2021-2028

Market Overview

The global erbitux market size was valued at US$ XX million in 2020 and is estimated to reach US$ XX million by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).

Erbitux is approved to treat patients with colorectal cancer that has spread to other parts of the body. The generic name for the brand-name drug Erbitux is Cetuximab. When referring to the generic drug name Cetuximab, health care professionals may use the trade name Erbitux or another name C225 in some cases.

Market Dynamics

The factor driving the global Erbitux market is the growing demand for the treatment of metastatic colorectal cancer and head and neck cancer.

The growing demand for the treatment of metastatic colorectal cancer and head and neck cancer is expected to drive the market growth

Colorectal cancer (CRC) is one of the world's three deadliest cancers, with a poor prognosis and a high rate of metastasis. However, the early symptoms of CRC are subtle, and approximately 15–25 percent of patients with CRC were diagnosed as an advanced stage during the initial check-up. As a result, half of all patients with metastatic colorectal cancer (mCRC) are inoperable, resulting in recurrence and metastasis after treatment.

On 29th September 2021, the FDA approved Erbitux in combination with Braftovi (encorafenib) for pre-treated BRAF V600E-mutant metastatic colorectal cancer (CRC). The approval was based on findings from the phase 3 BEACON CRC trial, which revealed that the drug combination resulted in an average overall survival rate of 8.4 months compared to 5.4 months in the control group of patients who received irinotecan in combination with Erbitux or FOLFIRI (a chemotherapy combination used to treat metastatic colorectal cancer) in combination with Erbitux. It's a significant advancement because this cancer type is extremely aggressive once it spreads, and all other treatments have failed. Patients whose tumors contain the BRAF V600E mutation have a poor prognosis. After unsuccessful initial therapy, the median survival time is only four to six months, and they frequently have unpleasant symptoms such as abdominal swelling or bowel blockage. The trial demonstrated that this combination therapy extends people's lives, delays the onset of these symptoms, and improves their quality of life.

Side-effects of the drug is expected to hamper its market growth

Severe allergic reactions are a serious side effect of Erbitux. Allergic reactions are uncommon, but they can be fatal. Low blood pressure, shock, loss of consciousness, and a heart attack are all possible symptoms. Severe allergic reactions can occur at any point during treatment, but they are most common during the first dose. People who have a history of tick bites, a red meat allergy, or specific antibodies are at a higher risk of anaphylactic reactions. Other serious side effect of erbitux is a heart attack. Some people who received erbitux with radiation therapy or cetuximab with platinum-based chemotherapy and fluorouracil experienced heart attacks or died unexpectedly. Infusion-related reactions can also result in a heart attack. When erbitux was used in conjunction with radiation therapy, the overall incidence of late radiation toxicities (of any grade) was higher than when radiation therapy was used alone.

COVID-19 Impact Analysis

The COVID-19 pandemic had an impact on all stages of drug development, forcing many drugs development companies and clinical research organizations (CROs) to halt at least some and in many cases all their clinical trials. While pausing clinical studies is not uncommon (especially early in development), never have so many companies experienced a disruption of this magnitude at the same time. For instance, the company Merck’s Erbitux and Bavencio was impacted sequentially by COVID-19, their sales declined. Hence, COVID-19 impacted the global erbitux market growth negatively with halt in drug development process.

Segment Analysis

Based on dosage type, injection segment is expected to dominate the market

Injections are a type of parenteral drug administration because they do not involve absorption in the digestive tract. This allows the medication to be absorbed more quickly and eliminates the first-pass effect. Cetuximab is available as a solution (liquid) that is infused (slowly injected) into a vein. It is administered by injection into a vein as directed by a doctor, usually once every week or every two weeks. Cetuximab is administered slowly, and the infusion lasts up to 2 hours. Hence, it is given by injection mostly. Other medications may be prescribed to help prevent serious side effects or allergic reactions. Cetuximab is frequently used in conjunction with other cancer medications and/or radiation therapy. One hour after cetuximab infusion, a patient may be given another cancer medication.

For example, on September 8th, 2021, Eli Lilly and Company received the U.S. FDA approval for ERBITUX (cetuximab injection) in combination with BRAFTOVI (encorafenib), marketed by Pfizer, Inc., for the treatment of adult patients with metastatic colorectal cancer (CRC) who have a BRAF V600E mutation as detected by an FDA-approved test after prior therapy.

Geographical Analysis

North America region accounted for the largest market share in the global erbitux market

The increasing prevalence of colorectal cancer and presence of key players is expected to drive the market growth in this region.

According to the American Cancer Society, in both men and women, it is the third leading cause of cancer-related deaths and the second leading cause when men and women are combined. The number of colorectal cancer cases in the United States in 2021 will be 104,270 new cases of colon cancer and 45,230 new cases of rectal cancer. It is expected to kill 52,980 people in 2021.

On July 28th, 2021, a U.S based company Flatiron Health real-world data (RWD) supported the recent FDA approval of a new dosing regimen for ERBITUX (Eli Lilly and Company's cetuximab), which can have a direct positive impact on the lives of patients with metastatic colorectal cancer (CRC) or squamous cell carcinoma of the head and neck (SCCHN).

Competitive Landscape

The global erbitux market is moderately competitive with partnerships, mergers, and recent product launches by key players. Some of the major key players in the global erbitux market are Merck, Bristol-Myers Squibb, Eli Lilly, Manus Aktteva Biopharma LLP, Hubei xinkang pharmaceutical chemical co.,ltd., Array BioPharma Inc., Wuhan Sunrise Technology Development Company Limited, Chembest Research Laboratories Limited, NKMax and Pierre Fabre.

Merck

Overview: Merck is a multinational German science and technology company. The company is headquartered in Darmstadt and employs approximately 57,000 people and operates in 66 countries. The group consists of approximately 250 companies, the largest of which is Merck KGaA in Germany.

Product Portfolio: The company manufactures Erbitux 5 mg/mL solution for infusion (Cetuximab). It is supplied in vials containing 20 mL or 100 mL. Each pack contains 1 vial.

Key Development: On March 2nd, 2020, The National Medical Products Administration (NMPA) of China approved Merk’s ERBITUX (cetuximab) for the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck in combination with platinum-based therapy with fluorouracil.

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Target Audience

Service Providers/ Buyers

Industry Investors/Investment Bankers

Education & Research Institutes

Research Professionals

Emerging Companies

Manufacturers

Market Segmentation

Global Erbitux Market - By Dosage Type

Injection

Tablet

Other

Global Erbitux Market - By End-User

Hospital Pharmacy

Retail Pharmacies

Others

Global Erbitux Market - By Region

North America

Europe

South America

Asia Pacific

Middle East and Africa


1. Global Erbitux Market Methodology and Scope
1.1. Research Methodology
1.2. Research Objective and Scope of the Report
2. Global Erbitux Market – Market Definition and Overview
3. Global Erbitux Market – Executive Summary
3.1. Market Snippet by Dosage Type
3.2. Market Snippet by End-User
3.3. Market Snippet by Region
4. Global Erbitux Market -Market Dynamics
4.1. Market Impacting Factors
4.1.1. Drivers
4.1.1.1. The growing demand for the treatment of metastatic colorectal cancer and head and neck cancer
4.1.2. Restraints:
4.1.2.1. Side-effects of the drug
4.1.3. Opportunity
4.1.4. Impact Analysis
5. Global Erbitux Market – Industry Analysis
5.1. Porter's Five Forces Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis
5.5. Reimbursement Analysis
5.6. Unmet Needs
6. Global Erbitux Market – COVID-19 Analysis
6.1. Analysis of Covid-19 on the Market
6.1.1. Before COVID-19 Market Scenario
6.1.2. Present COVID-19 Market Scenario
6.1.3. After COVID-19 or Future Scenario
6.2. Pricing Dynamics Amid Covid-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion
7. Global Erbitux Market – By Dosage Type
7.1. Introduction
7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
7.1.2. Market Attractiveness Index, By Dosage Type
7.2. Injection*
7.2.1. Introduction
7.2.2. Market Size Analysis, US$ Mn, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
7.3. Tablet
7.3.1. Introduction
7.3.2. Market Size Analysis, US$ Mn, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
7.4. Other
8. Global Erbitux Market – By End-User
8.1. Introduction
8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User Segment
8.1.2. Market Attractiveness Index, By End-User Segment
8.2. Hospital Pharmacy*
8.2.1. Introduction
8.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
8.3. Retail Pharmacies
8.4. Others
9. Global Erbitux Market – By Region
9.1. Introduction
9.1.1. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
9.1.2. Market Attractiveness Index, By Region
9.2. North America
9.2.1. Introduction
9.2.2. Key Region-Specific Dynamics
9.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
9.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
9.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
9.2.5.1. U.S.
9.2.5.2. Canada
9.2.5.3. Mexico
9.3. Europe
9.3.1. Introduction
9.3.2. Key Region-Specific Dynamics
9.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
9.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
9.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
9.3.5.1. Germany
9.3.5.2. U.K.
9.3.5.3. France
9.3.5.4. Italy
9.3.5.5. Spain
9.3.5.6. Rest of Europe
9.4. South America
9.4.1. Introduction
9.4.2. Key Region-Specific Dynamics
9.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
9.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
9.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
9.4.5.1. Brazil
9.4.5.2. Argentina
9.4.5.3. Rest of South America
9.5. Asia Pacific
9.5.1. Introduction
9.5.2. Key Region-Specific Dynamics
9.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
9.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
9.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
9.5.5.1. China
9.5.5.2. India
9.5.5.3. Japan
9.5.5.4. Australia
9.5.5.5. Rest of Asia Pacific
9.6. Middle East and Africa
9.6.1. Introduction
9.6.2. Key Region-Specific Dynamics
9.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dosage Type
9.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
10. Global Erbitux Market – Competitive Landscape
10.1. Key Developments and Strategies
10.2. Company Share Analysis
10.3. Product Benchmarking
11. Global Erbitux Market - Company Profiles
11.1. Merck*
11.1.1. Company Overview
11.1.2. Product Portfolio and Description
11.1.3. Key Highlights
11.1.4. Financial Overview
11.2. Bristol-Myers Squibb
11.3. Eli Lilly
11.4. Manus Aktteva Biopharma LLP
11.5. Hubei xinkang pharmaceutical chemical co.,ltd
11.6. Array BioPharma Inc.
11.7. NKMax
11.8. Pierre Fabre
11.9. Wuhan Sunrise Technology Development Company Limited
11.10. Chembest Research Laboratories Limited (LIST NOT EXHAUSTIVE)
12. Global Erbitux Market – DataM
12.1. Appendix
12.2. About Us and Services
12.3. Contact Us

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