Market Research Logo

Outsourcing in Drug Discovery: The Contract Research (CRO) Market, 3rd Edition

2008 has seen no decrease in the opportunities available for outsourcing drug discovery, for a number of reasons. New technologies increase the number of targets and accelerate the identification of active compounds. There is increasing pressure to develop new lead compounds due to the near-term loss of patent protection for many drug product. And there is also pressure to reduce the time spent in drug discovery and to bring drugs to market sooner, as well as the ever-present cost considerations.

Kalorama Information's Outsourcing in Drug Discovery offers unparalleled discussion of the drug discovery outsourcing market. It presents viewpoints from both customers and suppliers. Segments, size, and growth of the market are presented. The trend toward the increased use of offshore suppliers is covered in detail. The report also provides profiles of 23 suppliers, representative of those active in this market.

Segments covered in this report include:

  • Chemistry Services
    • Building Blocks
    • Compound Synthesis
    • Libraries
    • Process Research
    • Other Services

  • Biology Services
    • Protein Expression
    • Structural Analysis
    • Target Validation
    • Pathways Analysis
    • Other Services

  • Screening Services
    • Assay Development
    • Primary Screening
    • Secondary Screening

  • Lead Optimization
    • Early ADMET
    • Analogues Creation
    • Computational Support
    • Other services

In addition to market data and forecasts, the report covers issues such as:

  • What factors should a client consider when deciding whether to do a project in-house or outsource it?
  • Is it in the client's best interest to seek a domestic outsourcing partner, or go with an overseas supplier?
  • How does the client select the CRO that is best for him?
  • What are the best practices when working with a CRO?
  • How do you measure his effectiveness?
  • How do you avoid problems with your CRO?
  • How do you maximize benefits?

This report looks offshore at outsourcing suppliers based in three major areas: India, China, and Eastern Europe. The relative advantages each country provides are contrasted with some of their limitations. The report asses which projects are moving to which suppliers and why.


TABLE OF CONTENTS

CHAPTER ONE: EXECUTIVE SUMMARY
  • Overview
  • Scope and Methodology
  • Introduction
    • Pharmaceutical industry challenges
  • The Drug Discovery Process and Outsourcing
    • Accelerating the Drug Discovery Process
    • Bottlenecks in the Drug Discovery Process
    • Outsourcing to Increase Efficiency
  • The Outsourcing Decision
    • Developing an Outsourcing Plan
    • Contract Research Organization
    • Strategic Versus Tactical Outsourcing Model
    • Effective Communication Is Essentia
    • Mitigating the Challenges of Protecting IP Rights
  • Offshoring Contract Drug Discovery
    • Factors to Consider in Offshore Outsourcing
    • Benefits of Global Outsourcing
    • Cost Advantage
    • Concerns about Global Outsourcing
    • Outsourcing to China
    • WuXi China’s Largest CRO
    • First Chinese CRO Alliance
    • FDA to Establish Office at US Embassay in China
    • China's Handling of IP Rights and Laws
    • Outsourcing to India
    • India’s Handling of IP Rights and Laws
    • Outsourcing to Eastern Europe
  • Drug Discovery Outsourcing Market
    • Current Market and Forecast Summary
CHAPTER TWO: INTRODUCTION
  • Overview
    • Number of NME Filings in Decline While R&D Spending Rising
    • Ramping Up the Pipelines
  • Outsourcing Drug Discovery
  • The Outsourcing Decision
    • Decision Criteria
    • Factors to Consider in Offshore Outsourcing
    • Benefits of Global Outsourcing
      • Cost Advantage
      • Access to Talent and Technologies
      • Compressed Timelines
      • Increased Production
    • Concerns About Global Outsourcing
      • Intellectual Property Protection (IP)
      • Confidential Information and Trade Secrets
      • Fraud and Corruption
      • Meeting Regulatory Compliance Demands
      • Long Distance
  • Selecting a Contract Research Organization
    • Choosing the Right CRO
      • Experience is Paramount
      • Facility Standards
      • Excellent Track Record
    • Global Outsourcing
CHAPTER THREE: THE DRUG DISCOVERY PROCESS
  • Introduction—Discovery Stages
    • Target Identification
    • Target Validation
    • High Throughput Screening
    • Lead Optimization
  • Accelerating the Drug Discovery Process
  • Technologies Used in Drug Discovery
    • Combinatorial Chemistry
    • Bioinformatics/Pharmacogenomics
    • ADME/Tox Screening
    • High Throughput Screening
    • Computational Modeling and Bioinformatics
  • Addressing Bottlenecks in the Drug Discovery Process
  • Outsourcing to Increase Efficiency
    • Outsourcing to Access Novel Technologies
    • Bioinformatics
    • Lab-on-a-Chip: Microfluidics in Drug Discovery
CHAPTER FOUR: OUTSOURCING DRUG DISCOVERY
  • Overview
  • Contract Research Organizations
    • Introduction
    • Role of a CRO
    • Strategic Versus Tactical Outsourcing Model
    • The Tactical Model
    • The Strategic Model
    • Effective Communication is Essential for a Successful Partnership
    • Mitigating the Challenges of Protecting IP Rights
  • Offshoring Contract Drug Discovery
    • Introduction
    • Center of Gravity for the Pharmaceutical Industry Shifting from West to East
    • Evolution of Contract Drug Discovery in Asia
  • Outsourcing to China
    • Introduction
    • Multi-National Pharmaceutical Companies Establish Drug Discovery Facilities in China
    • Chinese Contract Research Organizations
      • WuXi China’s Largest CRO
      • First Chinese CRO Alliance
    • FDA to Establish Office at US Embassay in China
    • China's Handling of IP Rights and Laws
    • IP Rights Enforcement System
  • Outsourcing to India
    • Introduction
    • AstraZeneca Sets up Drug Discovery Facility in Bangalore
    • Drug Discovery Services in India
    • India’s Handling of IP Rights and Laws
      • Patent Filing Considerations
      • Limitations on Patentability
      • Compulsory Licenses
  • Outsourcing to Eastern Europe
    • Introduction
    • Russian and Ukraine CROs
CHAPTER FIVE: DRUG DISCOVERY OUTSOURCING MARKET
  • Overview
  • Current Market Size and Forecast
  • Contract Drug Discovery Competitors
    • Acquisitions to Gain Market Share or Entrance to the Market
  • Market Analysis by Segment
    • Chemistry Services Market and Forecast
    • Biology Services Market
    • High Throughput Screening Services Market
    • Lead Optimization Services Market
    • Current Market and Forecast
  • Market Growth Expanding Global Reach of Drug Discovery Services
CHAPTER SIX: COMPETITOR PROFILES
  • Albany Molecular Research, Inc.
    • History and Lines of Business
    • Drug Discovery Services
    • Financial Information
  • Asinex Ltd.
    • History and Lines of Business
    • Drug Discovery Services
  • BioDuro, Inc.
    • History and Lines of Business
    • Drug Discovery Services
      • Chemistry Services
      • Biology Services
    • Bridge Laboratories
      • History and Lines of Business
      • Drug Discovery Services
    • Services in U.S.
    • Services in China
    • Financial Information
  • Caliper Life Sciences
    • History and Lines of Business
    • Drug Discovery Services
    • Financial Information
  • Charles River Laboratories, Inc.
    • History and Lines of Business
    • Drug Discovery Services
    • Financial Information
  • Chembiotek Research
    • History and Lines of Business
    • Drug Development Services
  • ChemBridge Research Laboratories, Inc.
    • History and Lines of Business
    • Drug Discovery Services
  • Chemical Diversity Inc.
    • History and Lines of Business
      • Drug Discovery Services
      • Lead Optimization Services
      • High Throughput Services
      • Biologically Annotated Libraries
      • Focused Diversity
  • deCODE Chemistry and Biostructures
    • History and Lines of Business
    • Drug Discovery Services
      • Structural Biology Services
      • High Throughput Screening & Assay Services
      • Lead Optimization
      • Financial Information
  • Enamine Ltd.
    • History and Lines of Business
    • Drug Discovery Services
      • Screening Compounds
      • Screening Compounds From REAL Database®
      • Lead Optimization
      • Discovery Chemistry and Custom Synthesis
      • Research
  • Evotec OAI
    • History and Lines of Business
    • Drug Discovery Services
      • Assay Development Services
      • High throughput Screening
      • Medicinal Chemistry Services
      • Compound Library Services
    • Financial Information
  • GVK Biosciences Private Limited
    • History and Lines of Business
    • Drug Discovery Services
      • Bioinformatics
      • Chemoinformatics
      • Structural Biology
      • Biology Services
  • Hutchison MediPharma Ltd.
    • History and Lines of Business
    • Drug Discovery Services
      • Discovery Chemistry
      • Discovery Biology
      • Discovery Pharmacology
      • Drug Metabolism and Pharmacokinetics (DMPK)
  • J-Star Research, Inc.
    • History and Lines of Business
    • Drug Discovery Services
  • Jubilant Biosys Ltd.
    • History and Lines of Business
    • Drug Discovery Services
    • Discovery Informatics
    • Discovery Research
    • Drug Development
    • IT Services
  • MDS Pharma Services
    • History and Lines of Business
    • Drug Discovery Services
    • Financial Information
  • Medicilon Inc.
    • History and Lines of Business
    • Drug Discovery Services
      • Custom Chemical Synthesis
      • Pharmacokinetics
      • Metabolism Services
      • Bioanalytical Services
      • Structural Biology Services
      • Other Biological Services
  • Pharmacopeia Drug Discovery, Inc.
    • History and Lines of Business
    • Drug Discovery Services
      • Lead Optimization
      • ADME and Toxicity Characteristics of New Molecules
      • In vivo Optimization
      • Early ADME/Tox Determination
    • Financial Information
  • Ricerca Biosciences, LLC
    • History and Lines of Business
    • Drug Discovery Services
    • Financial Information
  • Scynexis, Inc.
    • History and Lines Business
    • Drug Discovery Services
      • Medicinal Chemistry
      • Custom Synthesis
      • High Throughput Purification & Analysis
      • ADMET & Bioanalytical Services
      • Bioanalytical Capabilities
      • Data Management And Collaboration
  • Shanghai ChemPartner Co.,Ltd.
    • History and Lines of Business
    • Drug Discovery Services
    • Discovery Chemistry
    • Library Generation
    • Analytical Chemistry
    • Medicinal Chemistry
    • ADME Studies
    • Natural Product Chemistry
    • Computational Chemistry and Drug Design
  • WuXI PharmaTech Co. Ltd.
    • History and Lines of Buisness
    • Drug Discovery Services
    • Discovery Chemistry Services
    • Analytical Services
    • Biological Services
    • Financial Information

APPENDIX: COMPANY DIRECTORY

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

  • Exhibit 1-1: Drug Discovery Timeline: Research to Viable Product to Commercialization

  • Exhibit 1-2: NMEs and New BLAs Filed, 1996-2007

  • Exhibit 1-3: Global R&D Spending, 1996-2007

  • Exhibit 1-4: Global Drug Discovery Outsourcing Market 2005-2013

  • Exhibit 1-5: Share of Outsourced Drug Discovery Market by Segment (Biology Services, Chemistry Services, Lead Optimization, High Throughput Screening) 2007
CHAPTER TWO: INTRODUCTION

  • Exhibit 2-1: Number of NMEs and New BLAs Filed 1996-2007

  • Exhibit 2-2: Global R&D Spending 1996-2007

  • Exhibit 2-3: Factors Involved in Making Outsourcing Decisions
CHAPTER THREE: THE DRUG DISCOVERY PROCESS

  • Exhibit 3-1: The Drug Discovery Process

  • Exhibit 3-2: Drug Discovery Timeline: Research to Viable Product to Commercialization

  • Exhibit 3-3: Bioinformatics/Pharmacogenomics: The Role of the “-Omics”

  • Exhibit 3-4: Causes of New Drug Attrition

  • Exhibit 3-5: Drug Discovery Processes Frequently Outsourced

  • Exhibit 3-6: Bioinformatics as a Central Hub A Schematic of Discovery Disciplines and Methods
CHAPTER FOUR: OUTSOURCING DRUG DISCOVERY

  • Exhibit 4-1: Major Chinese Drug Discovery CROs (Company, Location, Services)

  • Exhibit 4-2: Major Indian Drug Discovery CROs (Company, Location, Services)

  • Exhibit 4-3: Major CROs Operating in Russia and the Ukraine
CHAPTER FIVE: DRUG DISCOVERY OUTSOURCING MARKET

  • Exhibit 5-1: Global Drug Discovery Outsourcing Market 2005-2013

  • Exhibit 5-2: Contract Drug Discovery Services by Market Segment (Chemistry, Biology, High-Throughput Screening, Lead Optimization) 2005-2013

  • Exhibit 5-3: Leading Contractors by Market Segment

  • Exhibit 5-4: Major Acquisitions in Drug Discovery Outsourcing

  • Exhibit 5-5: Market Share of the Segments within the Drug Discovery Market 2007

  • Exhibit 5-6: Chemistry Services Market: Revenues, Annual Growth, and Share of the Outsourced Drug Discovery Market 2005-2013

  • Exhibit 5-7: Chemistry Market Revenue by Service Type (Building Blocks Compound Synthesis, Libraries, Process Research, Other Services) 2007

  • Exhibit 5-8: Biology Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market 2005-2013

  • Exhibit 5-9: Biology Market Revenue by Service Type (Protein Expression, Structural Analysis, Target Validation, Pathways Analysis, Other Service) 2007

  • Exhibit 5-10: Screening Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market 2005-2013

  • Exhibit 5-11: Screening Services Market Revenue by Service Type (Assay Development, Primary Screening, Secondary Screening) 2007

  • Exhibit 5-12: Lead Optimization Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market 2005-2013

  • Exhibit 5-13: Lead Optimization Services Market by Service Type (Early ADME/Tox, Create Analogues,Computational Support, and Other Services) 2007

  • Exhibit 5-14: Global Expansion of Drug Discovery Services: A Selection of Companies Expanding East and West

Download our eBook: How to Succeed Using Market Research

Learn how to effectively navigate the market research process to help guide your organization on the journey to success.

Download eBook

Share this report