Soluble Guanylate Cyclase (sGC or EC 18.104.22.168) - Pipeline Review, H2 2019
According to the recently published report 'Soluble Guanylate Cyclase (sGC or EC 22.214.171.124) - Pipeline Review, H2 2019'; Soluble Guanylate Cyclase (sGC or EC 126.96.36.199) pipeline Target constitutes close to 30 molecules. Out of which approximately 27 molecules are developed by companies and remaining by the universities/institutes.
Soluble Guanylate Cyclase (sGC or EC 188.8.131.52) - Soluble guanylyl cyclase (sGC) is the known receptor for nitric oxide. Binding of nitric oxide to the heme moiety of the cyclase induces its capacity to synthesize the second messenger cGMP. Although the changes in the state of the heme moiety upon exposure of enzyme to NO and its correlation to the stimulation of sGC catalytic activity.
The report 'Soluble Guanylate Cyclase (sGC or EC 184.108.40.206) - Pipeline Review, H2 2019' outlays comprehensive information on the Soluble Guanylate Cyclase (sGC or EC 220.127.116.11) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Soluble Guanylate Cyclase (sGC or EC 18.104.22.168) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I and Preclinical stages are 3, 6, 4 and 14 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 2 and 1 molecules, respectively. Report covers products from therapy areas Cardiovascular, Ophthalmology, Metabolic Disorders, Respiratory, Gastrointestinal, Hematological Disorders, Infectious Disease, Oncology, Central Nervous System, Dermatology, Genetic Disorders, Genito Urinary System And Sex Hormones, Immunology and Musculoskeletal Disorders which include indications Glaucoma, Ocular Hypertension, Pulmonary Arterial Hypertension, Diabetic Nephropathy, Diastolic Heart Failure, Open-Angle Glaucoma, Sickle Cell Disease, Acute Heart Failure, Acute Respiratory Distress Syndrome, Alzheimer's Disease, Chronic Kidney Disease (Chronic Renal Failure), Chronic Thromboembolic Pulmonary Hypertension, Coronary Artery Disease (CAD) (Ischemic Heart Disease), Cystic Fibrosis, Diabetic Foot Ulcers, Duchenne Muscular Dystrophy, Inflammation, Ischemic Stroke, Liver Diseases, Liver Fibrosis, Lung Disease, Mycobacterium Infections, Non-Alcoholic Steatohepatitis (NASH), Onychomycosis (Tinea Unguium), Osteoporosis, Pancreatic Cancer, Prostate Cancer, Pulmonary Hypertension, Stroke, Systolic Heart Failure, Tinea Pedis (Athlete Foot), Vascular Dementias, Vaso-Occlusive Crisis Associated With Sickle Cell Disease and Wounds.
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