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Skeletal Disease Drug Development Pipeline Review, 2017

Skeletal Disease Drug Development Pipeline Review, 2017

Summary


This report provides an overview of the skeletal disease pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for osteoporosis, post-menopausal osteoporosis and osteoarthritis (OA).

OA is one of the most common forms of arthritis. It is a chronic condition in which the cartilage breaks down. There are a total of 116 products in development for this indication, by 87 companies and 8 academic institutions. Key companies operating in this pipeline space include Arcarios, Nordic Bioscience, Rottapharm Biotech and the University of Toledo.

Osteoporosis, or thinning bones, makes bones weak and more likely to break. Risk factors for osteoporosis include aging, being female, low body weight, low sex hormones or menopause, smoking, and some medications. There are a total of 112 products in development for this indication, by 80 companies and 16 academic institutions. Key companies operating in this pipeline space include Max Biopharma, Omeros, Affilogic laboratories, Amgen and the University of Wisconsin Madison.

Postmenopausal osteoporosis is the most common form of osteoporosis. It affects many women after menopause. There are a total of 13 products in development for this indication, by ten companies. Key companies operating in this pipeline space include Amgen and Ipsen.

The predominant targets within OA are prostaglandin G/H synthases 1 and 2, although a wide range of targets, including extracellular matrix-organizing proteins and interleukins, are being studied. Likewise, within both osteoporosis and the post-menopausal subtype, a broad range of molecular targets are being studied. The targets being most frequently studied are the parathyroid hormone receptor, tumor necrosis factor ligand superfamily member 11 and sclerostin.

Scope

  • Which companies are the most active within the pipeline for osteoporosis and OA therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of osteoporosis and OA therapeutics?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


  • GBI Research Report Guidance
  • Executive Summary
  • Introduction
    • Skeletal Disease Report Coverage
    • Osteoarthritis – Overview
    • Osteoporosis – Overview
    • Post Menopausal Osteoporosis – Overview
  • Therapeutics Development
    • Osteoarthritis
      • Pipeline Overview
        • Table Figure 1: Number of Products under Development for Osteoarthritis
        • Table Number of Products under Development for Osteoarthritis
      • Pipeline by Companies
        • Table Figure 2: Number of Products under Development by Companies, Osteoarthritis
        • Table Number of Products under Development by Companies, Osteoarthritis
      • Pipeline by Universities/Institutes
        • Table Figure 3: Number of Products under Development by Universities/Institutes, Osteoarthritis
        • Table Number of Products under Development by Universities/Institutes, Osteoarthritis
      • Products under Development by Companies
        • Table Products under Development by Companies, Osteoarthritis
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Osteoarthritis
    • Osteoporosis
      • Pipeline Overview
        • Table Figure 4: Number of Products under Development for Osteoporosis
        • Table Number of Products under Development for Osteoporosis
      • Pipeline by Companies
        • Table Figure 5: Number of Products under Development by Companies, Osteoporosis
        • Table Number of Products under Development by Companies, Osteoporosis
      • Pipeline by Universities/Institutes
        • Table Figure 6: Number of Products under Development by Universities/Institutes, Osteoporosis
        • Table Number of Products under Development by Universities/Institutes, Osteoporosis
      • Products under Development by Companies
        • Table Products under Development by Companies, Osteoporosis
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Osteoporosis
    • Post Menopausal Osteoporosis
      • Pipeline Overview
        • Table Figure 7: Number of Products under Development for Post Menopausal Osteoporosis
        • Table Number of Products under Development for Post Menopausal Osteoporosis
      • Pipeline by Companies
        • Table Figure 8: Number of Products under Development by Companies, Post Menopausal Osteoporosis
        • Table Number of Products under Development by Companies, Post Menopausal Osteoporosis
      • Products under Development by Companies
        • Table Products under Development by Companies, Post Menopausal Osteoporosis
  • Therapeutics Assessment
    • Osteoarthritis
      • Assessment by Target
        • Table Figure 9: Number of Products by Top 10 Targets, Osteoarthritis
        • Table Figure 10: Number of Products by Stage and Top 10 Targets, Osteoarthritis
        • Table Number of Products by Stage and Target, Osteoarthritis
      • Assessment by Mechanism of Action
        • Table Figure 11: Number of Products by Top 10 Mechanism of Actions, Osteoarthritis
        • Table Figure 12: Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis
        • Table Number of Products by Stage and Mechanism of Action, Osteoarthritis
      • Assessment by Route of Administration
        • Table Figure 13: Number of Products by Routes of Administration, Osteoarthritis
        • Table Figure 14: Number of Products by Stage and Routes of Administration, Osteoarthritis
        • Table Number of Products by Stage and Route of Administration, Osteoarthritis
      • Assessment by Molecule Type
        • Table Figure 15: Number of Products by Top 10 Molecule Types, Osteoarthritis
        • Table Figure 16: Number of Products by Stage and Top 10 Molecule Types, Osteoarthritis
        • Table Number of Products by Stage and Molecule Type, Osteoarthritis
    • Osteoporosis
      • Assessment by Target
        • Table Figure 17: Number of Products by Top 10 Targets, Osteoporosis
        • Table Figure 18: Number of Products by Stage and Top 10 Targets, Osteoporosis
        • Table Number of Products by Stage and Target, Osteoporosis
      • Assessment by Mechanism of Action
        • Table Figure 19: Number of Products by Top 10 Mechanism of Actions, Osteoporosis
        • Table Figure 20: Number of Products by Stage and Top 10 Mechanism of Actions, Osteoporosis
        • Table Number of Products by Stage and Mechanism of Action, Osteoporosis
      • Assessment by Route of Administration
        • Table Figure 21: Number of Products by Top 10 Routes of Administration, Osteoporosis
        • Table Figure 22: Number of Products by Stage and Top 10 Routes of Administration, Osteoporosis
        • Table Number of Products by Stage and Route of Administration, Osteoporosis
      • Assessment by Molecule Type
        • Table Figure 23: Number of Products by Top 10 Molecule Types, Osteoporosis
        • Table Figure 24: Number of Products by Stage and Top 10 Molecule Types, Osteoporosis
        • Table Number of Products by Stage and Molecule Type, Osteoporosis
    • Post Menopausal Osteoporosis
      • Assessment by Target
        • Table Figure 25: Number of Products by Targets, Post Menopausal Osteoporosis
        • Table Figure 26: Number of Products by Stage and Targets, Post Menopausal Osteoporosis
        • Table Number of Products by Stage and Target, Post Menopausal Osteoporosis
      • Assessment by Mechanism of Action
        • Table Figure 27: Number of Products by Mechanism of Actions, Post Menopausal Osteoporosis
        • Table Figure 28: Number of Products by Stage and Mechanism of Actions, Post Menopausal Osteoporosis
        • Table Number of Products by Stage and Mechanism of Action, Post Menopausal Osteoporosis
      • Assessment by Route of Administration
        • Table Figure 29: Number of Products by Routes of Administration, Post Menopausal Osteoporosis
        • Table Figure 30: Number of Products by Stage and Routes of Administration, Post Menopausal Osteoporosis
        • Table Number of Products by Stage and Route of Administration, Post Menopausal Osteoporosis
      • Assessment by Molecule Type
        • Table Figure 31: Number of Products by Molecule Types, Post Menopausal Osteoporosis
        • Table Figure 32: Number of Products by Stage and Molecule Types, Post Menopausal Osteoporosis
        • Table Number of Products by Stage and Molecule Type, Post Menopausal Osteoporosis
  • Companies Involved in Therapeutics Development
    • Osteoarthritis
      • A. Menarini Industrie Farmaceutiche Riunite Srl
        • Table Osteoarthritis – Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl
      • AbbVie Inc
        • Table Osteoarthritis – Pipeline by AbbVie Inc
      • Abiogen Pharma SpA
        • Table Osteoarthritis – Pipeline by Abiogen Pharma SpA
      • Ablynx NV
        • Table Osteoarthritis – Pipeline by Ablynx NV
      • Achelios Therapeutics Inc
        • Table Osteoarthritis – Pipeline by Achelios Therapeutics Inc
      • Addex Therapeutics Ltd
        • Table Osteoarthritis – Pipeline by Addex Therapeutics Ltd
      • Amgen Inc
        • Table Osteoarthritis – Pipeline by Amgen Inc
      • Amura Holdings Ltd
        • Table Osteoarthritis – Pipeline by Amura Holdings Ltd
      • Arcarios BV
        • Table Osteoarthritis – Pipeline by Arcarios BV
      • Asahi Kasei Pharma Corp
        • Table Osteoarthritis – Pipeline by Asahi Kasei Pharma Corp
      • Asklepios BioPharmaceutical Inc
        • Table Osteoarthritis – Pipeline by Asklepios BioPharmaceutical Inc
      • Astellas Pharma Inc
        • Table Osteoarthritis – Pipeline by Astellas Pharma Inc
      • Biopharm GmbH
        • Table Osteoarthritis – Pipeline by Biopharm GmbH
      • Bone Therapeutics SA
        • Table Osteoarthritis – Pipeline by Bone Therapeutics SA
      • Can-Fite BioPharma Ltd
        • Table Osteoarthritis – Pipeline by Can-Fite BioPharma Ltd
      • Cardax Inc
        • Table Osteoarthritis – Pipeline by Cardax Inc
      • Cellular Biomedicine Group Inc
        • Table Osteoarthritis – Pipeline by Cellular Biomedicine Group Inc
      • Cipla Ltd
        • Table Osteoarthritis – Pipeline by Cipla Ltd
      • Corestem Inc
        • Table Osteoarthritis – Pipeline by Corestem Inc
      • Dong-A Socio Holdings Co Ltd
        • Table Osteoarthritis – Pipeline by Dong-A Socio Holdings Co Ltd
      • Evgen Pharma Plc
        • Table Osteoarthritis – Pipeline by Evgen Pharma Plc
      • F. Hoffmann-La Roche Ltd
        • Table Osteoarthritis – Pipeline by F. Hoffmann-La Roche Ltd
      • Galapagos NV
        • Table Osteoarthritis – Pipeline by Galapagos NV
      • Gemphire Therapeutics Inc
        • Table Osteoarthritis – Pipeline by Gemphire Therapeutics Inc
      • GeneFrontier Corp
        • Table Osteoarthritis – Pipeline by GeneFrontier Corp
      • Genequine Biotherapeutics GmbH
        • Table Osteoarthritis – Pipeline by Genequine Biotherapeutics GmbH
      • GlaxoSmithKline Plc
        • Table Osteoarthritis – Pipeline by GlaxoSmithKline Plc
      • HSRx Group
        • Table Osteoarthritis – Pipeline by HSRx Group
      • InKemia IUCT Group SA
        • Table Osteoarthritis – Pipeline by InKemia IUCT Group SA
      • International Stem Cell Corp
        • Table Osteoarthritis – Pipeline by International Stem Cell Corp
      • Jeil Pharmaceutical Co Ltd
        • Table Osteoarthritis – Pipeline by Jeil Pharmaceutical Co Ltd
      • Jenrin Discovery Inc
        • Table Osteoarthritis – Pipeline by Jenrin Discovery Inc
      • K-Stemcell Co Ltd
        • Table Osteoarthritis – Pipeline by K-Stemcell Co Ltd
      • Kang Stem Biotech Co Ltd
        • Table Osteoarthritis – Pipeline by Kang Stem Biotech Co Ltd
      • Levolta Pharmaceuticals Inc
        • Table Osteoarthritis – Pipeline by Levolta Pharmaceuticals Inc
      • LG Chem, Ltd.
        • Table Osteoarthritis – Pipeline by LG Chem, Ltd.
      • Marina Biotech Inc
        • Table Osteoarthritis – Pipeline by Marina Biotech Inc
      • Medivir AB
        • Table Osteoarthritis – Pipeline by Medivir AB
      • Merck KGaA
        • Table Osteoarthritis – Pipeline by Merck KGaA
      • Mesoblast Ltd
        • Table Osteoarthritis – Pipeline by Mesoblast Ltd
      • Mor Research Application Ltd
        • Table Osteoarthritis – Pipeline by Mor Research Application Ltd
      • NicOx SA
        • Table Osteoarthritis – Pipeline by NicOx SA
      • Nordic Bioscience A/S
        • Table Osteoarthritis – Pipeline by Nordic Bioscience A/S
      • Novartis AG
        • Table Osteoarthritis – Pipeline by Novartis AG
      • NovelMed Therapeutics Inc
        • Table Osteoarthritis – Pipeline by NovelMed Therapeutics Inc
      • Omeros Corp
        • Table Osteoarthritis – Pipeline by Omeros Corp
      • Ono Pharmaceutical Co Ltd
        • Table Osteoarthritis – Pipeline by Ono Pharmaceutical Co Ltd
      • OrthoCyte Corp
        • Table Osteoarthritis – Pipeline by OrthoCyte Corp
      • Osteologix Holdings Plc
        • Table Osteoarthritis – Pipeline by Osteologix Holdings Plc
      • Pfizer Inc
        • Table Osteoarthritis – Pipeline by Pfizer Inc
      • Pharmalink AB
        • Table Osteoarthritis – Pipeline by Pharmalink AB
      • Philogen SpA
        • Table Osteoarthritis – Pipeline by Philogen SpA
      • PhytoHealth Corp
        • Table Osteoarthritis – Pipeline by PhytoHealth Corp
      • PLx Pharma Inc
        • Table Osteoarthritis – Pipeline by PLx Pharma Inc
      • ProteoThera Inc
        • Table Osteoarthritis – Pipeline by ProteoThera Inc
      • Regeneus Ltd
        • Table Osteoarthritis – Pipeline by Regeneus Ltd
      • Regulaxis SAS
        • Table Osteoarthritis – Pipeline by Regulaxis SAS
      • Rottapharm Biotech Srl
        • Table Osteoarthritis – Pipeline by Rottapharm Biotech Srl
      • Samumed LLC
        • Table Osteoarthritis – Pipeline by Samumed LLC
      • Seikagaku Corp
        • Table Osteoarthritis – Pipeline by Seikagaku Corp
      • Stelis Biopharma Pvt Ltd
        • Table Osteoarthritis – Pipeline by Stelis Biopharma Pvt Ltd
      • Takeda Pharmaceutical Company Ltd
        • Table Osteoarthritis – Pipeline by Takeda Pharmaceutical Company Ltd
      • TissueGene Inc
        • Table Osteoarthritis – Pipeline by TissueGene Inc
      • Yooyoung Pharmaceutical Co Ltd
        • Table Osteoarthritis – Pipeline by Yooyoung Pharmaceutical Co Ltd
      • Yuhan Corp
        • Table Osteoarthritis – Pipeline by Yuhan Corp
      • Yungjin Pharm Co Ltd
        • Table Osteoarthritis – Pipeline by Yungjin Pharm Co Ltd
      • Zimmer Biomet Holdings Inc
        • Table Osteoarthritis – Pipeline by Zimmer Biomet Holdings Inc
    • Osteoporosis
      • Addex Therapeutics Ltd
        • Table Osteoporosis – Pipeline by Addex Therapeutics Ltd
      • Alize Pharma SAS
        • Table Osteoporosis – Pipeline by Alize Pharma SAS
      • Alvogen Korea Co Ltd
        • Table Osteoporosis – Pipeline by Alvogen Korea Co Ltd
      • Amgen Inc
        • Table Osteoporosis – Pipeline by Amgen Inc
      • Amura Holdings Ltd
        • Table Osteoporosis – Pipeline by Amura Holdings Ltd
      • BiologicsMD Inc
        • Table Osteoporosis – Pipeline by BiologicsMD Inc
      • Bone Biologics Corp
        • Table Osteoporosis – Pipeline by Bone Biologics Corp
      • Bristol-Myers Squibb Company
        • Table Osteoporosis – Pipeline by Bristol-Myers Squibb Company
      • Cellmid Ltd
        • Table Osteoporosis – Pipeline by Cellmid Ltd
      • ChoDang Pharm Co Ltd
        • Table Osteoporosis – Pipeline by ChoDang Pharm Co Ltd
      • Chugai Pharmaceutical Co Ltd
        • Table Osteoporosis – Pipeline by Chugai Pharmaceutical Co Ltd
      • Corium International Inc
        • Table Osteoporosis – Pipeline by Corium International Inc
      • Critical Pharmaceuticals Ltd
        • Table Osteoporosis – Pipeline by Critical Pharmaceuticals Ltd
      • Daiichi Sankyo Company Ltd
        • Table Osteoporosis – Pipeline by Daiichi Sankyo Company Ltd
      • ElexoPharm GmbH
        • Table Osteoporosis – Pipeline by ElexoPharm GmbH
      • EndoCeutics Inc
        • Table Osteoporosis – Pipeline by EndoCeutics Inc
      • Entera Bio Ltd
        • Table Osteoporosis – Pipeline by Entera Bio Ltd
      • Enteris BioPharma Inc
        • Table Osteoporosis – Pipeline by Enteris BioPharma Inc
      • Enzo Biochem Inc
        • Table Osteoporosis – Pipeline by Enzo Biochem Inc
      • F. Hoffmann-La Roche Ltd
        • Table Osteoporosis – Pipeline by F. Hoffmann-La Roche Ltd
      • Gador SA
        • Table Osteoporosis – Pipeline by Gador SA
      • GL Pharm Tech Corp
        • Table Osteoporosis – Pipeline by GL Pharm Tech Corp
      • Glide Pharmaceutical Technologies Ltd
        • Table Osteoporosis – Pipeline by Glide Pharmaceutical Technologies Ltd
      • Hanmi Pharmaceuticals Co Ltd
        • Table Osteoporosis – Pipeline by Hanmi Pharmaceuticals Co Ltd
      • Haoma Medica Ltd
        • Table Osteoporosis – Pipeline by Haoma Medica Ltd
      • Immunovo BV
        • Table Osteoporosis – Pipeline by Immunovo BV
      • Immunwork Inc
        • Table Osteoporosis – Pipeline by Immunwork Inc
      • Intas Pharmaceuticals Ltd
        • Table Osteoporosis – Pipeline by Intas Pharmaceuticals Ltd
      • Ipsen SA
        • Table Osteoporosis – Pipeline by Ipsen SA
      • Kaken Pharmaceutical Co Ltd
        • Table Osteoporosis – Pipeline by Kaken Pharmaceutical Co Ltd
      • Lead Discovery Center GmbH
        • Table Osteoporosis – Pipeline by Lead Discovery Center GmbH
      • Ligand Pharmaceuticals Inc
        • Table Osteoporosis – Pipeline by Ligand Pharmaceuticals Inc
      • Lotus Pharmaceutical Co Ltd
        • Table Osteoporosis – Pipeline by Lotus Pharmaceutical Co Ltd
      • Lupin Ltd
        • Table Osteoporosis – Pipeline by Lupin Ltd
      • Merck & Co Inc
        • Table Osteoporosis – Pipeline by Merck & Co Inc
      • Mereo Biopharma Group Plc
        • Table Osteoporosis – Pipeline by Mereo Biopharma Group Plc
      • NIBEC
        • Table Osteoporosis – Pipeline by NIBEC
      • Omeros Corp
        • Table Osteoporosis – Pipeline by Omeros Corp
      • Oncobiologics Inc
        • Table Osteoporosis – Pipeline by Oncobiologics Inc
      • Osteologix Holdings Plc
        • Table Osteoporosis – Pipeline by Osteologix Holdings Plc
      • Paras Biopharmaceuticals Finland Oy
        • Table Osteoporosis – Pipeline by Paras Biopharmaceuticals Finland Oy
      • Pfenex Inc
        • Table Osteoporosis – Pipeline by Pfenex Inc
      • PhytoHealth Corp
        • Table Osteoporosis – Pipeline by PhytoHealth Corp
      • R Pharm
        • Table Osteoporosis – Pipeline by R Pharm
      • Ribomic Inc
        • Table Osteoporosis – Pipeline by Ribomic Inc
      • Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
        • Table Osteoporosis – Pipeline by Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd
      • Shin Poong PharmCo Ltd
        • Table Osteoporosis – Pipeline by Shin Poong PharmCo Ltd
      • Sinil Pharmaceutical Co Ltd
        • Table Osteoporosis – Pipeline by Sinil Pharmaceutical Co Ltd
      • Stelis Biopharma Pvt Ltd
        • Table Osteoporosis – Pipeline by Stelis Biopharma Pvt Ltd
      • Sumitomo Dainippon Pharma Co Ltd
        • Table Osteoporosis – Pipeline by Sumitomo Dainippon Pharma Co Ltd
      • Terpenoid Therapeutics Inc
        • Table Osteoporosis – Pipeline by Terpenoid Therapeutics Inc
      • TSH Biopharm Corporation Ltd
        • Table Osteoporosis – Pipeline by TSH Biopharm Corporation Ltd
      • Uni-Bio Science Group Ltd
        • Table Osteoporosis – Pipeline by Uni-Bio Science Group Ltd
      • Viking Therapeutics Inc
        • Table Osteoporosis – Pipeline by Viking Therapeutics Inc
      • Wroclawskie Centrum Badan EIT+ Sp z oo
        • Table Osteoporosis – Pipeline by Wroclawskie Centrum Badan EIT+ Sp z oo
      • Yooyoung Pharm Co Ltd
        • Table Osteoporosis – Pipeline by Yooyoung Pharm Co Ltd
      • Zydus Cadila Healthcare Ltd
        • Table Osteoporosis – Pipeline by Zydus Cadila Healthcare Ltd
    • Post Menopausal Osteoporosis
      • Amgen Inc
        • Table Post Menopausal Osteoporosis – Pipeline by Amgen Inc
      • Enteris BioPharma Inc
        • Table Post Menopausal Osteoporosis – Pipeline by Enteris BioPharma Inc
      • Intas Pharmaceuticals Ltd
        • Table Post Menopausal Osteoporosis – Pipeline by Intas Pharmaceuticals Ltd
      • Ipsen SA
        • Table Post Menopausal Osteoporosis – Pipeline by Ipsen SA
      • Ligand Pharmaceuticals Inc
        • Table Post Menopausal Osteoporosis – Pipeline by Ligand Pharmaceuticals Inc
      • Lupin Ltd
        • Table Post Menopausal Osteoporosis – Pipeline by Lupin Ltd
      • NIBEC
        • Table Post Menopausal Osteoporosis – Pipeline by NIBEC
      • Oncobiologics Inc
        • Table Post Menopausal Osteoporosis – Pipeline by Oncobiologics Inc
      • Paras Biopharmaceuticals Finland Oy
        • Table Post Menopausal Osteoporosis – Pipeline by Paras Biopharmaceuticals Finland Oy
  • Dormant Projects
    • Osteoarthritis
      • Table Osteoarthritis – Dormant Projects
    • Osteoporosis
      • Table Osteoporosis – Dormant Projects
    • Post Menopausal Osteoporosis
      • Table Post Menopausal Osteoporosis – Dormant Projects
  • Discontinued Products
    • Osteoarthritis
      • Table Osteoarthritis – Discontinued Products
    • Osteoporosis
      • Table Osteoporosis – Discontinued Products
    • Post Menopausal Osteoporosis
      • Table Post Menopausal Osteoporosis – Discontinued Products
  • Product Development Milestones
    • Osteoarthritis
      • Featured News & Press Releases
    • Osteoporosis
      • Featured News & Press Releases
    • Post Menopausal Osteoporosis
      • Featured News & Press Releases
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

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