Global Immunology Market to 2022 - Large pipeline and competitive market to drive long-term market growth
Immune-mediated inflammatory diseases are a very common set of chronic disorders that affect 5–7% of western populations. Although they are often disparate in terms of their symptoms and key patient demographics, they are pathophysiologically linked, being characterized by dysregulation of immune pathways and an inappropriate immune response. Generally, disease-modifying anti-rheumatic drugs, a highly genericized class of systemic small-molecule-based agents, are used in the first-line treatment of these diseases. These are supplemented in many cases by shorter-term glucocorticoid therapy, another class of highly genericized systemic agents.
However, as these therapies often fail to elicit an adequate long-term response, a large second-line therapy segment has emerged in these markets, beginning with the approval of Remicade (infliximab) and Enbrel (etanercept) in 1998. This segment consists largely of premium systemic monoclonal Antibodies (mAbs), which are highly commercially successful due to their widespread usage and high cost. Although the patents for many of these mAbs either have already expired or are due to expire during the forecast period, the market is expected to experience continued growth.
Although the patents for many of these mAbs either have already expired or are due to expire during the forecast period, the market is expected to experience continued growth, from $61.5 billion in 2015 to $74.2 billion in 2022, at a compound annual growth rate of 2.71%.
Global Immunology Treatment Market Will Exceed $74 Billion by 2022, says GBI Research
Despite the imminent patent expiry of many therapies, the global immunology treatment market is set to expand, from $61.5 billion in 2015 to reach $74.2 billion in 2022, says business intelligence provider GBI Research.
According to the company’s latest report*, the immunology treatment market’s Compound Annual Growth Rate (CAGR) will equal a relatively stable 2.71%, due to practical and regulatory barriers to entry for biosimilars that are not present for small molecule generics, and a moderately strong late-stage pipeline.
Dominic Trewartha, Managing Analyst for GBI Research, says: “This market is a lucrative area as up to 7% of western populations are thought to be affected by chronic immunological disorders. Consequently, the pharmaceutical pipeline for immunology is considerable, with 1,896 products currently in active development.
“While 85 of these are in Phase III of the process, it must be acknowledged that 73% of these pipeline products are in early developmental stages.”
GBI Research’s study suggests there are a number of prospective products expected to achieve strong annual revenues during the forecast period, although these are not anticipated to achieve revenues comparable to those generated by the current strongest-selling immunology products.
Trewartha explains: “To date, the most clinically and commercially effective drugs have been in a class of compounds known as monoclonal Antibodies (mAbs), which includes blockbuster products such as Humira (adalimumab) and Remicade (infliximab).
“APB-501, a biosimilar of Humira, which was the best-selling drug of 2014 worldwide, is anticipated to generate annual revenues of almost $1 billion by 2022, making it an exceptionally strong-performing non-patented drug.”
The analyst adds that while the immunology therapeutics market is a very commercially active area, with a number of exceptionally high-selling products present, revenues for these key drugs are expected to undergo a steady decline towards the end of the period.
Trewartha concludes: “GBI Research believes that revenues for immunology therapeutics will only significantly decline in the long term, beyond the forecast period. This is due to the protective effect of the practical and regulatory challenges in fielding biosimilar products, which reduces the impact of patent expiries on biologics, compared with small molecules.”
*Global Immunology Market to 2022 - Large pipeline and competitive market to drive long-term market growth
This report provides analysis of the immune-mediated inflammatory diseases treatment pipeline, stratified by stage of development, molecule type and molecular target. It includes information on the current clinical and commercial landscape, and the composition of the immunology therapeutics space in terms of dominant molecule types and targets, as well as highlighting key market players and their future prospects.
This report was built using data and information sourced from proprietary databases, primary and secondary research, and in-house analysis conducted by GBI Research’s team of industry experts.
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