Colorectal Cancer Therapeutics in Major Developed Markets to 2020 - Increased Uptake of High Priced Drugs to Offset the Impact of Generics
GBI Research, the leading business intelligence provider, has released its latest research, “Colorectal Cancer Therapeutics in Major Developed Markets to 2020 - Increased Uptake of High Priced Drugs to Offset the Impact of Generics”, which provides in-depth analysis of the Colorectal Cancer (CRC) therapeutics market in the eight major geographies of the US, Canada, the UK, France, Germany, Spain, Italy and Japan. The report provides an estimation of the market size for 2013, along with market forecast until 2020. It also covers disease epidemiology, treatment algorithms, treatment patterns, in-depth pipeline analysis, and deal analysis.
The CRC therapeutics market in the eight major markets is expected to grow at a Compound Annual Growth Rate (CAGR) of 1.8% to $9.4 billion by 2020. The US had the largest market share in 2013, equivalent to a global share of 44.1%, followed by Japan and Germany with 14.7% and 11.9% respectively. Spain had the lowest market share of the leading eight at 4.1%. All markets covered in the report are expected to witness a slower growth rate than Japan, which will grow at a CAGR of 5%. However, this moderate growth will be stymied by the expected uptake of lower-priced biosimilar versions of bevacizumab and cetuximab due to the expiration of the patents of Avastin and Erbitux in the latter half of the forecast period. Also expected is the launch of generic versions of capecitabine, which will also affect the market. However, this will be offset by the launch of premium-priced emerging therapies. Stivarga is expected to be one of the biggest drivers of growth in the CRC market, primarily due to its expected line extension in the first-line metastatic setting as a maintenance treatment for patients with resected liver metastases. The launch of Lonsurf (TAS-102), approved in Japan in 2014, in the third- and fourth-line settings will further increase the pharmacological treatment rates in these lines, which will give patients a more tolerable alternative to Stivarga. The moderate uptake of other late-stage pipeline products, panitumumab and Xilonix, following their expected approval, is expected to drive additional growth within this market.
The CRC pipeline is highly robust, with potential drug candidates across various Phases of clinical development. With nearly 400 active pipeline molecules, the majority of the investigational drug candidates are being evaluated for the treatment of CRC in advanced stages, either as first-line or second-line therapies. The current investigational pipeline candidates include new combination therapies and targeted therapies, as well as promising immunotherapies and chemotherapy drug candidates. As well as these active progressing pipeline molecules, the pipeline also includes nearly 180 molecules that are either inactive or discontinued.
The report analyzes treatment usage patterns, market characterization, the pipeline, and key licensing and co-development deals in the eight major markets: the US, the UK, France, Germany, Spain, Italy, Japan and Canada. It includes -
Colorectal Cancer Treatment Market Value to Hit $9.4 Billion by 2020, says GBI Research
Reference Code: GBIHC352MR
Publication Date: January 2015
The value of the Colorectal Cancer (CRC) therapeutics market will increase moderately, from $8.3 billion in 2013 to $9.4 billion by 2020, representing a Compound Annual Growth Rate (CAGR) of 1.8%, according to business intelligence provider GBI Research.
The company’s latest report* states that this growth, which will occur across eight major developed countries, namely the US, UK, France, Germany, Spain, Italy, Japan and Canada, will be limited by the patent expirations of Avastin and Erbitux during the forecast period, which will prompt the uptake of lower-priced biosimilar versions of these drugs.
However, Saurabh Sharma, Senior Analyst for GBI Research, says that despite its patent expiration, Avastin is expected to retain its market-leading position in the global CRC space through to 2020.
Sharma explains: “Avastin is heavily prescribed in both first- and second-line settings, regardless of the patient’s K-Ras status. Its dominance is consistent across both the metastatic K-Ras wild-type and mutation-positive settings, despite the availability of epidermal growth factor receptor inhibitors for the treatment of K-Ras wild-type disease.
“Additionally, Stivarga is expected to be one of the biggest drivers of growth in the CRC market, due primarily to its anticipated line extension as a maintenance treatment in the first-line metastatic setting for patients with resected liver metastases.”
The analyst adds that while multiple new pipeline agents are expected to be launched in the CRC therapeutics market over the forecast period, none of these drugs will have a dramatic impact on the overall arena.
Sharma continues: “The currently marketed brands will continue to enjoy dominance due to their incorporation in the earlier and more lucrative lines of treatment.
“A number of new agents are likely to enter the market, including the anti-angiogenesis inhibitors Cyramza and nintedanib. However, these drugs will enter the competitive second- and later-line metastatic segments of the CRC therapeutics space.”
*Colorectal Cancer Therapeutics in Major Developed Markets to 2020 - Increased Uptake of High Priced Drugs to Offset the Impact of Generics
This report provides analysis of colorectal cancer treatment usage patterns, market characterization, the pipeline, and key licensing and co-development deals in eight major markets, namely the US, UK, France, Germany, Spain, Italy, Japan and Canada. The report includes annualized historic and forecast data from 2013 through to 2020.
This report was built using data and information sourced from proprietary databases, primary and secondary research, and in-house analysis conducted by GBI Research’s team of industry experts.
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