Intrahepatic Cholangiocarcinoma (ICC) - Pipeline Insight, 2019 report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Intrahepatic Cholangiocarcinoma pipeline landscape is provided which includes the disease overview and Intrahepatic Cholangiocarcinoma treatment guidelines. The assessment part of the report embraces, in depth Intrahepatic Cholangiocarcinoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Intrahepatic Cholangiocarcinoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Intrahepatic Cholangiocarcinoma Understanding
Intrahepatic Cholangiocarcinoma (ICC) originated from the liver parenchyma beyond the second order bile ducts and belongs to a family of aggressive Cholangiocarcinomas, a rare and heterogeneous malignant neoplasm with epithelial cell of biliary duct and has the histologic and biochemical features of cholangiocyte differentiation. Receptor tyrosine kinases such as IL-6 receptor, c-MET, and the EGFR family members ERBB2 and ERBB1 are key signaling pathways in ICC. Aberrant activation of these receptor tyrosine kinases causes constitutive activation of downstream signaling cascades (i.e., JAK/ STAT3, PI3K/Akt, ERK1/2, and p38MAPK) resulting in dysregulation of cell senescence, cell cycle regulation and proliferation, and apoptosis. Common symptoms of ICC include malaise, cachexia, abdominal pain, night sweats, fatigue and/or jaundice, associated or not with systemic manifestations, etc. The risk factors for developing ICC includes Primary sclerosing cholangitis, parasitic infections, intrahepatic biliary stones (hepatolithiasis), liver cirrhosis, viral infection, and others. The recently proposed classification of ICCs subdivided the tumors into conventional, bile ductular, or intraductal neoplasm type, or rare variants (combined hepatocellular ICC, undifferentiated ICC, squamous/adenosquamous type). The conventional type include a small duct or peripheral type and large duct or perihilar type. The bile ductular and combined hepatocellular-ICC might have originated from hepatic progenitor cells (HPCs) (as a neural cell adhesion molecule, a marker of HPC has been detected).
Intrahepatic Cholangiocarcinoma Pipeline Development Activities
The report provides insights into different therapeutic candidates in discovery and preclinical, phase 1, phase 2, and phase 3 stage. Drugs under development as a monotherapy or combination therapy are also included. It also analyses key players involved in Intrahepatic Cholangiocarcinoma targeted therapeutics development with respective active and dormant or discontinued projects. Intrahepatic Cholangiocarcinoma pipeline report covers 17+ companies. Some of the key players include Delcath Systems (Melphalan/HDS), Sirnaomics (STP705), RedHill Biopharma (Opaganib), etc.
The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university web sites and industry-specific third party sources, etc.
Intrahepatic Cholangiocarcinoma Analytical Perspective by DelveInsight
• In-depth Intrahepatic Cholangiocarcinoma Commercial Assessment of products
This report provides an in-depth Commercial Assessment of therapeutic drugs have been included which comprises of collaborations, Licensing, Acquisition –Deal Value Trends. The sub-segmentation is described in the report which includes Company-Company Collaborations (Licensing / Partnering), Company-Academia Collaborations, and Acquisition analysis in both Graphical and tabulated form.
• Intrahepatic Cholangiocarcinoma Clinical Assessment of products
The report comprises of comparative clinical assessment of products by development stage, product type, route of administration, molecule type, and MOA type across this indication.
Scope of the report
• The Intrahepatic Cholangiocarcinoma report provides an overview of therapeutic pipeline activity for Intrahepatic Cholangiocarcinoma across the complete product development cycle including all clinical and non-clinical stages
• It comprises of detailed profiles of Intrahepatic Cholangiocarcinoma therapeutic products with key coverage of developmental activities including technology, collaborations, licensing, mergers and acquisition, funding, designations and other product related details
• Detailed Intrahepatic Cholangiocarcinoma Research and Development progress and trial details, results wherever available, are also included in the pipeline study
• Therapeutic assessment of the active pipeline products by development stage, product type, route of administration, molecule type, and MOA type
• Coverage of dormant and discontinued pipeline projects along with the reasons if available across Intrahepatic Cholangiocarcinoma
Reasons to Buy
• Establish a comprehensive understanding of the current pipeline scenario across Intrahepatic Cholangiocarcinoma to formulate effective R&D strategies
• Assess challenges and opportunities that influence Intrahepatic Cholangiocarcinoma R&D
• Develop strategic initiatives by understanding the focus areas of leading companies.
• Gather impartial perspective of strategies of the emerging competitors having potentially lucrative portfolio in this space and create effective counter strategies to gain competitive advantage
• Get in detail information of each product with updated information on each project along with key milestones
• Devise Intrahepatic Cholangiocarcinoma in licensing and out licensing strategies by identifying prospective partners with progressing projects for Intrahepatic Cholangiocarcinoma to enhance and expand business potential and scope
• Our extensive domain knowledge on therapy areas support the clients in decision-making process regarding their therapeutic portfolio by identifying the reason behind the inactive or discontinued drugs*Please Note:* The report will be delivered in 2 business days upon order confirmation.
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