Pandemic Outbreaks in the Past Decade: A BCC Research Overview
Report Includes:
- An overview of the pandemic outbreaks occurred over the last decade (2010-2020)
- Discussion of several serious epidemiological outbreaks, their socioeconomic impact, R&D efforts, treatment and diagnostics, clinical trial landscape, and regulatory and reimbursement landscape
- Data corresponding to number of confirmed cases and reported deaths (globally and country wise) due to various pandemics, including novel coronavirus disease (COVID-19), SARS, MERS, HIV/AIDS, H1N1, Ebola virus etc.
- Correlation of coronavirus (Covid-19) outbreak to previous epidemiological outbreaks in terms of policies and measures of prevention and control, and the lessons learned thereafter
- Insight into key scientific breakthroughs and pipeline products targeting infectious disease treatments, including the novel coronavirus disease and its antibody-based clinical program (antibody to MERS-CoV infection)
- Chapter 1 Introduction
- Study Goals and Objectives
- Reasons for Doing This Study
- Scope of Report
- Information Sources
- Methodology
- Analyst's Credentials
- Related BCC Research Reports
- Chapter 2 Introduction to Pandemics
- Pathogenic Microbes and Infectious Diseases: 1973-2019
- Factors Contributing to the Emergence of Infectious Diseases
- Human Demographics and Behavior
- Technology
- The Role of Needles
- Economic Development and Land Use
- International Travel
- Microbial Adaptation
- Antibiotic Development
- Classifying Viral Outbreaks, Epidemics and Pandemics
- Current and Potential Epidemics with Pandemic Potential
- Current and Potential Pandemics
- Current Technologies for Addressing Potential Pandemic Threats
- Biological Weapons for Terrorism
- The Next Pandemic
- Types of Zoonotic Viruses
- A Brief History of Global Pandemics
- Bubonic Plague (1300 to the Present)
- Cholera (1916-1966)
- The Spanish Influenza Pandemic (1918)
- Asian Flu Pandemic (1957-1958)
- HIV/AIDS Pandemic (1980 to the Present)
- Influenza A-H1N1 (2009 to the Present)
- Malaria (2700 BC to the Present)
- Severe Acute Respiratory Syndrome (SARS) (2002-2003)
- Tuberculosis (4000 BC to the Present)
- Treatments for Infectious Diseases
- Prevention
- Vaccination
- Pharmaceutical Treatments
- Chapter 3 H1N1 Influenza (Swine Influenza)
- Etiology
- Epidemiology
- Pathophysiology
- Types of Influenza Viruses
- Influenza Virus A
- Influenza Virus B
- Influenza Virus C
- Diagnosis and Evaluation
- Real-Time Polymerase Chain Reaction
- Nucleotide Sequencing
- Phylogenetic Analysis
- Treatment and Management
- Prevention of Swine to Human Viral Transmission
- Prevention of Human-to-Human Transmission
- Vaccines
- Antiviral Treatments
- The WHO and Containment for Pandemic Influenza
- International Influenza Vaccine Stockpile Orders
- Pre-pandemic Vaccination
- Biomedical Advanced Research and Development Authority (BARDA)
- Antiviral Resistance
- Recreated Viruses
- Immaterialized Market Risk
- Media Coverage and Vaccinations
- Pandemic Preparedness Plans
- United States
- Japan
- China
- Brazil
- United Kingdom
- Chapter 4 Ebola Virus Disease
- Etiology
- Epidemiology
- Clinical Manifestations
- Diagnosis
- Treatment/Management
- Supportive Care
- Therapeutics
- Vaccines and Prevention
- Chapter 5 Middle East Respiratory Syndrome
- Etiology
- Epidemiology
- Geographical Distribution
- Sources of Infection
- Risk Factors and Transmission
- Pathophysiology
- Clinical Features
- Diagnosis
- Molecular Diagnostics
- Serological Assays
- Treatment and Management
- Antiviral Agents
- Convalescent Plasma
- Antibiotic Therapy
- Intensive Care Management
- New Treatments
- Prevention
- Advances in Vaccine Development
- Priorities: MERS Research, Surveillance, Management, and Control
- Establishing a One Health Global Consortium
- Priority Studies at the Animal-Human-Environmental Interface
- Priority Studies in Human Populations
- Priority Studies for Vaccines, Therapeutics, and Rapid Diagnostics
- Chapter 6 Coronavirus Disease 2019 (SARS-CoV-2)
- Symptoms of COVID-19
- COVID-19 Progression
- Incubation Period
- Epidemiology
- Case Fatality Rate (CFR)
- Global Confirmed Cases and Confirmed Deaths Due to COVID-19
- COVID-19 Research and Development
- Diagnostics and Medtech
- The Need to Reinvent Ventilators
- Clinical Trials on COVID-19
- Chapter 7 Lessons Learned from History
- Maintaining Essential Healthcare Services
- Access to Prevention, Safety Measures, Testing and Treatment
- Quarantine and Isolation
- International Efforts to Strengthen the Global Outbreak Response System
- Africa Centers for Disease Control and Prevention
- Coalition for Epidemic Preparedness Innovations
- European Medical Corps
- Regional Disease Surveillance Systems Enhancement Program
- The WHO Global Health Emergency Workforce
- The WHO R&D Blueprint
- World Bank Pandemic Emergency Financing Facility
- Chapter 8 Appendix
- Acronyms
- List of Tables
- Table 1 : Pathogenic Bacteria, Parasites and Viruses, 1973-2019
- Table 2 : History of Antibiotic Discovery and Approval, 1935-2013
- Table 3 : CDC: Six Phases of Classification of Viral Pandemics
- Table 4 : Technologies for Addressing Potential Pandemic Threats
- Table 5 : Diseases That Have Been or Can Be Weaponized
- Table 6 : Commercial Products of H1N1 Influenzas Diagnostics
- Table 7 : Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017
- Table 8 : Essential and Desirable Elements of the WHO Influenza Pandemic Preparedness Plan
- Table 9 : Japan’s Action Plan for Influenza Pandemic Preparedness
- Table 10 : China’s Influenza Pandemic Warning Levels
- Table 11 : Brazil’s Influenza Pandemic Warning Levels and Action
- Table 12 : Ebola Outbreaks Between 1976 and 2014
- Table 13 : Clinical Features of Ebola Virus Disease, by Stage
- Table 14 : Overview of Investigational Therapeutics Evaluated in Clinical Trials on Ebola Virus Disease During the 2013-2016 West African Outbreak
- Table 15 : Key Vaccines with Accelerated Clinical Development During the 2013-2016 Ebola Virus Disease Outbreak
- Table 16 : Molecular Diagnostic Tests for MERS-CoV Diagnosis, Single Assays
- Table 17 : Molecular Diagnostic Tests for MERS-CoV Diagnosis, Multiplex Assays
- Table 18 : Serology Tests for MERS-CoV Diagnosis
- Table 19 : Potential Therapies for MERS-CoV Infection
- Table 20 : Vaccines in the Pipeline for the Prevention of MERS-CoV Infection
- Table 21 : COVID-19 Symptoms by Percentage of Patients
- Table 22 : Case Fatality Rate of COVID-19, by Region, March 2020
- Table 23 : Case Fatality Rate of COVID-19, by Selected Country
- Table 24 : COVID-19: Confirmed Cases and Deaths, by Country, May 14, 2020
- Table 25 : COVID-19 Therapeutic Interventions in Development, by Biopharmaceutical Companies in Collaboration
- Table 26 : COVID-19 Therapeutics in Development, by Biopharmaceutical Company
- Table 27 : COVID-19 Vaccines in Development, by Biopharmaceutical Companies in Collaboration
- Table 28 : COVID-19 Vaccines in Development, by Biopharmaceutical Company
- Table 29 : Modifiable Breathing Devices Eligible for EUAs, by Company
- Table 30 : Number of Clinical Trials on COVID-19, by Phase
- Table 31 : Number of Clinical Trials on COVID-19, by Intervention
- Table 32 : Clinical Trials on COVID-19, by Country
- Table 33 : High-Level Initiatives Established Since the Ebola Crisis
- Table 34 : List of Acronyms
- List of Figures
- Figure 1 : Number of Approved WHO Influenza Centers, by WHO Dedignated Region
- Figure 2 : Targeted Pre-pandemic Influenza Vaccine Stockpiles Based on Population Demand for Selected Countries
- Figure 3 : Geographical Distribution of Reported Human Infections of MERS-CoV
- Figure 4 : Infographic Comparison of CFR and Cases of the Three Major Beta Coronaviruses: MERS, SARS, and COVID-19
- Figure 5 : Distribution of Clinical Trials on COVID-19, by Phase
- Figure 6 : Distribution of Clinical Trials on COVID-19, by Intervention
- Figure 7 : Distribution of Clinical Trials on COVID-19, by Country
- Figure 8 : The Role of High-Level Initiatives in Enhancing the Three Main Phases of Global Outbreak Preparedness
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