|
Published by: BCC Research
Published: Jan. 1, 2004 - 200 Pages
Table of Contents
Introduction
Study Goals And Objectives
Reasons For Doing This Study
Contribution Of The Study
Scope And Format
Methodology And Information Sources
Author's Credentials
Related Publications
Bcc Online Services
Disclaimer
Summary
Summary Table:
U.S. Markets For Dna Microarrays And Microarray Materials, Through 2007 ($ Millions)
Summary Figure:
U.S. Markets For Dna Microarrays And Microarray Materials, 2002 And 2007 ($ Millions)
Industry Structure
Introduction
Introduction (Continued)
Microarrays And Microfluidics Devices
Producers Of Dna Biochips And Microarrays: Photolithographic Chips And Glass Arrays
Photolithographic Microarrays
Affymetrix Substrates
Affymetrix Biomolecules
Sequence Information Of Affymetrix Biomolecules
Affymetrix Marker Molecules
Overall Production Costs
Photolithographic Microarray Developers
Photolithographic Microarray Processors
Table 1 Firms Offering Affymetrix Slide Processing
The Glass Array Industry
A Brief History Of Glass Microarrays
Spotted And Unspotted Glass Arrays
Spotted And Unspotted Glass Arrays (Continued)
Spotted Arrays
Table 2 Spotted Dna Microarray Manufacturers, 2002
Unspotted Arrays
Unspotted Arrays (Continued)
Table 3 Vendors Of Supplies And Equipment To The Unspotted Microarray Market
Microarray Production By Volume: High-Volume Producers
Table 4 High-Volume Dna Microarray Producers (Glass And Photolithographic), 2002
The Low-Volume Microarray Industry
Table 5 Microarray Production On A Volume Basis, 2002 And 2007 (%)
Licensing In The Microarray Industry
A Brief History Of Licensing In The Microarray Industry
Licensing Involving Fluorophores
Effects Of Licensing On The U.S. Industry
Table 6 Effects Of Licensing On The Dna Microarray Industry
Barrier To Foreign Competition
Barriers To Entry Of New Technology
Decreased Competition
Intellectual Property Involving Biomolecules
Table 7 Methods For Handling Intellectual Property (Ip) In Microarray And Biochip Production
Sequence Information Producers
Costs
Litigation Possibilities
Overall Use
The Protein Chip Industry
Table 8 Protein Microarray Producers
Table 9 Protein Producers Of Biochips, By Type
The Microfluidics Chip Industry
Table 10 Firms In The Microfluidics Industry
Materials For Microarrays And Microfluidics Devices
Materials For Microarrays .. (Continued)
Biochip And Microarray Substrates
Glass Substrates
Table 11 Glass And Polymer Use In Substrates, 2002 And 2007 (%)
Unspotted Substrate Producers
Table 12 Suppliers Of Unspotted Glass Substrates For Biochips, 2002
The Spotted Glass Substrate Industry
History Of The Agreement Between Amersham And Surmodics
Polymer Substrates
Table 13 Suppliers Of Polymer Substrates For Biochips, 2002
Silicon Substrates
Biomolecules
Dna Producers
Dna Oligomers
Table 14 Captive And Open Production Of Dna Oligomers For Microarrays, 2002 And 2007
Open Production Of Dna Oligomers In Glass Arrays
A Brief History Of Dna Oligomer Production
Table 15 Oligomeric Dna Producers, 2002
Oligo Pricing
Purified Oligomers
Oligomer Modifications
Production Of Cdna In The Glass Array Industry
Table 16 Commercial Producers Of Cloned Dna For Microarrays
Table 17 Captive Vs. Open Cdna Production
Marker Molecules
Table 18 Dna Label Suppliers, 2002
Fluorophore Labeling Types
Direct Label Producers
Table 19 Direct Dna Label Producers
Indirect Label Producers
Table 20 Indirect Dna Label Producers
Company Profiles
Affymetrix, Inc.
Genisphere, Inc.
Xenopore Corp.
Surmodics
Idt
Enzo Life Sciences, Inc.
Iconix Pharmaceuticals, Inc.
Incyte Corp.
Agilent Technologies
Amersham Biosciences
Perkinelmer
Qiagen Gmbh
Sigma-Genosys
Bd Biosciences Clontech
Corning, Inc.
Genicon Sciences Corp.
Technology Overview
What Is A Biochip?
Static Biochips
What A Static Biochip Is
Table 21 Static Biochip Components
Substrates
Probe Molecules
Marker Molecules
What A Dna Microarray Does
What A Dna Microarray Does (Continued)
Quantification Using Microarrays
The Larger Gene Expression Picture
The Larger Gene Expression Picture (Continued)
The Larger Gene Expression Picture (Continued)
The Larger Gene Expression Picture (Continued)
Microarray Design
Table 22 Key Challenges In Designing Microarray Probes
Base Pair Mismatches
Poor Binding
Hybridization
Variable Signal Strengths
Interpretation Of Microarrays
Intramicroarray Variability
Intermicroarray Variability
Variations In Analysis
Challenges To Microarray Materials
Table 23 Challenges To Materials Used In Microarrays
Substrates
Probes
Marker Molecules
Dna Microarray Performance Requirements
Table 24 Dna Microarray Requirements
Firm Tethering
Unhindered Binding
Using Larger Dna Molecules
No Cross-Contamination
Unreactive Surface
Current Dna Microarrays
Photolithography Technology
Photolithography Technology (Continued)
The Incomplete Reaction Problem
Probe Design
Development Trends
Glass Arrays
Amersham's Coating Technology
Agilent Technology
Probe Technology
Comparison Of Inkjet And Photolithographic Technology
Table 25 Comparison Of Photolithographic And Inkjet Biochip Production Technologies
Production Rates
Requires Masks
Adaptability
Cross-Contamination
Feature Size
Probe Accessibility
Probe Purity
Overall Performance
Market Acceptance
Protein Microarrays
Table 26 Challenges In Detecting Proteins
Difficult To Detect
Complex In Formation
Lack Of Binding
Posttranslational Modification
Costs
Competing Technologies
Summary
Materials Technology
Substrates
A Brief History Of Substrate Development
Table 27 Comparison Of Porous And Nonporous Substrates
Materials
Coatings
Control Of Spot Size
Diffusion Mechanisms
Glass And Polymer Substrates
Table 28 Comparison Of Polymer And Glass Substrates For Biochips And Arrays
High-Throughput Applicability
Can Be Used With Photolithography Or Inkjet?
Surface Smoothness And Machinability
Easily Coated
Types Of Coatings
The Importance Of Coatings
Relevance Of Coatings In The Courtroom
Glass Coating Technology For Substrates
Uv Coatings
Covalent Coatings
Table 29 Comparison Of Uv And Covalent Coatings For Substrates
Utility With Production Technologies
Free Radicals
Monolayers
Spacer Requirements
Patents
Markets
Probe Technology
Table 30 Probe Requirements
Selectivity
Tight Binding
Ease Of Manufacture
Cdna Technology
Table 31 Problems With Pcr
Time Consuming
Breakdown
Accuracy
Expensive
Sensitivity
Selectivity
Marker Technology
Table 32 Comparison Of Detector Technology
Accuracy
Sensitivity
Ease Of Use
Challenges In Labeling Dna Microarrays
Table 33 Challenges In The Microarray Labeling Process
Specific Binding
Must Fluoresce Or Signal In Proportion To Binding
Must Not Hinder Hybridization
Must Be Stable
Must Emit A Clean Signal
Microfluidics Technology
Table 34 Comparison Of Static And Dynamic Biochips And Arrays
Use
Flow
Substrates
Applications
Ease Of Use
Ease Of Use (Continued)
Products
Introduction
The Overall Biochip Market
Table 35 Markets For Dna And Protein Microarrays And Microfluidics Devices, Through 2007 (Thousand Units And $ Millions)
Figure 1 Markets For Dna And Protein Microarrays And Microfluidics Devices, 2002 And 2007 ($ Millions)
The Overall Biochip Market (Continued)
Dna Microarrays
Table 36 Photolithography And Glass Microarray Markets, Through 2007 (Thousand Units And $ Millions)
Figure 2 Photolithography And Glass Microarray Markets, 2002, 2003 And 2007 ($ Millions)
Dna Glass Arrays
Table 37 Spotted And Unspotted Glass Array Markets, Through 2007 (Thousand Units And $ Millions)
Figure 3 Spotted And Unspotted Glass Array Markets, 2002, 2003 And 2007 ($ Millions)
Industry Trends
Industry Trends (Continued)
Table 38 Comparison Of Prespotted And Unspotted Microarrays
Ease Of Use
Production Methodology
Costs
Unspotted Arrays By Market
Table 39 Unspotted Glass Microarrays In Industry And Academia, Through 2007 (Thousand Units And $ Millions)
Figure 4 Unspotted Glass Microarrays In Industry And Academia, 2002, 2003 And 2007 ($ Millions)
Microarrays By Type
Table 40 Glass Microarrays By Type: Cdna And Oligo, Through 2007 (Thousand Units And $ Millions)
Figure 5 Glass Microarrays By Type: Cdna And Oligo, 2002, 2003 And 2007 ($ Millions)
Cdna And Oligo Microarrays By Market
Table 41 Cdna And Oligo Glass Microarrays In Industry, Through 2007 (Thousand Units And $ Millions)
Figure 6 Cdna And Oligo Glass Microarrays In Industry, 2002, 2003 And 2007 ($ Millions)
Table 42 Cdna And Oligo Glass Microarrays Used In Academic Research, Through 2007 (Thousand Units And $ Millions)
Figure 7 Cdna And Oligo Glass Microarrays Used In Academic Research, 2002, 2003 And 2007 ($ Millions)
Materials Used In Microarrays
Table 43 Materials Used In Dna Microarrays, Through 2007 ($ Millions)
Figure 8 Materials Used In Dna Microarrays, 2002 And 2007 ($ Millions)
Substrates
Coated And Uncoated Substrates
Table 44 Glass Substrates By Coating, As Used In Glass Arrays, Through 2007 (Thousand Units And $ Millions)
Figure 9 Glass Substrates By Coating, As Used In Glass Arrays, 2002 And 2007 ($ Millions)
Glass Substrates By Coating Type
Table 45 Glass Substrates By Coating, As Used In Glass Arrays, Through 2007 (Thousand Units And $ Millions)
Figure 10 Glass Substrates By Coating, As Used In Glass Arrays, 2002 And 2007 ($ Millions)
Table 46 Glass Substrates By Coating Type, 2002 And 2007 (%)
Biomolecules
Dna Probes By Type
Cdna
Cdna By Markets: Pharmaceutical
Academic Markets
Table 47 Markets For Cdna In Glass Microarrays, Through 2007 ($ Millions)
Figure 11 Markets For Cdna In Glass Microarrays, 2002, 2003 And 2007 ($ Millions)
Oligomeric Dna
Oligomeric Dna By Production Methodology
Table 48 Comparison Of In Situ And Independently Synthesized Dna Oligomers
Production Technology
Oligomer Length
Accuracy And Quality Control
Cross-Contamination
Production Costs
Table 49 Markets For Dna Oligomers And Amidites In Dna Microarrays, Through 2007 ($ Millions)
Protein Probes
Marker Molecules
Table 50 Comparison Of Direct And Indirect Labeling
Table 51 Direct And Indirect Labeling, 2002, 2003 And 2007 (%)
Marker Molecules By Technology
Table 52 Comparison Of Various Marker Molecule Technologies
Stability
Instrumentation
Costs
Table 53 Marker Molecule Markets, Through 2007 ($ Millions)
Market Applications
Introduction
Dna Microarray Markets
Table 54 Industrial And Academic Microarray Markets, Through 2007 (Units And $ Thousands)
Microarray Applications
Table 55 Comparison Of Three Proposed Microarray Applications: Expression Profiling, Diagnosis And Snp Detection
Current Use
Technology Developments
Diagnostics
Theoretical Underpinnings Of Microarray Applications
Expression Profiling
Snps
Diagnostics
The Academic Research Market
Microarray Production In Academia
Table 56 Reasons For Core Facilities
Microarray Production In Academia (Continued)
Microarray Production In Academia (Continued)
Numbers Of Core Facilities
Table 57 Academic Markets For Microarrays (Including Processing Costs), Through 2007 (Units And $ Thousands)
Pricing Of Arrays In Academia
Array Costs
Table 58 Breakdown Of Costs For Running A Glass Array In Academia
Substrate/Oligomer Costs
Processing Costs
Amplification
Hybridization
Dna Synthesis Kit
Marker Molecules
Photolithographic
Glass Arrays
Microarray Funding
The Catch-22 Of Nih Funding
Industrial Market Applications
Types Of Microarrays Used By Industry: Glass And Photolithographic Arrays
Table 59 Industrial Markets For Microarrays (Including Processing Costs), Through 2007 (Units And Dollars In Thousands)
Pricing Of Microarrays Used In Industry
Photolithographic Arrays
Glass Arrays
Processing Costs
Trends In Microarray Use
AbstractOver the past few years, the markets for DNA based microarrays have exploded. These microarrays are used in both academic research and drug discovery. From a market that could be measured in the tens of millions five years ago, DNA microarrays have undergone a period of explosive growth to become a several hundred million dollar industry today. While DNA microarray markets have grown, so too have the markets for the material used to produce microarrays: the substrates, probes and marker molecules. This report examines the market for the materials used to produce DNA microarrays as well as the markets for microarrays themselves. This report also extrapolates demand for these materials using current technology, as well as future demand based on new and competitive technology.
Get Full Details About This Report >>
|
