Future Horizons in the Global Nucleic Acid Testing Market: Supplier Shares and Sales Forecasts for 35 Tests and Applications by CountryPublished by: Venture Planning Group Published: Aug. 28, 2012 - 1050 Pages Table of ContentsGLOBAL NUCLEIC ACID TESTING MARKETNew Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers Introduction Worldwide Market And Technology Overview A. DNA Sequencing 1. Introduction 2. Sequencing Methods 3. Autoradiography 4. The Human Genome Project 5. Sequencing Automation 6. Image Scanners 7. Fluorescent Detection 8. Gene Profiling 9. Gene Expression 10. Polymorphism Screening 11. Protein Interaction Networks B. DNA And RNA Probe Technology 1. Basic Principles 2. Probe Preparation 3. The DNA Probe Test a. Sample Preparation b. Hybridization c. Separation d. Detection/Measurement 4. Test Formats a. Filter Hybridization b. Southern Blot c. Northern Blot d. In Situ Hybridization e. Others 5. Labeling Techniques 6. Amplification Methods O Polymerase Chain Reaction - Temperature Cyclers - PCR Variations * Immuno-PCR * QC-PCR * DAP-PCR O Strand Displacement Activation O TMA O Ligase Chain Reaction O Branched DNA - Hybridization Protection Assay O Nucleic-Acid Sequence-Based Amplification O Self-Sustained Sequence Replicase O Others - Ampliprobe - CAR - CAS - CPT - Dendritic Polymer Technology - ISO-CR - LAT - Probe Networks - RAMP - Repair Chain Reaction - Rolling Circles - Sequence Independent Gene Amplification - Sequence Initiation Reaction - SISPA C. Detection Technologies 1. Radioactive Methods a. Overview b. Major Isotopes O P-32 O S-35 O H-3 O I-125 2. Non-Isotopic Methods a. Enzymatic Labels b. Chemical Labeling O Indirect Chemical Labeling O Direct Chemical Labeling c. Fluorescence d. Chemiluminescence e. Electrical Conductivity D. Instrumentation Review 1. Abbott LCx 2. Autogenomics Infinity 3. Beckman Coulter/Biomek FK 4. Becton Dickinson SDA 5. Bio-Rad GeneScope 6. Gen-Probe Tigris 7. Nanosphere Verigen Series 8. Roche Cobas Amplicor 9. Tecan LS Series E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip - Liquid Transportation and Mixing - Separation - Reaction - Detection F. Pharmacogenomics G. Major Applications 1. Microbiology/Infectious Diseases a. Overview b. Major Infectious Diseases * AIDS O Structure and Composition O Classification O AIDS Origins O Animal Lentivirus Systems O Virus Receptors O HIV Infections in Humans - Pathogenesis and Pathology O CD4T Lymphocytes and Memory Cells O Monocytes and Macrophages O Lymphoid Organs O Neural Cells O Viral Coinfections - Clinical Findings O Plasma Viral Load O Pediatric AIDS - Neurologic Disease - Opportunistic Infections - Cancer O Immunity O Laboratory Diagnosis - Virus Isolation - Serology - Viral Nucleic Acid/Antigen Detection O Epidemiology - Worldwide Spread of AIDS - United States - Routes of Transmission O Prevention, Treatment, And Control - Antiviral Drugs - Vaccines O Transmission HIV in Blood Products O HIV Transmission in Transplant and Artificial Insemination Recipients O Diagnostic Tests - Enzyme Immunoassay Interpretation - Specificity, Sensitivity and Predictive Value O Competition Assays O Western Blot Technique O Immuno-Fluorescence Assays (IFA) O Radioimmunoprecipitation O HIV-1/HIV-2 Combination Testing O Methods of HIV-Antigen Detection O Antigen Assays and Blood Screening O Urine Tests O DNA Probes - Overview - Quantitative PCR - In Situ PCR - Needed Improvements O Viral Load/Drug Resistance Testing O Genotype and Phenotype Testing O Blood Banking Considerations * Adenovirus O Background O Diagnostic Tests O Vaccines and Drugs O Adeno-Associated Viruses (AAV) * Anthrax/Bacillus Anthracis O Background O Diagnostic Tests O Vaccines and Drugs * Babesiosis O Background * BEA and Other Bartonella Diseases O Background O Diagnostic Tests O Vaccines and Drugs * Chagas Disease O Background * Campylobacter O Background O Diagnostic Tests - Culture Identification O Vaccines and Drugs * Chlamydia O Background - Chlamydia psittaci - Chlmaydia pneumoniae - Chlamydia trachomatis O Diagnostic Tests O Vaccines and Drugs * Creutzfeldt-Jakob’s Disease O Background O Blood Transmission O Diagnostic Tests O Major Commercial and Academic Players - Bayer - Disease Sciences/Bio Tec Global - Imperial College School of Medicine - Ortho-Clinical Diagnostics - Pall - ProMetic Life Sciences - Proteome Sciences/Idexx - Q-One Biotech - Serono - U.S. Agricultural Research Service O Drugs O Vaccines * Cytomegalovirus O Background - Chorioretinitis - Gastrointestinal - Central Nervous System Disease O Diagnostic Tests O Vaccines and Drugs * Ebola Virus O Background - Epidemiology - Clinical Syndromes O Diagnostic Tests O Vaccines and Drugs * EchoVirus O Background - Acute Aseptic Meningitisis - Encephalitis - Exanthems - Respiratory Disease - Myopericarditis - Neonatal Infections O Diagnostic Tests O Vaccines and Drugs * Encephalitis O Background O Diagnostic Tests O Vaccines and Drugs * Enteroviruses O Background O Diagnostic Tests - Viral Isolation and Identification - Antibody Tests O Vaccines and Drugs * Epstein-Barr Virus O Background O Diagnostic Tests O Vaccines and Drugs * Gonorrhea O Background O Diagnostic Tests O Vaccines and Drugs * Hepatitis O Hepatitis A O Hepatitis B - Structure and Composition - Replication O Hepatitis C O Hepatitis D (Delta) O Hepatitis E O Hepatitis G O Hepatitis Infections Pathology O Clinical Findings O Laboratory Tests - Hepatitis A - Hepatitis B - Hepatitis C - Hepatitis D - Hepatitis E O Virus-Host Immune Reactions O Epidemiology - Hepatitis A - Hepatitis B - Hepatitis C - Hepatitis D (Delta) O Vaccines and Drugs * Herpes Simplex Virus O Background O Diagnostic Tests O Vaccines and Drugs * Legionella O Background O Diagnostic Tests O Vaccines and Drugs * Lyme Disease O Background - Clinical Description - Clinical Case Definition - Laboratory Criteria for Diagnosis - Case Classification O Diagnostic Tests O Vaccines and Drugs * Malaria * Mycoplasma O Background - Ureaplasma Urealyticum & Mycoplasma Hominis O Diagnostic Tests O Vaccines and Drugs * Papillomaviruses/HPV O Background - HPV in Cancer - Cervical Neoplasm O Diagnostic Tests O Vaccines and Drugs - Prevention * Parvovirus B19 O Background - Microbiology - Epidemiology - Clinical Syndromes - Erythema Infectiosum (Slapped Cheek) - Adult Polyarthropathy - Transient Aplastic Crisis - Transient Pancytopenia - Red Cell Aplasia in Immunocompromised - Perinatal Infections O Diagnostic Test O Vaccines and Drugs * Pneumonia O Background O Diagnostic Tests O Vaccines and Drugs * Polyomaviruses O Background O Diagnostic Tests O Vaccines and Drugs * Salmonellosis O Background O Diagnostic Tests O Vaccines and Drugs * Shigellosis O Background O Diagnostic Tests O Vaccines and Drugs * Streptococci O Background O Diagnostic Tests O Vaccines and Drugs - Group A Streptococci - Group B Streptococci * Toxoplasmosis O Background O Diagnostic Tests O Vaccines and Drugs * Tuberculosis O Background O Diagnostic Tests - Microscopic Characteristics - Cultural Characteristics - Skin Tests - MDRTB O Vaccines and Drugs * West Nile Virus O Background - Clinical Syndromes O Diagnostic Tests O Vaccines and Drugs * Yersinia O Background O Diagnostic Tests O Vaccines and Drugs c. Antibiotic Susceptibility 2. Cancer Testing a. Overview b. Major Cancer Types * Prostate * Lung * Colon and Rectum * Breast * Skin * Uterine * Leukemia * Oral c. Oncogenes O Abl/abl-bcr O AIB1 O BRCA1 O CD44 O C-fos O C-myb O C-myc O CYP17 O Erb-B O HPC1 O N-myc O P40 O P51 O P53 O PIK3CA O PTI-1 O Ras O Reg O Sis O Src 3. Genetic Diseases a. Overview b. Nucleic Acid Amplification c. Chromosome Imaging d. Genomics Technologies e. Proteomics Technologies f. Current Pharmacogenomic Tests g. Future Pharmacogenomic Testing h. Major Diseases * Achondroplasia * Autosomal Dominant Polycystic Kidney Disease * Cancer * Cosmetogenomics * Cystic Fibrosis * Down's Syndrome * Duchenne and Becker Muscular Dystrophy * Factor V (Leiden) * Factor IX Deficiency * Fragile X Syndrome * Heart Disease * Hemochomatosis * Hemophilia * Huntington's Disease * Maternal-Fetal Incompatibility * Multiple Endocrine Neoplasia * Phenylketonuria (PKU) * Polycystic Kidney Disease (PKD) * Prenatal Screening * Retinitis Pigmentosa * Retinoblastoma * Sickle Cell Anemia * Spinal Muscular Atrophy * Vitamin B12 Metabolism i. Social Issues and Concerns 4. Forensic Testing a. Overview b. Multilocus and Single Locus Probes * Multilocus Probes * Single Locus Probes * PCR and RFLP c. The FBI d. DNA Profile Data Banks * U.S.A. * U.K. e. Judicial Implementation f. Major Crime Categories g. Factors Contributing to the DNA Probe Market Expansion * Technology Availability * Use of Hair as Evidence h. Wildlife Forensics 5. Paternity Testing/HLA Typing 6. Other Applications a. Disease Susceptibility Testing b. Cardiovascular Diseases c. Diabetes d. Alzheimer's Disease e. Plasma Purification f. Organ Transplantation g. Water Contamination h. Others G. Cost Analysis 1. Equipment 2. Consumables H. Competing/complementing Technologies 1. Monoclonal Antibodies/Immunoassays 2. RNA Probes 3. Two-Dimensional Electrophoresis 4. Flow Cytometry I. Reimbursement Issues J. Worldwide Market Overview 1. Business Environment 2. Market Structure 3. Market Size and Growth France A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares Germany A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares Italy A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares Japan A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares Spain A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares U.K. A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares U.S.A. A. Executive Summary B. Business Environment 1. Health Care Expenditures 2. Cost Consciousness 3. Reimbursement 4. Industry Consolidation 5. Managed Care a. HMO b. PPO 6. Hospitals 7. Admissions 8. Length of Stay 9. Industry Diversification 10. Physician Demographics 11. Population Aging a. Chronic Illness b. Disease Incidence c. Susceptibility to Iatrogenesis d. Multiple Illness Cases 12. Laboratory Regulations 13. FDA Reform C. Market Structure 1. Hospitals 2. Commercial/Private Laboratories 3. Blood Banks D. Market Size, Growth and Major Suppliers’ Sales and Market Shares Major Product Development Opportunities A. Instrumentation B. Reagent Kits and Test Systems/panels C. Computers, Software and Automation D. Auxiliary Products Design Criteria For Decentralized Testing Products Alternative Market Penetration Strategies A. Internal Development B. Collaborative Arrangements C. University Contracts D. Distribution Strategies For Decentralized Testing Markets 1. Marketing Approaches 2. Product Complexity 3. Customer Preference 4. Established Suppliers 5. Emerging Suppliers 6. Major Types Of Distributors 7. Market Segmentation Potential Market Entry Barriers And Risks A. Market Maturity B. Cost Containment C. Competition D. Technological Edge And Limitations E. Patent Protection F. Regulatory Constraints G. Decentralized Testing Market Challenges Competitive Profiles - Abbott - Aclara - Affymetrix - Agilent - Ambion - Applera - Applied Gene Technologies - Beckman Coulter - Becton Dickinson - Biokit - BioMerieux - Biotest - Boston Biomedica - Caliper - Cepheid - Chiron - Decode - Diadexus - Digene - Eiken - Enzo - Exact Sciences - Fujirebio - Gen-Probe - Gene Tec - Illumina - Innogenetics - Kreatech - Li-Cor - Molecular Diagnostics - Myriad Genetics - Nanogen - Nuvelo - Orchid Biosciences - Qiagen - Roche - Sangtec - Sequenom - Scienion - Sierra Diagnostics - Shimadzu - Takara Bio - Tepnel Life Sciences - Tecan Group - Third Wave Appendixes Appendix I: Major Companies Developing or Marketing NAT Reagents and Test Kits Appendix II: Major Universities and Research Centers Developing NAT Technologies Appendix III: Glossary of Terms Appendix IV: Currency Exchange Rates List of Tables Major Companies Developing or Marketing Thermocyclers Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests Major Companies Developing or Marketing CMV NAT And Other Direct Identification Tests Major Companies Developing or Marketing EBV NAT And Other Direct Identification Tests Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests Major Companies Developing or Marketing Cancer NAT Tests Major Companies Developing or Marketing NAT Assays For Genetic Diseases Worldwide, Laboratories Performing DNA Sequencing By Country Worldwide, NAT Market, Potential Laboratory Universe by Country Worldwide, NAT Volume Forecast by Country Worldwide, NAT Market Forecast by Country Summary Table France, NAT Volume And Sales Forecast by Major Application France, Laboratories Performing DNA Sequencing By Market Segment France, NAT Market Potential Laboratory Universe by Market Segment France, NAT Volume Forecast By Major Application France, Major Infectious Disease NAT Volume Forecast France, Infectious Disease Screening NAT Volume Forecast France, NAT Market Forecast By Major Application France, Infectious Disease Screening NAT Reagent Market Forecast by Test France, NAT Market By Major Supplier France, HIV/Hepatitis NAT Market By Major Supplier Summary Table Germany, NAT Volume And Sales Forecast by Major Application Germany, Laboratories Performing DNA Sequencing by Market Segment Germany, NAT Market Potential Laboratory Universe By Market Segment Germany, NAT Volume Forecast By Major Application Germany, Major Infectious Disease NAT Volume Forecast Germany, Infectious Disease Screening NAT Volume Forecast Germany, NAT Market Forecast By Major Application Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test Germany, NAT Market by Major Supplier Germany, HIV/Hepatitis NAT Market by Major Supplier Summary Table Italy, NAT Volume And Sales Forecast by Major Application Italy, Laboratories Performing DNA Sequencing by Market Segment Italy, NAT Market Potential Laboratory Universe by Market Segment Italy, NAT Volume Forecast By Major Application Italy, Major Infectious Disease NAT Volume Forecast Italy, Infectious Disease Screening NAT Volume Forecast Italy, NAT Market Forecast By Major Application Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test Italy, NAT Market By Major Supplier Italy, HIV/Hepatitis NAT Market By Major Supplier Summary Table Japan, NAT Volume And Sales Forecast by Major Application Japan, Laboratories Performing DNA Sequencing by Market Segment Japan, NAT Market Potential Laboratory Universe by Market Segment Japan, NAT Volume Forecast By Major Application Japan, Major Infectious Disease NAT Volume Forecast Japan, Infectious Disease Screening NAT Volume Forecast Japan, NAT Market Forecast By Major Application Japan, Infectious Disease Screening NAT Market Forecast by Test Japan, NAT Market By Major Supplier Japan, HIV/Hepatitis NAT Market by Major Supplier Summary Table Spain, NAT Volume And Sales Forecast by Major Application Spain, Laboratories Performing DNA Sequencing by Market Segment Spain, NAT Market, Potential Laboratory Universe by Market Segment Spain, NAT Volume Forecast by Major Application Spain, Major Infectious Disease NAT Volume Forecast Spain, Infectious Disease Screening NAT Volume Forecast Spain, NAT Market Forecast By Major Application Spain, Infectious Disease Screening NAT Reagent Market Forecast by Test Spain, NAT Market By Major Supplier Spain, HIV/Hepatitis NAT Market by Major Supplier Summary Table U.K., NAT Volume And Sales Forecast by Major Application U.K., Laboratories Performing DNA Sequencing by Market Segment U.K., NAT Market Potential Laboratory Universe by Market Segment U.K., NAT Volume Forecast By Major Application U.K., Major Infectious Disease NAT Volume Forecast U.K., Infectious Disease Screening NAT Volume Forecast U.K., NAT Market Forecast By Major Application U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test U.K., NAT Market by Major Supplier Summary Table U.S.A., NAT Volume And Sales Forecast by Major Application U.S.A., Laboratories Performing DNA Sequencing by Market Segment U.S.A., NAT Market, Potential Laboratory Universe by Market Segment U.S.A., NAT Volume Forecast By Major Application U.S.A., Major Infectious Disease NAT Volume Forecast U.S.A., Infectious Disease Screening NAT Volume by Test Forecast U.S.A., NAT Market Forecast By Major Application U.S.A., Infectious Disease Screening NAT Reagent Market Forecast by Test U.S.A., NAT Market by Major Supplier U.S.A., HIV/Hepatitis C NAT Market By Major Supplier U.S.A., West Nile Virus NAT Market By Major Supplier AbstractThis comprehensive seven-country, 1,050-page report is designed to help current suppliers and potential market entrants identify and evaluate major business opportunities emerging in the NAT market during this decade.Highlights - Business and technological trends in seven major markets - Five- and ten-year test volume and sales forecasts - Market shares of leading competitors - Feature comparison of major analyzers - Profiles of market players and start-up firms developing innovative technologies and products - Specific product and business opportunities for instrument and consumable suppliers. Rationale The NAT market is unquestionably the most rapidly growing segment of the in vitro diagnostics industry. The next ten years will witness significant developments in reagent systems and automation, as well as introduction of a wide range of new products that will require innovative marketing approaches. The rate of market penetration into routine clinical laboratories, however, will depend on the introduction of cost-effective and automated systems with amplification methods. In order to successfully capitalize on the opportunities presented by the NAT market, many companies are already exploiting new molecular technologies as corporate strategic assets, managed in support of business and marketing strategies. Integrating new technology planning with business and corporate strategies will be one of the most challenging tasks for diagnostic companies during the next ten years. Geographic Coverage - France - Germany - Italy - Japan - Spain - UK - USA Worldwide Market Overview - Laboratories performing DNA sequencing and NAT by country and market segment. - Ten-year test volume and sales projections by country. Market Segmentation Analysis - Sales and market shares of major suppliers of NAT reagent kits and components. - Ten-year test volume and sales forecasts for major applications, including: - Infectious Diseases - Forensic Testing - Cancer - Paternity Testing/HLA Typing - Genetic Diseases - Others - Ten-year test volume and sales projections for over 30 NAT assays. - A comprehensive analysis of the sequencing market, by country and laboratory segment, including: - Industrial - Academic - Government - Commercial - Detailed market segmentation analysis, including review of the market dynamics, trends, structure, size, growth and major suppliers, by country. Product/Technology Review - Comparison of leading NATanalyzers from Abbott, Beckman Coulter, BD, Bio-Rad, Gen-Probe, Roche, Tecan and other suppliers. - Extensive review of NAT technologies, test formats, detection methodologies, trends in testing automation and over 30 target/signal amplification methods, including: - PCR - bDNA - SDA - NASBA - TMA - SSSR, and others - LCR - Worldwide listings of companies, universities and research centers developing new NAT technologies and products. Competitive Assessments - Extensive strategic assessments of major suppliers and emerging market entrants,including their sales, product portfolios, marketing tactics, collaborative arrangements and new technologies/products in R&D. - Comprehensive listings of companies developing and marketing NAT products, by test and application. Opportunities and Strategic Recommendations - Specific new product development opportunities with potentially significant market appeal during the next ten years. - Design criteria for new products. - Alternative market penetration strategies. - Potential market entry barriers and risks. - Business planning issues and concerns. Methodology This report is based on a combination of primary and secondary information sources, including interviews with laboratory directors and executives of leading diagnostic companies and start-up firms developing innovative technologies and products in the U.S., five major European countries and Japan. In addition to primary sources of information, a comprehensive review of the most recent technical and business publications, manufacturer product and financial literature, as well as Venture Planning Group’s proprietary data base was conducted. Contains 1050 pages and 96 tables Please note: The delivery time for the electronic version of this report is between 1-3 business days to allow the preparation of an updated version prior to dispatch. Get full details about this report >> |
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