Epigenetics

Published by: Global Industry Analysts

Published: Feb. 1, 2010 - 361 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW

Epigenetics: An Introduction

Cancer: The Key Focus Area for Epigenetics

Histone Changes as Biomarkers: An Emerging Field

Future of Epigenetics

2. GLOBAL MARKET OVERVIEW

Scope of Epigenetics

Oncology

Psychiatry

Outlook of Epigenetic Treatments

Current and Future Analysis

Market Segmentation

Therapeutics

Diagnostics

Research Tools

Epigenetics Stretching to hESC Research

Epigenetics: Transforming from Special Niche to Widespread Collection of Tools

Pros and Cons of First Generation Epigenetics Drugs

Advances in Epigenetics Technologies, Therapeutics and Diagnostics

Outlook for Product Positioning and Innovation

Epigenetic Community Initiatives

Patent Law in Japan

3. COMPETITION

Epigenomics Pioneers the Epigenetics Diagnostics

Merck Leads HDAC Inhibitors Market

Huge Potential for Novel Therapies

Combination Therapy

Novel Technologies

4. PRODUCT OVERVIEW

Epigenetics - Definition

Categories of Signals in Epigenetics

Introduction

Etymology and Meaning

Epigenetics - Molecular Base

Mechanisms

Chromatin Remodeling and DNA Methylation

RNA Transcripts and Programmed Proteins

Prions

Structural Inheritance Systems

Functions and Outcomes

Development

Medicine

Evolution

Epigenetics in Microorganisms

5. PRODUCT LAUNCHES

Epigentek Group Launches New Measures for DNA Methylation Shifts

QIAGEN Introduces EpiTect® HRM™ PCR Kit

Enzo Biochem Rolls Out Wide-Ranging Epigenetics Tools

Applied Biosystems Unveils Novel Small RNA Expression Analysis Solution

Sigma-Aldrich Launches Imprint™ Methylated DNA Quantification Kit

Sigma-Aldrich Unveils ChIP Kit for Epigenetic Research

Pyrosequencing Introduces New PyroMark™ Q24

Qiagen Expands Epitect Portfolio

Applied Biosystems Introduces New SOLiD™ 3 System

6. RECENT INDUSTRY ACTIVITY

Merck Merges with Schering-Plough

Celldex Therapeutics Acquires CuraGen

NCCN Upgrades Vidaza to Category 1

PrognosDx Health Obtains UCLA Epigenetics Technology Rights

PROGEN Posts Positive Results from Preclinical Epigenetics Product

Pharmacyclics Announces Positive Scientific Results from PCI-24781 Clinical Trial Targeting HDAC

CellCentric Signs Agreement with Takeda

Orion Genomics and Novartis Ink Multi-Year Collaboration and License Agreement

SuperGen Collaborates with GlaxoSmithKline

QIAGEN to Acquire SABiosciences

QIAGEN Takes Over DxS

CellCentric Expands Number of Researchers

Roche NimbleGen Enters into Collaboration with Sigma-Aldrich

Quest Diagnostics Gains biomarker license from Epigenomics

Babraham Institute Launches New Epigenomics Sequencing Facility

Active Motif Enters into Licensing Agreement with City of Hope

NIH to Grant US$62 Million for Epigenetic Research

Rush University Medical Center Obtains US$5.5 Million Grant from NIH

Celgene Takes Over Pharmion

Eisai Takes Over MGI PHARMA

Affymetrix Acquires Panomics

QIAGEN Takes Over Biotage’s Biosystems

Millipore Corporation and Agilent Technologies Collaborate

Invitrogen Signs License Agreement with Genisphere

Invitrogen and IMBcom Proprietary Ink Licensing Agreement

OncoMethylome Sciences and QIAGEN Sign Licensing Agreement

Pharmacyclics Characterizes Highly Selective HDAC Inhibitor

Celgene’s Vidaza Gains Approval for MDS and AML in Europe

Medistem Enters into Epigenetics Collaboration

Orion Geomics Obtains License for IGF2 Gene from Johns Hopkins

Progen Pharmaceuticals Acquires CellGate

BioServe Purchases Genomics Collaborative

Sigma-Aldrich and Epigentek Signs Licensing Agreement

Constellation Pharmaceuticals and BioTrove Enter into R&D Collaboration

7. RECENT RESEARCH FINDINGS

Salk Institute Researchers Present Full Epigenome Map

Baylor College of Medicine Recognizes Epigenetic Affects on Obesity

Prenatal Starvation Could Cause Epigenetic Modifications

John Hopkins Scientists Reveal Epigenetic Modifications Take Place Over Lifetime

Advances in Epigentic Regulation Focuses on Breast Cancer

8. FOCUS ON SELECT PLAYERS

Celgene Corporation (US)

CellCentric Ltd. (UK)

Epigenomics AG (Germany)

Epigentek Group, Inc. (US)

Genpathway, Inc. (US)

Merck & Co., Inc. (US)

MGI Pharma, Inc. (US)

Millipore Corporation (US)

OncoMethylome Sciences S.A (Belgium)

Orion Genomics (US)

9. GLOBAL MARKET PERSPECTIVE

Table 1: World Recent Past, Current & Future Analysis for Epigenetics by Application Area - Drug Discovery, Diagnostics and Others Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2015 (includes corresponding Graph/Chart)

Table 2: World 10-Year Perspective for Epigenetics by Application Area - Percentage Breakdown of Dollar Sales for Drug Discovery, Diagnostics, and Others Markets for Years 2006, 2009, & 2015 (includes corresponding Graph/Chart)

III. COMPETITIVE LANDSCAPE

Abstract

This report analyzes the Global market for Epigenetics in US$ Million by the following Application Areas: Drug Discovery, Diagnostics, and Others. Annual forecasts are provided for the period 2006 through 2015. The report profiles 39 companies including many key and niche players worldwide such as Celgene Corporation, CellCentric Ltd., CellCentric Ltd., Epigentek Group, Inc., Genpathway, Inc., Merck & Co., Inc., MGI Pharma, Inc., Millipore Corporation, OncoMethylome Sciences S.A., and Orion Genomics. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

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