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Microarrays: Technologies, Applications, MarketsPublished by: CHI Insight Pharma Reports Published: Nov. 1, 2004 - 202 Pages Table of ContentsChapter 1. Introduction—Current State of Microarray Technology 1.1. A Brief History of Microarray Technology 1.2. DNA Microarray Technologies -Array Manufacturing Technologies --Synthesized Oligonucleotide Arrays --Spotted Arrays --Virtual Arrays --Universal Arrays 1.3. Protein Microarray Technology 1.4. Experimental Considerations -Sample Preparation and Processing --RNA Isolation --Target Amplification --Labeling --Hybridization -Data Collection, Processing, and Analysis --Detection --Data Processing and Analysis Chapter 2. Applications of DNA Microarray Technology 2.1. Gene Expression -Evolution of Gene Expression -Gene Expression Microarrays --Catalog Arrays --Custom Arrays --Homebrew Arrays --Bead Arrays -Research Applications --Basic Research --Pharmaceutical Research --Diagnostic Gene Expression 2.2. Microarrays for Other Applications -Genotyping Applications --Microarray-Based Commercial Genotyping Activity --Microarray-Based Genotyping Applications -Microbial Applications -Comparative Genomic Hybridization Chapter 3. Future Directions for DNA Microarray Technology 3.1. Technologies -Variations of Basic DNA Microarray Technology -High-Throughput Array Technology -Variant Array Types -General Comments 3.2. Future Directions in Microarray Applications -Basic Research -Drug Discovery and Development -Diagnostics -General Comments Chapter 4. The Microarray Market 4.1. Competition in the Microarray Market -Custom Array Market -High-Throughput Array Market -New Players 4.2. Growth Trends in the Microarray Market 4.3. Deal-Making in the Microarray Market Chapter 5. Expert Interviews and Selected Company Profiles 5.1. Expert Interviews -Matthew Cooper, PhD, Biogen Idec -David Craford, Affymetrix -Jennifer Dent, CombiMatrix -Wendell Jones, PhD and Steve Casey, Expression Analysis -Kyle Kolaja, Iconix -Mel Kronick, PhD, Agilent Technologies -Shawn Levy, PhD, Vanderbilt Microarray Shared Resource -Stanley Rose, PhD, NimbleGen 5.2. Extended Company Profiles -Affymetrix -Agilent Technologies -CombiMatrix -GE Healthcare Bio-Sciences -NimbleGen 5.3. Selected Company Profiles -Agilix Corporation -Axon Instruments -Gene Logic -High Throughput Genomics -Illumina -Luminex -MetriGenix -Nanogen -Pamgene -Silicon Genetics References Glossary Index AbstractMicroarrays: Technologies, Applications, Markets provides insightful and innovative business strategies and market acumen for companies striving to capitalize on the many evolving opportunities in this profitable but challenging business sector. The following critical areas are covered in detail to present a complete competitive view of the microarray market:• Current and emerging applications of DNA microarray technologies are reviewed and assessed. • Growth trends are analyzed for genome-wide arrays for both major and less prevalent organisms, medium-density special-purpose arrays, custom arrays, and high-throughput entries. Potential market sizes versus predicted growth rates are considered. • The DNA microarray market and the competitive environment are analyzed, including expanded company profiles and SWOT analysis of the market leaders and their technologies. The profiles examine each company’s alliances, intellectual property portfolio, and advantages over competing technologies. • In addition to the first-tier players, the report evaluates the technologies and strategies of new entrants to the market who are developing new tools to challenge and extend the status quo. • The untapped market potential of high-throughput array technology is discussed. As pharmaceutical and biotechnology companies increasingly identify biomarkers, the emphasis will increasingly fall on high-throughput arrays for a number of activities downstream from discovery, with emphasis on toxicogenomics for drug safety prediction.
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