2012 Italy Nucleic Acid Testing Market Outlook: Growth Opportunities and StrategiesPublished by: Venture Planning Group Published: Apr. 23, 2012 - 850 Pages Table of ContentsIntroductionWorldwide Market And Technology Overview A. DNA Sequencing 1. Introduction 2. Sequencing Methods 3. Autoradiography 4. The Human Genome Project 5. Sequencing Automation 6. Image Scanners 7. Fluorescent Detection 8. Gene Profiling 9. Gene Expression 10. Polymorphism Screening 11. Protein Interaction Networks B. DNA And RNA Probe Technology 1. Basic Principles 2. Probe Preparation 3. The DNA Probe Test a. Sample Preparation b. Hybridization c. Separation d. Detection/Measurement 4. Test Formats a. Filter Hybridization b. Southern Blot c. Northern Blot d. In Situ Hybridization e. Others 5. Labeling Techniques 6. Amplification Methods O Polymerase Chain Reaction - Temperature Cyclers - PCR Variations * Immuno-PCR * QC-PCR * DAP-PCR O Strand Displacement Activation O TMA O Ligase Chain Reaction O Branched DNA - Hybridization Protection Assay O Nucleic-Acid Sequence-Based Amplification O Self-Sustained Sequence Replicase O Others - Ampliprobe - CAR - CAS - CPT - Dendritic Polymer Technology - ISO-CR - LAT - Probe Networks - RAMP - Repair Chain Reaction - Rolling Circles - Sequence Independent Gene Amplification - Sequence Initiation Reaction - SISPA - Solid Phase Amplification C. Detection Technologies 1. Radioactive Methods a. Overview b. Major Isotopes O P-32 O S-35 O H-3 O I-125 2. Non-Isotopic Methods a. Enzymatic Labels b. Chemical Labeling O Indirect Chemical Labeling O Direct Chemical Labeling c. Fluorescence d. Chemiluminescence e. Electrical Conductivity D. Instrumentation Review 1. Abbott LCx 2. Beckman Coulter/Biomek FK 3. Becton Dickinson SDA 4. Bio-Rad GeneScope 5. Gen-Probe Tigris 6. Roche Cobas Amplicor 7. Tecan LS Series E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip - Liquid Transportation and Mixing - Separation - Reaction - Detection F. Pharmacogenomics G. Major Applications 1. Microbiology/Infectious Diseases a. Overview b. Major Infectious Diseases * AIDS O Structure and Composition O Classification O AIDS Origins O Animal Lentivirus Systems O Virus Receptors O HIV Infections in Humans - Pathogenesis and Pathology O CD4T Lymphocytes and Memory Cells O Monocytes and Macrophages O Lymphoid Organs O Neural Cells O Viral Coinfections - Clinical Findings O Plasma Viral Load O Pediatric AIDS - Neurologic Disease - Opportunistic Infections - Cancer O Immunity - Virus Isolation - Serology - Viral Nucleic Acid/Antigen Detection O Epidemiology - Worldwide Spread of AIDS - United States - Routes of Transmission O DNA Probes - Overview - Quantitative PCR - In Situ PCR - Needed Improvements O Viral Load/Drug Resistance Testing O Genotype and Phenotype Testing O Blood Banking Considerations * Adenovirus O Background O Diagnostic Tests O Vaccines and Drugs O Adeno-Associated Viruses (AAV) * Anthrax/Bacillus Anthracis O Background O Diagnostic Tests O Vaccines and Drugs * Babesiosis O Background * BEA and Other Bartonella Diseases O Background O Diagnostic Tests O Vaccines and Drugs * Chagas Disease O Background * Campylobacter O Background O Diagnostic Tests - Culture Identification O Vaccines and Drugs * Chlamydia O Background - Chlamydia psittaci - Chlmaydia pneumoniae - Chlamydia trachomatis O Diagnostic Tests O Vaccines and Drugs * Creutzfeldt-Jakob’s Disease O Background O Blood Transmission O Diagnostic Tests O Major Commercial and Academic Players - Bayer - Disease Sciences/Bio Tec Global - Imperial College School of Medicine - Ortho-Clinical Diagnostics - Pall - ProMetic Life Sciences - Proteome Sciences/Idexx - Q-One Biotech - Serono - U.S. Agricultural Research Service O Drugs O Vaccines * Cytomegalovirus O Background - Chorioretinitis - Gastrointestinal - Central Nervous System Disease O Diagnostic Tests O Vaccines and Drugs * Ebola Virus O Background - Epidemiology - Clinical Syndromes O Diagnostic Tests O Vaccines and Drugs * EchoVirus O Background - Acute Aseptic Meningitisis - Encephalitis - Exanthems - Respiratory Disease - Myopericarditis - Neonatal Infections O Diagnostic Tests O Vaccines and Drugs * Encephalitis O Background O Diagnostic Tests O Vaccines and Drugs * Enteroviruses O Background O Diagnostic Tests - Viral Isolation and Identification - Antibody Tests O Vaccines and Drugs * Epstein-Barr Virus O Background O Diagnostic Tests O Vaccines and Drugs * Gonorrhea O Background O Diagnostic Tests O Vaccines and Drugs * Hepatitis O Hepatitis A O Hepatitis B - Structure and Composition - Replication O Hepatitis C O Hepatitis D (Delta) O Hepatitis E O Hepatitis G O Hepatitis Infections Pathology O Clinical Findings O Laboratory Tests - Hepatitis A - Hepatitis B - Hepatitis C - Hepatitis D - Hepatitis E O Virus-Host Immune Reactions O Epidemiology - Hepatitis A - Hepatitis B - Hepatitis C - Hepatitis D (Delta) O Vaccines and Drugs * Herpes Simplex Virus O Background O Diagnostic Tests O Vaccines and Drugs * Legionella O Background O Diagnostic Tests O Vaccines and Drugs * Lyme Disease O Background - Clinical Description - Clinical Case Definition - Laboratory Criteria for Diagnosis - Case Classification O Diagnostic Tests O Vaccines and Drugs * Malaria * Mycoplasma O Background - Ureaplasma Urealyticum & Mycoplasma Hominis O Diagnostic Tests O Vaccines and Drugs * Papillomaviruses/HPV O Background - HPV in Cancer - Cervical Neoplasm O Diagnostic Tests O Vaccines and Drugs - Prevention * Parvovirus B19 O Background - Microbiology - Epidemiology - Clinical Syndromes - Erythema Infectiosum (Slapped Cheek) - Adult Polyarthropathy - Transient Aplastic Crisis - Transient Pancytopenia - Red Cell Aplasia in Immunocompromised - Perinatal Infections O Diagnostic Test O Vaccines and Drugs * Pneumonia O Background O Diagnostic Tests O Vaccines and Drugs * Polyomaviruses O Background O Diagnostic Tests O Vaccines and Drugs * Salmonellosis O Background O Diagnostic Tests O Vaccines and Drugs * Shigellosis O Background O Diagnostic Tests O Vaccines and Drugs * Streptococci O Background O Diagnostic Tests O Vaccines and Drugs - Group A Streptococci - Group B Streptococci * Toxoplasmosis O Background O Diagnostic Tests O Vaccines and Drugs * Tuberculosis O Background O Diagnostic Tests - Microscopic Characteristics - Cultural Characteristics - Skin Tests - MDRTB O Vaccines and Drugs * West Nile Virus O Background - Clinical Syndromes O Diagnostic Tests O Vaccines and Drugs * Yersinia O Background O Diagnostic Tests O Vaccines and Drugs c. Antibiotic Susceptibility 2. Cancer Testing a. Overview b. Major Cancer Types * Prostate * Lung * Colon and Rectum * Breast * Skin * Uterine * Leukemia * Oral c. Oncogenes O Abl/abl-bcr O AIB1 O BCL-2 O BRCA1 O CD44 O C-fos O C-myb O C-myc O CYP17 O Erb-B O HPC1 O N-myc O P40 O P51 O P53 O PIK3CA O PTI-1 O Ras O Reg O Sis O Src 3. Genetic Diseases a. Overview b. Nucleic Acid Amplification c. Chromosome Imaging d. Genomics Technologies e. Proteomics Technologies f. Current Pharmacogenomic Tests g. Future Pharmacogenomic Testing h. Major Diseases * Achondroplasia * Autosomal Dominant Polycystic Kidney Disease * Cancer * Cosmetogenomics * Cystic Fibrosis * Down's Syndrome * Duchenne and Becker Muscular Dystrophy * Factor V (Leiden) * Factor IX Deficiency * Fragile X Syndrome * Heart Disease * Hemochomatosis * Hemophilia * Huntington's Disease * Maternal-Fetal Incompatibility * Multiple Endocrine Neoplasia * Phenylketonuria (PKU) * Polycystic Kidney Disease (PKD) * Prenatal Screening * Retinitis Pigmentosa * Retinoblastoma * Sickle Cell Anemia * Spinal Muscular Atrophy * Vitamin B12 Metabolism i. Social Issues and Concerns 4. Forensic Testing a. Overview b. Multilocus and Single Locus Probes * Multilocus Probes * Single Locus Probes * PCR and RFLP c. The FBI d. DNA Profile Data Banks * U.S.A. * U.K. e. Judicial Implementation f. Major Crime Categories g. Factors Contributing to the DNA Probe Market Expansion * Technology Availability * Use of Hair as Evidence h. Wildlife Forensics 5. Paternity Testing/HLA Typing 6. Other Applications a. Disease Susceptibility Testing b. Cardiovascular Diseases c. Diabetes d. Alzheimer's Disease e. Periodontal Disease f. Plasma Purification g. Organ Transplantation h. Water Contamination i. Other H. Competing/complementing Technologies 1. Monoclonal Antibodies/Immunoassays 2. RNA Probes 3. Two-Dimensional Electrophoresis 4. Flow Cytometry Italy A. Executive Summary B. Business Environment C. Market Structure D. Market Size, Growth And Major Suppliers’ Sales And Market Shares Major Product Development Opportunities A. Instrumentation B. Reagent Kits and Test Systems/panels C. Computers, Software and Automation D. Auxiliary Products Design Criteria For Decentralized Testing Products Alternative Market Penetration Strategies A. Internal Development B. Collaborative Arrangements C. University Contracts D. Distribution Strategies For Decentralized Testing Markets 1. Marketing Approaches 2. Product Complexity 3. Customer Preference 4. Established Suppliers 5. Emerging Suppliers 6. Major Types Of Distributors 7. Market Segmentation Potential Market Entry Barriers And Risks A. Market Maturity B. Cost Containment C. Competition D. Technological Edge And Limitations E. Patent Protection F. Regulatory Constraints G. Decentralized Testing Market Challenges Competitive Profiles - Abbott - Affymetrix - Agilent - Applied Gene Technologies - Arca - Beckman Coulter/Danaher - Becton Dickinson - Biokit - BioMerieux - Bio-Rad - Biotest - Caliper - Cepheid - Decode - Diadexus - Eiken - Enzo - Exact Sciences - Fujirebio - Gen-Probe - Hologic - Illumina - Innogenetics/Solvay - Kreatech - Li-Cor Biosciences - Life Technologies - Monogram Biosciences - Myriad Genetics - Nanogen/Elitech - Novartis - Orchid CellMark - Ortho-Clinical Diagnostics - Proteome Sciences - Qiagen - Roche - Scienion - Sequenom - Shimadzu - Siemens - Sierra Molecular - Takara Bio - Tecan Group Appendixes Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology Appendix II: Glossary of Terms Appendix III: Currency Exchange Rates List of Tables Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests Oncogenes Potential Application in Cancer Diagnosis Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases Summary Table Italy, Molecular Diagnostics Test Volume And Sales Forecast by Major Application Italy, Laboratories Performing DNA Sequencing by Market Segment Italy, Molecular Diagnostics Market Potential Laboratory Universe by Market Segment Italy, Molecular Diagnostics Test Volume Forecast By Major Application Italy, Major Infectious Disease Molecular Diagnostics Test Volume Forecast Italy, Infectious Disease Screening NAT Volume Forecast Italy, Molecular Diagnostics Market Forecast By Major Application Italy, Infectious Disease Screening Nat Reagent Market Forecast by Test Italy, Molecular Diagnostics Market By Major Supplier Italy, HIV/Hepatitis NAT Market By Major Supplier AbstractHighlights
- Cancer - Forensic Testing - Genetic Diseases - Paternity Testing/HLA Typing
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