Nucleic Acid Therapies in Oncology Drug Pipeline Update 2012Published by: BioSeeker Group AB Published: Feb. 21, 2012 Table of Contents
AbstractNucleic acid therapies in oncology includes: Gene Therapy, DNA vaccine, Other DNA technologies, RNA Interference (RNAi), Small interfering RNA (siRNA), Antisense RNA and Ribozymes.There are today 204 companies plus partners developing 229 nucleic acid therapy drugs in 520 developmental projects in cancer. In addition, there are 7 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 177 drugs. Nucleic Acid Therapies In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 173 different targets. These targets are further categorized on in the software application by 55 classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. How May Drug Pipeline Update Be of Use?
Drug Pipeline Update at a Glance Investigators Includes more than 204 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. Developmental stage This Drug Pipeline Update contains 229 nucleic acid therapy drugs in development, which have a total of 520 developmental projects in cancer. In addition there are suspended and ceased drugs. Pipeline Breakdown According to Number of Drugs Marketed# 3 Pre-registration# 1 Phase III# 12 Phase II# 61 Phase I# 60 Preclinical# 170 No Data# 2 Suspended# 7 Ceased# 177 Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included nucleic acid therapy drugs are also in development for 95 other indications, where of 53 are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 173 different targets, divided into 55 classifications of molecular function:
Target Expression Profile Direct links are provided from inside the application to 192 protein expression profiles of 123 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath.
Mechanism In total there are different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of. System Requirements
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