Phospholipids and Sphingolipids of Milk - Key players, innovators and Industry AnalysisPublished by: Dolcera Corporation Published: Nov. 17, 2011 - 46 Pages Table of Contents
AbstractPhospholipids and sphingolipids of milk form an integral part of Milk Fat Globule Membrane (MFGM). MFGM is a protein-lipid biopolymer that originates from the apical surface of mammary epithelial cells and surrounds fat globules in milk. The phospholipids and membrane glycoproteins found in MFGM likely interact extensively with the gut epithelia during digestion, both physically and biochemically. Moreover, MFGM has a relatively high concentration of sphingolipids, which in purified form have been demonstrated to be protective against colon cancer.Phospholipids represent a major portion of total lipids of buttermilk and skim milk, reflecting presence of proportionately larger amounts of membrane materials in these products. The phospholipids and sphingolipids in milk are gaining interest due to their nutritional and technological qualities. Sphingolipids and their derivatives are highly bioactive compounds with anti-cancer, bacteriostatic and cholesterol-lowering properties. Moreover sphingolipids and their metabolites help reduction of the number of aberrant crypt foci (clusters of abnormal tube-like glands in the lining of the colon and rectum), shift in tumor type (malignant ¨ benign), protect the liver from fat- and cholesterol-induced steatosis (abnormal retention of lipids within a cell), suppress gastrointestinal pathogens, myelination of the developing central nervous system, age-related diseases. Phosphatidylserine (PS) is observed to have positive effects on Alzheimerfs patients and also helps restore normal memory on a variety of tasks. Phosphatidylcholine (PC) supports liver recovery from toxic chemical attack or viral damage and protects the human GI mucosa against toxic attack. Lyso-Phosphatidylcholine (lyso-PC) exhibits bacteriostatic and bactericidal capacity. Dolcera report focuses on finding the key innovators and the industry ecosystem through relevant patents, clinical trials and university data encompassing the extraction, modification of phospholipids and sphingolipids from milk and their application in variety of products. The relevant keywords used in the search were obtained after an extensive study of relevant scientific articles and patents. The relevant class codes for the search were obtained from the control patents and keyword based searches coupled with manual search of classification index. Dolcera has retrieved around 300 relevant patents related to phospholipids and sphingolipids, covering over 42 worldwide patenting authorities. The report highlights year-wise patent activity (trend line) along with the key industrial players in the field. Patents were categorized on the basis of patent focus- whether extraction or purification, process for improving functionality of phospholipids and sphingolipids, application in food, pharma and cosmetic formulations. The categorized patents were further analyzed to determine the key players under each category. A comprehensible result in the form of Dolcera dashboard has been given. Dashboard links the Companies in each category to their patents, hence making an interactive platform for analysis. Furthermore, patents have been mapped to commercially available products produced by the respective assignees and other licensees. Get full details about this report >> |
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