Special Report: Ankylosing Spondylitis-Surveyed Rheumatologists Await Non-TNF-Alpha Inhibitor Therapies in an Underserved Market

Published by: Decision Resources

Published: Jun. 6, 2011


Table of Contents

Executive Summary

Strategic Considerations

Stakeholder Implications

Introduction

Disease Overview

Ankylosing Spondylitis in Perspective: The Spondyloarthropathies

Disease Definition, Etiology, and Pathophysiology

Symptoms and Peripheral Involvement

Diagnosis and Disease Progression

Epidemiology and Patient Populations

Overview

Methods

Current Treatment

NSAIDs and Conventional DMARDs

TNF-á Inhibitors Approved for AS Treatment

Agents Used Off-Label

UCB’s Cimzia

Other Marketed Agents with Use/Potential in Ankylosing Spondylitis

Emerging Therapies for Ankylosing Spondylitis

Novartis’s AIN-457

Regeneron Pharmaceuticals/Sanofi’s SAR-153191 (REGN-88)

Pfizer’s Tofacitinib

Celgene’s Apremilast

Pfizer/Ablynx’s ATN-103 (PF-05230896)

2010 Market and Market Outlook

Outlook for TNF-á Inhibitors

General AS Market Outlook

Bibliography

About the Authors

Look for relevant insight within these Spectrum series and related Spectrum reports:

Abstract

AS remains a significantly underserved market, despite the major impact that TNF-á inhibitors have had on the treatment of the disease. A significant percentage of the AS patients treated by 50 U.S. rheumatologists surveyed by Decision Resources in February 2011 are TNF-á inhibitor-refractory; these patients need alternative therapies. Therefore, the AS market still offers much opportunity to companies developing drugs with novel mechanisms of action.

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