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Disease INFOPACK: Chlamydia trachomatis

Published by: VacZine Analytics

Published: May. 1, 2008 - 50 Pages


Table of Contents


Executive summary (1)

Executive summary (2)

Authors Note

The Pathogen

Serovars

Clinical Features

Pathogenesis

Host Response

Transmission

Risk Factors

Prevention and Control

Diagnosis

Treatment

Morbidity

Morbidity (cont.)

Pelvic Inflammatory Disease

Pelvic Inflammatory Disease - Incidence

Natural History of Infection

Global Incidence

US Incidence

UK Incidence

Reasons for Continuing Increase

Cases by Age and Sex (US)

Cases by Age and Sex (UK)

Reasons for Gender Difference

US Prevalence

US Prevalence (sex, age group - 2007)

UK Prevalence (sex, age group - 2007)

Prevalence: Selected Countries

Gardasil Registration Studies

Regional Prevalence

Calculation of Regional Prevalence

Comments on Data Accuracy

Key Issues and Challenges

Opportunities for New Treatments

Appendix I - Back-up

Appendix II - Bibliography

Appendix III - About VacZine Analytics

Abstract

Chlamydia trachomatis is an intracellular Gram-negative bacterium and a leading cause worldwide of sexually-transmitted disease and preventable blindness. The pathogen is a major cause of serious reproductive complications in the female with outcomes such as pelvic inflammatory disease (PID) and ectopic pregnancies. Although diagnosed infections with Chlamydia trachomatis are curable with antibiotic therapy the vast majority infections are “silent” and unrecognized. This is of concern due to continued transmission especially among individuals below 30 years of age. This DiseaseINFOPACK report is an expert review of the current literature regarding Chlamydia trachomatis. Particular emphasis has been placed on proprietary calculations of global incidence and prevalence based on available literature and “in-house” methodology. Key issues and challenges with regard to developing an effective prophylatic vaccine are also noted.

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