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U.S. COPD Market - Therapeutic Overview and Patient Outlook

Published by: Frost & Sullivan

Published: Jun. 18, 2007 - 80 Pages


Table of Contents


1. Executive Summary

1. Executive Summary

1. Introduction


2. Total Market

1. Research Scope and Methodology

1. Scope and Segmentation

2. Research Methodology

2. Disease Overview

1. Introduction

2. Disease Definition

3. Symptoms

4. Risk Factors

5. Diagnosis

6. Treatments

7. Drug Delivery Methods

8. Disease Statistics

9. Competitive Structure

3. Patient Outlook

1. Patient Forecasts

4. General Market Trends

1. Challenges

2. Strategic Recommendations for Challenges

3. Market Drivers

4. Market Restraints


3. Marketed Therapies Overview

1. Overview

1. Bronchodilators

2. Anti-inflammatories

3. Combination Therapies

4. Novel Therapeutic Approaches


4. Appendix

1. Decision Support Databases

1. Chronic Obstructive Pulmonary Disease Population

2. Prevalence of Male Smokers

3. Prevalence of Female Smokers

4. Population 65 and Over

5. Prevalence of Asthma




List of Figures


Chapter 2


COPD Market: Competitive Structure (U.S.), 2006

COPD Market: Diagnosed Male Population Forecast by Age Group (U.S.), 2003-2013

COPD Market: Diagnosed Female Population Forecast by Age Group (Millions) (U.S.), 2003-2013

COPD Market: Chronic Bronchitis and Emphysema Population By Gender (U.S.), 2006-2013

COPD Market: Impact of Top Industry Challenges (U.S.), 2007-2013

COPD Market: Strategies Addressing Market Challenges (U.S.), 2007-2013

COPD Market: Market Drivers Ranked in Order of Impact (U.S), 2007-2013

COPD Market: Market Restraints Ranked in Order of Impact (U.S.), 2007-2013

Chapter 3


COPD Market: Short-Acting Beta-2 Agonists (U.S.), 2006

COPD Market: Long-Acting Beta-2 Agonists (U.S.), 2006

COPD Market: Anticholinergics (U.S.), 2006

COPD Market: Methylxanthines (U.S.), 2006

COPD Market: Combination Bronchodilators (U.S.), 2006

COPD Market: Inhaled Corticosteroids (U.S.), 2006

COPD Market: Oral Corticosteroids (U.S.), 2006

COPD Market: Anti-Leukotrienes (U.S.), 2006

COPD Market: Combination Therapies (U.S.), 2006

COPD Market: Selected Novel Therapeutic Pipeline Compounds (U.S.), 2006

Abstract

The Frost & Sullivan research service titled U.S. COPD Market: Therapeutic Overview and Patient Outlook provides insight into marketed products, patient forecasts, and selected therapeutic approaches that are outside of current marketed areas. In this research, Frost & Sullivan's expert analysts thoroughly examine the following markets: bronchodilators, anti-inflammatories, combination therapies, and novel therapeutic approaches.

COPD remains one of the Leading Under-diagnosed Diseases

Chronic obstructive pulmonary disease or COPD is a slow progressing disease, characterized by airflow obstruction, which consists of both chronic bronchitis and emphysema. The disease remains incurable and current treatments are only able to help relieve symptoms and slow the progression of the disease rather than reverse any lung damage. While around 13.6 million Americans have been diagnosed with this disease, it is estimated that an additional 15 million Americans have the disease but remain undiagnosed. This makes COPD one of the leading under-diagnosed diseases in the U.S. According to the National Institute of Health, COPD is currently the fourth-leading cause of death in the U.S. and is expected to ascend to the third position by 2020.

Smoking is the largest contributing factor to the development of COPD. Although the number of adult smokers decreased in the last decade, these numbers seem to have leveled off with the smoking rate staying virtually the same. "Furthermore, with an estimated 45 million current smokers and 45.9 million former smokers in the U.S. the COPD patient population is expected to expand," notes the analyst of this research service. "This could increase the number of people requiring treatment for this disease and subsequently maintain positive revenue growth."

Poor Patient Compliance Restraining Market Growth

One of the major obstacles in the expansion of the U.S. COPD market is the high rate of patient noncompliance. COPD is cited as having the fourth-highest rate of patient noncompliance. It is estimated that the prescription compliance rate for these patients is under 50 percent, and many experts believe that actual compliance rates are much lower. For example, in The Lung Health Study, it was determined that for bronchodilators, compliance as measured by canister weight was actually 10 percent lower then reported compliance rates. Another study found that compliance rates for patient use of inhaled corticosteroids were as low as 18 percent. Moreover, medications used to treat COPD come with side-effects, which often discourage patients from long-term use of these products. Side-effects for COPD medications are magnified with multiple medications and this amplifies the problem as the typical COPD patient is prescribed several different medications.

Developing drugs that required less frequent dosing could go a long way in addressing compliance concerns. The success of products such as Spiriva and Advair that require less frequent dosing only reconfirms the need for more convenient treatment options. "Going forward, the number of Americans diagnosed with COPD is expected to increase by 34.5 percent from 13.6 million to 18.4 million in 2013," says the analyst. "This increase can be attributed to several factors including the increased growth in the older age segments of the population, the high number of current and former smokers, and an increase in screening for COPD."

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