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Chronic Lymphocytic Leukemia: Monoclonal Antibodies Will Drive Steady Growth

Published by: Decision Resources

Published: Jun. 14, 2006 - 24 Pages

Price reduced due to age.

Table of Contents


Contents Introduction

Overview of Chronic Lymphocytic Leukemia

Disease Characteristics

Etiology and Pathophysiology

Symptoms

Staging and Survival

Epidemiology

Role of Biological Markers in Prognosis

Current Treatment Options for Chronic Lymphocytic Leukemia

Treatment Decisions

First-Line Therapies

Second-Line Therapies

Third-Line Therapies

Emerging Therapies for Chronic Lymphocytic Leukemia

Monoclonal Antibodies

Rituximab

Lumiliximab

Other Monoclonal Antibodies

Immunotoxins

Cell-Cycle Inhibitors

Antisense Oligonucleotides

Market Outlook

Table 1 Common Staging Systems Used in the Treatment of CLL

Table 2 Select Current Therapies Used for the Treatment of CLL, 2006

Table 3 NCI Definition of Response to Treatment in CLL Patients

Table 4 Select Emerging Therapies for the Treatment of CLL in the United States, 2006

Figure 1 Treatment Algorithm for Chronic Lymphocytic Leukemia

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Current research is focusing on the urgent unmet need for agents that improve survival. Improved responses from treatment regimens that combine targeted biological agents with established chemotherapy, as well as increased drug therapy for early-stage patients who are likely to progress based on potential prognostic markers, have already begun and will continue to create market opportunities and propel steady growth of the CLL market. In this report, we provide an overview of CLL, including its staging, epidemiology, and biological markers. We discuss the current treatments and promising late-stage agents in development for CLL, as well as the market outlook though 2010.

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