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Conference Documentation: Advances and Progress in Drug Design

Conference Documentation: Advances and Progress in Drug Design

SMi presents the 15th Annual Advances and Progress in Drug Design 2016, with a strong focus on advanced biophysical technologies and combinatorial methods enabling greater insight of biologics and drug interaction.

Hosted over two days, this international conference will provide an exclusive opportunity to gain new insight on small molecule-protein fragments, IMI Open PHACTS project for data mining work flows, and structure-based models combining hit finding strategies of fragment leads.

Inspiring talks will also highlight developments in the quality control of misfolded proteins, solvent effects, and protein-ligand stability; identifying whether the bound conformation of protein-ligand structure gives the lowest energy state and the impact of drug design.

Join us for a keynote address on reviving covalent drug design in oncology from Pfizer, and a case study session on target validation of NCE’s through fragment screening and opportunities for antibodies as guidance tools from UCB.


Day 1
8:30
Registration & Coffee
9:00
Chairman's Opening Remarks
Gregg Siegal, Chief Executive Officer, ZoBio
9:10
OPENING ADDRESS: Driving biophysics in drug discovery
Gregg Siegal, Chief Executive Officer, ZoBio
9:50
A toolbox for fragment optimisation
Gianni Chessari, Director, Astex Pharmaceuticals
10:30
Morning Coffee
11:00
Structure based drug design within the lipid bilayer
Tove Sjogren, Associate Director, AstraZeneca
11:40
Organizing 3D Project Data for Structure-Based Drug Design
Howard Feldman, Principal Scientist, Chemical Computing Group
12:20
Networking Lunch
13:30
KEYNOTE ADDRESS: Reviving covalent drug design: Discovery of PF-04457845, an irreversible FAAH inhibitor with exquisite selectivity
Doug Johnson, Research Fellow, Pfizer
14:10
Industry Spotlight: Quality control of Misfolded protein response- via PPP1R15A inhibition by the highly selective first-in-class IFB-088 to treat genetic misfolding diseases
Philippe Guedat, Chief Executive Officer, INFLECTIS BIOSCIENCE
14:50
Design Strategies for compound libraries in High Throughput Screening
Stevan Djuric, Senior Director, Abbott Labortories
15:30
Afternoon Tea
16:00
eHOMO calculations as a predictor for mutagenesis propensity of compounds
Jordi Munoz Muriedas, Investigator, GSK
16:40
Linked open data in drug discovery: where are we?
Herman van Vlijmen, Senior Director, Janssen
17:20
Exploring uncharted kinome territory by mining structural information
Simone Fulle, Research Group Leader, BioMed X Innovation Center
18:00
Chairman’s Closing Remarks and Close of Day One
Gregg Siegal, Chief Executive Officer, ZoBio
18:10
Sponsored Drinks Reception
Day 2
8:30
Registration & Coffee
9:00
Chairman's Opening Remarks
Gregg Siegal, Chief Executive Officer, ZoBio
9:10
OPENING ADDRESS: Structure-based drug discovery inspired by fragments: Methods, design and binding affinity
Hans Matter, Senior Scientist, Sanofi-Aventis
9:50
Water mapping on drug design
Benjamin Tehan, Senior Computational Chemist, Heptares Therapeutics
10:30
Morning Coffee
11:00
Structure based drug design of the first known inhibitors of PHGDH
Atilla Ting, Computational Chemist, AstraZeneca
11:40
Growing a baby: identifying and optimising quality leads and overcoming restraints in drug discovery
Manuel Molina, Research Scientist, Eli Lilly
12:20
Networking Lunch
13:30
Deducing the dynamics of protein-complex supramolecular assemblies through structural-based drug design
Armin Ruf, Section Head Biostructure, Roche
14:10
Optimising ADME properties
Alexander Hillisch, Director, Medicinal Chemistry , Bayer
14:50
Fragment-based approach at UCB
Marta Westwood, Principal Scientist, UCB Pharma
15:30
Afternoon Tea
16:20
Biophysical screening tools for compound validation
Alexey Rak, Head of Bio Structure & Biophysics, Sanofi
16:40
Assessment of binding kinetics and “slow-off” rates
Matthias Frech, Director, Merck KGaA
17:20
Enabling Biophysical tools for hit lead generation
Xavier Barril, ICREA Research Professor, Barcelona University
17:20
Chairman’s Closing Remarks and Close of Day Two
Gregg Siegal, Chief Executive Officer, ZoBio

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