Nuclear Factor Erythroid 2 Related Factor 2 - Pipeline Review, H2 2020
According to the recently published report 'Nuclear Factor Erythroid 2 Related Factor 2 - Pipeline Review, H2 2020'; Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2) pipeline Target constitutes close to 40 molecules. Out of which approximately 34 molecules are developed by companies and remaining by the universities/institutes.
Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2) - Nuclear factor (erythroid-derived 2)-like 2 or Nrf2 is a transcription factor encoded by the NFE2L2 gene. It binds to antioxidant response elements in the promoter regions of target genes. It is important for the coordinated up-regulation of genes in response to oxidative stress. It is involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
The report 'Nuclear Factor Erythroid 2 Related Factor 2 - Pipeline Review, H2 2020' outlays comprehensive information on the Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I and Preclinical stages are 2, 5, 5 and 22 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 5 and 1 molecules, respectively.
Report covers products from therapy areas Central Nervous System, Immunology, Metabolic Disorders, Oncology, Cardiovascular, Respiratory, Gastrointestinal, Genetic Disorders, Musculoskeletal Disorders, Ophthalmology, Dermatology, Genito Urinary System And Sex Hormones, Infectious Disease, Hematological Disorders and Toxicology which include indications Multiple Sclerosis, Psoriasis, Diabetic Nephropathy, Chronic Obstructive Pulmonary Disease (COPD), Systemic Sclerosis (Scleroderma), Chronic Kidney Disease (Chronic Renal Failure), Coronavirus Disease 2019 (COVID-19), Friedreich Ataxia, Huntington Disease, Mitochondrial Myopathy, Neurodegenerative Diseases, Non-Alcoholic Steatohepatitis (NASH), Osteoarthritis, Pulmonary Arterial Hypertension, Relapsing Remitting Multiple Sclerosis (RRMS), Retinal Degeneration, Type 2 Diabetes, Acne Vulgaris, Acute Respiratory Distress Syndrome, Adrenoleukodystrophy (Adrenomyeloneuropathy/ Schilder-Addison Complex), Age Related Macular Degeneration, Alport Syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Asbestosis, Aspiration Pneumonitis, Asthma, Atherosclerosis, Breast Cancer, Bullous Pemphigoid, Cardiomyopathy, Cerebral Vasospasm, Diabetic Complications, Diffuse Large B-Cell Lymphoma, Duchenne Muscular Dystrophy, Encephalomyelitis, Focal Segmental Glomerulosclerosis (FSGS), Glioblastoma Multiforme (GBM), Idiopathic Pulmonary Fibrosis, Idiopathic Pulmonary Hypertension, IgA Nephropathy (Berger's Disease), Ischemia Reperfusion Injury, Ischemic Stroke, Keloids, Kennedy’s Disease (Spinal and Bulbar Muscular Atrophy), Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy), Lung Injury, Medulloblastoma, Metastatic Breast Cancer, Metastatic Melanoma, Neuroblastoma, Non Alcoholic Fatty Liver Disease (NAFLD), Non-Hodgkin Lymphoma, Non-Small Cell Lung Cancer, Osteoarthritis Pain, Osteoporosis, Ovarian Cancer, Parkinson's Disease, Pervasive Developmental Disorder (PDD), Plaque Psoriasis (Psoriasis Vulgaris), Polycystic Kidney Disease, Post-Myocardial Infarction, Primary Progressive Multiple Sclerosis (PPMS), Prostate Cancer, Pulmonary Hypertension, Radiodermatitis, Refractory Medulloblastoma, Retinopathy, Sickle Cell Disease, Spinocerebellar Ataxia (SCA), Subacute Necrotizing Encephalomyelopathy (Leigh Disease), Type 1 Diabetes (Juvenile Diabetes) and Ulcerative Colitis.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
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