Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2018
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) pipeline Target constitutes close to 33 molecules. Out of which approximately 29 molecules are developed by companies and remaining by the universities/institutes. The latest report Complement C5 - Pipeline Review, H2 2018, outlays comprehensive information on the Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Complement component 5 is a protein is encoded by the C5 gene. Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Unknown stages are 1, 4, 5, 2, 1, 15 and 1 respectively.
Similarly, the universities portfolio in Preclinical and Discovery stages comprises 3 and 1 molecules, respectively. Report covers products from therapy areas Hematological Disorders, Immunology, Ophthalmology, Gastrointestinal, Cardiovascular, Central Nervous System, Dermatology, Genito Urinary System And Sex Hormones, Infectious Disease, Oncology, Other Diseases, Respiratory and Undisclosed which include indications Paroxysmal Nocturnal Hemoglobinuria, Atypical Hemolytic Uremic Syndrome (Nondiarrhea - Associated Hemolytic Uremic Syndrome), Myasthenia Gravis, Chronic Inflammation, Autoimmune Disorders, Atopic Keratoconjunctivitis, Bullous Pemphigoid, Choroidal Neovascularization, Geographic Atrophy, Intermediate Uveitis, Lupus Nephritis, Neuromyelitis Optica (Devic’s Syndrome), Posterior Uveitis, Acute Lung Injury, Age Related Macular Degeneration, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis), Bacterial Sepsis, Cardiovascular Inflammation, Community Acquired Pneumonia, End-Stage Kidney Disease (End-Stage Renal Disease or ESRD), Glomerulonephritis, Guillain-Barre Syndrome, Hidradenitis Suppurativa, Inflammation, Ischemia, Ischemia Reperfusion Injury, Juvenile Macular Degeneration (Stargardt Disease), Liver Transplant Rejection, Lung Adenocarcinoma, Multiple Organ Failure (Multiple Organ Dysfunction Syndrome), Polypoidal Choroidal Vasculopathy, Rheumatoid Arthritis, Sepsis, Septic Shock, Subarachnoid Hemorrhage, Traumatic Brain Injury, Typical Hemolytic Uremic Syndrome (Shiga-Toxin Associated Hemolytic Uremic Syndrome), Unspecified, Uveitis and Wet (Neovascular / Exudative) Macular Degeneration.
Furthermore, this report also reviews key players involved in Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
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