Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Pipeline Review, H2 2018
Summary
Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) pipeline Target constitutes close to 38 molecules. Out of which approximately 33 molecules are developed by companies and remaining by the universities/institutes. The latest report Alpha Synuclein - Pipeline Review, H2 2018, outlays comprehensive information on the Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Alpha-synuclein is a protein normally found in cells all over the body. It is one of the key players in Parkinson’s. In Parkinson’s it forms clumps inside the specific nerve cells that produce the chemical dopamine. It is involved in the regulation of dopamine release and transport. It induces fibrillization of microtubule-associated protein tau. It reduces neuronal responsiveness to various apoptotic stimuli, leading to decreased caspase-3 activation.
The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 4, 5, 19 and 5 respectively. Similarly, the universities portfolio in Preclinical stages comprises 5 molecules, respectively. Report covers products from therapy areas Central Nervous System, Metabolic Disorders, Gastrointestinal, Genetic Disorders, Infectious Disease, Oncology and Ophthalmology which include indications Parkinson's Disease, Multiple System Atrophy (MSA or Shy-Drager Syndrome or Multi-System Degeneration), Alzheimer's Disease, Lewy body Dementia, Neurodegenerative Diseases, Amyloidosis, Constipation, Down Syndrome, Familial Amyloid Neuropathies, Glaucoma, Human Immunodeficiency Virus (HIV) Infections (AIDS), Huntington Disease, Metastatic Breast Cancer, Schizophrenia, Spinal Cord Injury, Traumatic Brain Injury and Type 2 Diabetes.
Furthermore, this report also reviews key players involved in Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA)
- The report reviews Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics and enlists all their major and minor projects
- The report assesses Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) targeted therapeutics
Reasons to buy- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Introduction
- Global Markets Direct Report Coverage
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Overview
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Companies Involved in Therapeutics Development
- AC Immune SA
- AFFiRiS AG
- BioArctic AB
- Biogen Inc
- Denali Therapeutics Inc
- Fulcrum Therapeutics Inc
- Genmab A/S
- ICB International Inc
- MedImmune LLC
- Neuropore Therapies Inc
- nLife Therapeutics SL
- Priavoid GmbH
- ProMIS Neurosciences Inc
- Prothena Corp Plc
- QR Pharma Inc
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Drug Profiles
- ABL-301 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Antibodies to Inhibit Alpha-Synuclein for Glaucoma - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Antibody to Inhibit Alpha Synuclein for Parkinson's Disease and Multiple System Atrophy - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Antibody to Inhibit Alpha-Synuclein for Neurodegenerative Diseases - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ASD-004 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AV-1947D - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AV-1948D - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AV-1949D - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AV-1950D - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AV-1950R - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- BAN-0805 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- BIIB-054 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- CLR-01 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- DPC-003 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ENT-01 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- LuAF-82422 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- MEDI-1341 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Monoclonal Antibodies to Inhibit Alpha Synuclein for Parkinson's Disease and Lewy Body Dementia - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Monoclonal Antibodies to Inhibit Tau, Amyloid Beta and Alpha-Synuclein for Neurodegenerative Diseases - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Monoclonal Antibody to Inhibit Alpha Synuclein for Central Nervous System Disorders - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- NLFPD-1233 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- NPT-088 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- NPT-10018A - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- NPT-189 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- NPT-20011 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- PD-01 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- PD-03 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- PD-04 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Posiphen - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- PRX-002 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- quinpramine - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Small Molecule to Inhibit Alpha-Synuclein for Parkinson's Disease - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Small Molecule to Inhibit Alpha-Synuclein for Parkinson's Disease - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Small Molecules to Inhibit Alpha-Synuclein and Lcn2 for Parkinson's Disease - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Small Molecules to Inhibit Alpha-Synuclein for Parkinson's Disease - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Synthetic Peptide to Inhibit Alpha Synuclein for Parkinson’s Disease - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- trehalose - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- UB-312 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Dormant Products
- Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA) - Product Development Milestones
- Featured News & Press Releases
- Jun 26, 2018: ProMIS Neurosciences Unique Discovery Platform Generates Potential New Antibody Therapeutics for Neurodegenerative Diseases
- Jun 19, 2018: Prothena Announces Phase 1b Clinical Trial Results Of PRX002/RG7935 For Parkinson's Disease Published In JAMA Neurology
- Jun 18, 2018: New immunotherapy could stop progression of Parkinson’s disease
- May 14, 2018: AFFiRiS Announces Encouraging Long-term Data from a Series of First-in-Human Studies Using AFFITOPE PD01A Targeting Oligomeric Alpha-synuclein in Early Parkinson's Disease Patients
- Mar 28, 2018: Proclara Biosciences Presents Preclinical Data Supporting the Development of GAIM-Based Therapies for Peripheral Amyloidoses at the 16th International Symposium on Amyloidosis
- Mar 26, 2018: Enterin's Phase 2a RASMET Study in Patients With Parkinson's Disease Completes Enrollment
- Mar 15, 2018: AC Immune prepares for a first in human study of a promising positron emission tomography tracer for Parkinson's disease
- Mar 01, 2018: AFFiRiS Announces Results of a Phase I Clinical Study Using AFFITOPEs PD01A
- Mar 01, 2018: AFFiRiS Announces Results of a Phase I Clinical Study Using AFFITOPEs PD03A
- Dec 04, 2017: ICBII Announces the Filing of Orphan Drug Designation Application for the Use of alpha-Synuclein-SMART Molecule in the Treatment of Multiple System Atrophy
- Nov 14, 2017: Proclara Biosciences Presents New Preclinical Data on GAIM-Based Therapy NPT088 at Society for Neuroscience Annual Meeting
- Nov 14, 2017: Proclara Biosciences Presents New Preclinical Data on GAIM-Based Therapy NPT189 at Society for Neuroscience Annual Meeting
- Oct 13, 2017: BioArctic's Patent for its Product Candidate Antibody BAN0805, for Parkinson's Disease, is Now Granted in Europe
- Jul 18, 2017: Proclara Biosciences Presents New Preclinical Data Supporting the Development of NPT189 at Alzheimer’s Association International Conference (AAIC) 2017
- Jul 17, 2017: Proclara Biosciences Announces Pipeline Progress
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Number of Products under Development by Stage of Development, H2 2018
- Number of Products under Development by Therapy Areas, H2 2018
- Number of Products under Development by Indication, H2 2018
- Number of Products under Development by Companies, H2 2018
- Number of Products under Development by Companies, H2 2018 (Contd..1)
- Products under Development by Companies, H2 2018
- Products under Development by Companies, H2 2018 (Contd..1), H2 2018
- Products under Development by Companies, H2 2018 (Contd..2), H2 2018
- Number of Products under Investigation by Universities/Institutes, H2 2018
- Products under Investigation by Universities/Institutes, H2 2018
- Number of Products by Stage and Mechanism of Actions, H2 2018
- Number of Products by Stage and Route of Administration, H2 2018
- Number of Products by Stage and Molecule Type, H2 2018
- Pipeline by AC Immune SA, H2 2018
- Pipeline by AFFiRiS AG, H2 2018
- Pipeline by BioArctic AB, H2 2018
- Pipeline by Biogen Inc, H2 2018
- Pipeline by Denali Therapeutics Inc, H2 2018
- Pipeline by Fulcrum Therapeutics Inc, H2 2018
- Pipeline by Genmab A/S, H2 2018
- Pipeline by ICB International Inc, H2 2018
- Pipeline by MedImmune LLC, H2 2018
- Pipeline by Neuropore Therapies Inc, H2 2018
- Pipeline by nLife Therapeutics SL, H2 2018
- Pipeline by Priavoid GmbH, H2 2018
- Pipeline by ProMIS Neurosciences Inc, H2 2018
- Pipeline by Prothena Corp Plc, H2 2018
- Pipeline by QR Pharma Inc, H2 2018
- Dormant Products, H2 2018
- Dormant Products, H2 2018 (Contd..1), H2 2018
- List of Figures
- Number of Products under Development by Stage of Development, H2 2018
- Number of Products under Development by Therapy Areas, H2 2018
- Number of Products under Development by Top 10 Indications, H2 2018
- Number of Products by Stage and Mechanism of Actions, H2 2018
- Number of Products by Routes of Administration, H2 2018
- Number of Products by Stage and Routes of Administration, H2 2018
- Number of Products by Molecule Types, H2 2018
- Number of Products by Stage and Molecule Types, H2 2018