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Cognitive Impairment Disorders Drug Development Pipeline Review, 2018

Cognitive Impairment Disorders Drug Development Pipeline Review, 2018

Summary


Due to the complex and highly sophisticated nature of the central nervous system (CNS), the pathophysiology of these disorders is not well understood. Currently, marketed drugs for cognitive impairment disorders act by slowing disease progression or treating symptoms.

The total number of products under development for CIAS, dementia, mild cognitive impairment and Alzheimer's disease is 33, 109, 35 and 645, respectively. Key companies operating in these pipelines include Eli Lilly and Co., Bristol-Myers Squibb, Pfizer and AstraZeneca.

The majority of products under development for these disorders are small molecules, due to their ability to cross the blood-brain barrier and their proven commercial success in this area. In addition, the majority of products are neuromodulators, impacting the dopaminergic, serotonergic and glutamatergic systems. There is diversity within each indication in terms of molecule type and molecular targets.

This report “Cognitive Impairment Disorders Drug Development Pipeline Review, 2018” provides an overview of the pipeline landscape for cognitive impairment disorders. It comprehensively documents therapeutics under development for cognitive impairment associated with schizophrenia (CIAS), dementia, mild cognitive impairment and Alzheimer's disease, and features dormant and discontinued products.

Scope

  • Which companies are the most active within the pipeline for cognitive impairment disorders?
  • Which pharmaceutical approaches are most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened within this field?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


  • GBI Research Report Guidance
  • Executive Summary
  • Introduction
    • Cognitive Impairment Disorders Report Coverage
    • Cognitive Impairment Associated With Schizophrenia (CIAS) - Overview
    • Dementia - Overview
    • Mild Cognitive Impairment - Overview
    • Alzheimer's Disease - Overview
  • Therapeutics Development
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Pipeline Overview
        • Table Figure 1: Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products under Development for Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Pipeline by Companies
        • Table Figure 2: Number of Products under Development by Companies, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products under Development by Companies, Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Products under Development by Companies
        • Table Products under Development by Companies Cognitive Impairment Associated With Schizophrenia (CIAS)
    • Dementia
      • Pipeline Overview
        • Table Figure 3: Number of Products under Development for Dementia
        • Table Number of Products under Development for Dementia
      • Pipeline by Companies
        • Table Figure 4: Number of Products under Development by Companies, Dementia
        • Table Number of Products under Development by Companies, Dementia
      • Pipeline by Universities/Institutes
        • Table Figure 5: Number of Products under Development by Universities/Institutes, Dementia
        • Table Number of Products under Development by Universities/Institutes, Dementia
      • Products under Development by Companies
        • Table Products under Development by Companies, Dementia
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Dementia
    • Mild Cognitive Impairment
      • Pipeline Overview
        • Table Figure 6: Number of Products under Development for Mild Cognitive Impairment
        • Table Number of Products under Development for Mild Cognitive Impairment
      • Pipeline by Companies
        • Table Figure 7: Number of Products under Development by Companies, Mild Cognitive Impairment
        • Table Number of Products under Development by Companies, Mild Cognitive Impairment
      • Pipeline by Universities/Institutes
        • Table Figure 8: Number of Products under Development by Universities/Institutes, Mild Cognitive Impairment
        • Table Number of Products under Development by Universities/Institutes, Mild Cognitive Impairment
      • Products under Development by Companies
        • Table Products under Development by Companies, Mild Cognitive Impairment
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Mild Cognitive Impairment
    • Alzheimer's Disease
      • Pipeline Overview
        • Table Figure 9: Number of Products under Development for Alzheimer's Disease
        • Table Number of Products under Development for Alzheimer's Disease
      • Pipeline by Companies
        • Table Figure 10: Number of Products under Development by Companies, Alzheimer's Disease
        • Table Number of Products under Development by Companies, Alzheimer's Disease
      • Pipeline by Universities/Institutes
        • Table Figure 11: Number of Products under Development by Universities/Institutes, Alzheimer's Disease
        • Table Number of Products under Development by Universities/Institutes, Alzheimer's Disease
      • Products under Development by Companies
        • Table Products under Development by Companies, Alzheimer's Disease
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Alzheimer's Disease
  • Therapeutics Assessment
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Assessment by Target
        • Table Figure 12: Number of Products by Top 10 Targets, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Figure 13: Number of Products by Stage and Top 10 Targets, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products by Stage and Target, Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Assessment by Mechanism of Action
        • Table Figure 14: Number of Products by Top 10 Mechanism of Actions, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Figure 15: Number of Products by Stage and Top 10 Mechanism of Actions, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products by Stage and Mechanism of Action, Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Assessment by Route of Administration
        • Table Figure 16: Number of Products by Routes of Administration, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Figure 17: Number of Products by Stage and Routes of Administration, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products by Stage and Route of Administration, Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Assessment by Molecule Type
        • Table Figure 18: Number of Products by Molecule Types, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Figure 19: Number of Products by Stage and Molecule Types, Cognitive Impairment Associated With Schizophrenia (CIAS)
        • Table Number of Products by Stage and Molecule Type, Cognitive Impairment Associated With Schizophrenia (CIAS)
    • Dementia
      • Assessment by Target
        • Table Figure 20: Number of Products by Top 10 Targets, Dementia
        • Table Figure 21: Number of Products by Stage and Top 10 Targets, Dementia
        • Table Number of Products by Stage and Target, Dementia
      • Assessment by Mechanism of Action
        • Table Figure 22: Number of Products by Top 10 Mechanism of Actions, Dementia
        • Table Figure 23: Number of Products by Stage and Top 10 Mechanism of Actions, Dementia
        • Table Number of Products by Stage and Mechanism of Action, Dementia
      • Assessment by Route of Administration
        • Table Figure 24: Number of Products by Top 10 Routes of Administration, Dementia
        • Table Figure 25: Number of Products by Stage and Top 10 Routes of Administration, Dementia
        • Table Number of Products by Stage and Route of Administration, Dementia
      • Assessment by Molecule Type
        • Table Figure 26: Number of Products by Top 10 Molecule Types, Dementia
        • Table Figure 27: Number of Products by Stage and Top 10 Molecule Types, Dementia
        • Table Number of Products by Stage and Molecule Type, Dementia
    • Mild Cognitive Impairment
      • Assessment by Target
        • Table Figure 28: Number of Products by Top 10 Targets, Mild Cognitive Impairment
        • Table Figure 29: Number of Products by Stage and Top 10 Targets, Mild Cognitive Impairment
        • Table Number of Products by Stage and Target, Mild Cognitive Impairment
      • Assessment by Mechanism of Action
        • Table Figure 30: Number of Products by Top 10 Mechanism of Actions, Mild Cognitive Impairment
        • Table Figure 31: Number of Products by Stage and Top 10 Mechanism of Actions, Mild Cognitive Impairment
        • Table Number of Products by Stage and Mechanism of Action, Mild Cognitive Impairment
      • Assessment by Route of Administration
        • Table Figure 32: Number of Products by Routes of Administration, Mild Cognitive Impairment
        • Table Figure 33: Number of Products by Stage and Routes of Administration, Mild Cognitive Impairment
        • Table Number of Products by Stage and Route of Administration, Mild Cognitive Impairment
      • Assessment by Molecule Type
        • Table Figure 34: Number of Products by Molecule Types, Mild Cognitive Impairment
        • Table Figure 35: Number of Products by Stage and Molecule Types, Mild Cognitive Impairment
        • Table Number of Products by Stage and Molecule Type, Mild Cognitive Impairment
    • Alzheimer's Disease
      • Assessment by Target
        • Table Figure 36: Number of Products by Top 10 Targets, Alzheimer's Disease
        • Table Figure 37: Number of Products by Stage and Top 10 Targets, Alzheimer's Disease
        • Table Number of Products by Stage and Target, Alzheimer's Disease
      • Assessment by Mechanism of Action
        • Table Figure 38: Number of Products by Top 10 Mechanism of Actions, Alzheimer's Disease
        • Table Figure 39: Number of Products by Stage and Top 10 Mechanism of Actions, Alzheimer's Disease
        • Table Number of Products by Stage and Mechanism of Action, Alzheimer's Disease
      • Assessment by Route of Administration
        • Table Figure 40: Number of Products by Top 10 Routes of Administration, Alzheimer's Disease
        • Table Figure 41: Number of Products by Stage and Top 10 Routes of Administration, Alzheimer's Disease
        • Table Number of Products by Stage and Route of Administration, Alzheimer's Disease
      • Assessment by Molecule Type
        • Table Figure 42: Number of Products by Top 10 Molecule Types, Alzheimer's Disease
        • Table Figure 43: Number of Products by Stage and Top 10 Molecule Types, Alzheimer's Disease
        • Table Number of Products by Stage and Molecule Type, Alzheimer's Disease
  • Companies Involved in Therapeutics Development
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Astellas Pharma Inc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Astellas Pharma Inc
      • AstraZeneca Plc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by AstraZeneca Plc
      • Bristol-Myers Squibb Co
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Bristol-Myers Squibb Co
      • Cadent Therapeutics
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Cadent Therapeutics
      • Coronis NeuroSciences Ltd
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Coronis NeuroSciences Ltd
      • Eli Lilly and Co
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Eli Lilly and Co
      • F. Hoffmann-La Roche Ltd
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by F. Hoffmann-La Roche Ltd
      • H. Lundbeck AS
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by H. Lundbeck AS
      • Heptares Therapeutics Ltd
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Heptares Therapeutics Ltd
      • Intra-Cellular Therapies Inc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Intra-Cellular Therapies Inc
      • Iproteos SL
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Iproteos SL
      • Pfizer Inc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Pfizer Inc
      • Sage Therapeutics Inc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Sage Therapeutics Inc
      • Saniona AB
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Saniona AB
      • Spherium Biomed SL
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Spherium Biomed SL
      • Takeda Pharmaceutical Co Ltd
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Takeda Pharmaceutical Co Ltd
      • Vanda Pharmaceuticals Inc
        • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline by Vanda Pharmaceuticals Inc
    • Dementia
      • Acadia Pharmaceuticals Inc
        • Table Dementia - Pipeline by Acadia Pharmaceuticals Inc
      • Accera Inc
        • Table Dementia - Pipeline by Accera Inc
      • Acorda Therapeutics Inc
        • Table Dementia - Pipeline by Acorda Therapeutics Inc
      • Actinogen Medical Ltd
        • Table Dementia - Pipeline by Actinogen Medical Ltd
      • Adamas Pharmaceuticals Inc
        • Table Dementia - Pipeline by Adamas Pharmaceuticals Inc
      • AgeneBio Inc
        • Table Dementia - Pipeline by AgeneBio Inc
      • Alector LLC
        • Table Dementia - Pipeline by Alector LLC
      • Allergan Plc
        • Table Dementia - Pipeline by Allergan Plc
      • Anavex Life Sciences Corp
        • Table Dementia - Pipeline by Anavex Life Sciences Corp
      • Asceneuron SA
        • Table Dementia - Pipeline by Asceneuron SA
      • Axon Neuroscience SE
        • Table Dementia - Pipeline by Axon Neuroscience SE
      • Axovant Sciences Ltd
        • Table Dementia - Pipeline by Axovant Sciences Ltd
      • Biogen Inc
        • Table Dementia - Pipeline by Biogen Inc
      • Boehringer Ingelheim GmbH
        • Table Dementia - Pipeline by Boehringer Ingelheim GmbH
      • Cortice Biosciences Inc
        • Table Dementia - Pipeline by Cortice Biosciences Inc
      • Daewoong Pharmaceutical Co Ltd
        • Table Dementia - Pipeline by Daewoong Pharmaceutical Co Ltd
      • Denali Therapeutics Inc
        • Table Dementia - Pipeline by Denali Therapeutics Inc
      • Dr. August Wolff GmbH & Co KG Arzneimittel
        • Table Dementia - Pipeline by Dr. August Wolff GmbH & Co KG Arzneimittel
      • Echo Pharmaceuticals BV
        • Table Dementia - Pipeline by Echo Pharmaceuticals BV
      • Eisai Co Ltd
        • Table Dementia - Pipeline by Eisai Co Ltd
      • Eli Lilly and Co
        • Table Dementia - Pipeline by Eli Lilly and Co
      • H. Lundbeck AS
        • Table Dementia - Pipeline by H. Lundbeck AS
      • Hyundai Pharmaceutical Co Ltd
        • Table Dementia - Pipeline by Hyundai Pharmaceutical Co Ltd
      • Ildong Pharmaceutical Co Ltd
        • Table Dementia - Pipeline by Ildong Pharmaceutical Co Ltd
      • Intellect Neurosciences Inc
        • Table Dementia - Pipeline by Intellect Neurosciences Inc
      • Intra-Cellular Therapies Inc
        • Table Dementia - Pipeline by Intra-Cellular Therapies Inc
      • IRLAB Therapeutics AB
        • Table Dementia - Pipeline by IRLAB Therapeutics AB
      • Ironwood Pharmaceuticals Inc
        • Table Dementia - Pipeline by Ironwood Pharmaceuticals Inc
      • Johnson & Johnson
        • Table Dementia - Pipeline by Johnson & Johnson
      • M3 Biotechnology Inc
        • Table Dementia - Pipeline by M3 Biotechnology Inc
      • MediPost Co Ltd
        • Table Dementia - Pipeline by MediPost Co Ltd
      • Neuraltus Pharmaceuticals Inc
        • Table Dementia - Pipeline by Neuraltus Pharmaceuticals Inc
      • Neurimmune Holding AG
        • Table Dementia - Pipeline by Neurimmune Holding AG
      • Oryzon Genomics SA
        • Table Dementia - Pipeline by Oryzon Genomics SA
      • P2D Bioscience
        • Table Dementia - Pipeline by P2D Bioscience
      • Pacific Northwest Biotechnology LLC
        • Table Dementia - Pipeline by Pacific Northwest Biotechnology LLC
      • Pharmasum Therapeutics AS
        • Table Dementia - Pipeline by Pharmasum Therapeutics AS
      • Prana Biotechnology Ltd
        • Table Dementia - Pipeline by Prana Biotechnology Ltd
      • ProMIS Neurosciences Inc
        • Table Dementia - Pipeline by ProMIS Neurosciences Inc
      • Sage Therapeutics Inc
        • Table Dementia - Pipeline by Sage Therapeutics Inc
      • Sinil Pharmaceutical Co Ltd
        • Table Dementia - Pipeline by Sinil Pharmaceutical Co Ltd
      • Stemedica Cell Technologies Inc
        • Table Dementia - Pipeline by Stemedica Cell Technologies Inc
      • Sumitomo Dainippon Pharma Co Ltd
        • Table Dementia - Pipeline by Sumitomo Dainippon Pharma Co Ltd
      • Suven Life Sciences Ltd
        • Table Dementia - Pipeline by Suven Life Sciences Ltd
      • TauRx Therapeutics Ltd
        • Table Dementia - Pipeline by TauRx Therapeutics Ltd
      • Theranexus SAS
        • Table Dementia - Pipeline by Theranexus SAS
      • Vicore Pharma AB
        • Table Dementia - Pipeline by Vicore Pharma AB
      • Voyager Therapeutics Inc
        • Table Dementia - Pipeline by Voyager Therapeutics Inc
      • WAVE Life Sciences Ltd
        • Table Dementia - Pipeline by WAVE Life Sciences Ltd
      • WhanIn Pharmaceutical Co Ltd
        • Table Dementia - Pipeline by WhanIn Pharmaceutical Co Ltd
    • Mild Cognitive Impairment
      • AbbVie Inc
        • Table Mild Cognitive Impairment - Pipeline by AbbVie Inc
      • AgeneBio Inc
        • Table Mild Cognitive Impairment - Pipeline by AgeneBio Inc
      • Avraham Pharmaceuticals Ltd
        • Table Mild Cognitive Impairment - Pipeline by Avraham Pharmaceuticals Ltd
      • Biogen Inc
        • Table Mild Cognitive Impairment - Pipeline by Biogen Inc
      • CereSpir Inc
        • Table Mild Cognitive Impairment - Pipeline by CereSpir Inc
      • Eisai Co Ltd
        • Table Mild Cognitive Impairment - Pipeline by Eisai Co Ltd
      • Eli Lilly and Co
        • Table Mild Cognitive Impairment - Pipeline by Eli Lilly and Co
      • Genzyme Corp
        • Table Mild Cognitive Impairment - Pipeline by Genzyme Corp
      • IntelGenx Corp
        • Table Mild Cognitive Impairment - Pipeline by IntelGenx Corp
      • Krenitsky Pharmaceuticals Inc
        • Table Mild Cognitive Impairment - Pipeline by Krenitsky Pharmaceuticals Inc
      • Neuron Biopharma SA
        • Table Mild Cognitive Impairment - Pipeline by Neuron Biopharma SA
      • Octapharma AG
        • Table Mild Cognitive Impairment - Pipeline by Octapharma AG
      • Pfizer Inc
        • Table Mild Cognitive Impairment - Pipeline by Pfizer Inc
      • Sage Therapeutics Inc
        • Table Mild Cognitive Impairment - Pipeline by Sage Therapeutics Inc
      • SBI Pharmaceuticals Co Ltd
        • Table Mild Cognitive Impairment - Pipeline by SBI Pharmaceuticals Co Ltd
      • Suven Life Sciences Ltd
        • Table Mild Cognitive Impairment - Pipeline by Suven Life Sciences Ltd
      • Takeda Pharmaceutical Co Ltd
        • Table Mild Cognitive Impairment - Pipeline by Takeda Pharmaceutical Co Ltd
      • Therapix Biosciences Ltd
        • Table Mild Cognitive Impairment - Pipeline by Therapix Biosciences Ltd
    • Alzheimer's Disease
      • AB Science SA
        • Table Alzheimer's Disease - Pipeline by AB Science SA
      • AbbVie Inc
        • Table Alzheimer's Disease - Pipeline by AbbVie Inc
      • AC Immune SA
        • Table Alzheimer's Disease - Pipeline by AC Immune SA
      • Acadia Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Acadia Pharmaceuticals Inc
      • Accera Inc
        • Table Alzheimer's Disease - Pipeline by Accera Inc
      • Actinogen Medical Ltd
        • Table Alzheimer's Disease - Pipeline by Actinogen Medical Ltd
      • Acumen Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Acumen Pharmaceuticals Inc
      • Addex Therapeutics Ltd
        • Table Alzheimer's Disease - Pipeline by Addex Therapeutics Ltd
      • Aequus Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Aequus Pharmaceuticals Inc
      • AFFiRiS AG
        • Table Alzheimer's Disease - Pipeline by AFFiRiS AG
      • Alector LLC
        • Table Alzheimer's Disease - Pipeline by Alector LLC
      • Allergan Plc
        • Table Alzheimer's Disease - Pipeline by Allergan Plc
      • Allgenesis Biotherapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Allgenesis Biotherapeutics Inc
      • Allinky Biopharma
        • Table Alzheimer's Disease - Pipeline by Allinky Biopharma
      • ALSP Inc
        • Table Alzheimer's Disease - Pipeline by ALSP Inc
      • Alzhyme Pty Ltd
        • Table Alzheimer's Disease - Pipeline by Alzhyme Pty Ltd
      • Alzinova AB
        • Table Alzheimer's Disease - Pipeline by Alzinova AB
      • AlzProtect SAS
        • Table Alzheimer's Disease - Pipeline by AlzProtect SAS
      • Amarantus Bioscience Holdings Inc
        • Table Alzheimer's Disease - Pipeline by Amarantus Bioscience Holdings Inc
      • Amgen Inc
        • Table Alzheimer's Disease - Pipeline by Amgen Inc
      • Anavex Life Sciences Corp
        • Table Alzheimer's Disease - Pipeline by Anavex Life Sciences Corp
      • Annexon Inc
        • Table Alzheimer's Disease - Pipeline by Annexon Inc
      • Aphios Corp
        • Table Alzheimer's Disease - Pipeline by Aphios Corp
      • Apodemus AB
        • Table Alzheimer's Disease - Pipeline by Apodemus AB
      • Applied Research using OMIC Sciences SL
        • Table Alzheimer's Disease - Pipeline by Applied Research using OMIC Sciences SL
      • Aptevo Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Aptevo Therapeutics Inc
      • Araclon Biotech SL
        • Table Alzheimer's Disease - Pipeline by Araclon Biotech SL
      • Archer Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Archer Pharmaceuticals Inc
      • ArmaGen Inc
        • Table Alzheimer's Disease - Pipeline by ArmaGen Inc
      • Asceneuron SA
        • Table Alzheimer's Disease - Pipeline by Asceneuron SA
      • Astellas Pharma Inc
        • Table Alzheimer's Disease - Pipeline by Astellas Pharma Inc
      • AstraZeneca Plc
        • Table Alzheimer's Disease - Pipeline by AstraZeneca Plc
      • Aucta Pharmaceuticals LLC
        • Table Alzheimer's Disease - Pipeline by Aucta Pharmaceuticals LLC
      • Avineuro Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Avineuro Pharmaceuticals Inc
      • Axon Neuroscience SE
        • Table Alzheimer's Disease - Pipeline by Axon Neuroscience SE
      • Axovant Sciences Ltd
        • Table Alzheimer's Disease - Pipeline by Axovant Sciences Ltd
      • Axsome Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Axsome Therapeutics Inc
      • Axxam SpA
        • Table Alzheimer's Disease - Pipeline by Axxam SpA
      • AZTherapies Inc
        • Table Alzheimer's Disease - Pipeline by AZTherapies Inc
      • Beactica AB
        • Table Alzheimer's Disease - Pipeline by Beactica AB
      • Berg LLC
        • Table Alzheimer's Disease - Pipeline by Berg LLC
      • BioArctic AB
        • Table Alzheimer's Disease - Pipeline by BioArctic AB
      • Biogen Inc
        • Table Alzheimer's Disease - Pipeline by Biogen Inc
      • Biohaven Pharmaceutical Holding Company Ltd
        • Table Alzheimer's Disease - Pipeline by Biohaven Pharmaceutical Holding Company Ltd
      • BioHealthonomics Inc
        • Table Alzheimer's Disease - Pipeline by BioHealthonomics Inc
      • Boryung Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Boryung Pharmaceutical Co Ltd
      • Bristol-Myers Squibb Co
        • Table Alzheimer's Disease - Pipeline by Bristol-Myers Squibb Co
      • Bsim2
        • Table Alzheimer's Disease - Pipeline by Bsim2
      • Cantabio Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Cantabio Pharmaceuticals Inc
      • Cardax Inc
        • Table Alzheimer's Disease - Pipeline by Cardax Inc
      • Carna Biosciences Inc
        • Table Alzheimer's Disease - Pipeline by Carna Biosciences Inc
      • Celon Pharma SA
        • Table Alzheimer's Disease - Pipeline by Celon Pharma SA
      • CHA Bio & Diostech Co Ltd
        • Table Alzheimer's Disease - Pipeline by CHA Bio & Diostech Co Ltd
      • Clera Inc
        • Table Alzheimer's Disease - Pipeline by Clera Inc
      • Cognition Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Cognition Therapeutics Inc
      • Cognosci Inc
        • Table Alzheimer's Disease - Pipeline by Cognosci Inc
      • CohBar Inc
        • Table Alzheimer's Disease - Pipeline by CohBar Inc
      • Connexios Life Sciences Pvt Ltd
        • Table Alzheimer's Disease - Pipeline by Connexios Life Sciences Pvt Ltd
      • ConSynance Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by ConSynance Therapeutics Inc
      • Corium International Inc
        • Table Alzheimer's Disease - Pipeline by Corium International Inc
      • Coronis NeuroSciences Ltd
        • Table Alzheimer's Disease - Pipeline by Coronis NeuroSciences Ltd
      • Cortice Biosciences Inc
        • Table Alzheimer's Disease - Pipeline by Cortice Biosciences Inc
      • Cotinga Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Cotinga Pharmaceuticals Inc
      • Crossbeta Biosciences BV
        • Table Alzheimer's Disease - Pipeline by Crossbeta Biosciences BV
      • Cypralis Ltd
        • Table Alzheimer's Disease - Pipeline by Cypralis Ltd
      • Daiichi Sankyo Co Ltd
        • Table Alzheimer's Disease - Pipeline by Daiichi Sankyo Co Ltd
      • Daval International Ltd
        • Table Alzheimer's Disease - Pipeline by Daval International Ltd
      • Denali Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Denali Therapeutics Inc
      • Diffusion Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Diffusion Pharmaceuticals Inc
      • Dongkook Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Dongkook Pharmaceutical Co Ltd
      • Eisai Co Ltd
        • Table Alzheimer's Disease - Pipeline by Eisai Co Ltd
      • Eli Lilly and Co
        • Table Alzheimer's Disease - Pipeline by Eli Lilly and Co
      • Endece LLC
        • Table Alzheimer's Disease - Pipeline by Endece LLC
      • Ensemble Therapeutics Corp
        • Table Alzheimer's Disease - Pipeline by Ensemble Therapeutics Corp
      • Epigen Biosciences Inc
        • Table Alzheimer's Disease - Pipeline by Epigen Biosciences Inc
      • Evotec AG
        • Table Alzheimer's Disease - Pipeline by Evotec AG
      • F. Hoffmann-La Roche Ltd
        • Table Alzheimer's Disease - Pipeline by F. Hoffmann-La Roche Ltd
      • Genentech Inc
        • Table Alzheimer's Disease - Pipeline by Genentech Inc
      • Genervon Biopharmaceuticals LLC
        • Table Alzheimer's Disease - Pipeline by Genervon Biopharmaceuticals LLC
      • Genzyme Corp
        • Table Alzheimer's Disease - Pipeline by Genzyme Corp
      • GlaxoSmithKline Plc
        • Table Alzheimer's Disease - Pipeline by GlaxoSmithKline Plc
      • GliaCure Inc
        • Table Alzheimer's Disease - Pipeline by GliaCure Inc
      • Glialogix Inc
        • Table Alzheimer's Disease - Pipeline by Glialogix Inc
      • Golden Biotechnology Corp
        • Table Alzheimer's Disease - Pipeline by Golden Biotechnology Corp
      • Grifols SA
        • Table Alzheimer's Disease - Pipeline by Grifols SA
      • H. Lundbeck AS
        • Table Alzheimer's Disease - Pipeline by H. Lundbeck AS
      • Hemostemix Inc
        • Table Alzheimer's Disease - Pipeline by Hemostemix Inc
      • Heptares Therapeutics Ltd
        • Table Alzheimer's Disease - Pipeline by Heptares Therapeutics Ltd
      • HitGen LTD
        • Table Alzheimer's Disease - Pipeline by HitGen LTD
      • ICB International Inc
        • Table Alzheimer's Disease - Pipeline by ICB International Inc
      • Ichor Medical Systems Inc
        • Table Alzheimer's Disease - Pipeline by Ichor Medical Systems Inc
      • Icure Pharmaceutical Inc
        • Table Alzheimer's Disease - Pipeline by Icure Pharmaceutical Inc
      • ID Pharma Co Ltd
        • Table Alzheimer's Disease - Pipeline by ID Pharma Co Ltd
      • Immungenetics AG
        • Table Alzheimer's Disease - Pipeline by Immungenetics AG
      • Immunwork Inc
        • Table Alzheimer's Disease - Pipeline by Immunwork Inc
      • Impel NeuroPharma Inc
        • Table Alzheimer's Disease - Pipeline by Impel NeuroPharma Inc
      • India Globalization Capital Inc
        • Table Alzheimer's Disease - Pipeline by India Globalization Capital Inc
      • Insys Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Insys Therapeutics Inc
      • IntelGenx Corp
        • Table Alzheimer's Disease - Pipeline by IntelGenx Corp
      • Intellect Neurosciences Inc
        • Table Alzheimer's Disease - Pipeline by Intellect Neurosciences Inc
      • Intra-Cellular Therapies Inc
        • Table Alzheimer's Disease - Pipeline by Intra-Cellular Therapies Inc
      • Io Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Io Therapeutics Inc
      • Ionis Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Ionis Pharmaceuticals Inc
      • Ironwood Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Ironwood Pharmaceuticals Inc
      • Jeil Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Jeil Pharmaceutical Co Ltd
      • Jiangsu Kanion Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd
      • Johnson & Johnson
        • Table Alzheimer's Disease - Pipeline by Johnson & Johnson
      • K-Stemcell Co Ltd
        • Table Alzheimer's Disease - Pipeline by K-Stemcell Co Ltd
      • Kadmon Corp LLC
        • Table Alzheimer's Disease - Pipeline by Kadmon Corp LLC
      • Karuna Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Karuna Pharmaceuticals Inc
      • Krenitsky Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Krenitsky Pharmaceuticals Inc
      • Kyowa Hakko Kirin Co Ltd
        • Table Alzheimer's Disease - Pipeline by Kyowa Hakko Kirin Co Ltd
      • Lead Discovery Center GmbH
        • Table Alzheimer's Disease - Pipeline by Lead Discovery Center GmbH
      • Les Laboratoires Servier SAS
        • Table Alzheimer's Disease - Pipeline by Les Laboratoires Servier SAS
      • Lipopharma Therapeutics SL
        • Table Alzheimer's Disease - Pipeline by Lipopharma Therapeutics SL
      • Living Cell Technologies Ltd
        • Table Alzheimer's Disease - Pipeline by Living Cell Technologies Ltd
      • Lupin Ltd
        • Table Alzheimer's Disease - Pipeline by Lupin Ltd
      • M3 Biotechnology Inc
        • Table Alzheimer's Disease - Pipeline by M3 Biotechnology Inc
      • ManRos Therapeutics
        • Table Alzheimer's Disease - Pipeline by ManRos Therapeutics
      • MedDay SA
        • Table Alzheimer's Disease - Pipeline by MedDay SA
      • Medesis Pharma SA
        • Table Alzheimer's Disease - Pipeline by Medesis Pharma SA
      • MedImmune LLC
        • Table Alzheimer's Disease - Pipeline by MedImmune LLC
      • MEDRx Co Ltd
        • Table Alzheimer's Disease - Pipeline by MEDRx Co Ltd
      • MEI Pharma Inc
        • Table Alzheimer's Disease - Pipeline by MEI Pharma Inc
      • Merck & Co Inc
        • Table Alzheimer's Disease - Pipeline by Merck & Co Inc
      • Microlin Bio Inc
        • Table Alzheimer's Disease - Pipeline by Microlin Bio Inc
      • MindImmune Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by MindImmune Therapeutics Inc
      • Mitsubishi Tanabe Pharma Corp
        • Table Alzheimer's Disease - Pipeline by Mitsubishi Tanabe Pharma Corp
      • ModGene Pharma LLC
        • Table Alzheimer's Disease - Pipeline by ModGene Pharma LLC
      • Montisera Ltd
        • Table Alzheimer's Disease - Pipeline by Montisera Ltd
      • NAL Pharmaceuticals Ltd
        • Table Alzheimer's Disease - Pipeline by NAL Pharmaceuticals Ltd
      • Nanomerics Ltd
        • Table Alzheimer's Disease - Pipeline by Nanomerics Ltd
      • NeoNeuro SAS
        • Table Alzheimer's Disease - Pipeline by NeoNeuro SAS
      • Neuraltus Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Neuraltus Pharmaceuticals Inc
      • Neurim Pharmaceuticals Ltd
        • Table Alzheimer's Disease - Pipeline by Neurim Pharmaceuticals Ltd
      • Neuro Bio Ltd
        • Table Alzheimer's Disease - Pipeline by Neuro Bio Ltd
      • Neuro-Sys SAS
        • Table Alzheimer's Disease - Pipeline by Neuro-Sys SAS
      • NeuroGenetic Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by NeuroGenetic Pharmaceuticals Inc
      • NeuroNascent Inc
        • Table Alzheimer's Disease - Pipeline by NeuroNascent Inc
      • NeurOp Inc
        • Table Alzheimer's Disease - Pipeline by NeurOp Inc
      • Neuropore Therapies Inc
        • Table Alzheimer's Disease - Pipeline by Neuropore Therapies Inc
      • Neurotez Inc
        • Table Alzheimer's Disease - Pipeline by Neurotez Inc
      • New World Laboratories Inc
        • Table Alzheimer's Disease - Pipeline by New World Laboratories Inc
      • NoNO Inc
        • Table Alzheimer's Disease - Pipeline by NoNO Inc
      • Novartis AG
        • Table Alzheimer's Disease - Pipeline by Novartis AG
      • Nymox Pharmaceutical Corp
        • Table Alzheimer's Disease - Pipeline by Nymox Pharmaceutical Corp
      • Oryzon Genomics SA
        • Table Alzheimer's Disease - Pipeline by Oryzon Genomics SA
      • Otsuka Holdings Co Ltd
        • Table Alzheimer's Disease - Pipeline by Otsuka Holdings Co Ltd
      • Ovensa Inc
        • Table Alzheimer's Disease - Pipeline by Ovensa Inc
      • Oxstem Ltd
        • Table Alzheimer's Disease - Pipeline by Oxstem Ltd
      • P2D Bioscience
        • Table Alzheimer's Disease - Pipeline by P2D Bioscience
      • Pain Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Pain Therapeutics Inc
      • Peptron Inc
        • Table Alzheimer's Disease - Pipeline by Peptron Inc
      • Pharmaxis Ltd
        • Table Alzheimer's Disease - Pipeline by Pharmaxis Ltd
      • Pharnext SA
        • Table Alzheimer's Disease - Pipeline by Pharnext SA
      • Phoenix Biotechnology Inc
        • Table Alzheimer's Disease - Pipeline by Phoenix Biotechnology Inc
      • Prevacus Inc
        • Table Alzheimer's Disease - Pipeline by Prevacus Inc
      • Priavoid GmbH
        • Table Alzheimer's Disease - Pipeline by Priavoid GmbH
      • Probiodrug AG
        • Table Alzheimer's Disease - Pipeline by Probiodrug AG
      • Progenra Inc
        • Table Alzheimer's Disease - Pipeline by Progenra Inc
      • ProMIS Neurosciences Inc
        • Table Alzheimer's Disease - Pipeline by ProMIS Neurosciences Inc
      • ProQR Therapeutics NV
        • Table Alzheimer's Disease - Pipeline by ProQR Therapeutics NV
      • Proteome Sciences Plc
        • Table Alzheimer's Disease - Pipeline by Proteome Sciences Plc
      • Proteostasis Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Proteostasis Therapeutics Inc
      • QR Pharma Inc
        • Table Alzheimer's Disease - Pipeline by QR Pharma Inc
      • Quimatryx SL
        • Table Alzheimer's Disease - Pipeline by Quimatryx SL
      • Radius Health Inc
        • Table Alzheimer's Disease - Pipeline by Radius Health Inc
      • Regenera Pharma Ltd
        • Table Alzheimer's Disease - Pipeline by Regenera Pharma Ltd
      • reMYND NV
        • Table Alzheimer's Disease - Pipeline by reMYND NV
      • Rodos BioTarget GmbH
        • Table Alzheimer's Disease - Pipeline by Rodos BioTarget GmbH
      • Sage Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Sage Therapeutics Inc
      • Samjin Pharm Co Ltd
        • Table Alzheimer's Disease - Pipeline by Samjin Pharm Co Ltd
      • Samumed LLC
        • Table Alzheimer's Disease - Pipeline by Samumed LLC
      • SanBio Inc
        • Table Alzheimer's Disease - Pipeline by SanBio Inc
      • Sangamo Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Sangamo Therapeutics Inc
      • Sanofi
        • Table Alzheimer's Disease - Pipeline by Sanofi
      • SBI Pharmaceuticals Co Ltd
        • Table Alzheimer's Disease - Pipeline by SBI Pharmaceuticals Co Ltd
      • SeneXta Therapeutics SA
        • Table Alzheimer's Disease - Pipeline by SeneXta Therapeutics SA
      • Serometrix LLC
        • Table Alzheimer's Disease - Pipeline by Serometrix LLC
      • Shire Plc
        • Table Alzheimer's Disease - Pipeline by Shire Plc
      • Signum Biosciences Inc
        • Table Alzheimer's Disease - Pipeline by Signum Biosciences Inc
      • Simcere Pharmaceutical Group
        • Table Alzheimer's Disease - Pipeline by Simcere Pharmaceutical Group
      • Spectrum Pharmaceuticals Inc
        • Table Alzheimer's Disease - Pipeline by Spectrum Pharmaceuticals Inc
      • Spherium Biomed SL
        • Table Alzheimer's Disease - Pipeline by Spherium Biomed SL
      • Summit Therapeutics Plc
        • Table Alzheimer's Disease - Pipeline by Summit Therapeutics Plc
      • Suven Life Sciences Ltd
        • Table Alzheimer's Disease - Pipeline by Suven Life Sciences Ltd
      • T3D Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by T3D Therapeutics Inc
      • Takeda Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Takeda Pharmaceutical Co Ltd
      • TauRx Therapeutics Ltd
        • Table Alzheimer's Disease - Pipeline by TauRx Therapeutics Ltd
      • TechnoPhage SA
        • Table Alzheimer's Disease - Pipeline by TechnoPhage SA
      • Teikoku Pharma USA Inc
        • Table Alzheimer's Disease - Pipeline by Teikoku Pharma USA Inc
      • Telocyte LLC
        • Table Alzheimer's Disease - Pipeline by Telocyte LLC
      • Tetra Discovery Partners LLC
        • Table Alzheimer's Disease - Pipeline by Tetra Discovery Partners LLC
      • Tonix Pharmaceuticals Holding Corp
        • Table Alzheimer's Disease - Pipeline by Tonix Pharmaceuticals Holding Corp
      • Toyama Chemical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Toyama Chemical Co Ltd
      • Treventis Corp
        • Table Alzheimer's Disease - Pipeline by Treventis Corp
      • UCB SA
        • Table Alzheimer's Disease - Pipeline by UCB SA
      • Varinel Inc
        • Table Alzheimer's Disease - Pipeline by Varinel Inc
      • Virobay Inc
        • Table Alzheimer's Disease - Pipeline by Virobay Inc
      • VLP Therapeutics LLC
        • Table Alzheimer's Disease - Pipeline by VLP Therapeutics LLC
      • Voyager Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by Voyager Therapeutics Inc
      • vTv Therapeutics Inc
        • Table Alzheimer's Disease - Pipeline by vTv Therapeutics Inc
      • Vybion Inc
        • Table Alzheimer's Disease - Pipeline by Vybion Inc
      • Xigen SA
        • Table Alzheimer's Disease - Pipeline by Xigen SA
      • Zensun (Shanghai) Sci & Tech Co Ltd
        • Table Alzheimer's Disease - Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd
      • Zhejiang Hisun Pharmaceutical Co Ltd
        • Table Alzheimer's Disease - Pipeline by Zhejiang Hisun Pharmaceutical Co Ltd
  • Dormant Projects
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Dormant Projects
    • Dementia
      • Table Dementia - Dormant Projects
    • Mild Cognitive Impairment
      • Table Mild Cognitive Impairment - Dormant Projects
    • Alzheimer's Disease
      • Table Alzheimer's Disease - Dormant Projects
  • Discontinued Products
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Table Cognitive Impairment Associated With Schizophrenia (CIAS) - Discontinued Products
    • Dementia
      • Table Dementia - Discontinued Products
    • Mild Cognitive Impairment
      • Table Mild Cognitive Impairment - Discontinued Products
    • Alzheimer's Disease
      • Table Alzheimer's Disease - Discontinued Products
  • Product Development Milestones
    • Cognitive Impairment Associated With Schizophrenia (CIAS)
      • Featured News & Press Releases
    • Dementia
      • Featured News & Press Releases
    • Mild Cognitive Impairment
      • Featured News & Press Releases
    • Alzheimer's Disease
      • Featured News & Press Releases
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

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