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Cancer Supportive Care Drug Development Pipeline Review, 2017

Cancer Supportive Care Drug Development Pipeline Review, 2017

Summary

Anorexia is defined as the loss of the desire to eat. Progressive wasting is common in many types of cancer and is one of the most important factors leading to early death in cancer patients. Advanced cancer undergo a wasting syndrome associated with cancer anorexia-cachexia and asthenia, which is associated with weakness, fatigue, and a poor quality of life. There are a total of 24 products in development for this indication, by 18 companies and four academic institutions.

Bone metastasis occurs when cancer cells spread from their original site to a bone. Signs and symptoms of bone metastasis include bone pain, broken bones, urinary incontinence, bowel incontinence and weakness in the legs. There are a total of 32 products in development for this indication, by 22 companies and four academic institutions. Key companies operating in this pipeline space include MetCure Therapeutics, Applied Integrin Sciences, Eli Lilly, and Tel Aviv University.

Cancer pain can be defined as a complex sensation that reflects both damage to the body and the body's response to the damage. Pain may arise due to tumor compressing or infiltrating tissue, from treatments and diagnostic procedures, or from skin, nerve and other changes caused by either the body's immune response or hormones released by the tumor. There are a total of 52 products in development for this indication, by 40 companies and four academic institutions. Key companies operating in this pipeline space include Komipharm, Trillium Therapeutics, AstraZeneca, Insys Therapeutics, Klaria Pharma and Pharmaleads.

The majority of products in cancer anorexia-cachexia syndrome target the growth hormone secretagogue receptor type 1, although there are a range of other molecular targets in development. Within bone metastasis, the most common molecular targets are the tumor necrosis factor ligand superfamily member 11, and the hepatocyte growth factor receptor, along with a range of others. Finally, within cancer pain, neurotransmitters such as the mu type opioid receptor, and a range of ion channels, are the most common type of target, reflecting the pain treatment landscape in general.

This report provides an overview of the Cancer Supportive Care pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for cancer anorexia-cachexia syndrome, bone metastasis and cancer pain, and features dormant and discontinued projects.

Scope

  • Which companies are the most active within each pipeline?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in this disease area?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


  • GBI Research Report Guidance
  • Executive Summary
  • Introduction
    • Cancer Supportive Care Report Coverage
    • Cancer Anorexia-Cachexia Syndrome - Overview
    • Bone Metastasis - Overview
    • Cancer Pain - Overview
  • Therapeutics Development
    • Cancer Anorexia-Cachexia Syndrome
      • Pipeline Overview
        • Table Figure 1: Number of Products under Development for Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products under Development for Cancer Anorexia-Cachexia Syndrome
      • Pipeline by Companies
        • Table Figure 2: Number of Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome
      • Pipeline by Universities/Institutes
        • Table Figure 3: Number of Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome
      • Products under Development by Companies
        • Table Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome
    • Bone Metastasis
      • Pipeline Overview
        • Table Figure 4: Number of Products under Development for Bone Metastasis
        • Table Number of Products under Development for Bone Metastasis
      • Pipeline by Companies
        • Table Figure 5: Number of Products under Development by Companies, Bone Metastasis
        • Table Number of Products under Development by Companies, Bone Metastasis
      • Pipeline by Universities/Institutes
        • Table Figure 6: Number of Products under Development by Universities/Institutes, Bone Metastasis
        • Table Number of Products under Development by Universities/Institutes, Bone Metastasis
      • Products under Development by Companies
        • Table Products under Development by Companies, Bone Metastasis
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Bone Metastasis
    • Cancer Pain
      • Pipeline Overview
        • Table Figure 7: Number of Products under Development for Cancer Pain
        • Table Number of Products under Development for Cancer Pain
      • Pipeline by Companies
        • Table Figure 8: Number of Products under Development by Companies, Cancer Pain
        • Table Number of Products under Development by Companies, Cancer Pain
      • Pipeline by Universities/Institutes
        • Table Number of Products under Development by Universities/Institutes, Cancer Pain
      • Products under Development by Companies
        • Table Products under Development by Companies, Cancer Pain
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Cancer Pain
  • Therapeutics Assessment
    • Cancer Anorexia-Cachexia Syndrome
      • Assessment by Target
        • Table Figure 9: Number of Products by Top 10 Targets, Cancer Anorexia-Cachexia Syndrome
        • Table Figure 10: Number of Products by Stage and Top 10 Targets, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products by Stage and Target, Cancer Anorexia-Cachexia Syndrome
      • Assessment by Mechanism of Action
        • Table Figure 11: Number of Products by Top 10 Mechanism of Actions, Cancer Anorexia-Cachexia Syndrome
        • Table Figure 12: Number of Products by Stage and Top 10 Mechanism of Actions, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products by Stage and Mechanism of Action, Cancer Anorexia-Cachexia Syndrome
      • Assessment by Route of Administration
        • Table Figure 13: Number of Products by Routes of Administration, Cancer Anorexia-Cachexia Syndrome
        • Table Figure 14: Number of Products by Stage and Routes of Administration, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products by Stage and Route of Administration, Cancer Anorexia-Cachexia Syndrome
      • Assessment by Molecule Type
        • Table Figure 15: Number of Products by Molecule Types, Cancer Anorexia-Cachexia Syndrome
        • Table Figure 16: Number of Products by Stage and Molecule Types, Cancer Anorexia-Cachexia Syndrome
        • Table Number of Products by Stage and Molecule Type, Cancer Anorexia-Cachexia Syndrome
    • Bone Metastasis
      • Assessment by Target
        • Table Figure 17: Number of Products by Top 10 Targets, Bone Metastasis
        • Table Figure 18: Number of Products by Stage and Top 10 Targets, Bone Metastasis
        • Table Number of Products by Stage and Target, Bone Metastasis
      • Assessment by Mechanism of Action
        • Table Figure 19: Number of Products by Top 10 Mechanism of Actions, Bone Metastasis
        • Table Figure 20: Number of Products by Stage and Top 10 Mechanism of Actions, Bone Metastasis
        • Table Number of Products by Stage and Mechanism of Action, Bone Metastasis
      • Assessment by Route of Administration
        • Table Figure 21: Number of Products by Routes of Administration, Bone Metastasis
        • Table Figure 22: Number of Products by Stage and Routes of Administration, Bone Metastasis
        • Table Number of Products by Stage and Route of Administration, Bone Metastasis
      • Assessment by Molecule Type
        • Table Figure 23: Number of Products by Molecule Types, Bone Metastasis
        • Table Figure 24: Number of Products by Stage and Molecule Types, Bone Metastasis
        • Table Number of Products by Stage and Molecule Type, Bone Metastasis
    • Cancer Pain
      • Assessment by Target
        • Table Figure 25: Number of Products by Top 10 Targets, Cancer Pain
        • Table Figure 26: Number of Products by Stage and Top 10 Targets, Cancer Pain
        • Table Number of Products by Stage and Target, Cancer Pain
      • Assessment by Mechanism of Action
        • Table Figure 27: Number of Products by Top 10 Mechanism of Actions, Cancer Pain
        • Table Figure 28: Number of Products by Stage and Top 10 Mechanism of Actions, Cancer Pain
        • Table Number of Products by Stage and Mechanism of Action, Cancer Pain
      • Assessment by Route of Administration
        • Table Figure 29: Number of Products by Routes of Administration, Cancer Pain
        • Table Figure 30: Number of Products by Stage and Routes of Administration, Cancer Pain
        • Table Number of Products by Stage and Route of Administration, Cancer Pain
      • Assessment by Molecule Type
        • Table Figure 31: Number of Products by Molecule Types, Cancer Pain
        • Table Figure 32: Number of Products by Stage and Molecule Types, Cancer Pain
        • Table Number of Products by Stage and Molecule Type, Cancer Pain
  • Companies Involved in Therapeutics Development
    • Cancer Anorexia-Cachexia Syndrome
      • Abreos Biosciences Inc
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Abreos Biosciences Inc
      • Acacia Pharma Ltd
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Acacia Pharma Ltd
      • Aeterna Zentaris Inc
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Aeterna Zentaris Inc
      • Incyte Corp
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Incyte Corp
      • Lakewood-Amedex Inc
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Lakewood-Amedex Inc
      • Novartis AG
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Novartis AG
      • Paradigm Biopharmaceuticals Ltd
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Paradigm Biopharmaceuticals Ltd
      • RaQualia Pharma Inc
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by RaQualia Pharma Inc
      • Viking Therapeutics Inc
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Viking Therapeutics Inc
      • Zeria Pharmaceutical Co Ltd
        • Table Cancer Anorexia-Cachexia Syndrome - Pipeline by Zeria Pharmaceutical Co Ltd
    • Bone Metastasis
      • Ablynx NV
        • Table Bone Metastasis - Pipeline by Ablynx NV
      • Amgen Inc
        • Table Bone Metastasis - Pipeline by Amgen Inc
      • Amura Holdings Ltd
        • Table Bone Metastasis - Pipeline by Amura Holdings Ltd
      • BiologicsMD Inc
        • Table Bone Metastasis - Pipeline by BiologicsMD Inc
      • ChemoCentryx Inc
        • Table Bone Metastasis - Pipeline by ChemoCentryx Inc
      • CSPC Pharmaceutical Group Limited
        • Table Bone Metastasis - Pipeline by CSPC Pharmaceutical Group Limited
      • Deciphera Pharmaceuticals LLC
        • Table Bone Metastasis - Pipeline by Deciphera Pharmaceuticals LLC
      • Eli Lilly and Co
        • Table Bone Metastasis - Pipeline by Eli Lilly and Co
      • Lupin Ltd
        • Table Bone Metastasis - Pipeline by Lupin Ltd
      • Mirati Therapeutics Inc
        • Table Bone Metastasis - Pipeline by Mirati Therapeutics Inc
      • Oncobiologics Inc
        • Table Bone Metastasis - Pipeline by Oncobiologics Inc
      • Oncodrone BV
        • Table Bone Metastasis - Pipeline by Oncodrone BV
      • OPKO Health Inc
        • Table Bone Metastasis - Pipeline by OPKO Health Inc
      • R Pharm
        • Table Bone Metastasis - Pipeline by R Pharm
      • Redx Pharma Plc
        • Table Bone Metastasis - Pipeline by Redx Pharma Plc
      • Serene LLC
        • Table Bone Metastasis - Pipeline by Serene LLC
      • Taiho Pharmaceutical Co Ltd
        • Table Bone Metastasis - Pipeline by Taiho Pharmaceutical Co Ltd
      • Terpenoid Therapeutics Inc
        • Table Bone Metastasis - Pipeline by Terpenoid Therapeutics Inc
    • Cancer Pain
      • Alexza Pharmaceuticals Inc
        • Table Cancer Pain - Pipeline by Alexza Pharmaceuticals Inc
      • AngioChem Inc
        • Table Cancer Pain - Pipeline by AngioChem Inc
      • Aoxing Pharmaceutical Company Inc
        • Table Cancer Pain - Pipeline by Aoxing Pharmaceutical Company Inc
      • Aphios Corp
        • Table Cancer Pain - Pipeline by Aphios Corp
      • AstraZeneca Plc
        • Table Cancer Pain - Pipeline by AstraZeneca Plc
      • ChironWells GmbH
        • Table Cancer Pain - Pipeline by ChironWells GmbH
      • Colby Pharmaceutical Co
        • Table Cancer Pain - Pipeline by Colby Pharmaceutical Co
      • ConSynance Therapeutics Inc
        • Table Cancer Pain - Pipeline by ConSynance Therapeutics Inc
      • Daewoong Pharmaceutical Co Ltd
        • Table Cancer Pain - Pipeline by Daewoong Pharmaceutical Co Ltd
      • Daiichi Sankyo Co Ltd
        • Table Cancer Pain - Pipeline by Daiichi Sankyo Co Ltd
      • Dompe Farmaceutici SpA
        • Table Cancer Pain - Pipeline by Dompe Farmaceutici SpA
      • Fujimoto Pharmaceutical Corp
        • Table Cancer Pain - Pipeline by Fujimoto Pharmaceutical Corp
      • Grunenthal GmbH
        • Table Cancer Pain - Pipeline by Grunenthal GmbH
      • Hisamitsu Pharmaceutical Co Inc
        • Table Cancer Pain - Pipeline by Hisamitsu Pharmaceutical Co Inc
      • Immupharma Plc
        • Table Cancer Pain - Pipeline by Immupharma Plc
      • Insys Therapeutics Inc
        • Table Cancer Pain - Pipeline by Insys Therapeutics Inc
      • IntelGenx Corp
        • Table Cancer Pain - Pipeline by IntelGenx Corp
      • iX Biopharma Ltd
        • Table Cancer Pain - Pipeline by iX Biopharma Ltd
      • Klaria Pharma Holding AB
        • Table Cancer Pain - Pipeline by Klaria Pharma Holding AB
      • Komipharm International Co Ltd
        • Table Cancer Pain - Pipeline by Komipharm International Co Ltd
      • KPI Therapeutics Inc
        • Table Cancer Pain - Pipeline by KPI Therapeutics Inc
      • Medlab Clinical Ltd
        • Table Cancer Pain - Pipeline by Medlab Clinical Ltd
      • Nanomerics Ltd
        • Table Cancer Pain - Pipeline by Nanomerics Ltd
      • Neurocentrx Pharma Ltd
        • Table Cancer Pain - Pipeline by Neurocentrx Pharma Ltd
      • Nippon Kayaku Co Ltd
        • Table Cancer Pain - Pipeline by Nippon Kayaku Co Ltd
      • Orion Corporation
        • Table Cancer Pain - Pipeline by Orion Corporation
      • Pain Therapeutics Inc
        • Table Cancer Pain - Pipeline by Pain Therapeutics Inc
      • Pfizer Inc
        • Table Cancer Pain - Pipeline by Pfizer Inc
      • Pharmaleads SA
        • Table Cancer Pain - Pipeline by Pharmaleads SA
      • Recordati SpA
        • Table Cancer Pain - Pipeline by Recordati SpA
      • Ribomic Inc
        • Table Cancer Pain - Pipeline by Ribomic Inc
      • Trillium Therapeutics Inc
        • Table Cancer Pain - Pipeline by Trillium Therapeutics Inc
      • Virobay Inc
        • Table Cancer Pain - Pipeline by Virobay Inc
      • WEX Pharmaceuticals Inc
        • Table Cancer Pain - Pipeline by WEX Pharmaceuticals Inc
  • Dormant Projects
    • Cancer Anorexia-Cachexia Syndrome
      • Table Cancer Anorexia-Cachexia Syndrome - Dormant Projects
    • Bone Metastasis
      • Table Bone Metastasis - Dormant Projects
    • Cancer Pain
      • Table Cancer Pain - Dormant Projects
  • Discontinued Products
    • Cancer Anorexia-Cachexia Syndrome
      • Table Cancer Anorexia-Cachexia Syndrome - Discontinued Products
    • Bone Metastasis
      • Table Bone Metastasis - Discontinued Products
    • Cancer Pain
      • Table Cancer Pain - Discontinued Products
  • Product Development Milestones
    • Cancer Anorexia-Cachexia Syndrome
      • Featured News & Press Releases
    • Bone Metastasis
      • Featured News & Press Releases
    • Cancer Pain
      • Featured News & Press Releases
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

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