The New Future of Biotechnology: Enabling Technologies and Star Products

Published by: BCC Research

Published: Jan. 1, 2001 - 199 Pages

Table of Contents

Introduction

• Objectives And Goals Of Study
  
  
• Contribution Of The Study And For Whom
  
  
• Study Scope And Format
  
  
• Methodology
  
  
• Information Sources
  
  
• Related Bcc Work Credentials Including Work Done By Other Authors
  
  
• BCC On-Line Services
  
  

Overview

• The New Biotechnology In Perspective
  
• New Medicines In The New Millennium
  
  
• Biotechnology Drugs Move From The Exception To Mainstream
  
  
• Role Of Biotechnology And Biomedical Research In Drug Development
  
  
• Pending Biotech Product Approvals In The U.S.
  
  
• A Steady Increase In The Number Of Biotechnology Drugs
  
  
• Size Of The Market
  
  
  
• Emerging Drug Discovery Technologies
  
  
• What Can Be Expected From Biotechnology In 10, 20, And 40 Years
  
  
• Nanotechnology
  
  

Enabling Technologies

• Genomics
  
  
• What Is The Genome?
  
  
• The Human Genome Project
  
  
• The Business Of Genomics And Post-Genomics
  
  
• Gene Mining
  
  
• Gene Mapping
  
  
• Gene Function
  
  
• Gene Sequencing
  
  
• Gene Expression
  
  
• Proteins¾Beyond Genes
  
  
• Development Of New Medicines
  
  
• Selected Proteins Discovered Using Genomics That Are Now In Clinical Trials
  
  
• Customized Medicine
  
  
• Biochips
  
  
• Competitors
  
  
• Protein Chips
  
  
• Lab Chips
  
  
• Dna Chips In Development
  
  
• Proteomics
  
  
• What Is Proteomics?
  
  
• From Genomics To Proteomics To Drug Discovery
  
  
• Old Technologies Used To Understand Proteomics
  
  
• The Edman Reaction AND 2-D Gel Electrophoresis
  
  
• Emerging Technologies In The Study Of Proteomics
  
  
• Mass Spectrometry IN Protein Identification
  
  
• New Technologies IN THE Analysis OF Proteins AND Protein Networks
  
  
• Solution-Phase Proteomics
  
  
• Protein Interaction Mapping
  
  
• Genomic Bioprinting
  
  
• Gene Expression Cascades
  
  
• Protein Chips
  
  
• Fluorescent Polyacrylamdide Gel Electrophoresis (Page) AND Digital Imaging AND Analysis
  
  
• The First Protein Interaction Map Of An Entire Genome
  
  
• Pharmacogenomics
  
  
• Snps And Their Role In Drug Discovery
  
  
• The Significance Of Tailor-Made Drugs
  
  
• Pharmaceuticals Gear-Up For Pharmacogenomics
  
  
• The Pharmaceutical Consortium
  
  
• The Tools For Snp Genotyping
  
  
• Hardware
  
  
• Software
  
  
• Reagents
  
  
• Dna Microarrays
  
  
• Mass Spectrometry
  
  
• High-Efficiency Fluorescence Polarization (Hefp)
  
  
• The Impact Of Genomics And Pharmocogenomics On Medicine And Disease Treatment
  
  
• Major Players In The Pharmacogenomics Market
  
  
• Ethical Issues In Genetic Testing For Pharmacogenomics
  
  
• Bioinformatics
  
  
• Scope, Applications And Obstacles Facing Bioinformatics Technology
  
  
• Sources Of Bioinformatics Data
  
  
• Dna Sequencing Data
  
  
• Gene Expression Data
  
  
• Protein Data
  
  
• Medical Genetics Data
  
  
• Bioinformatics In Drug Discovery
  
  
• An Example OF Bioinformatics Technology IN Drug Discovery
  
  
• Factors Influencing The Growth Of Bioinformatics
  
  
• Competitors In Bioinformatics
  
  
• A Great Career Opportunity
  
  

Products: Therapeutic Antibodies And Gene Therapy

• Commercial Therapeutic Antibodies
  
  
• Polyclonal And Monoclonal Antibodies
  
  
• The Impact OF Genomics ON THE Development OF Monoclonal Antibody Products
  
  
• Competition FROM Small Molecule Drugs
  
  
• The Path To Humanized Antibodies
  
  
• Transgenic Human Antibodies And Antibodies Generated By Phage Display Technology
  
  
• Bispecific Antibodies
  
  
• Antibodies Currently In Clinical Trials
  
  
• Patent Issues Related To Monoclonal Antibodies
  
  

Gene Therapy

• Why Gene Therapy?
  
  
• Delivery Of Genes As Drugs
  
  
• Synthetic Vectors AND Viral Vectors
  
  
• Gene Expression Systems
  
  
• Antisense
  
  
• Mechanism Of Antisense Drug Action
  
  
• Antisense Drug Development
  
  
• Antisense Drugs On The Market
  
  
• Antisense Clinical Trials
  
  

The Market For Enabling Technologies, Therapeutic Antibodies, Gene Therapy And Antisense

• The Market For Genomics Technologies
  
  
• Gene Sequencing
  
  
• Polymorphism Analysis
  
  
• Gene Expression
  
  
• Applied Markets
  
  
• Cancer Genotyping
  
  
• Viral Genotyping
  
  
• The Hiv Diagnostic Market
  
  
• The Hiv Screening Market
  
  
• Challenges OF Genotype Drift
  
  
• Methods OF Viral Genotyping
  
  
• The Market FOR Viral Genotyping
  
  
• Diagnostics And Disease Management
  
  
• The Market FOR Dna Microarrays
  
  
• The Market For Proteomics
  
  
• The Market For Pharmacogenomics
  
  
• The Market For Bioinformatics
  
  
• The Market For Therapeutic Antibodies
  
  
• The Market For Therapeutic Polyclonal Antibody Products
  
  
• The Market For Therapeutic Monoclonal Antibodies
  
  
• Leading Therapeutic Indications Of Approved And Pending Antibody Products
  
  
• The Gene Therapy Market
  
  
• The Market For Antisense Drugs
  
  

The Resurgent Biotechnology Industry

• The Leading Biotechnology Companies
  
  
• Research And Development Expenditures By Biotech Companies
  
  
• The Great Biotech Sale
  
  
• The Great Ipo Stampede Of 2000
  
  
• The Biotechnology And Biopharmaceutical Industry
  
  
• The Boom In Biopharmaceutical Drug Discovery
  
  
• Biotechnology And Chemistry Working Together
  
  
• The Top Tier Biopharmaceutical Companies
  
  
• Stress In The Biopharmaceutical Industry
  
  
• The Rising Cost Of Research And Development
  
  
• Decrease In Sales
  
  
• Drug Development And Approval Is Slow And Uncertain
  
  
• Innovation And A Healthy Pipeline Is Costly
  
  

Profiles Of Selected Biotechnology Companies

• Abgenix, Inc.
  
  
• Affymetrix, Inc.
  
  
• Business Overview
  
  
• Financial Information
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Biosource Proteomics, Inc.
  
  
• Celera Genomics
  
  
• Curagen Corp.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Gene Logic, Inc.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Genentech, Inc.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Genome Therapeutics Corp.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Genomic Solutions
  
  
• Genetac Biochip Solution
  
  
• Biochip Production
  
  
• Gridding
  
  
• Hybridization
  
  
• Colony Picking AND Rearraying
  
  
• Imaging
  
  
• Genetac Integrator Analysis Software
  
  
• Investigator Proteomic Solution
  
  
• Investigator Maldi-Tof System
  
  
• Investigator Proms Prep Station
  
  
• Investigator 2-D Electrophoresis
  
  
• Investigator Gel Processor
  
  
• Sypro Ruby Gel Stain
  
  
• Investigator 2-D Gel Analysis Software
  
  
• Protein Picking AND Protein Digestion
  
  
• Genzyme Transgenics
  
  
• Human Genome Sciences, Inc.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Idec Pharmaceuticals Corp.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Incyte Genomics
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Isis Pharmaceuticals, Inc.,
  
  
• Medarex, Inc.
  
  
• Millennium Pharmaceuticals, Inc.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Products
  
  
• Myriad Genetics, Inc.
  
  
• Business Overview
  
  
• Corporate Strategy
  
  
• Leading Product Candidates
  
  
• Oxford Glycosciences
  
  
• Protein Design Labs
  
  
• Targeted Genetics
  
  
  
  

List Of Tables

Summary Table:
The Market For Selected Biotechnology Enabling Technologies And Products, Through 2005


1 Potential Blockbuster Drugs In The Near Future


2 Biotech Drugs Awaiting Fda Approval In July 2000


3 Worldwide Sales Of Selected Biotechnology Drugs, 1999


4 The Market For Medical Biotechnology Products, Through 2005


5 High-Throughput Technologies Used In Analysis Of Gene Expression Levels


6 Selected Human Proteins In Development As Drugs


7 Major Players In The Various Genomics And Post-Genomics Technologies


8 Selected Competitors In The Biochip Market


9 Feature Comparisons Of Selected Array Technologies


10 Emerging Technologies In The Field Of Proteomics


11 Biotechnology Companies Involved In Proteomics


12 The Snp Consortium


13 The Impact Of Genomics And Pharmocogenomics On Medicine And Disease Treatment


14 Major Players In The Pharmacogenomics Market


15 Bioinformatics Technology: Areas, Applications And Obstacles


16 Technologies And Research Associated With Dna Sequencing Data


17 Technologies And Research Associated With Gene Expression Data


18 Technologies And Research Associated With Protein Data


19 Technologies And Research Associated With Medical Genetics Data


20 Selected Companies In The Bioinformatics Business


21 Antibodies In Development For Autoimmune Disorders


22 Antibodies In Development For Blood Disorders


23 Antibodies In Development For Cancer And Related Conditions


24 Antibodies In Development For Digestive Disorders


25 Antibodies In Development For Eye Disorders


26 Antibodies In Development For Heart Disease


27 Antibodies In Development For Infectious Diseases


28 Antibodies In Development For Neurological Disorders


29 Antibodies In Development For Respiratory Diseases


30 Antibodies In Development For Skin Disorders


31 Antibodies In Development For Transplantation Applications


32 Antibodies In Development For Other Indications


33 Selected Gene Therapy Clinical Trials Currently Underway


34 Selected Gene Therapy Drugs Under Development Based On Disease Categories


35 Major Antisense Technologies


36 Selected Antisense Drug Clinical Trials Currently Underway


37 Companies Developing Antisense Drugs


38 Applications Markets For Genomics-Based Products And Services, Through 2005


39 The Market For Gene Sequencing, Through 2005


40 The Market For Microarrays Used In Polymorphism Analysis, Through 2005


41 The Market For Gene Expression, Through 2005


42 The Market For Viral Genotyping, Through 2005


43 The Market For Microarrays (Dna Chips), Through 2005


44 The Market For Proteomics, Through 2005


45 The Market For Pharmacogenomic Services And Devices, Through 2005


46 The Market For Bioinformatics, Through 2005


47 Worldwide Sales Of Polyclonal And Monoclonal Antibodies As Drugs, Through 2005


48 Selected Polyclonal Antibodies: Worldwide Sales, Through 2005


49 Selected Therapeutic Monoclonal Antibodies: Worldwide Sales, Through 2005


50 Therapeutic Applications Of Selected Antibodies: Worldwide Sales, Through 2005


51 The Market For Cancer Gene Therapy Drugs: 2000 And 2005


52 The Market For Gene Therapy Drugs (Excluding Cancer), 2000 And 2005


53 The Market For Gene Therapy Products, 2000 And 2005


54 The Market For Antisense Drugs, Through 2005


55 Biotechnology Companies Making Profits, Through 2001


56 Top Ten Publicly Owned Biotechnology Companies, 1999


57 R&D Expenditires By The Top 20 Biotechnology Companies, 1999


58 Research And Development Expenditures, 1988 And 1998


59 Biologics-Based Chemical-Based Drugs For Various Diseases In Development


60 Top Tier Companies


61 Abgenix' S Xenomouse Technology Collaborators


62 Abgenix's Antibody Drugs In Clinical Trials


63 Affymetrix's Revenues For Genechip Products And Subscription Fees, 1998-2003


64 Selected Affymetrix Customers


65 Affymetrix's Product Portfolio


66 Curagen's Collaborative Alliances


67 Genome Therapeutics' Collaborative Agreements


68 Genomics Solutions' Collaborators


69 Genzyme Corp. And Genzyme Transgenics Development Pipeline


70 Idec's Collaborative Arrangements


71 Idec's Product Pipeline


72 Incyte's Revenues, Through 2004


73 Applications Of Incyte's Technologies


74 Isis'S Drug Pipeline


75 Medarex's Drug Development Pipeline


76 Myriad Genetics' Strategic Alliances


77 Myriad Genetics' Gene-Based Products/Discovery Pipeline


78 Myriad Genetics' Pipeline Of Near-Term Gene Discoveries


79 Ogs's Proteomics Alliances


80 Pdl's Antibody Products


81 Targeted Genetics Products In Clinical Trials


82 Targeted Genetics' Collaborators

List Of Figures

Summary Figure:
The Market For Selected Biotechnology Enabling Technologies And Products, Through 2005


1 Biotechnology Medicines Entering Clinical Trials, Through 2000


2 Percentage Of Genomics-Based Drugs By Therapeutic Category, 2000 And 2005


3 Drug Development Using Bioinformatics


4 Market Share Held By Bioinformatics Providers, Through 2005


5 Evolution Of Therapeutic Mabs


6 Antisense Drug Action


7 Antisense Drug Development


8 Applications Markets For Genomics-Based Products And Services, 1999-2005


9 The Market For Gene Expression, Through 2005


10 The Market For Viral Genotyping, 1999-2005


11 The Market For Microarrays (Dna Chips), 1999-2005


12 The Market For Pharmacogenomic Services And Devices, 1999-2005


13 Worldwide Sales Of Polyclonal And Monoclonal Antibodies As Drugs, 1999-2005


14 Therapeutic Applications Of Selected Antibodies: Worldwide Sales, 1999-2005


15 Convergence Of Biotechnology And Chemistry In Therapeutic Drug Development

Abstract

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