Advances in Cancer Therapy

Published by: Kalorama Information

Published: Feb. 1, 2001 - 394 Pages

Table of Contents

Chapter One

Executive Summary

Introduction

Scope And Methodology

Size And Growth Of The Market

Market Trends

The Nature Of The Industry

The New Technologies

Chapter Two

Introduction

• What Is Cancer?
  
• Who Gets Cancer?
  

Point Of View

Chapter Three

Cancer Epidemiology

Market Population Trends

• Variations In Global Cancer Incidence
  

Cancer Prevalence Trends

Cancer Incidence Trends

Chapter Four

Cancer Therapy Markets

Market Overview

• Antineoplastic Drugs
  
• Cytotoxic Drugs
  
• Hormonal Drugs
  
• Adjunctive/Side-Effect Management Drugs
  
• Hematopoietic Restoration
  
• Severe Pain Management
  
• Opportunistic Infection Control
  
• International Market Overview
  

Chapter Five

Current Therapeutic Approaches And Technology

• How Cancer Is Treated
  
• Sur
  
• Laser Surgery
  
• Electrosurgery
  
• Cryosurgery
  
• Radiation Therapy (Radiotherapy
  
• External Radiation Therapy
  
• Internal Radiation Therapy
  
• Chemotherapy
  
• Hormone Therapy
  
• Biological Therapy
  

Chapter Six

Advanced Cancer Therapeutics And The New Paradigm

• The New Paradigm
  
• Emerging Approaches To Cancer Therapy And Management: An Overview
  

Chapter Seven

Immunological And Vaccine Approaches

• The Technological Basis For Cancer Immunotherapy
  
• Cytokine Therapeutics
  
• Genetic Cytokine Stimulation
  
• Cancer Vaccines
  
• Modified Antibodies
  
• Alternative Approaches To Cancer Immunotherapy
  
• Progress In Cancer Immunotherapy
  
• Limitations Of Immune Therapy
  
• The Commercial Outlook
  

Chapter Eight

Antiproliferative Approaches

• Angiogenesis Regulators
  
• Angiogenic Regulators In Tumor Vascularization
  
• Progress In Angiogenesis Inhibitor Development
  
• The Commercial Outlook
  

Chapter Nine

Photodynamic Therapy

• Mechanism Of Action
  
• Photosensitizers
  
• The Benefits And Limitations Of Pdt
  
• Applications Of Pdt In Cancer
  
• The Commercial Outlook
  

Chapter Ten

Gene Therapy Approaches

• Gene Therapy: Barriers And Drivers
  
• The Technology Of Gene Therapy
  
• Physical Gene Insertion Approaches
  
• Direct Injection Of Genetic Material
  
• Microprojectile Injection
  
• Electroporation
  
• Lithotriptic Shock Wave Insertion
  
• Chemical Gene Insertion Approaches
  
• Chemical Transfection
  
• Lipofection
  
• Cytofection
  
• Liposomal Transfer
  
• Biological Gene Insertion Approaches
  
• Retrovirus Gene Vectors
  
• Adenoviral Gene Vectors
  
• Adeno-Associated Viruses (Aavs)
  
• Herpesvirus Gene Vectors (Hsv-1)
  
• Other Biological Vectors
  
• Artificial Chromosome Gene Vectors
  
• Ligand/Receptor Gene Vectors
  
• Types And Effects Of Therapeutic Genes
  
• Phenotype Alteration With Tumor Suppressor Genes
  
• Phenotype Alteration With Oncogenes
  
• Induction/Reduction Of Multidrug Resistance
  
• Induction Of Cellular Toxicity By Gene Transfer
  
• The Last Word In Gene Therapy
  
• The Commercial Outlook
  

Chapter Eleven

Cell Cycle And Apoptosis Approaches

• Apoptosis
  
• Inducing Apoptosis In Tumors
  
• Cell Cycle-Based Cancer Therapeutics
  
• The Commercial Outlook
  

Chapter Twelve

Company Profiles

Abgenix, Inc.

Agouron Pharmaceuticals, Inc

Amgen, Inc.

Biomira, Inc.

Bristol-Myers Squibb Co.

British Biotech Plc

Collagenex Pharmaceutics, Inc.

Corixa, Corp.

Dusa Pharmaceuticals, Inc.

Genta, Inc.

Genzyme Molecular Oncology

Isis Pharmaceuticals, Inc.

Morphosys Ag

Onxy Pharmaceuticals, Inc

Pharmacyclics, Inc

Ribozyme Pharmaceuticals, Inc

Sugen, Inc

Vical, Inc.

Competitive Summary

Chapter Thirteen

Conclusions And Strategic Implications

• First Conclusion
  
• Implications
  
• Second Conclusion
  
• Implications
  
• Third Conclusion
  
• Implications
  
• Fourth Conclusion
  
• Implications
  
• Fifth Conclusion
  
• Implications
  
• Sixth Conclusion
  
• Implications
  
• Seventh Conclusion
  
• Implications
  
• Eighth Conclusion
  
• Implications
  
• Ninth Conclusion
  
• Implications
  
• Tenth Conclusion
  
• Implications
  
• Eleventh Conclusion
  
• Implications
  
• Twelfth Conclusion
  
• Implications
  
• Thirteenth Conclusion
  
• Implications
  
• Fourteenth Conclusion
  
• Implications
  

Appendix A

Glossary

Appendix B

Company Names And Addresses

List of Exhibits

Chapter One: Executive Summary

Table 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006 (Us$ Billions)

Figure 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006

Figure 1-2: Distribution By Segment Of Cancer Therapeutics Markets: 2000

Chapter Three: Cancer Epidemiology

Table 3-1: Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)

Figure 3-1: Trends In The Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)

Table 3-2: Estimated Cancer Prevalence In The Major World Healthcare Markets: 1998 - 2000 (Millions)

Figure 3-2: Trends In The Cancer Prevalence Rates For The World's Major Healthcare Markets: 1998 - 2006 (Patients Per 100,000 Population)

Table 3-3: Estimated Incidence (New Cases) Of Selected Cancers In The World's Major Healthcare Markets: 2000 (Thousands)

Figure 3-3: Distribution Of Major Cancer Incidences In The Seven Major World Healthcare Markets:2000

Chapter Four: Cancer Therapy Markets

Figure 4-1: Growth In The Cancer Therapeutics Markets For The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)

Table 4-1: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)

Figure 4-2: Historic And Future Growth In Antineoplastic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006

Figure 4-3: Historic And Future Growth In Adjunctive And Side-Effect Management Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)

Table 4-2: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets By Region: 1998 - 2006 (Us$ Billions)

Figure 4-4: Historic And Future Growth In Regional Cancer Therapeutic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)

Chapter Five: Current Therapeutic Approaches And Technology

Table 5-1: Therapeutic Options In The Treatment Of Cancer

Table 5-2: Commonly Used Chemotherapeutics For Specific Cancers

Table 5-3: Commonly Used Hormone Therapeutics For Specific Cancers

Chapter Six: Advanced Cancer Therapeutics And The New Paradigm

Figure 6-1: Cancer Patient Survival As A Function Of Therapeutic Mode

Table 6-1: Emerging Cancer Therapies

Table 6-2: Comparison Of Emerging Cancer Therapies

Table 6-3: Emerging Cancer Therapies: Developmental Risks

Figure 6-2: Timeline For Advanced Cancer Therapeutic Development

Table 6-4: Estimated Peak Market Potentials For Advanced Cancer Therapeutics (Us$ Millions)

Chapter Seven: Immunological And Vaccine Approaches

Table 7-1: Cytokines And Growth Factors That Influence The Immune System In Cancer Patients

Table 7-2: Immune Response-Enhancing Herbs

Table 7-3: Active Clinical Trials Involving Cancer Immunotherapy

Chapter Eight: Antiproliferative Approaches

Table 8-1: Endogenous Angiogenesis Regulators

Table 8-2: Key Angiongenesis Inhibitors In Development

Table 8-3: Active Clinical Trials Involving Antiangiogenesis In Cancer Therapy

Chapter Nine: Photodynamic Therapy

Table 9-1: Photosensitizers In Application With Cancer Photodynamic Therapy

Table 9-2: Active Clinical Trials Involving Photodynamic Therapy For Cancer

Chapter Ten: Gene Therapy Approaches

Table 10-1: Physical Gene Transfer Technologies

Table 10-2: Chemically Assisted Gene Transfer Technologies

Table 10-3: Viral Vector Gene Transfer Technologies

Table 10-4: Active Clinical Trials Involving Genetic Therapy For Cancer

Chapter Eleven: Cell Cycle And Apoptosis Approaches

Table 11-1: Representative Chemotherapeutic Agents Employed On The Basis Of Cell Cycle Selectivity

Table 11-2: Cell Cycle Regulators

Table 11-3: Cell Cycle Regulators By Phase

Abstract

These thoughts are being shaped and driven by a variety of forces:

• A new paradigm that would make use of the patient's natural immune and control systems
• The vast array of developing knowledge in the area of cells
• New products under development based on the immune system and cell function or death
• Critical strategic alliances between researched-based pharmaceutical and biotech

This MarketResearch.com study focuses on the five key segments that will impact advanced cancer therapy:

• Immunological and vaccine approaches
• Antiproliferative approaches
• Photodynamic therapy
• Gene therapy approaches
• Cell cycle and apoptosis approaches

The report provides detailed company profiles, which include:

• Current products
• Product pipeline
• Key strategic alliances (large and small)
• Discussions of the core technologies R&D activities

The study provides forecast information and examines selected dynamics and cancer statistics for the 7 major world markets.

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