Targeted Drug Delivery Technologies: Players, products & prospects to 2018 (Volume IV)

Published by: Espicom Healthcare Intelligence

Published: Jun. 26, 2009 - 118 Pages

Table of Contents

EXECUTIVE SUMMARY

INTRODUCTION

Overview of delivery technologies for targeted delivery: past, present & future

Leading technology platforms for systemic targeted drug delivery

Systemic targeted delivery: motivators & resistors

Motivators

Systemic targeted delivery technology motivators

Resistors

Systemic targeted delivery technology resistors

TARGETED DELIVERY TECHNOLOGIES

Types of systemic targeted delivery platform in development in the pharma industry

Targeting ligands

Antibody fragment conjugate delivery

Antibody-directed enzyme pro-drug targeted delivery

Peptide-induced release for targeted delivery

Small molecule conjugate delivery

Nucleomic mediated targeted intranuclear delivery

Cobalamin mediated targeted intracellular delivery

Non-biological targeting platforms

Magnetically targeted delivery

Photosensitive targeted delivery

Current therapeutic applications for systemic targeted delivery

Leading systemic targeted products in development

Approved systemic and targeted drugs

Future commercial applications & opportunities

STRATEGIES OF DRUG DELIVERY COMPANIES

Leading targeted drug delivery companies

Leading systemic targeted delivery specialists

Partnerships & acquisitions

Strategic alliances

Strategic acquisitions

Recent market activity in targeted delivery companies

Intellectual Property

Targeted drug delivery patents

THE TARGETED DELIVERY MARKET

Now 2009

Approved targeted delivery product sales

Future 2018

Global targeted-release product sales

Novel targeted delivery product sales

COMPETITOR ANALYSIS

Movers & Shakers: Cutting edge or losing their grip

Movers & shakers in targeted drug delivery systems

Abraxis Biosciences (www.abraxisbio.com)

Proprietary delivery technology

Abraxis Protosphere - nab technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Abraxis’ product pipeline

Sales forecasts of products utilising the delivery technology

Abraxis’ targeted sales forecasts

Competitor Ratio Analysis

Access Pharmaceuticals (www.accesspharma.com)

Proprietary delivery technology

Cobalamin targeted delivery

Schematic of targeted nanoparticle

Targeted delivery of cancer subtypes via folate polymer, Vitamin B12 polymer and biotin polymers

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Access Pharmaceuticals’ product pipeline

Sales forecasts of products utilising the delivery technology

Access Pharmaceuticals’ sales forecasts

Competitor Ratio Analysis

ALZA Corporation (www.alza.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ALZA’s targeted product pipeline

Sales forecasts of products utilising the delivery technology

ALZA’s drug delivery sales

Competitor Ratio Analysis

ArmaGen Technologies (www.armagen.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ArmaGen Technologies’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Avidimer Therapeutics (www.avidimer.com)

Proprietary delivery technology

Targeted avidimer for methotrexate delivery

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Avidimer’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Calando Pharmaceuticals (www.calandopharma.com)

Proprietary delivery technology

Schematic of Cyclosert technology

Schematic of RONDEL technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Calando’s product pipeline

Sales forecasts of products utilising the delivery technology

Calando’s sales forecasts

Competitor Ratio Analysis

Cell Therapeutics (www.ctiseattle.com)

Proprietary delivery technology

CTI’s polyglutamate polymer technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

CTI’s product pipeline

Sales forecasts of products utilising the delivery technology

CTI’s targeted drug delivery sales

Competitor Ratio Analysis

Cerulean Pharma Inc (www.ceruleanrx.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Cerulean’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Copernicus Therapeutics (www.cgsys.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Copernicus’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

CytImmune Sciences Inc (www.cytimmune.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

CytImmune’s’ product pipeline

Sales forecasts of products utilising the delivery technology

CytImmune’s sales forecasts

Competitor Ratio Analysis

Diatos SA (www.diatos.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Diatos’ product pipeline

Sales forecasts of products utilising the delivery technology

Diatos’ targeted drug delivery sales

Competitor Ratio Analysis

Enzon Pharmaceuticals, Inc. (www.enzon.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Enzon’s product pipeline

Sales forecasts of products utilising the delivery technology

Enzon’s targeted product sales

Competitor Ratio Analysis

Endocyte Inc. (www.endocyte.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Endocyte’s product pipeline

Sales forecasts of products utilising the delivery technology

Endocyte’s targeted drug delivery sales

Competitor Ratio Analysis

Eurand (www.eurand.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Eurand’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

ImmunoGen (www.immunogen.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ImmunoGen’s product pipeline

Sales forecasts of products utilising the delivery technology

ImmunoGen’s targeted delivery sales

Competitor Ratio Analysis

ImaRx Therapeutics (www.imarx.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ImaRx’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

NanoBioMagnetics, Inc (www.nanobmi.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NanoBioMagnetics’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Nanobiotix (www.nanobiotix.com)

Proprietary delivery technology

Nanobiotix’ NanoXray

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Nanobiotix’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

NanoCarrier (www.nanocarrier.co.jp)

Proprietary delivery technology

NanoCoat technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NanoCarrier’s product pipeline

Sales forecasts of products utilising the delivery technology

NanoCarrier’s targeted drug delivery sales

Competitor Ratio Analysis

Nano Interface Technology (www.nanointerfacetech.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NITI’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Nektar Therapeutics (www.nektar.com)

Proprietary delivery technology

Large molecule conjugate delivery

Small molecule conjugate delivery

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Nektar’s product pipeline

Sales forecasts of products utilising the delivery technology

Nektar’s targeted sales forecasts

Competitor Ratio Analysis

NeoPharm (www.neopharm.com)

Proprietary delivery technology

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NeoPharm’s product pipeline

Sales forecasts of products utilising the delivery technology

NeoPharm’s targeted product pipeline

Competitor Ratio Analysis

Novosom AG (www.novosom.com)

Proprietary delivery technology

Schematic of SMARTICLES mechanism of targeted delivery

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Novosom’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

PCI Biotech Holding ASA (www.pcibiotech.com)

Proprietary delivery technology

Potential applications for improving the delivery of a range of drug types

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

PCI’s product pipeline

Sales forecasts of products utilising the delivery technology

PCI’s targeted product sales

Competitor Ratio Analysis

Quest PharmaTech (www.questpharmatech.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Quest PharmaTech’s product pipeline

Sales forecasts of products utilising the delivery technology

Quest PharmaTech’s targeted product sales

Competitor Ratio Analysis

Seattle Genetics (www.seattlegenetics.com)

Proprietary delivery technology

Schematic of ADC’s

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Seattle Genetic’s product pipeline

Sales forecasts of products utilising the delivery technology

Seattle Genetic’s targeted delivery sales

Competitor Ratio Analysis

Spherics, Inc (www.spherics.com)

Proprietary delivery technology

Spherics’ Oral Targeted Delivery Technologies

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Spheric’s product pipeline

Sales forecasts of products utilising the delivery technology

Spheric’s product sales

Competitor Ratio Analysis

Starpharma (www.starpharma.com)

Proprietary delivery technology

Starpharma’s polyvalent dendrimers

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Starpharma’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Supratek Pharma Inc. (www.supratek.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Supratek’s product pipeline

Sales forecasts of products utilising the delivery technology

Supratek’s product sales

Competitor Ratio Analysis

Tekmira Pharmaceuticals Corporation (www.tekmirapharm.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Tekmira’s product pipeline

Sales forecasts of products utilising the delivery technology

Tekmira’s sales forecasts

Competitor Ratio Analysis

APPENDIX 1

Global targeted approved drugs sales 2008-2018 (US$ millions)

APPENDIX 2

Global targeted developmental drugs sales 2008-2018 (US$ millions)

APPENDIX 3

Competitor Ratio Analysis Criteria

Key targeted delivery companies by 2018

GLOSSARY

ACRONYMS

BIBLIOGRAPHY

Endnotes

Abstract

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