Optimizing Synthetic RNAi: Perspectives from the Pharmaceutical and Biotech Industry

Published by: BioInformatics, LLC

Published: Dec. 1, 2006 - 115 Pages

Table of Contents

Section 1. Analysis and Interpretation of Survey Results

Executive Overview

Study Objectives

Customer Profile

Research Objectives

Experimental Design

Product Requirements

Market Potential

Throughput and Market Growth

Future Trends

Supplier Performance

Preferred Suppliers

Customer Satisfaction

Brand Share

Brand Health

Section 2. Study Methodology and Demographics

Methodology

Definition of Terms

Demographics

Questionnaire

Section 3. Presentation of Survey Data

Experimental Design

Currently use synthetic siRNA

Primary research objective of RNAi experiments

Primary species studied in RNAi research

Cell types primarily used

Typical method of measuring the effectiveness of RNAi-induced gene silencing

Percent reduction in gene expression that is usually required

siRNA Selection

Percentage of total RNAi experiments for which each type of synthetic siRNA is used

Preferred type of siRNA

Synthesis scale typically ordered for preferred type of siRNA

Order turn-around time normally required for preferred type of siRNA

Typical specifications for preferred type of siRNA

Strandedness

Quantity

Format

Level of purification usually ordered for preferred type of siRNA

Most common modification ordered for preferred type of siRNA

Preferred method for ordering pre-designed or validated siRNA

Primary way of designing custom siRNA

Experimental Throughput

Typical number of unique synthetic siRNAs utilized per gene target

Average number of gene targets analyzed per month

Expected change in the number of gene targets analyzed

Choosing the siRNA Supplier

Brands of synthetic siRNA currently used

Primary brand of synthetic siRNA

Percentage of RNAi experiments for which each brand of siRNA is used

Relative amount of money spent on each brand of siRNA

Evaluating the Primary Supplier’s Performance

Satisfaction with specific product features of synthetic siRNA from primary supplier

Formats available

Modifications available

Purification options

Purity

Reduction of target gene expression

Specificity of gene suppression

Stability in cells

Time-to-results

Transfectability

Overall satisfaction with synthetic siRNA from primary supplier

Happiness with the performance of synthetic siRNA from primary supplier

Familiarity with other RNAi products from primary supplier

Level of acceptability of synthetic siRNA prices from primary supplier

Ease of obtaining synthetic siRNA from primary supplier

Helpfulness of customer service from primary supplier

Helpfulness of technical service from primary supplier

Likelihood of recommending synthetic RNAi products from primary supplier to a colleague

Future Trends in Nucleic Acid-Based Gene Silencing

Identifying which molecules would be the most useful in advancing research goals in:

Gene function analysis

Genome-wide screening

Therapeutic applications

Improvement to siRNA that would most convince scientists to try a new supplier’s siRNA

DemographicsSection

4. Appendices

Insights and Perspectives

Cross-Tabulations of Survey Data

Other Recent Publications

About BioInformatics

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Abstract

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