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Impact of Nano Materials in Drug Delivery & Human Tissue Engineering

Published by: Drug and Market Development Publishing

Published: Oct. 1, 2006 - 195 Pages


Table of Contents


Chapter 1: Executive Summary




Chapter 2: Nanomaterials Relating to the Drug Discovery, Drug Delivery & Tissue Engineering Industries

Nanoparticles


Quantum Dots (QDs)

Gold Colloids

Gold & Quantum Dots for Molecular Diagnostics

Magnetic Nanoparticles

Dendrimers

Nanoshells

Carbon Nanotubes & Nanotube Matrices

Multiplex Molecular Tagging with QDs, Nanotags, and Nanoprisms

Nanobarcodes

Biobarcode Assay for Proteins

Nanoparticle-based Colorimetric DNA Detection Method

Liposomes

Multilayered Nanoparticles


New MRI Nanomaterials as Probes for Imaging Agents—Gadolinium in Fullerenes & Quantum Dots


Molecular Imaging


Drug Delivery and Therapeutics—Bioavailability through Nanocrystals


Rexin G—An FDA Approved Targeted Delivery System.(TDS)

Nanocrystals in Immunohistochemistry & Nanomedicine

Fullerenes for Delivering Therapeutic Molecules

Injectable & Topical Platforms Enhanced by Nanoparticluate Technologies

Nanotechnologies with Biochips & Protein chips


Nano Biosensors


Nanowire Biosensors using Boron-doped Silicon Nanowire

Viral Nanosensor

Probes Encapsulated by Biologically Localized Embedding Nanosensors

New Nano-based Biosensor Technologies in Market


Nano Tissue Engineering—Nanophase Biomaterials


Biocompatible Polymer Nanofibers


Nanochemicals Against Cancer


Nanodrugs and Companies Targeting Cancer


Nanobiotechnology’s Contributions to the Pharmaceutical/Medical Sectors




Chapter 3: Commercial Pharmaceutical & Tissue Engineering Product Applications Using Nano Materials

Nano Technology and the Pharmaceutical/Tissue Engineering Product Applications Market in 2005

Nanoengineering and Emerging Nanotechnology


Nanoparticles

Carbon Nanoparticles and Nanotubes Market


Medical & Healthcare Diagnostic Devices Markets


Reporter Molecules and Molecular Tags for Biomolecular Detection

Biosensors

Contrast and Imaging Agents for MRI and PET


Nanobiotechnology Utility in the Drug Discovery and Delivery Process


Solubilizing Pre-existing Drugs and Enhancing Controlled Drug Delivery

Improved Drug Formulations

Controlled Released Drugs

Multifunctional Drug Delivery Platforms

Targeted Drug Delivery Platforms

Targeted Drug Delivery

Devices for Targeted Drug Delivery


Medical & Tissue Engineering Nano Material-based Products in 2005


Wound Dressings and Wound Repair

Stents and Catheters

Implants and Prosthetics


Future Markets of Pharmaceutical and Medical “Nano Material-based” Products


Ongoing Clinical Trials using Nano material-based drugs

National Nanotechnology Advisory Panel Evaluation of the US Nano Sector Markets




Chapter 4: Health, Environmental, and Societal Impacts of Nanoparticles

Free Nanoparticles


Free Nanoparticle Safety Needs To Be Assessed

Potential Exposure Routes

Nanoparticles Can Be Toxic by Inhalation or through Skin Exposure

Factors Affecting Deleterious Effects of Nanomaterials

Eco-toxicity—On the Environment and on Other Species

Possible Adverse Health Issues


Regulatory Issues of Nanotechnology


Royal Society & Royal Academy of Engineering July 2004 UK Report

The US FDA


Future Considerations

Social Science Issues


Societal Impacts

Personal Safety versus Covert Surveillance

Is the Science Fiction Larger than the Science of Nanotechnology?




Chapter 5: Global Investments by Private and Federal Resources

Private Funding Accounts for Almost 40-50 % of Investment in the Nanotechnology Sector

Global Distribution of Funding Sources of Nanotechnology

Private Venture Capital Funding in the US Market

Similarities between Nanotechnology, Semiconductor Industry, and DNA Technologies

Patents as Indicators of the Maturity of Nanotech Investments


Big Pharma’s Stumbling Block—dying Patents

Global Distribution of Patents and Academic Publications in Nano Areas—The Rise of China


World Leaders in Nano Investment—US, Japan, EU & China


United States has invested.$4.7 Billion Since 2001

Japan Spent.$800 Million for Nanobiotechnology In 2005

China will have Invested.$600 Million by 2007

Investments by Other Asian Countries

$1 Billion from Germany, France UK & Sweden


Nanotechnology Global Investment was Approximately $9 Billion in 2005




Chapter 6: Nanobiotechnology Companies

Nano Material Manufacturing Companies to Watch


Dendrimer, Fullerene & Nanotube-based Companies

Nano Arrays & Molecular Tag Companies


List of Nanobiotechnological Companies




Chapter 7: Company Profiles




TABLE OF EXHIBITS

Exhibit 2.1. A Dendrimer Nanoparticle Complex

Exhibit 2.2. Structure of a.Carbon Nanotube

Exhibit 2.3. PCR of a.Biobarcode Assay with Nanoparticles

Exhibit 2.4. A Drug Carrying Liposome

Exhibit 2.5. A Model of the C60 Buckministerfullerene

Exhibit 2.6. Boron-doped Silicon Nanowire

Exhibit 2.7. Nanotech Applications in the Fight Against Cancer

Exhibit 2.8. Nanotechnology Tools and Platforms that Affect the Pharmaceutical & . Medical Industries

Exhibit 3.1. Nano-enhanced Pharmaceutical Nano Products

Exhibit 3.2. Medical/Tissue Engineering Nano Products in 2005

Exhibit 3.3. Nanotechnology Application Markets

Exhibit 3.4. 2005 Nanoparticle Based Products

Exhibit 3.5 Number of Nanomaterial Companies

Exhibit 3.6. Nanomaterials and Nano Tool Market Forecast

Exhibit 3.7. Reporter Molecules and Molecular Tags for Biomolecular Detection

Exhibit 3.8. Biosensor-based Devices

Exhibit 3.9. MRI and PAT Contrast and Imaging Agents

Exhibit 3.10 The Pharmaceutical Drug Discovery Process

Exhibit 3.11 Examples of Nano-enhanced Drug Discovery and Delivery Platforms

Exhibit 3.12. Improved Formulations of Approved Drugs

Exhibit 3.13 Nano-based Drug Delivery Platforms

Exhibit 3.14 Controlled Release Options

Exhibit 3.15 Multifunctional Drug Delivery Applications

Exhibit 3.16 Targeted Drug Delivery Platforms

Exhibit 3.17 Devices for Targeted Drug Delivery

Exhibit 3.18 Tissue Engineering Applications

Exhibit 3.19 Wound Dressings and Wound Repair

Exhibit 3.20 Stents and Catheters

Exhibit 3.21 Dental and Prosthetic Implants

Exhibit 3.22 Current Clinical Trials using Nano Material based Chemistries

Exhibit 3.23 NNI Evaluation of Nanosector Markets

Exhibit 4.1. Dimensions of Biological Molecules in the Nanometer Range

Exhibit 5.1. The Global Nanotechnology Market

Exhibit 5.2. Global Venture Capital Investment into Nanobiotechnology

Exhibit 5.3. VC and Government funding for Japan, USA and EU in Terms of Numbers of Players

Exhibit 5.4. Number of Nanotech Related Patents

Exhibit 5.5. Publications in ISI Web of Science Databases

Exhibit 5.6. Global Government Funding of Nanotechnology

Exhibit 5.7. US 2006 Budget of Nanotechnology Segments

Exhibit 6.1. Companies Leading the Field in Arrays and Molecular Tags

Exhibit 6.2. List of Nanotech Companies

Abstract

D&MD’s new market analysis report - Impact of Nano Materials in Drug Delivery & Human Tissue Engineering - provides a market driven top down approach that identifies existing products using nano based knowledge to strengthen their capabilities and provides a description of the product’s market niche to pinpoint future trends. A recent analysis of more than 200 commercially available products that use nano-based technological enhancements in the pharmaceutical, medical or healthcare field is reinforcing the notion that “incremental” modifications of existing drugs, drug delivery devices and tissue engineering products enhanced by nano innovations is beginning to harvest revenue.

About the Author

Gautam Thor received his PhD in Neurobiology in 1983 from The Tata Institute of Fundamental Research, India where he got interested in the study of the growth of the visual system that has resulted in the recent formation of Coded Imagery to commercialize some aspects of these studies. He has also researched at UCSD in the field of Neuroimmunology and is the author of numerous scientific and medical publications through NeuroConsultants, and, is internationally recognized for his expertise in human diagnostics.

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