Nanopore Sequencing Patent Landscape Analysis

Nanopore sequencing is one of the next-generation sequencing (NGS) technologies believed to be capable of revolutionizing DNA analysis.Different modalities of nanopore sequencing have been developed over time,including protein nanopores, solid-state nanopores, and hybrid nanopores. The technology enables production of ultra-long reads at very high speeds, reducing sample preparation time as well as the data-processing time required to reassemble the reads into their original sequence.

The analysis of the time-evolution of patent publications shows an important increase in nanopore sequencing-related patenting activity from 2008 – 2013.This increase follows the work of academic research teams (Harvard University and University of California) that proved the concept of nanopore sequencing.

Even though the industrial players developing nanopore-based sequencing are steadily gaining importance, Harvard’s patent portfolio remains the strongest,followed by Illumina, Agilent, University of California, and Roche, whose influence in the IP landscape is growing. In fact, Roche is now the most prolific applicant in nanopore sequencing. Contrarily, Oxford Nanopore Technologies’ patent portfolio is not the strongest, but the company benefits from the numerous partnerships it has with universities (Harvard, University of California, and Boston University). Moreover, several companies with strong experience in microelectronics and semiconductors (Hitachi, IBM, Samsung Electronics, Intel, and Global Foundries) have recently filed patents claiming solid-state nanopores.

Most main patent assignees have developed an international IP strategy.American players have a strong presence in the US and Europe. Some European companies are also well ranked, and a few Asian firms play a significant rolein the patent protection of nanopore sequencing.

Patents are categorized by nanopore technology (protein,solid-state, and hybrid) and by main application. Also, IP trends and the relative strength of each main patent assignee was analyzed. These findings reveal that solid-state nanopore-related patents are more numerous than those related to protein nanopore or hybrid nanopore. From an IP perspective, Roche leads for technologies related to protein nanopore, and Oxford Nanopore Technologies leads the solid-state nanopore and hybrid nanopore segments.Regarding applications, the main patented application for nanopore sequencing is oncology. Plant genetics, epigenetics, and transcriptomics are also important application domains for nanopore sequencing. Among the main applications for nanopore sequencing, microbiome analysis is the most recent,but already a few companies are positioned in this segment.

KnowMade’s study includes IP profiles for key players and a description of their key patents. The key-patent analysis includes the legal state of the family for each of the main territories, the number of received citations, the review of main claims, the description of interesting features disclosed about the innovation, and relevant figures illustrating how the innovation works. This section also covers patents involved in litigations.

This report also includes an Excel database containing the>7,200 patents analyzed in this study. This useful database allows formulti-criteria searches and includes patent publication numbers, hyperlinks to original documents, priority date, title, abstract, patent assignees, and each patent’s current legal status, as well as nanopore technologies and applications.

Oxford Nanopore Technologies, Roche, Illumina, Pacific Biosciences of California, Quantapore, Electronic Bioscience, Stratos Genomics,Two Pore Guys, Hitachi, Agilent Technologies, Thermo Fisher Scientific, Sequenom, Intel, IBM, Global Foundries, Abbott, Becton Dickinson, BGI, Nugen Technologies, Quantum Biosystems, Samsung, Bio Rad, Lux Bio, Twist Bioscience, 0x Genomics, Caris Life Sciences, Quantumdx, Dovetail Genomics, Celemics, Grail, GATC Biotech, Arima Genomics, Excilone, Twinstrand Biosciences, and more


Report’s Key Features

PDF >170 slides
Excel file >7,200 patents
IP trends, including time-evolution of published patents, and countries of patent filings

Ranking of main patent assignees
Key players’ IP position and relative strength of their patent portfolios
IP analysis of nanopore technologies (solid-state nanopores, protein nanopores,and hybrid nanopores)
IP analysis of applications (oncology, plant genetics, infectiology, etc.)
Main patent litigations
Description of key players and key patents
Excel database with all patents analyzed in this report, including technology segmentation



Nanopore sequencing
Scope of the report
Key features of the report
Objectives of the report
Related reports

Patent search, selection and analysis
Search strategy
Key patent identification
Terminologies for patent analysis



Time evolution of patent publications
Countries of patent filings
Time evolution by country of filing
Ranking of most prolific patent applicants
Mapping of main current IP holders
Mapping of main current IP applicants

Strength index of patent portfolios
Patent citation analysis
IP blocking potential of patent applicants 
Time evolution for main patent applicants
Countries of filings for main patent applicants
Summary of applicant’s patent portfolios
Patent applicants IP network
IP leadership of patent applicants
Granted patents near expiration
Degree of specialization
Potential future plaintiffs

Technical Segmentation by Technology
Main Assignees by Technology
Time Evolution by Technology
Time Evolution by Country
Legal Status by Technology

Technical Segmentation by Application
Main Assignees by Application
Time Evolution by Application
Legal Status by Application

Illumina vs Oxford Nanopore Technologies
Pacific Biosciencesvs Oxford Nanopore Technologies
University of California vs Roger Chen and Genia Technologies

Harvard University
University of California
Chinese University of Hong Kong
Oxford Nanopore Technologies
Two Pore Guys
Pacific Bio sciences of California
Agilent Technologies
Thermo Fisher Scientific

For each selected player:
Company profile and news
Summary of the patent portfolio
Key patents families




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