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Global Cord Blood Banking Industry Report 2018

Global Strategic Report

After a rapid growth period through the mid-2000s, the global cord blood banking industry reached saturation and stabilized through approximately 2012. Since that time, the market has been aggressively consolidating. This has created both serious threats and novel opportunities for the industry.

Serious threats to the industry include low rates of utilization for stored cord blood, expensive cord blood transplantation procedures, difficulty educating obstetricians about cellular therapies, and an increasing trend toward industry consolidation.

There are also emerging opportunities for the industry, such as accelerated regulatory pathways for cell therapies in leading healthcare markets worldwide, including the United States, Japan, Europe and South Korea.

Cord Blood Industry Trends

New themes are impacting the industry, including the pairing of stem cell storage services with genetic and genomic testing services, as well as reproductive health services. Cord blood banks are diversifying into new types of stem cell storage, including umbilical cord tissue storage, placental blood and tissue, amniotic fluid and tissue, and dental pulp.

Cord blood banks are also investigating means of becoming integrated therapeutic companies, with LifebankUSA becoming an asset of the augmented immunity and longevity company Celularity and Americord announcing in a press release that it “intends to launch its first therapeutic product offering sometime in 2018.”

With approximately 450 companies offering cord blood banking services worldwide, maturation of the market means that each company is fighting harder for market share.

Cord Blood Industry Consolidation

Growing numbers of investors are now entering the marketplace, with M&A activity accelerating in the U.S. and abroad. In the United States, AMAG Pharmaceuticals sold Cord Blood Registry (CBR) to GI partners for $530 million in June 2018. AMAG had previously bought CBR for $700 million in 2015. GI Partners, a private equity investment firm, simultaneously acquired CBR and California Cryobank (CCB) to merge the companies into a single entity that will be the global leader in stem cell storage and reproductive tissue services.

Holding companies are also emerging as a global theme, allowing for increased operational efficiency and economy of scale. Cryoholdco has established itself as the market leader within Latin America. Created in 2015, Cryoholdco is a holding company that will control nearly 200,000 stem cell units by the end of 2018. It now owns six cord blood banks, as well as a dental stem cell storage company.

Globally, networks of cord blood banks are also commonplace, with Sanpower Group establishing dominance in Asia. Although Sanpower has been quiet about its operations, its website states:

“In 2016, Sanpower Group and its subsidiary Nanjing Cenbest announced their participation in founding a foundation to buy CO. In the same year, Nanjing Cenbest also acquired Shandong Cord Blood Bank. As a result, Sanpower now holds 4 licenses out of only 7 issued provincial-level cord blood bank licenses in China. It has reserved over 900,000 cord blood samples at home, and the associated reserves amount to almost 1,200,000 when counting in the Cordlife reserves across Southeast Asian countries and regions.”

This positions Sanpower Group and its subsidiary Nanjing Cenbest as the world’s largest cord blood banking operator not only in China and Southeast Asia, but in the world.

The number of cord blood banks in Europe has dropped by approximately one-third over the past ten years, from approximately 150 to 100. The industry leaders in this market segment include FamiCord Group, who has executed a dozen M&A transactions, and Vita34, who has executed approximately a half dozen. Stemlab, the largest cord blood bank in Portugal, also executed three acquisition deals prior to being acquired by FamiCord in July 2018.

FamiCord is now the leading stem cell bank in Europe, controlling over 263,000 cord blood and tissue units among its network of banks and over 347,000 biological samples of all types. This places it among the leading cord blood banks worldwide.

Dozens of other cord blood industry acquisitions have also occurred worldwide, with the highest frequency occurring within the United States, Europe, and Latin America.

Digital Competition for Cord Blood Banking Services

Digital competition for cord blood has been growing increasingly competitive. The term “cord blood” has now become one of the 20 most expensive search terms on Google. Winning online traffic through Google AdWords for the search phrase “Cord Blood” now costs $45.87 in the United States.

The cost for acquiring traffic through Google AdWords for the phrase “Cord Blood” is $32.91 when all geographies are allowed.

Cord Blood Expansion Technologies

Because cord blood utilization is largely limited to use in pediatric patients, growing investment is flowing into ex vivo cord blood expansion technologies.

Key strategies being explored for this purpose include:

Nicotinamide-mediated (NAM) expansion
Notch ligand
SR-1
UM171
PGE2
Enforced fucosylation

Currently, the following companies have ex vivo cord blood expansion products in Phase II clinical trials:

Gamida Cell Ltd
Nohla Therapeutics
Excellthera
Magenta Therapeutics has a Phase I trial underway for its cord blood expansion technology.

Growing numbers of investors are also entering the cord blood banking marketplace, led by groups such as GI Partners, ABS Capital Partners & HLM Management, KKR & Company, Bay City Capital, GTCR, LLC, Excalibur, and more.

Global Cord Blood Banking Industry Dynamics

In 2008, a Taiwanese company, HealthBanks Biotech Company Ltd. became the first company to offer cord tissue storage. It was not until July 2010 that the first private U.S. cord blood bank began offering the service (Cord Blood Registry). Since then, the trend of cord tissue storage has had a major impact on the cord blood banking industry, with many cord blood banks worldwide now offering the service.

In China, the government shocked the industry by announcing that only one cord blood bank would be allowed to operate within each province, and official government support, authorization, and permits would be required.

In Italy and France, it is illegal to privately store one’s cord blood, which has fully eliminated the potential for a private market to exist within the region.

In Ecuador, the government is now creating the first public cord blood bank and has instituted laws such that private cord blood banks cannot approach women about private cord blood banking options during the first six months of pregnancy. This created a crisis for the private banks, and there are now only two remaining in Ecuador.

Most recently, India’s Central Drugs Standard Control Organization (CDSCO) restricted commercial banking of stem cells from most biological materials, including cord tissue, placenta, and dental pulp stem cells, leaving only umbilical cord blood banking as “permitted and licensed” within the country.

While market factors can vary by geography, it is crucial to have a global understanding of the market. Research advances, clinical trial findings, and technology advances do not know

international boundaries.The cord blood market is global in nature and understanding dynamics limited to your region is not sufficient for making strategic, informed, and profitable decisions.

Cord Blood Report Highlights

This 265 page reports includes:

Market size determinations for cord blood and tissue storage, with projections to 2022
Volumes of cord blood and cord tissue storage worldwide
Rates of worldwide cord blood storage (units per year)
Rates of cord blood utilization
Trend rate data for umbilical cord blood grants, patents, and scientific publications
Clinical trial analysis, including comparison of cord blood vs. cord tissue trials
Current and future conditions treatable with cord blood
Regulatory pathways affecting cord blood banking in major healthcare markets
Digital marketing assessment and comparison of industry leaders
Competitive environment analysis, including identification of market leaders
Leading investors within the cord blood marketplace
Medical opinions of cord blood banking
Crucial trends and unmet market needs

And more

Companies Mentioned

ABS Capital Partners & HLM Management
AllCells
AMAG Pharmaceuticals
AlphaCord
Americord
Bay City Capital
BioEden
Biocell Center
Biosafe
CariCord
Cell Care (Australia)
Cesca Therapeutics
China Cord Blood Corporation (CCBC)
CorCell
Cord Blood Registry (CBR)
Cordlife
Core23 BioBank
Crioestaminal
Cryo-Cell International
Cryoholdco
Cryolife
CryoSave
Dentcell
Excalibur
FamilyCord
Fate Therapeutics
Future Health Biobank
Gamida Cell Ltd.
GeneCell International
Genesis Bank
GI Parnters
GTCR, LLC
HealthBaby
HealthBanks Biotech Company Ltd
Human Longevity Inc.
Insception Lifebank
KKR & Company
LifebankUSA
LifeCell International
Lonza
MAZE
MiracleCord
Nanjing Cenbest
Natera, Inc. (EverCordTM)
New England Cord Blood Bank
National Cord Blood Program (NCBP) at the New York Blood Center
Nohla Therapeutics
Novartis
PacifiCord
PerkinElmer
Pluristem Therapeutics
Precious Cells Group (now in administration, along with Pharmacells Ltd.)
PromoCells
ReeLabs
Sanpower Group
Shandong Cord Blood Bank
Stem Cell Cryobank
STEMCELL Technologies
StemCyte
Thermo Fisher Scientific
Transcell Biologics Pvt Ltd,
VAULT SC Inc.
ViaCord
Vita34 AG
And More


  • SUMMARY OF METHODOLOGY
  • Abstract
    • Global Market Requires Global Understanding
    • Cord Blood Stem Cells, Compared to Other Stem Cell Alternatives
    • Awareness Levels as a Factor Impacting Market Penetration
    • Digital Competition for Cord Blood
    • Key Report Findings
  • Timeline of Key Events
    • Table Timeline of Key Events within the Cord Blood Industry
  • Technical & Medical Characteristics of Cord Blood
    • Introduction to Cord Blood and Cord Tissue
    • Definitions and Nomenclature
    • Technical Advantages of Cord Blood
    • Likelihood of Needing a Stem Cell Transplant
      • Table Childhood Probability of Requiring a Stem Cell Transplant
      • Table Adulthood Probability of Requiring a Stem Cell Transplant
    • Comparison of Cord Blood, Bone Marrow, & Peripheral Blood Stem Cell Transplant
    • Conditions Treatable with Cord Blood Transplant
      • Table Disease Categories Treatable with Hematopoietic Stem Cell Transplantation (HSCT)
      • Table Disease Categories That May Be Treatable with HSCT in the Future
  • Cord Blood Market Overview
    • Stem Cell Storage Service Offerings
    • Public vs. Private Cord Blood Storage
      • Table Free Cord Blood Programs for Families in Need in the U.S.
  • Cord Tissue Market Overview
    • History of Cord Tissue Storage
    • Comparison of Cord Blood & Cord Tissue Storage
    • Clinical Trials Investigating Cord Tissue Derived Mesenchymal Stem Cells (CT-MSCs)
      • Table Clinical Trials Investigating the Use of Cord Tissue Derived Mesenchymal Stem Cells (CT-MSCs)
      • Table Clinical Trials Underway Involving Use of Wharton's Jelly, a Rich Source of Cord Tissue MSCs
    • Sources of Mesenchymal Stem Cells
      • Table Adult Sources for Mesenchymal Stem Cell (MSC) Isolation
      • Table Fetal Sources for Mesenchymal Stem Cell (MSC) Isolation
    • Market Penetration of Cord Tissue Storage within the U.S.
      • Table U.S. Cord Blood Banks Offering Cord Tissue Storage in 2013
      • Table U.S. Cord Blood Banks Offering Cord Tissue Storage in 2015
    • Market Penetration of Cord Tissue Storage Worldwide
      • Table Percent of Cord Blood Banks Worldwide Offering Cord Tissue Storage Services
    • Pricing of Cord Tissue Storage (Global Analysis)
      • Table Pricing Structures for Umbilical Cord Tissue
  • Benefits of Mesenchymal Stem Cells
    • Key Dates in the Discovery of MSCs
    • Physical Assessment of MSCs
    • Benefits of MSCs Relative to Other Stem Cells
      • Well-Characterized
      • Non-Controversial
      • Diverse Differentiation Potential
      • Ease of Growth in Culture
      • Flexible Propagation
      • Clinically Relevant Volumes
      • Role as Regulatory Cells
      • Delivery of Gene Products
      • Favorable Immune Status
      • Commercially Available Research Tools
  • Cord Blood Industry Accreditations
    • Overview of Cord Blood Industry Accreditation
    • AABB Accreditation
      • Table Countries Containing AABB Accredited Cord Blood Banks
  • Key Processing Technologies within the Cord Blood Marketplace
    • AutoXpress(R) Platform ("AXP(R)") and BioArchive System (By Thermogenesis, a Division of Cesca Therapeutics in Rancho Cordova, California, USA)
    • Sepax (By Biosafe, in Eysins, Switzerland)
    • PrepaCyte(R)-CB (By BioE in St. Paul, Minnesota, USA) - Cryo-Cell Purchased Rights to it in 2015
    • Cord Blood 2.0TM (By Americord, in New York, NY, USA)
    • Other Cord Blood Processing Technologies
  • Strategic Collaborations: Key Alliances within the Cord Blood Industry
    • Cord Blood Registry and Women's Health Alliance (Largest Women's Healthcare Groups)
    • ViaCord and Destination Maternity (Largest Retailer of Maternity Clothing)
    • Precious Cells Miracle and the Croydon Health Services NHS Trust
    • CarePilot and "Cord for Life" (Lifeforce Cryobank's Cord Blood Storage Program)
    • Cesca Therapeutics and UpState Public Cord Blood Bank
    • New York Blood Center and Pluristem Therapeutics Collaborate on Adjuvant Therapy for Cord Blood Transplantation
  • Pairing Cord Blood Banking with Prenatal / Neonatal / Maternal Health Services
    • Natera, a leader in genetic testing, launches EverCord™ Cord Blood and Tissue Banking Services (March 2017)
    • ViaCord, owned by parent company PerkinElmer, launched Newborn Genetic Screening (August 2017)
    • Human Longevity Inc. acquired LifeBankUSA (owned by Celgene); LifeBankUSA Now Passed to Celularity, Inc.
    • AMAG Pharmaceuticals acquired Cord Blood Registry to bolster its portfolio of maternal health products (June 2015)
    • Donor Egg Bank offers free processing of its clients' newborn cord blood through its sister company, FamilyCord
  • Cord Blood Industry Consolidation (Mergers and Acquisitions)
    • Global Analysis of Mergers & Acquisitions
    • Role of Holding Companies within the Global Cord Blood Industry
  • Technologies for Cord Blood Stem Cell Expansion
    • Key Strategies for Cord Blood Expansion
    • Case Study: Gamida Cell as an Industry Leader in Cord Blood Expansion Technology
  • Diversification of Stem Cell Storage Services
    • Table Types of Stem Cell Banking
    • Dental Stem Cell Storage
      • Table Companies Offering Dental Stem Cell Storage, Including Cord Blood Banks and Specialty Companies
    • Adipose-Derived Stem Cell Storage
      • Table Companies Offering Adipose-Derived Stem Cell Storage (Both Cord Blood Banks and Specialty Companies)
    • Other Types of Stem Cell Storage
  • Comparison of U.S. Cord Blood Market Leaders
    • Cord Blood Registry
    • ViaCord
    • Cryo-Cell International
    • Comparison of Top 3 Private U.S. Cord Blood Banks
      • Table Unique Differentiators for CBR, ViaCord, and Cryo-Cell
      • Table Comparison of Services and Features Among Leading U.S. Private Cord Blood Banks
      • Table Comparative Analysis of Pricing Among Leading U.S. Private Cord Blood Banks
  • Comparison of Global Cord Blood Market Leaders
    • Cryo-Save Group (an Esperite N.V Company)
      • Table Esperite N.V. Subsidiaries Operating Worldwide198
    • China Cord Blood Corporation (Owned by Sanpower Group)
    • LifeCell International
    • Comparison of International Cord Blood Banks
      • Table Comparison of Services and Features Among Leading Private Cord Blood Banks Worldwide
  • SWOT Analysis for Cord Blood Industry
    • Strengths
      • Table STRENGTHS OF THE GLOBAL CORD BLOOD BANKING MARKET
    • Weaknesses
      • Table WEAKNESSES OF THE GLOBAL CORD BLOOD BANKING MARKET
    • Opportunities
      • Table OPPORTUNITIES WITHIN THE GLOBAL CORD BLOOD BANKING MARKET
    • Threats
      • Table THREATS TO THE GLOBAL CORD BLOOD BANKING MARKET
  • Regulation of the Cord Blood Marketplace
    • Regulation of HCT/Ps by the U.S. FDA
    • 21st Century Cures Act and REGROW Act
    • Accelerated Approval Pathways for Cell Therapies in Japan
    • Accelerated Approval Regulator Pathways Worldwide
  • Trend Rate Analysis
    • Scientific Publication Rate Analysis
      • Table Trend Rate Analysis of Cord Blood and Cord Tissue Scientific Publications
    • Grant Funding Analysis
      • Table Trend Rate Analysis of Cord Blood Grants (RePORTER Tool)
    • Patent Analysis
      • Table Patents Containing "Cord Blood" in the Title or Abstract (Google Patent Search)
      • Table Breakdown of Cord Blood Patents by Country
      • Table Cord Blood Banks Securing Cord Blood Patents as the Assignee
    • Clinical Trial Analysis
      • Table Cord Blood Clinical Trials Registered at ClinicalTrials.gov
      • Table Geographic Breakdown of "Cord Blood" Clinical Trials Registered at ClinicalTrials.gov
    • Market Penetration Rate of Cord Blood Storage
  • Cord Blood Online Marketing Analysis
    • Cost to Win Online Traffic for the Term "Cord Blood" in Google AdWords
    • Cost to Win Online Traffic for the Term "Cord Tissue" in Google AdWords
      • Table Google AdWords Pay-Per-Click Prices for Cord Blood Related Search Terms
  • Key Cord Blood Industry Benchmarks
    • Medical Society Opinions of Cord Blood Banking
      • Table Cord Blood Banking Opinions Issued by Medical Societies
    • Rates of Parental Awareness
    • Rates of Worldwide Storage, by Year
      • Table Cord Blood Units in the Bone Marrow Donors Worldwide Database
    • Transplant Data
      • Table Transplants by Cell Source (Donor registry of the C.W. Bill Young Cell Transplantation Program, including the National Cord Blood Inventory) 262
    • Impact of Haploidentical Transplant
  • Quality Guarantee Comparison
    • Table Comparison of Quality Guarantees Among Private U.S. Cord Blood Banks (Ranked by Value of the Guarantee)
  • Market Size Analysis
    • Definitions
    • Methodology
      • Roll-up all competitor sales ("Gold Standard")
      • Use a weighted analysis of industry leaders ("Silver Standard")
      • Survey customers for how much they spend in the market ("Bronze Standard")
    • Types of Market Participants
      • Largest Market Participants
        • Table Number of Cord Blood and Tissue Units Stored in Largest Private Cord Blood Banks
      • Mid-Sized Market Participants
        • Table Number of Cord Blood and Tissue Units Stored by Mid-Sized Private Cord Blood Banks
      • Small Sized Market Participants
      • Public Cord Blood Banking Sector
        • Table Percent of Total Global Market by Type of Cord Blood Bank
      • Summary of Findings
        • Table Breakdown of Global Market by Type of Participant
    • Market Size Determination for Cord Blood and Tissue Banking Market
      • Table Trends in Cord Blood Industry Growth by Geography and Sector
      • Table Global Cord Blood and Tissue Banking Market, by Type of Market Participant
      • Table Market Contribution in USD ($) by Type of Market Participant
    • Market Segmentation for All Applications of Cord Blood and Cord Tissue
      • Biobanking
      • Use in Hematopoietic Stem Cell Transplantation (HSCT)
      • Cellular Therapies
      • Genetic Manipulation
      • Research Tools
        • Table Comparison of Stem Cell Publication Rates by Stem Cell Type
    • Market Size Determinations by Market Segment
      • Table Market Size Determinations by Market Segment
      • Table Market Contribution in USD ($) by Market Segment
  • Cord Blood Industry Leadership
    • Cord Blood Industry Authorities
    • Top Ten Most Influential Cord Blood Banks Worldwide
  • Global Cord Blood Conferences and Events
    • Table Global Cord Blood Conference and Events
  • Investors and Acquisitions Impacting the Global Cord Blood Industry
    • Table Industry Investors within the Cord Blood Market
    • Table Major Acquisitions within the Global Cord Blood Market
    • Investors Impacting the Global Cord Blood Market
    • Three Strange Similarities between Acquisition of Cord Blood Registry & ViaCord
      • Table Comparison of Acquisition of Cord Blood Registry by AMAG Pharmaceuticals and ViaCord by PerkinElmer
  • Geographic Analysis of Evolving Cord Blood Industry Conditions
    • China
    • France and Italy
    • Taiwan
    • Ecuador
    • South Africa
    • Brazil
  • Summary of Conclusions
    • Conditions Treatable with Hematopoietic Stem Cell Transplant (Including Cord Blood Transplant)
    • AABB Accredited Cord Blood Banks Worldwide307
    • List of U.S. Cord Blood Banks by Type of Bank (Private, Hybrid, or Public)
    • Global List of Cord Blood Banks Worldwide

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