The Neurotechnology Industry 2011 Report

Published by: NeuroInsights, LLC

Published: May. 25, 2011 - 563 Pages


Table of Contents

1: Executive Summary

The Brain Industry Revealed

Neuropharmaceuticals

Neurodevices

Neurodiagnostics

Investment Risks and Opportunities

Translating Neuroscience into Neurotech

The Neurotech Market Opportunity

NASDAQ NeuroInsights Neurotech Index

Neurotechnology and Society

Key Industry Facts and Findings

Market Overview

Industry Overview

Venture Financing

Public Market Activity

Global Growth Drivers

Other Findings

2: Trends and Drivers

Converging Technology Drivers

Stem Cells and Neuroregeneration

Neuroimaging, Diagnostics and Disease Treatment

Crossing the Blood Brain Barrier

Demographic Drivers

More People Living Longer

Social Drivers

The Lifestyle Improvement Market

Medical Tourism

Economic Drivers

Global Economic Burden of Brain-Related Illness

Rising Health Care Costs

Research Funding

US Government Research Funding

Stem Cell Funding

International Government Research Funding

Foundations Focus on the Brain

Regulatory Trends

World Regulatory Agencies

Global Clinical Trials

Intellectual Property Trends

Global Intellectual Property Protection

Patent Expirations

Patent Activity in the United States

3: Neuropharmaceutical Sector

Neuropharmaceutical Sector Overview

Trends in Neuropharmaceuticals

Spotlight on Big Pharma

Neuropharmaceutical Partnering and Licensing

Neurology Markets and Pipelines

Alzheimer’s Disease (AD)

AAMI and MCI

Epilepsy and Seizure Disorders

Huntington's disease

Migraine

Multiple Sclerosis

Parkinson’s Disease

Sleep Disorders

Restless Legs Syndrome

Stroke

Traumatic Brain Injury

Psychiatry Markets and Pipelines

Addiction

Anxiety Disorders

Attention Disorders

Depressive Disorders

Bipolar Disorder

Obesity

Schizophrenia

Cognitive Impairment Associated with Schizophrenia

Sensory Markets and Pipelines

Pain

Retinal Disorders

4: Stem Cells and Neuroregeneration

Defining Stem Cell Markets and Players

Therapeutics

Drug Discovery Tools

Stem Cell Banking

Stem Cell Approaches

Background

The Science of Transplantion

Controlling Immune Rejection and Infection

Sources and Harvesting of Stem Cells

Embronic Stem Cells

Fetal Stem Cells

Adult Stem Cells

Stimulation of Endogenous Stem Cells

Stem Cells Scientific Hurdles

Markets and Treatments in Development

Alzheimer’s Disease

Amyotrophic Lateral Sclerosis (ALS)

Hearing Loss

Huntington’s Disease (HD)

Multiple Sclerosis (MS)

Parkinson’s Disease

Retinal Disorders

Spinal Cord Injury (SCI)

Stroke

Other CNS Diseases

5: Neurodevice Sector

Neurodevice Sector Overview

Neurodevice Markets

FDA Classification and Approval Process

Neurodevice Sector Trends

Neuroprosthetic Devices

Cochlear Implants

Retinal Implants

Motor Prostheses and Brain Computer Interfaces

Neuromodulation Devices

Neuromodulation Device Clinial Trials and Recent Approvals

Deep Brain Stimulation

Essential Tremor

Parkinson’s Disease

Primary Dystonia

Severe Obsessive Compulsive Disorder

Treatment-Resistant Depression

Epilepsy

Traumatic Brain Injury and Stroke

Transcranial Magnetic Stimulation (TMS)

Alzheimer's

Treatment Resistant Depression

Migraine

Spinal Cord Stimulation (SCS)

Chronic and Neuropathic Pain

Spinal Cord Injury

Vagus Nerve Stimulation (VNS)

Epilepsy

Treatment-Resistant Depression

Obesity

Peripheral Stimulation

Balance

Drug Delivery

Fecal Incontinence

Foot Drop

Hypertension

Migraine

Neuropathic Pain

Restless Legs Syndrome

Sleep Apnea

Stroke

Urinary Conditions

Gastric Modulation and Obesity

Neurosurgical devices

Neurosurgical Navigation and Equipment

Image Guided Navigation (IGN)

Intraoperative Magnetic Resonance Imaging (iMRI)

Automated Surgical Systems

Brain Monitoring

Temperature Control Systems

Neurovascular Intervention

Ischemic Stroke

Catheters, Stents and Perfusion devices

Retrieval and Protection devices

Ultrasound Thrombolysis

Hemorrhagic Stroke

Coils

Liquid Embolics

Stents

Neurosoftware

Attention Deficit Disorder

Cognition and Aging

Emotional Wellbeing

Learning Disabilities and Autism

Pain

The Neurotechnology Industry 2011 Report: Exhibits, Tables, and Charts

1-1: Number of Individuals Afflicted by Indication, US and Worldwide, Top 15 Indications

1-2: Global Pharmaceutical Sales by Indication, 2010

1-3: Neurotechnology Industry Taxonomy

1-4: Proportion of Patient Population Segmented by Neurotech Market Opportunity

1-5: NASDAQ NeuroInsights Neurotech Index Performance vs. S&P500, NASQAQ Composite, and NASDAQ Biotechnology Index

2-1: Projected Percentage Increase in Global Populations aged 65 and over, 1994-2020

2-2: Neuropharmaceutical Patent Expirations and Generic Competition, 2003-2015

2-3: Neurotechnology Patent Approvals, US, 1985-2007

2-4: Neuropharmaceutical Patent Approvals, US, 1985-2007

2-5: Neurodevice Patent Approvals, US, 1985-2007

2-6: Neurodiagnostic Patent Approvals, US, 1985-2007

2-7: Selected US Foundations with a Significant focus on Brain Research and Education

2-8: Most Generous Philanthropists for Medical and Brain Research

2-9: Global Stem Cell Policy Map

3-1: Neuropharmaceutical Revenues by Indication (2010)

3-2: FDA Pharmaceutical Approval Process

3-3: Big Pharma neuropharmaceutical revenues

3-4: Neuropharmaceutical Partnering and Licensing Deals 2004-Q1 2011

3-5: Clinical Trials for Alzheimer’s disease (company, compound, phase, mechanism)

3-6: Clinical Trials for AAMI and MCI (company, compound, phase, mechanism)

3-7: Clinical Trials for Epilepsy (company, compound, phase, mechanism)

3-8: Clinical Trials for Huntington’s disease (company, compound, phase, mechanism)

3-9: Clinical Trials for Migraine (company, compound, phase, mechanism)

3-10: Clinical Trials for Multiple sclerosis (company, compound, phase, mechanism)

3-11: Clinical Trials for Parkinson’s disease (company, compound, phase, mechanism)

3-12: Clinical Trials for sleep disorders (company, compound, phase, mechanism)

3-13: Clinical Trials for stroke Treatment (company, compound, phase, mechanism)

3-14: Clinical Trials for traumatic brian injury(company, compound, phase, mechanism)

3-15: Number of People with Addiction and Impulse Control Disorders (WW and US)

3-16: Clinical Trials for addition and substance abuse (company, compound, phase, mechanism)

3-17: Clinical Trials for anxiety disorders (company, compound, phase, mechanism)

3-18: Clinical Trials for ADHD (company, compound, phase, mechanism)

3-19: Clinical Trials for Depressive disorders (company, compound, phase, mechanism)

3-20: Clinical Trials for Obesity Treatment (company, compound, phase, mechanism)

3-21: Clinical Trials for Schizophrenia and psychosis (company, compound, phase, mechanism)

3-22: Clinical Trials for Retinal disorders (company, compound, phase, mechanism)

3-23: Clinical Trials for Nociceptive Pain (company, compound, phase, mechanism)

3-23: Clinical Trials for Neuropathic Pain (company, compound, phase, mechanism)

4-1: FDA Classification and Approval Process for Medical Devices

4-2: Neurodevice Acquisition and Investment Activity: Medtronic, Boston Scientific, J&J

4-3: Neurodevice Markets and Revenues (Neuroprosthetic, Neuromodulation, Neurosurgical, Neurofeedback)

4-4: Neuromodulation Device Clinical Trials

5-1: Neurodiagnostics Markets and Annual Growth (Neuroimaging, In Vitro Diagnostics, Neuroinformatics)

5-2: FDA Approval and Insurance Reimbursement of Diagnostics

5-3: Neuroimaging Technology (CT, MRI, fMRI, PET, SPECT, EEG, MEG)

5-6: Alzheimer’s Disease Neuroimaging Initiative

5-7: Neuroinformatics Data Storage

5-8: Paul Allen Brain Atlas Project and IBM Blue Brain Project

6-1: Total US Venture Capital Investment, 1999-2010

6-2: US Life Science Venture Capital Investment, 1999-2010

6-3: US Neurotechnology Venture Capital Investment, 1999-2010

6-4: Neurotech as Percent of Life Science Venture Investment, 1999-2010

6-5: Top Five Neurotechnology Venture Capital Financings, 2001-2010

6-6: Top 12 Neurotech Venture Capital Firms with Investments

7-1: Neurotechnology Initial Public Offerings US, 2004-Q1 2011

7-2: Selected Neurotech M&A Activity, 2004-Q1 2011

7-3: Neurotech Index Companies 2011

7-4: Neurotech Index Company Fundamentals

7-5: Index Company Performance

8-1 Leading Neurotechnology Research Centers

8-2 Neurotech Research Centers and Affiliated Institutes, Funding, Recent Significant Investments, Reputation, Translation of Discoveries to Industry

8-3: UCSF

8-4: UCLA

8-5: Harvard University

8-6: Stanford University

8-7: MIT

8-8: Columbia University

8-9: Washington University

8-10: University College London

8-11: Karolinska Institute

8-12: RIKEN Brain Science Institute

9-1 NeuroInsights’ Leading Neurotech Nexus Ratings

9-2 Conclusions and Policy Recommendations

10-1 Neuropharmaceutical Companies Private Profiles (status, funding, location, investment, descriptions, investors)

10-2 Neuropharmaceutical Companies Public Profiles (status, symbol, HQ, market cap revenues, description)

10-3 Neurodevice Companies Private Profiles (status, funding, location, investment, descriptions, investors)

10-4 Neurodevice Companies Public Profiles (status, symbol, HQ, market cap revenues, description)

10-5 Neurodiagnostic Companies Private Profiles (status, funding, location, investment, descriptions, investors)

10-6 Neurodiagnostic Companies Public Profiles (status, symbol, HQ, market cap revenues, description)

Abstract

Drugs, Biologics, Stem Cells, Devices and Diagnostics for the Brain and Nervous System: Market Analysis and Strategic Investment Guide of the Global Neurological Disease and Psychiatric Illness Markets

Now in its seventh year, The Neurotechnology Industry 2011 Report is an expanded and updated 550 page report of brain and nervous system markets and treatments. It is the only publication to provide a comprehensive pipeline and market analysis to help investors, companies and entrepreneurs easily identify opportunities, understand the competitive landscape, determine risks and understand the dynamics of rapidly changing CNS markets.

The report includes detailed information on products in development globally for over 18 indications at 800 companies including Alzheimer's, addiction, ALS, anxiety, depressive disorders, epilepsy, migraine, mild cognitive impairment, Huntington's, multiple sclerosis, obesity, pain, Parkinson's, schizophrenia, age-related macular degeneration, sensory disorders, sleep disorders, traumatic brain injury and stroke.

Report Highlights

The Neurotechnology Industry 2011 Report provides a unified market-based framework to help executives, investors, and governments easily identify opportunities, understand the competitive landscape and visualize the dynamics of these rapidly growing markets.
  • More than 400 profiles of public and private neurotech companies including drugs, devices and diagnostics
  • 12 most active neurotech venture capital firms profiled with investments by market segment and U.S. neurotech venture capital trends (1999-Q12011)
  • Neurotech IPOs (2004-Q12011), M&A (2004-Q12011), Partnering and Licensing deals (2005-Q12011) and public neurotech stock performance
  • Pipelines and market analysis for 18 brain and nervous system illnesses including: addiction, Alzheimer's disease, anxiety, attention disorders, depression, epilepsy, hearing loss, insomnia, mild cognitive impairment, migraine, multiple sclerosis, obesity, pain, Parkinson's disease, retinal disorders, schizophrenia, stroke, and traumatic brain injury
  • Analysis of biological basis, current treatment options, and emerging therapeutic strategies
  • Analysis of compounds, cell therapies and devices in clinical trials (and abandoned) by company, mechanism of action and stage of development for each indication
  • Global and US market size, worldwide revenues for each indication
  • Extensive discussion of specific technological, demographic, regulatory and intellectual property trends


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