Clinical Trial Recruitment in Respiratory Diseases - Most Clinical Trial Activity Focused on Asthma and COPD

Published by: GBI Research

Published: Nov. 22, 2011 - 76 Pages


Table of Contents

1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Clinical Trial Recruitment in Respiratlory Diseases - Introduction
2.1 Introduction
2.2 GBI Research Report Guidance
3 Clinical Trial Recruitment in Respiratory Diseases - Overview
3.1 Clinical Trials Share by Therapeutic Area, 2005-2010
3.2 Clinical Trials by Major Pharmaceutical Companies, 2005-2010
4 Clinical Trials and Patient Recruitment for Asthma
4.1 Introduction
4.2 Number of Clinical Trials for Asthma
4.2.1 Number of Clinical Trials by Phase
4.2.2 Number of Clinical Trials for Asthma by Major Sponsors
4.2.3 Number of Clinical Trials for Asthma by Geography
4.2.4 Number of Clinical Trials for Asthma by Year
4.3 Prevalence Population for Asthma (2010-2017)
4.3.1 India
4.3.2 China
4.3.3 Brazil
4.4 Patient Recruitment for Asthma
4.4.1 Number of Patients Recruited by Phase of Clinical Trials
4.4.2 Number of Patients Recruited by Major Sponsors
4.4.3 Number of Patients Recruited by Geography
4.4.4 Number of Patients Recruited per Year
4.5 Average Number of Patients Recruited Per Trial
4.5.1 Average Number of Patients Recruited per Trial by Stage of Development
4.5.2 Average Number of Patients Recruited per Trial per Year
5 Clinical Trials and Patient Recruitment for COPD
5.1 Introduction
5.2 Number of Clinical Trials for COPD
5.2.1 Number of Clinical Trials by Phase
5.2.2 Number of Clinical Trials by Sponsor
5.2.3 Number of Clinical Trials by Geography
5.2.4 Number of Clinical Trials by Year
5.3 Prevalence Population for COPD (2010-2017)
5.3.1 India
5.3.2 China
5.3.3 Brazil
5.4 Patient Recruitment for COPD
5.4.1 Number of Patients Recruited By Phase of Clinical Trial
5.4.2 Number of Patients Recruited By Sponsor
5.4.3 Number of Patients Recruited By Geography
5.4.4 Number of Patients Recruited per Year
5.5 Average Number of Patients Recruited Per Trial
5.5.1 Average Number of Patients Recruited per Trial by Stage of Development
5.5.2 Average Number of Patients Recruited per Trial per Year
6 Clinical Trials and Patient Recruitment for Cystic Fibrosis (CF)
6.1 Introduction
6.2 Number of Clinical Trials for CF
6.2.1 Number of Clinical Trials by Phase
6.2.2 Number of Clinical Trials by Major Sponsor
6.2.3 Number of Clinical Trials by Geography
6.2.4 Number of Clinical Trials by Year
6.3 Patient Recruitment for CF
6.3.1 Number of Patients Recruited By Phase of Clinical Trial
6.3.2 Number of Patients Recruited by Major Sponsors
6.3.3 Number of Patients Recruited by Geography
6.3.4 Number of Patients Recruited per Year
6.4 Average Number of Patients Recruited Per Trial by Stage of Development
6.4.1 Average Number of Patients Recruited per Trial by Stage of Development
6.4.2 Average Number of Patients Recruited per Trial per Year
7 Clinical Trials and Patient Recruitment for Pulmonary Hypertension (PH)/ Pulmonary Arterial Hypertension (PAH)
7.1 Introduction
7.2 Number of Clinical Trials for PH
7.2.1 Number of Clinical Trials by Phase
7.2.2 Number of Clinical Trials by Major Sponsors
7.2.3 Number of Clinical Trials by Geography
7.2.4 Number of Clinical Trials by Year
7.3 Prevalence Population for Pulmonary Hypertension (2010-2017)
7.3.1 India
7.3.2 China
7.3.3 Brazil
7.4 Patient Recruitment for PH
7.4.1 Number of Patients Recruited By Phase of Clinical Trial
7.4.2 Number of Patients Recruited by Major Sponsors
7.4.3 Number of Patients Recruited By Geography
7.4.4 Number of Patients Recruited Per Year
7.5 Average Number of Patients Recruited Per Trial by Stage of Development
7.5.1 Average Number of Patients Recruited per Trial by Stage of Development
7.5.2 Average Number of Patients Recruited per Trial per Year
8 Appendix
8.1 Market Definitions
8.2 Abbreviations
8.3 Research Methodology
8.3.1 Clinical Trials Overview
8.3.2 Number of Clinical Trials
8.3.3 Patient Recruitment Status
8.3.4 Prevalence of Disease in India, China and Brazil (2010-2017)
8.3.5 Coverage
8.3.6 Secondary Research
8.3.7 Primary Research
8.3.8 Expert Panel Validation
8.4 Contact Us
8.5 Disclaimer
8.6 Sources
1.1 List of Tables
Table 1: Clinical Trial Recruitment in Respiratory Diseases, Global, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Table 2: Clinical Trial Recruitment in Respiratory Diseases, Asia, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Table 3: Clinical Trial Recruitment in Respiratory Diseases, Europe, Number of Ongoing Trials by Therapeutic Area, 2005-2010
Table 4: Clinical Trial Recruitment in Respiratory Diseases, Middle East, Ongoing Trials by Therapeutic Area, 2005-2010
Table 5: Clinical Trial Recruitment in Respiratory Diseases, South and Central America, Ongoing Trials by Therapeutic Area, 2005-2010
Table 6: Clinical Trial Recruitment in Respiratory Diseases, North America, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Table 7: Clinical Trial Recruitment in Respiratory Diseases, Rest of the World, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Table 8: Clinical Trial Recruitment in Respiratory Diseases, Global, Number of Clinical Trials by Major Pharmaceutical Companies, 2005-2010
Table 9: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Phase, 2000-2010
Table 10: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Table 11: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Geography, 2000-2010
Table 12: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials per Year, 2000-2010
Table 13: Clinical Trial Recruitment in Respiratory Diseases, Asthma, India, Prevalence Population, million, 2010-2017
Table 14: Clinical Trial Recruitment in Respiratory Diseases, Asthma, China, Prevalence Population, million 2010-2017
Table 15: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Brazil, Prevalence Population, million 2010-2017
Table 16: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Phase, 2000-2010
Table 17: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Table 18: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Geography, 2000-2010
Table 19: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited per Year, 2000-2010
Table 20: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Table 21: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Average Number of Patients Recruited per Trial per Year, 2000-2010
Table 22: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials, 2000-2010
Table 23: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Table 24: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials by Geography, 2000-2010
Table 25: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials per Year, 2000-2010
Table 26: Clinical Trial Recruitment in Respiratory Diseases, COPD, India, Prevalence Population, million, 2010-2017
Table 27: Clinical Trial Recruitment in Respiratory Diseases, COPD, China, Prevalence Population, million, 2010-2017
Table 28: Clinical Trial Recruitment in Respiratory Diseases, COPD, Brazil, Prevalence Population, million, 2010-2017
Table 29: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials per Year, 2000-2010
Table 30: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Table 31: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited by Geography, 2000-2010
Table 32: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited per Year, 2000-2010
Table 33: Clinical Trial Recruitment in Respiratory Diseases, COPD, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Table 34: Clinical Trial Recruitment in Respiratory Diseases, COPD, Average Number of Patients Recruited per Trial per Year, 2000-2010
Table 35: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Phase, 2000-2010
Table 36: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Table 37: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Geography, 2000-2010
Table 38: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials per Year, 2000-2010
Table 39: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Phase, 2000-2010
Table 40: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Table 41: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Geography, 2000-2010
Table 42: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited per Year, 2000-2010
Table 43: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Table 44: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Average Number of Patients Recruited per Trial per Year, 2000-2010
Table 45: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Phase, 2000-2010
Table 46: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Table 47: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Geography, 2000-2010
Table 48: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials per Year, 2000-2010
Table 49: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, India, Prevalence Population, 2010-2017
Table 50: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, China, Prevalence Population, 2010-2017
Table 51: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Brazil, Prevalence Population, 2010-2017
Table 52: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Phase, 2000-2010
Table 53: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Table 54: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Geography, 2000-2010
Table 55: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited per Year, 2000-2010
Table 56: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Table 57: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Average Number of Patients Recruited per Trial per Year, 2000-2010
1.2 List of Figures
Figure 1: Clinical Trial Recruitment in Respiratory Diseases, Global, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Figure 2: Clinical Trial Recruitment in Respiratory Diseases, Asia, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Figure 3: Clinical Trial Recruitment in Respiratory Diseases, Europe, Number of Ongoing Trials by Therapeutic Area, 2005-2010
Figure 4: Clinical Trial Recruitment in Respiratory Diseases, Middle East, Ongoing Trials by Therapeutic Area, 2005-2010
Figure 5: Clinical Trial Recruitment in Respiratory Diseases, South and Central America, Ongoing Trials by Therapeutic Area, 2005-2010
Figure 6: Clinical Trial Recruitment in Respiratory Diseases, North America, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Figure 7: Clinical Trial Recruitment in Respiratory Diseases, Rest of World, Ongoing Trials by Therapeutic Area, thousands, 2005-2010
Figure 8: Clinical Trial Recruitment in Respiratory Diseases, Global, Number of Clinical Trials by Major Pharmaceutical Companies, 2005-2010
Figure 9: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Phase, 2000-2010
Figure 10: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Figure 11: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials by Geography, 2000-2010
Figure 12: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Clinical Trials per Year, 2000-2010
Figure 13: Clinical Trial Recruitment in Respiratory Diseases, Asthma, India, Prevalence Population, million, 2010-2017
Figure 14: Clinical Trial Recruitment in Respiratory Diseases, Asthma, China, Prevalence Population, million, 2010-2017
Figure 15: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Brazil, Prevalence Population, million 2010-2017
Figure 16: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Phase, 2000-2010
Figure 17: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Figure 18: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited by Geography, 2000-2010
Figure 19: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Total Number of Patients Recruited per Year, 2000-2010
Figure 20: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Figure 21: Clinical Trial Recruitment in Respiratory Diseases, Asthma, Average Number of Patients Recruited per Trial per Year, 2000-2010
Figure 22: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials, 2000-2010
Figure 23: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Figure 24: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials by Geography, 2000-2010
Figure 25: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Clinical Trials per Year, 2000-2010
Figure 26: Clinical Trial Recruitment in Respiratory Diseases, COPD, India, Prevalence Population, million, 2010-2017
Figure 27: Clinical Trial Recruitment in Respiratory Diseases, COPD, China, Prevalence Population, million, 2010-2017
Figure 28: Clinical Trial Recruitment in Respiratory Diseases, COPD, Brazil, Prevalence Population, million, 2010-2017
Figure 29: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited by Phase, 2000-2010
Figure 30: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Figure 31: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited by Geography, 2000-2010
Figure 32: Clinical Trial Recruitment in Respiratory Diseases, COPD, Total Number of Patients Recruited per Year, 2000-2010
Figure 33: Clinical Trial Recruitment in Respiratory Diseases, COPD, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Figure 34: Clinical Trial Recruitment in Respiratory Diseases, COPD, Average Number of Patients Recruited per Trial per Year, 2000-2010
Figure 35: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Phase, 2000-2010
Figure 36: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Figure 37: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials by Geography, 2000-2010
Figure 38: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Clinical Trials per Year, 2000-2010
Figure 39: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Phase, 2000-2010
Figure 40: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Figure 41: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited by Geography, 2000-2010
Figure 42: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Total Number of Patients Recruited per Year, 2000-2010
Figure 43: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Figure 44: Clinical Trial Recruitment in Respiratory Diseases, Cystic Fibrosis, Average Number of Patients Recruited per Trial per Year, 2000-2010
Figure 45: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Phase, 2000-2010
Figure 46: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Major Sponsors, 2000-2010
Figure 47: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials by Geography (%), 2000-2010
Figure 48: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Clinical Trials per Year, 2000-2010
Figure 49: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, India, Prevalence Population, 2010-2017
Figure 50: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, China, Prevalence Population, 2010-2017
Figure 51: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Brazil, Prevalence Population, 2010-2017
Figure 52: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Phase, 2000-2010
Figure 53: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Major Sponsors, 2000-2010
Figure 54: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited by Geography (%), 2000-2010
Figure 55: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Total Number of Patients Recruited per Year, 2000-2010
Figure 56: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Average Number of Patients Recruited per Trial by Stage of Development, 2000-2010
Figure 57: Clinical Trial Recruitment in Respiratory Diseases, Pulmonary Hypertension, Average Number of Patients Recruited per Trial per Year, 2000-2010

Abstract

Clinical Trial Recruitment in Respiratory Diseases - Most Clinical Trial Activity Focused on Asthma and COPD

Summary

GBI Research’s report, “Clinical Trial Recruitment in Respiratory Diseases - Most Clinical Trial Activity Focused on Asthma and COPD”, provides an in-depth analysis of patient recruitment scenario for major indications under respiratory diseases. The report analyzes the number of clinical trials conducted for major indications. The report provides information about the total number of clinical trials conducted by phase, geography, major sponsors and the number of clinical trials conducted per year. Analysis of the total number of patients recruited for major indications is also carried out. The report analyzes the total number of patients recruited by phase of clinical trial, geography and major sponsors. Analysis of the average number of patients recruited per trial per year for various indications is also completed.

Clinical trials are conducted to find novel therapies for respiratory diseases. The cost and time for conducting clinical trials for respiratory diseases is higher than other diseases. This is due to costly and time consuming testing methods. Patients are required to be tested for a longer duration leading to an increase in the total time required for drug effectiveness than seen in other diseases. Changing environmental conditions along with increases in tobacco smoking, air pollution and urbanization has lead to an increase in the prevalence of respiratory diseases. Asthma, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis (CF) and Pulmonary Arterial Hypertension (PAH) are few of the major respiratory diseases for which an increased number of clinical trials are conducted in order to determine the most effective treatment.

In accordance to World Health Organization (WHO), the most common chronic disease among children is asthma. Asthma affects nearly 235 million people in the world. COPD was the cause of 5% of the total deaths in 2005. Tobacco smoking is the leading cause of COPD and in 2030. COPD will be the third leading cause of death. In light if this it becomes more important to find remedies for chronic respiratory diseases. CF is one of the most prevalent life-shortening diseases. It is a genetic disease which affects multiple organs.

It is important to recruit the right type and number of patients to check the efficacy and efficiency of drugs. Efficient patient recruitment leads to a decrease in the time and cost associated with patient recruitment. At present, the rate of new drug approvals is declining with every passing year. Pharmaceutical companies are under intense pressure to reduce the time required for drug development. There are many barriers to participation for the patients as well as the investigators who enroll patients into the trials. Advances in the diagnosis and treatment of respiratory diseases are leading to a greater interest of pharmaceutical companies in sponsoring research into respiratory diseases.

Scope
  • Insight on Clinical Trials conducted for major indications of respiratory diseases such as asthma, COPD, CF, PAH or Pulmonary Hypertension (PH) for the period 2000-2010.
  • The status of patient recruitment by geographical region, sponsor company, year and stage of development.
  • Analysis on the average number of patients recruited per trial for major indications per year.
  • Analysis on the average number of patients recruited per trial for major indications by stage of development.
  • The prevalence population in India, China and Brazil for all major indications from 2010-2017.
Reasons to buy
  • Identify and understand the status of clinical trials conducted for major respiratory indications from 2000-2010.
  • Build understanding of patient recruitment status by geography, sponsor company, year and stage of development.
  • Identify the prevalence population for the major indications till 2017.
  • Identify the average number of patients recruited by stage of development and across years for all major indications.
  • Identify the indication in which the maximum number of trials is conducted and and to which the maximum number of patients are recruited.


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