Dementia: Causes, Treatments, and Outlook 2011Published by: PharmaLive Special Reports Published: Aug. 1, 2011 - 68 Pages Table of Contents
AbstractNeurodegenerative diseases are the sixth-leading cause of death in high-income countries, with 35.6 million people suffering from dementia worldwide. This patient population is predicted to reach 115.4 million people by 2050. Up to 8% of all people over 65 years old have some form of dementia. Dementia prevalence about doubles for every five years of age starting at 60. Dementia caused by nervous system diseases, especially Alzheimer's disease, is increasing in frequency. Alzheimer's disease strikes nearly a half million new patients each year. There are only a handful of FDA-approved drugs for the treatment of Alzheimer's disease. These drugs temporarily reduce symptoms including memory problems, confusion, aggression, and a general decline in bodily functions. These medicines work by slowing down the disease activity that breaks down a key neurotransmitter or by regulating the activity of glutamate, a chemical messenger involved in learning and memory. Industry experts hope for a breakthrough Alzheimer's drug that will treat the underlying disease and stop or delay the cell damage that eventually leads to worsening of symptoms. A drug that can stop or reduce memory loss could generate annual sales exceeding $5 billion. Pfizer Inc. and Eisai Co. Ltd.'s Aricept is the top-selling drug for the treatment of dementia. Aricept is the first and only prescription medication approved by the FDA for the treatment of all stages of AD - mild, moderate and severe dementia of the Alzheimer's type.Aricept is not a cure for AD, but may help provide symptomatic benefits for some patients. For those who respond, symptoms may improve, stabilize or progress more slowly than patients who do not take Aricept. Aricept generated 2010 global sales of about $3.97 billion. Since Pfizer's loss of exclusivity in November 2010, other companies such as Teva are shipping generic versions of the top-selling medication. Get full details about this report >> |
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