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Pharmaceuticals and Politics: Will Political Opinion Affect the Future of HPV Vaccines?

Published by: Decision Resources

Published: Dec. 19, 2005


Table of Contents


Introduction

The Impact of HPV on World Health

HPV and Its Connection to Cervical Cancer

Prevalence and Mortality Due to Cervical Cancer

The Advisory Committee on Immunization Practices

The Debate Surrounding HPV Vaccines

Impact on the Pharmaceutical Industry




Table 1. Common Human Papillomavirus Subtypes and Related Diseases

Table 2. Prevalence of Cervical Cancer in the Major Pharmaceutical Markets, 2004-2014

Table 3. Current Members of the Advisory Committee for Immunization Practices




Figure 1. Recommended Childhood and Adolescent Immunization Schedule, U.S., 2005

Abstract

Human papillomavirus (HPV) is one of the most common sexually transmitted diseases and is responsible for the vast majority of cervical cancers worldwide. Treatment is a challenge because the immune response to the virus has not been well characterized, and the virus has a propensity to persist, produce recurrent clinical disease, and cause cancer. Merck's October 2005 announcement that its HPV vaccine, Gardasil, proved to be 100% effective in preventing cervical cancer has excited the medical community but has also triggered debate regarding its inclusion on the U.S. recommended schedule of vaccinations, an inclusion that is often critical for vaccines' commercial success. In this report, we review the prevalence of HPV; discuss Merck's Gardasil and GlaxoSmithKline's Cervarix HPV vaccines; profile the U.S. Advisory Committee on Immunization Practices, which determines which vaccines are included on the U.S. recommended schedule of vaccinations; examine the debate surrounding the vaccines' inclusion on the U.S. recommended schedule of vaccinations; and discuss the implications of this debate for the pharmaceutical industry as a whole.

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