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Conference Documentation: Immunogenicity

Understanding immunogenicity is a key challenge in the development of therapeutics with many biologics inducing undesirable immune responses directed towards the therapeutic resulting in reduced efficacy, anaphylaxis and occasionally life threatening autoimmunity. This conference explores the latest updates on the prediction and reduction of immunogenicity, clinical results and interpetations and optimising bioassays.

Led by selected case studies from leading drug developement teams, bioanalytical experts, and academics we aim to provide the insights and sharing necessary to deliver safe, efficacious large molecule drugs to improve the lives of patients.


Day 1
8:30
Registration & Coffee
9:00
Chair's Opening Remarks
Guilhem Richard, Computational Immunologist, EpiVax Inc
9:10
How to switch off unwanted immune responses
David Wraith, Chief Scientific Officer and Founder, Apitope International NV
9:50
Synthetic Vaccine Particles (SVPs) for the prevention of anti-drug antibodies
Kei Kishimoto , Chief Scientific Officer, Selecta Biosciences
10:30
Morning Coffee
11:00
Achieving immunological tolerance – are we there yet?
Farnaz Fallah-Arani, Group Leader, Pharmacology, UCB
11:40
Evaluation of the immunogenicity of orally administered recombinant human BSSL in a phase III clinical study in pre-term infants
Margareta Wiken, Bioanalytical Manager, Swedish Orphan Biovitrum
12:20
Networking Lunch
13:20
Early immunogenicity assessment of biotherapeutics: a decade at a glance
Sofie Pattijn, Chief Technology Officer, ImmunXperts
14:00
Predicting T cell immunogenicity; Moving beyond MHC binding
Morten Nielsen, Associate Professor, The Technical University Of Denmark
14:40
Afternoon Tea
15:20
Immune tolerant mice as the model for studying immunogenicity?
Grzegorz Kijanka, Postdoctoral Researcher , Leiden Academic Centre for Drug Research, Leiden University
16:00
Validation of cell based antibody neutralisation assays
Bassam Hallis, Head of Pre-Clinical Development, Public Health England
16:40
Mission Impossible? Tweaking Bridging ELISA to Achieve Required Drug Tolerance for ADA Detection of Therapeutic Antibodies
Linglong Zou, Director of Experimental Immunology, Teva Pharmaceuticals
17:20
Chair’s Closing Remarks and Close of Day One
Guilhem Richard, Computational Immunologist, EpiVax Inc
Day 2
8:30
Registration & Coffee
9:00
Chair's Opening Remarks
Sandra Garces, Rheumatologist Consultant and Researcher , Garcia de Orta’s Hospital
9:10
Predicting Immunogenicity in the Era of Personalized Medicine: A Need for Individual Risk Assessment
Guilhem Richard, Computational Immunologist, EpiVax Inc
9:50
Drug Immunogenicity: What have we learned from the use of biologics in clinical practice?
Sandra Garces, Rheumatologist Consultant and Researcher , Garcia de Orta’s Hospital
10:30
Morning Coffee
11:00
RG7787 - The coming of age of immunotoxins for solid tumour therapy. Are we there yet?
Gerhard Niederfellner, Head of Tumour Cell Biology, Pharma Research & Early Development , Roche Innovation Center Penzberg
11:40
Immunogenicity prediction and assessment of nanobodies
Chloe Ackaert, Postdoctoral Researcher, Cellular and Molecular Immunology, Free University Of Brussels
12:20
Networking Lunch
13:20
Peptide immunotherapy for the treatment of autoimmune disease – closer to a cure?
Emma Smith, Senior Group Leader, UCB
14:00
ABIRISK: using immunological signatures to predict immunogenicity
Marsilio Adriani, Postdoctoral Research Associate, University College London
14:40
Afternoon Tea
15:20
The two main outcomes of T cell amplification assays for immunogenicity prediction: T cell repertoire and epitopes
Bernard Maillere, Research Director and Head, Immunology Laboratory, Institute of Biology and Technologies
16:00
An integrated approach to managing immunogenicity risk and drug immune modulation
Jeremy Fry, Assay Specialist , ProImmune Ltd.
16:40
Chair's Closing Remarks and Close of Day Two
Sandra Garces, Rheumatologist Consultant and Researcher , Garcia de Orta’s Hospital

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