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Proteomics Research Markets: Instruments & Consumables (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other), Market Share and Trends

Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays.  Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways.  This report defines the proteomics research market for major technologies.  

Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis.  As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups: 

•      Mass Spectrometry
•      Liquid Chromatography
•      Electrophoresis

Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world.  Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment.  This report also explores proteomics research market by the current and forecast size of disease group market segments that include:

Oncology
Neurology
Cardiovascular
Other

As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis.  

The report notes the background, products and revenue of the major market players. Companies profiled include:

•        AB Sciex (Danaher) 
•        Agilent Technologies 
•        Bruker Corporation 
•        Thermo Fisher Scientific 
•        Waters Corporation 
•        Bio-Rad Laboratories 
•        GE Healthcare Life Sciences 
•        JEOL Ltd. 
•        Shimadzu Corporation

No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie.  The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis.   Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less’ workflow. 

This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications:

Triple Quadrupole (QqQ)
Time-of-flight (TOF)
Quadrupole-TOF (Q-TOF)
Ion Traps (IT,QIT,LIT)
Orbitraps
FT-ICR

The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials.  Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically. 

The following is among the topics addressed in this report:

•        Current Practices in Drug Discovery
•        The Translational Research Workflow
•        Proteomics in Biomarker Research           
•        Biomarker Discovery      
•        Biomarker Verification   
•        Biomarker Validation      
•        Company Market Shares by Research Instrument
•        Company Revenues and Detailed Product Offerings
•        Analyst Conclusions Regarding the Present and Future Market


Kalorama Information's market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions.  North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region.  The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions. 

United States
Europe 
Asia-Pacific
Rest of World (ROW)





    • Executive Summary
      • BACKGROUND
      • PROTEOMICS IN TRANSLATIONAL RESEARCH
        • Proteomics in Biomarker Research
        • Proteomics in Drug Target Research
      • PROTEOMICS RESEARCH INSTRUMENTS
        • Mass Spectrometry
          • Table Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT, Orbitrap, FT-ICR) - Resolution, Mass Accuracy, Sensitivity, Dynamic Range, Cost
          • Table Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps, TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020) ($ millions)
        • Liquid Chromatography
        • Electrophoresis
          • Table Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020) ($ millions)
      • INDUSTRY LANDSCAPE -MAJOR COMPETITORS
        • AB Sciex
        • Agilent Technologies
        • Bruker Corporation
        • Thermo Fisher Scientific
        • Waters Corporation
      • MAJOR CONCLUSIONS
    • Introduction to Proteomics Research
      • BACKGROUND
      • TRANSLATIONAL RESEARCH
      • PROTEOMICS AND THE `OMICS LANDSCAPE
      • THE ROLE OF PROTEINS IN BIOLOGICAL FUNCTIONING AND DISEASE
      • PROTEINS AS BIOMARKERS
      • PROTEOMICS RESEARCH SAMPLES
        • Table Proteomics Research Sample Comparison by Advantages/Disadvantages - Cell Culture, Dried Blood Spot, Plasma, Serum, Tissue, Whole Blood
      • CONCLUSION
    • Proteomics Research Technologies
      • BACKGROUND
      • MASS SPECTROMETRY
        • Table Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT, Orbitrap, FT-ICR) - Resolution, Mass Accuracy, Sensitivity, Dynamic Range, Cost
        • Triple Quadrupole
          • Table Triple Quadrupole Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
        • Time-of-Flight
          • Table Time-of-Flight / TOF Hybrid Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
        • Ion Trap / Orbitrap
          • Table Fourier Transform Ion Cyclotron Resonance Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
          • Table Quadrupolar, Linear and Hybrid Ion Trap Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
          • Table Orbitrap Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
        • Ion Sources
          • Table Major Vendor Electrospray Ionization Innovations Summary
          • Table Surface Analysis Ionization Technique Advantages/Disadvantages (MALDI, SELDI, DESI, LAESI)
        • Ion Activation
          • Table Ion Activation Method Advantages/Disadvantages (Low-Energy CID, High-Energy CID, SID, PSD, ISD, UVPD, IRMPD, ECD, ETD)
        • Reagents
      • ELECTROPHORESIS
        • Gel Electrophoresis
        • Off-Gel Electrophoresis
        • GelFree / Continuous Flow Electrophoresis / Free Flow Electrophoresis
        • Capillary Electrophoresis
          • Table Electrophoresis Method Advantages/Disadvantages (SDS-PAGE, 2DGE, DIGE, OFFGEL, GELFREE, Continuous and Free Flow, Capillary)
      • LIQUID CHROMATOGRAPHY
      • CONCLUSION
    • Proteomics Research Processes - Biomarker and Drug Target Development
      • BACKGROUND
        • Proteomics in Biomarker Research
        • Biomarker Discovery
          • Table Shotgun Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
          • Table Gel-Based Discovery Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
          • Table Capillary Electrophoresis-Based Discovery Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
          • Table Data-Independent Acquisition Discovery Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
          • Table Major Vendor DIA Product Comparison (Waters MSE, Thermo Fisher AIF, AB Sciex SWATH, Thermo Fisher MSX, Thermo Fisher PRM)
        • Biomarker Verification
          • Table Selected and Multiple Reaction Monitoring (SRM/MRM) Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
        • Biomarker Validation
      • PROTEOMICS IN DRUG TARGET RESEARCH (CHEMICAL PROTEOMICS)
        • Target Deconvolution
          • Table Chemical Proteomics/Drug Target Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
      • CONCLUSION
    • Proteomics Research Instrument Markets
      • BACKGROUND
      • MASS SPECTROMETRY MARKET IN PROTEOMICS RESEARCH
        • Table Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps, TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020) ($ millions)
        • Table Proteomics Research Mass Spectrometry Market by Company Share (2015) ($ millions)
      • LIQUID CHROMATOGRAPHY MARKET IN PROTEOMICS RESEARCH
        • Table Proteomics Research Liquid Chromatography Market (2015/2020) ($ millions)
        • Table Proteomics Research Liquid Chromatography Market by Company Share (2015) ($ millions)
      • ELECTROPHORESIS MARKET IN PROTEOMICS RESEARCH
        • Table Proteomics Research Electrophoresis Market (2015/2020) ($ millions)
      • PROTEOMICS RESEARCH MARKET OVERVIEW - TECHNOLOGIES, GEOGRAPHIES AND DISEASE
        • Table Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020) ($ millions)
        • Table Proteomics Research Market by Geography (North America, Europe, Asia-Pacific, ROW) (2015/2020) ($ millions)
        • Table Proteomics Research Market by Disease Area (Cardiovascular, Neurology, Oncology, Other) (2015) ($ millions)
      • CONCLUSION
    • Company Profiles
      • AB SCIEX (DANAHER)
        • Background
        • Products
          • Table AB Sciex Proteomics Products
        • Revenues
          • Table AB Sciex Revenue (2009-2014)
      • AGILENT TECHNOLOGIES
        • Background
        • Products
          • Table Agilent Technologies Proteomics Products
        • Revenues
          • Table Agilent Technologies Revenue (FY 2009-2014)
      • BRUKER CORPORATION
        • Background
        • Products
          • Table Bruker Corporation Proteomics Products
        • Revenues
          • Table Bruker Corporation Revenue (2009-2014)
      • THERMO FISHER SCIENTIFIC
        • Background
        • Products
          • Table Thermo Fisher Scientific Proteomics Products
        • Revenues
          • Table Thermo Fisher Scientific Revenue (2009-2014)
      • WATERS CORPORATION
        • Background
        • Products
          • Table Waters Corporation Proteomics Products
        • Revenue
          • Table Waters Corporation Revenue (2009-2014)
      • SECOND-TIER MARKET PLAYERS
      • BIO-RAD LABORATORIES
        • Background
        • Products
          • Table Bio-Rad Laboratories Proteomics Products
      • GE HEALTHCARE LIFE SCIENCES
        • Background
        • Products
          • Table GE Healthcare Life Sciences Proteomics Products
      • JEOL LTD.
        • Background
        • Products
          • Table JEOL Ltd. Proteomics Products
      • SHIMADZU CORPORATION
        • Background
        • Products
          • Table Shimadzu Corporation Proteomics Products

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