KOL Perspectives: Biomarker Potential of Type I IFN Gene Signature in Lupus

KOL Perspectives: Biomarker Potential of Type I IFN Gene Signature in Lupus

Summary

This KOL Insight briefing focuses on the IFN gene signature as a potential biomarker in Lupus.

The briefing includes analysis of KOL opinion on the following topic areas -

• Awareness of biomarkers and predictors of disease activity in lupus
• Usefulness of the type I IFN signature test to identify patients who are most likely to respond to IFN-targeting therapies
• Impact of availability of a biomarker on willingness to prescribe a therapy
• Implementing a potential IFN biomarker test in clinical practice
• Willingness to prescribe anifrolumab to patients who do not display the interferon biomarker
• Barriers to using IFN signature test to stratify patients in clinical practice
• Impact of data suggesting that high IFN gene expression is closely associated with SLE on opinion of anifrolumab’s efficacy
• Impact of data suggesting that high IFN gene expression is more closely associated with LN than IFN on opinion of anifrolumab’s efficacy

Key Highlights

• Majority of KOLs use complement & anti-DNA to monitor disease activity in clinical practice, while most are aware of the type I IFN signature test
• Most KOLs flagged that the type I IFN signature test will be useful to stratify patients most likely to respond to type I IFN-targeting therapies
• Most KOLs agreed that the availability of a biomarker would strongly influence their willingness to prescribe a therapy such as anifrolumab.

Scope

• The insight briefing is based on Sociable Pharma’s analysis of primary research with our lupus key opinion leaders (KOLs)
• In total, we conducted interviews with 14 KOLs: Seven Europe-based & seven US-based
• Interviews performed in December 2017
• KOL data is analyzed to produce: Charts summarizing KOL opinions
• Chart call-outs of key information & details
• KOL quotes
• Summary of KOL reporting trends
• Insight from Sociable Pharma's analysts.

Reasons to buy

• Combines Qualitative & semi-quantitative insight from key opinion leaders on Biomarker Potential of Type I IFN Gene Signature in Lupus
• Includes insight & recommendations from our disease-specific healthcare analysts
• Utilizes independent expert viewpoints to validate the impact of new clinical data & emerging trends on management of Lupus
• Provides cost-effective support for your advisory boards, with topics acting as a catalyst for further expert discussion.