Bronchiectasis Market Size and Trend Report including Epidemiology and Pipeline Analysis, Competitor Assessment, Unmet Needs, Clinical Trial Strategies and Forecast, 2021-2031

Bronchiectasis Market Size and Trend Report including Epidemiology and Pipeline Analysis, Competitor Assessment, Unmet Needs, Clinical Trial Strategies and Forecast, 2021-2031


Bronchiectasis, which has been given diagnostic code of J47.9 from the International Classification of Diseases, Tenth Edition (ICD-10), is defined by damage to the bronchi, causing abnormal dilation and scarring. The airways become inflamed with thick mucus that is difficult to clear, which build-up creates an environment for bacterial growth; uncontrolled bacterial growth leads to frequent infections. The cycle of repeated infections can in turn cause further damage to the airways. Bronchiectasis can occur throughout the lung or in a single section of lung. .

Bronchiectasis is still relatively poorly understood; increasing emphasis has been placed on the role of underlying factors, such as the presence of comorbidities, but the development of bronchiectasis is multifactorial. Contributing factors include infections, immunodeficiency, impaired mucociliary clearance, previous lung injury, airway lesions, concurrent chronic respiratory diseases, and connective tissue and/or autoimmune diseases. Although diagnosed prevalent cases of bronchiectasis are expected to increase by 21.3% across the 3MM, many symptomatic treatments are currently used off-label. The most frequently used drug classes are antibiotics, bronchodilators, and mucolytics. Antibiotics are most commonly used off-label to treat bronchiectasis patients whose lungs are colonized with bacteria as a prophylactic treatment, or to treat lung infections; they can be oral, IV, or inhaled depending on the severity and type of bacteria. Mucolytics and bronchodilators are used to alleviate symptoms by clearing airways of thick mucus and widening airways.

The bronchiectasis market in the 3MM was valued at $408.2M in 2021. The market is projected to grow at a Compound Annual Growth Rate (CAGR) of 9.0%, reaching $965.8 million by 2031, with pipeline agents adding over $450 million in sales. In 2021, inhaled antibiotics was the market-leading class with $265.6 million in sales and is expected to remain the leader with $314.5 million in sales in 2031. The major driver for this growth will be the anticipated launch of novel pipeline agents such as Fasenra and brensocatib which have forecasted 2031 sales of $171.2 million and $271.6 million, respectively.

Key Highlights

  • The bronchiectasis market will exhibit significant growth between 2021 and 2031, driven by the entry of several pipeline agents. These new entrants will transform the bronchiectasis market by providing more treatment options for patients suffering from frequent exacerbations.
  • In 2021, inhaled antibiotics was the market-leading class with $265.6 million in sales, and is expected to remain the leader with $314.5 million in sales in 2031
  • KOLs expressed enthusiasm for the late-stage agents Fasenra, an interleukin (IL) -5 inhibitor, and brensocatib, a dipeptidyl peptidase 1 (DPP-1) inhibitor, due to their new mechanisms of action and the innovation they would bring to the market; if approved they would both be the first in their respective classes.
  • The most important unmet needs in bronchiectasis are the lack of marketed drugs and the need for improved diagnosis. Despite having three pipeline agents in late-stage development, significant unmet need is expected to remain, representing an opportunity for developers in the bronchiectasis market
Key Questions Answered
  • What were the key bronchiectasis treatments available in 2021?
  • When will late-stage pipeline products launch, and how will they affect drug sales and the overall bronchiectasis market in the 3MM?
  • Which unmet needs will remain unaddressed in the forecast period and what opportunities remain for pharmaceutical companies?
  • Overview of bronchiectasis, including epidemiology, symptoms, diagnosis, and disease management.
  • Annualized bronchiectasis therapeutics market revenue, cost of therapy per patient, and treatment usage patterns; forecast from 2021 to 2031.
  • Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping, and implications of these factors for the bronchiectasis therapeutics market.
  • Pipeline analysis including comprehensive data assessing emerging trends and mechanisms of action under development for bronchiectasis treatment. The most promising candidates in Phase III and Phase IIb development are profiled.
  • Analysis of the current and future market competition in the global bronchiectasis therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Reasons to Buy

The report will enable you to -
  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
  • Develop business strategies by understanding the trends shaping and driving the global bronchiectasis therapeutics market.
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global bronchiectasis therapeutics market in the future.
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
  • Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.

1 Executive Summary
1.1 Executive Summary
2 Disease Overview
2.1 Overview of Bronchiectasis
2.2 Classification of Bronchiectasis
2.3 Bronchiectasis SWOT Analysis
3 Epidemiology
3.1 Diagnosed Prevalent Cases of Bronchiectasis, Men and Women, 2021-31
3.2 Sources and Methodology
4 Current Treatment Options
4.1 Treatment Paradigm
4.2 Marketed Products
4.3 Product Profile: Antibiotics (Oral, IV, Inhaled)
4.4 Product Profile: Bronchodilators
4.5 Product Profile: Bronchitol
4.6 Product Profile: Hypertonic Saline
5 Unmet Needs and Opportunities
5.1 Unmet Needs in Bronchiectasis
6 Pipeline Assessment
6.1 Bronchiectasis Pipeline Overview
6.2 Leading Pipeline Agents
6.3 Product Profile: AstraZeneca’s Fasenra (benralizumab)
6.4 Product Profile: Insmed’s Brensocatib
6.5 Product Profile: Kamada Pharmaceutical’s AAT inhibitor
6.6 Product Profile: Zambon Pharma’s NCFBE-1 & NCFBE-2
6.7 Product Profile: Novartis’s Icenticaftor
7 R&D Strategies
7.1 Trends in Clinical Trial Design in Bronchiectasis
7.2 Trends in Deal-Making in Bronchiectasis
8 Market Outlook
8.1 Bronchiectasis Market Forecast
8.2 Market Drivers and Barriers
9 Appendix
9.1 Bibliography
9.2 Primary Research: KOL Information
9.3 About the Authors
10 Contact Us

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