Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 22.214.171.124) - Drugs in Development, 2021
According to the recently published report 'Cyclin Dependent Kinase 2 - Drugs In Development, 2021'; Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 126.96.36.199) pipeline Target constitutes close to 25 molecules. Out of which approximately 22 molecules are developed by companies and remaining by the universities/institutes.
Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 188.8.131.52) - Cyclin-dependent kinase 2 is an enzyme encoded by the CDK2 gene. CDK2 is the catalytic subunit of the cyclin-dependent protein kinase complex which regulates progression through the cell cycle. Activity of CDK2 is especially critical during the G1 to S phase transition. CDK2 associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B).
The report 'Cyclin Dependent Kinase 2 - Drugs In Development, 2021' outlays comprehensive information on the Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 184.108.40.206) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 220.127.116.11) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase II, IND/CTA Filed, Preclinical and Discovery stages are 9, 1, 9 and 3 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 2 molecules, respectively.
Report covers products from therapy areas Oncology, Infectious Disease, Immunology, Ear Nose Throat Disorders, Metabolic Disorders and Respiratory which include indications Breast Cancer, Ovarian Cancer, Lung Cancer, Coronavirus Disease 2019 (COVID-19), Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer), Metastatic Breast Cancer, Pancreatic Cancer, Solid Tumor, Triple-Negative Breast Cancer (TNBC), Epithelial Ovarian Cancer, Fallopian Tube Cancer, Gastric Cancer, Glioblastoma Multiforme (GBM), Inflammation, Lymphoma, Non-Small Cell Lung Cancer, Peritoneal Cancer, Prostate Cancer, Unspecified Cancer, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Anaplastic Astrocytoma, Astrocytoma, Bile Duct Cancer (Cholangiocarcinoma), Colon Cancer, Colorectal Cancer, Cutaneous T-Cell Lymphoma, Cystic Fibrosis, Diffuse Large B-Cell Lymphoma, Endometrial Cancer, Gliosarcoma, Hearing Disorders, Hematological Tumor, Hepatocellular Carcinoma, High-Grade Glioma, Laryngeal Cancer, Mantle Cell Lymphoma, Metastatic Brain Tumor, Metastatic Colorectal Cancer, Metastatic Hepatocellular Carcinoma (HCC), Metastatic Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Multiple Myeloma (Kahler Disease), Myelodysplastic Syndrome, Neuroblastoma, Oligodendroglioma, Pediatric Diffuse Intrinsic Pontine Glioma, Peripheral T-Cell Lymphomas (PTCL), Pituitary ACTH Hypersecretion (Cushing Disease), Pseudomonas aeruginosa Infections, Refractory Acute Myeloid Leukemia, Refractory Chronic Lymphocytic Leukemia (CLL), Relapsed Acute Myeloid Leukemia, Relapsed Chronic Lymphocytic Leukemia (CLL), Rheumatoid Arthritis, Small-Cell Lung Cancer, T-Cell Lymphomas, Thymic Carcinoma, Thyroid Cancer, Unspecified B-Cell Lymphomas and Uterine Cancer.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
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