Sepsis- Pipeline Insight, 2022

Sepsis- Pipeline Insight, 2022

DelveInsight’s, “Sepsis- Pipeline Insight, 2022” report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Sepsis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

Global coverage

Sepsis: Understanding

Sepsis: Overview

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Sepsis is sometimes called septicemia or blood poisoning. If not recognized early, it can lead to septic shock, multiple organ failure and death. It is most frequently a serious complication of infection, particularly in low- and middle-income countries where it represents a major cause of maternal and neonatal morbidity and mortality. Sepsis develops when the immune system releases the chemicals in the bloodstream to fight an infection cause inflammation throughout the entire body instead. Sepsis cannot spread to other people. Sepsis can be a result of an infection, and some infections can be spread to others. Most sepsis is caused by bacterial infections. It can also be a result of other infections, including viral infections, such as COVID-19 or influenza. An infection of the bone, called osteomyelitis, could lead to sepsis. In people who are hospitalized, bacteria may enter through IV lines, surgical wounds, urinary catheters, and bed sores. Sepsis is more common in people with chronic medical conditions, such as diabetes, lung disease, cancer, and kidney disease, people with weakened immune systems, babies under 1 year of age, elderly people especially if they have other health problems. Most of the time, using a thermometer, it is pretty simple to determine heart rate (counting pulses per minute), fever, or hypothermia, as well as to count breaths per minute even at home. Although it may be more challenging to identify the source of the infection, sepsis is generally simple to detect in people who have symptoms of infection including a productive cough, dysuria, fevers, or a wound filled with pus. Septic shock is the most severe complication of sepsis and carries high mortality. Symptoms of septic shock are similar to those of severe sepsis, but it also include a significant drop in blood pressure. This drop in blood pressure can lead to heart failure, stroke, and failure of other organs, respiratory failure, and even death. In addition to the three stages of sepsis, several phases are exist within the first stage of sepsis. The late phase of sepsis is dominated by immune suppression, leading to the hypothesis that the immune system changes from hyper-inflammatory to hypo-inflammatory phases during sepsis.

""Sepsis- Pipeline Insight, 2022"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Sepsis pipeline landscape is provided which includes the disease overview and Sepsis treatment guidelines. The assessment part of the report embraces, in depth Sepsis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Sepsis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Sepsis R&D. The therapies under development are focused on novel approaches to treat/improve Sepsis.

Sepsis Emerging Drugs Chapters

This segment of the Sepsis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Sepsis Emerging Drugs

Thymosin alpha 1: SciClone Pharmaceuticals

Thymosin alpha 1, generically referred to as thymalfasin, is a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement. SciClone developed and launched Thymosin alpha 1, under the trade name Zadaxin, for the treatment of hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infections. The drug is also being developed for the treatment of COVID 2019 infections. Published scientific and clinical studies have shown that Thymosin alpha 1 helps to stimulate and direct the body’s immune response to eradicate infectious diseases, such as HBV, HCV, bacterial, and fungal infections; to fight certain cancers such as melanoma and liver cancer; and to enhance response to vaccines. Clinical trials have shown that Thymosin alpha 1 improves survival in patients in intensive care units being treated for sepsis from severe bacterial infections. The therapy is being evaluated in Phase III stage to treat Sepsis.

Alirocumab: Regeneron/Sanofi

Alirocumab injection is in a class of medications called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibodies. It works by blocking the production of LDL cholesterol in the body therefore decreasing the amount of cholesterol that may build up on the walls of the arteries.

Recombinant human plasma gelsolin: BioAegis Therapeutics

Rhu-plasma gelsolin is a host-directed immunotherapy treatment. It is expected to be effective against pneumonia caused by many different types of bacteria (bacterial pneumonia) and influenza (viral pneumonia), the severe inflammation resulting from covid 19 pneumonia, and sepsis which is often caused by pneumonia. Rhu-pGSN is a broad-acting threat-agnostic product that improves immune cell function at sites of injury by enhancing pathogen killing while also resolving inflammation. The product will target severe systemic inflammatory responses due to infection or injury to mitigate poor outcomes. A key step for this product is to initiate the next clinical trial and to scale up manufacturing to provide additional clinical supplies for these studies in more severely ill patients at risk for sepsis. This will move the program into Phase IIb to demonstrate proof of impact on clinical outcomes and to optimize cost of goods for clinical supplies and commercialization.

M6229: Matisse Pharmaceuticals

Matisse’s platform technology is based on the discovery that in many patients suffering from sepsis, proteins called histones are released by the innate immune system and dying cells into the blood stream, where they are toxic to other cells. Due to a self-enforcing cascade, people may die from organ failure within one or two days. Preclinical results have shown that by neutralizing the toxic histones with Matisse’s product M6229, the negative cascade is terminated by neutralization of cationic histones by anionic M6229. Matisse claims to have identified an elegant solution for treating one of the major complications in sepsis by using a non-anticoagulant fraction of heparin called M6229 to neutralize toxic circulatory histones.

STC3141: CGE Healthcare

STC3141 is a global innovative small molecule compound with a new mechanism of action independently developed by the CGE Healthcare Group. It can reverse the organ damage caused by the body’s excessive immune response by neutralizing extracellular free histones and neutrophil traps. It can be used for a variety of severe indications. The product has approved to conduct Phase Ib clinical studies for the treatment of sepsis in Australia in May 2020 and in Belgium in April 2022, respectively. STC3141 is now conducting Phase Ib clinical studies for the treatment of sepsis in Australia and Belgium, respectively.

Further product details are provided in the report……..

Sepsis: Therapeutic Assessment

This segment of the report provides insights about the different Sepsis drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Sepsis

There are approx. 40+ key companies which are developing the therapies for Sepsis. The companies which have their Sepsis drug candidates in the most advanced stage, i.e. phase III include, SciClone Pharmaceuticals.

Phases

DelveInsight’s report covers around 40+ products under different phases of clinical development like

Late stage products (Phase III)

Mid-stage products (Phase II)

Early-stage product (Phase I) along with the details of

Pre-clinical and Discovery stage candidates

Discontinued & Inactive candidates

Route of Administration

Sepsis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intra-articular

Intraocular

Intrathecal

Intravenous

Ophthalmic

Oral

Parenteral

Subcutaneous

Topical

Transdermal

Molecule Type

Products have been categorized under various Molecule types such as

Oligonucleotide

Peptide

Small molecule

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Sepsis: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Sepsis therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Sepsis drugs.

Sepsis Report Insights

Sepsis Pipeline Analysis

Therapeutic Assessment

Unmet Needs

Impact of Drugs

Sepsis Report Assessment

Pipeline Product Profiles

Therapeutic Assessment

Pipeline Assessment

Inactive drugs assessment

Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

How many companies are developing Sepsis drugs?

How many Sepsis drugs are developed by each company?

How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Sepsis?

What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Sepsis therapeutics?

What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?

What are the clinical studies going on for Sepsis and their status?

What are the key designations that have been granted to the emerging drugs?

Key Players

SciClone Pharmaceuticals

Grifols

Asahi Kasei Pharma

Regeneron/Sanofi

BioAegis Therapeutics

Pharmazz

ARTCLINE GmbH

Vivacelle Bio

Shionogi

Revimmune SAS

Inotrem

Enlivex Therapeutics

Adrenomed

Tianjin Chasesun Pharmaceutical Co., LTD

Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Matisse Pharmaceuticals

CGE Healthcare

Key Products

Thymosin alpha 1

Albutein

ART-123

Alirocumab

Recombinant human plasma gelsolin

Centhaquine

ARTICE therapy

VBI-S

Cefiderocol

CYT107

Nangibotide

Allocetra-OTS

Adrecizumab

Kukoamine B

SY 005

M6229

STC3141

RECCE 327

ST266

HY-209


Introduction
Executive Summary
Sepsis: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Sepsis– DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Comparative Analysis
Thymosin alpha 1: SciClone Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Comparative Analysis
Recombinant human plasma gelsolin: BioAegis Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Comparative Analysis
STC3141: CGE Healthcare
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Comparative Analysis
FEP-100: Fe Pharmaceuticals
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Sepsis Key Companies
Sepsis Key Products
Sepsis- Unmet Needs
Sepsis- Market Drivers and Barriers
Sepsis- Future Perspectives and Conclusion
Sepsis Analyst Views
Sepsis Key Companies
Appendix

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