Genome Editing: Technologies and Global Markets

Genome Editing: Technologies and Global Markets

The global market for genome editing totaled $206.0 million in 2014 and $395.0 million in 2015. The market should total over $2.0 billion by 2020, growing at a compound annual growth rate (CAGR) of 38.9% from 2015 to 2020.

This report provides:
An overview of the global markets and technologies for genome editing, a promising new approach that can overcome the shortcomings from site-directed mutagenesis and recombination based methods using relatively simple concepts.
Analyses of global market trends, with data from 2014, 2015, and projections of compound annual growth rates (CAGRs) through 2020.
A focus on the market size and segmentation of gene editing products, including gene editing tools, cell lines, animal models and potential clinical products.
Breakdowns of the market by region, industry, application, product and type, technology, and end-user.
A look at the recent technical breakthrough on the use of CRISPR/Cas9 and how it has fueled the rapid growth of the genome editing industry.
A look at other growth driving factors including: the need of precision medicine for accurate genome editing technology; the increased R&D expenditure in related industrial sectors (e.g. biopharma, agriculture, and energy); increased funding for genomics research and its technological advancements; increasing demand for synthetic genes in synthetic biology; Concerns that genetically modified crops can be reduced by applying gene editing technologies to non-trangenic plant breeding.
Exploration of emerging ethical issues.
A relevant patent analysis.
Profiles of key players in the industry.


SCOPE OF REPORT

This study is focused on the market side of genome editing, along with a comprehensive review of genome editing technologies with related latest progresses in the field. Different market segments for this specific market are covered. For example, application-based market segments include academic research, drug development, clinical therapy, non-transgenic breeding and other applications; and regional market segments include the U.S., Europe, Asia-Pacific and Rest of World.

Specifically, centered on the market itself and its environment, this report covers almost all aspects of the global genome editing industry, including its technologies, applications and markets, which are further segmented and analyzed by region, product type, application and technology. The report forecasts the sizes and trends of the global market as well as its each segment. It details recent technical breakthroughs as well as major technical issues to overcome before the genome editing is applied to clinic applications. The growth driving factors and the factors that may limit the market’s growth are identified. The ethical issues, regulatory issues and intellectual property right issues are discussed. The trends of patent publications, research publications and research funding in the genome editing area are analyzed. A competitive landscape, including various growth strategies and opportunities, are discussed. Comprehensive company profiles of the major players in the current genome editing field are also included in this report. In addition, the contract services market and clinical applications market are also discussed.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THIS STUDY
INTENDED AUDIENCE
SCOPE OF REPORT
METHODOLOGY
INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 MARKET SUMMARY
KEY DRIVERS FOR MARKET GROWTH
SUMMARY TABLE GLOBAL GENOME EDITING MARKET BY REGION, THROUGH 2020 ($ MILLIONS)
SUMMARY FIGURE GLOBAL GENOME EDITING MARKET BY REGION, 2014-2020 ($ MILLIONS)
CHAPTER 3 CURRENT GENOME EDITING TECHNOLOGIES
OVERVIEW
HISTORY OF GENOME EDITING
COMPARISON OF GENOME EDITORS
DISCOVERY OF CRISPR/CAS9
COMPONENTS OF CRISPR/CAS SYSTEMS
SGRNA
CAS9 NUCLEASES
HOW CRISPR/CAS WORKS
ADVANTAGES OF THE CRISPR/CAS9 SYSTEM
POPULARITY OF CRISPR GENOME EDITING
MAJOR TECHNOLOGICAL ISSUES
EFFICIENCY
SPECIFICITY/OFF-TARGET EFFECT
DELIVERY SYSTEMS
Viral Delivery Systems
Non-Viral Delivery Systems
Physical Delivery Systems
A NEW GENOME EDITING SYSTEM: CRISPR-CPF1
STUDIES ON TREATING DISEASES USING GENOME EDITING
IMPACTS OF GENOME EDITING
FUTURE OF CRISPR
CHAPTER 4 APPLICATIONS OF GENOME EDITING
INTRODUCTION
ACADEMIC RESEARCH
DRUG DISCOVERY AND DEVELOPMENT
CLINICAL THERAPY
NON-TRANSGENIC BREEDING
OTHER APPLICATIONS
CHAPTER 5 MARKET SEGMENTATION AND FORECAST
MARKET OVERVIEW
MAJOR PLAYERS
TABLE 1 MAJOR COMPANIES THAT HAVE BUSINESS RELATED TO GENOME EDITING
TABLE 2 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED BUSINESSES BY REGION, AS OF JANUARY 2016
FIGURE 1 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED BUSINESSES BY REGION, AS OF JANUARY 2016 (%)
TABLE 3 DISTRIBUTION OF COMPANIES THAT HAVE GENOME EDITING RELATED BUSINESSES BY STATE IN THE U.S., AS OF JANUARY 2016 (NUMBER/%)
MARKET SEGMENTS BY REGION
TABLE 4 GLOBAL MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 2 GLOBAL MARKET FOR GENOME EDITING BY REGION, 2014-2020 ($ MILLIONS)
FIGURE 3 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2014 (%)
FIGURE 4 GLOBAL GENOME EDITING MARKET SHARE BY REGION, 2020 (%)
MARKET SEGMENTS BY APPLICATION
TABLE 5 GLOBAL MARKETS FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($ MILLIONS)
FIGURE 5 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%)
FIGURE 6 GLOBAL MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%)
TABLE 6 U.S. MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($ MILLIONS)
FIGURE 7 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%)
FIGURE 8 U.S. MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%)
TABLE 7 EUROPEAN MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($ MILLIONS)
FIGURE 9 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%)
FIGURE 10 EUROPEAN MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%)
TABLE 8 ASIA-PACIFIC MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($ MILLIONS)
FIGURE 11 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2014 (%)
FIGURE 12 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY APPLICATION, 2020 (%)
TABLE 9 REST OF WORLD MARKET FOR GENOME EDITING BY APPLICATION, THROUGH 2020 ($ MILLIONS)
MARKET SEGMENTS BY TECHNOLOGY
TABLE 10 GLOBAL MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($ MILLIONS)
FIGURE 13 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%)
FIGURE 14 GLOBAL MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%)
TABLE 11 U.S. MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($ MILLIONS)
FIGURE 15 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%)
FIGURE 16 U.S. MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%)
TABLE 12 EUROPEAN MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($ MILLIONS)
FIGURE 17 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%)
FIGURE 18 EUROPEAN MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%)
TABLE 13 ASIA-PACIFIC MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($ MILLIONS)
FIGURE 19 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2014 (%)
FIGURE 20 ASIA-PACIFIC MARKET SHARES FOR GENOME EDITING BY TECHNOLOGY, 2020 (%)
TABLE 14 REST OF WORLD MARKET FOR GENOME EDITING BY TECHNOLOGY, THROUGH 2020 ($ MILLIONS)
MARKET SEGMENTS BY PRODUCT TYPE
TABLE 15 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
FIGURE 21 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE, 2014 (%)
FIGURE 22 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT TYPE, 2020 (%)
TABLE 16 U.S. MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
TABLE 17 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
TABLE 18 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
TABLE 19 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT TYPE, THROUGH 2020 ($ MILLIONS)
CHAPTER 6 CONTRACT SERVICES MARKET ANALYSIS
MARKET OVERVIEW
MAJOR PLAYERS
TABLE 20 MAJOR COMPANIES THAT PROVIDE GENOME EDITING RELATED SERVICES, AS OF JANUARY 31, 2016
MARKET SHARE AND PROJECTION
TABLE 21 GLOBAL MARKET FOR GENOME EDITING SERVICES BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 23 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION, 2014 (%)
FIGURE 24 GLOBAL MARKET SHARES FOR GENOME EDITING SERVICES BY REGION, 2020 (%)
COMPARISON WITH PRODUCT SEGMENT
TABLE 22 GLOBAL MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE, THROUGH 2020 ($ MILLIONS)
FIGURE 25 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND SERVICE, 2014 (%)
FIGURE 26 GLOBAL MARKET SHARES FOR GENOME EDITING BY PRODUCT AND SERVICE, 2020 (%)
TABLE 23 U.S. MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE, THROUGH 2020 ($ MILLIONS)
TABLE 24 EUROPEAN MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE, THROUGH 2020 ($ MILLIONS)
TABLE 25 ASIA-PACIFIC MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE, THROUGH 2020 ($ MILLIONS)
TABLE 26 REST OF WORLD MARKET FOR GENOME EDITING BY PRODUCT AND SERVICE, THROUGH 2020 ($ MILLIONS)
CHAPTER 7 RESEARCH MARKET ANALYSIS
MARKET OVERVIEW
MARKER SHARE AND PROJECTIONS
TABLE 27 GLOBAL ACADEMIC RESEARCH MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 27 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING BY REGION, 2014 (%)
FIGURE 28 GLOBAL ACADEMIC RESEARCH MARKET SHARES FOR GENOME EDITING BY REGION, 2020 (%)
PATENT ANALYSIS
TABLE 28 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY COUNTRY (NUMBER/%)
TABLE 29 DISTRIBUTION OF U.S. GENOME EDITING PATENTS AND PATENT APPLICATIONS AT WIPO BY STATE (NUMBER/%)
TABLE 30 DISTRIBUTION OF GENOME EDITING PATENTS AND PATENT APPLICATIONS AT WIPO BY PATENT OFFICE (NUMBER/%)
TABLE 31 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY YEAR, 2007-2015
TABLE 32 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT WIPO BY YEAR, 2007-2015
TABLE 33 GENOME EDITING PATENTS AND PATENT APPLICATIONS AT USPTO BY TECHNOLOGY, 2007-2015 (NUMBER/%)
FIGURE 29 GENOME EDITING PATENTS AND PATENT APPLICATIONS BY TECHNOLOGY, 2007-2015 (%)
PUBLICATION ANALYSIS
FIGURE 30 NUMBER OF CRISPR PUBLICATIONS BY YEAR, 2005-2015
FIGURE 31 NUMBER OF ZFNS PUBLICATIONS BY YEAR, 2005-2015
FIGURE 32 NUMBER OF TALENS PUBLICATIONS BY YEAR, 2011-2015
RESEARCH FUNDING ANALYSIS
TABLE 34 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($ MILLIONS)
FIGURE 33 NIH FUNDING FOR GENE/GENOME EDITING BY YEAR, 2007-2015 ($MILLIONS)
TABLE 35 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF GRANTS)
FIGURE 34 NIH-FUNDED RESEARCH GRANTS BY YEAR, 2007-2015 (NUMBER OF GRANTS)
CHAPTER 8 DRUG DEVELOPMENT MARKET ANALYSIS
MARKET OVERVIEW
MARKET SHARE AND FORECAST
TABLE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 35 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY REGION, 2014 (%)
FIGURE 36 GLOBAL DRUG DEVELOPMENT MARKET FOR GENOME EDITING BY REGION, 2020 (%)
CHAPTER 9 AGRICULTURAL BIOTECHNOLOGY MARKET ANALYSIS
MARKET OVERVIEW
MARKET SHARE AND FORECAST
TABLE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 37 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION, 2014 (%)
FIGURE 38 GLOBAL PLANT BREEDING MARKET FOR GENOME EDITING BY REGION, 2020 (%)
CHAPTER 10 CLINICAL MARKET ANALYSIS
MARKET OVERVIEW
MARKET SHARE AND FORECAST
FIGURE 39 GLOBAL CLINIC GENOME EDITING MARKET BY REGION, 2020 (%)
COMPARISON WITH NON-CLINICAL MARKET
TABLE 38 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS)
FIGURE 40 GLOBAL MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, 2020 (%)
TABLE 39 U.S. MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS)
TABLE 40 EUROPEAN MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS)
TABLE 41 ASIA-PACIFIC MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS)
TABLE 42 REST OF WORLD MARKET FOR GENOME EDITING BY CLINICAL PRODUCT AND NON-CLINICAL PRODUCT, THROUGH 2020 ($ MILLIONS)
CHAPTER 11 COMPETITION LANDSCAPE AND OPPORTUNITIES
OVERVIEW
GROWTH STRATEGIES
LICENSING AND AGREEMENTS
COLLABORATIONS WITH BIG BIOPHARMACEUTICAL COMPANIES
IN-HOUSE R&D PROGRAM
STARTUP
STRATEGIC ALLIANCE AND JOINT VENTURE
FOCUS ON SPECIFIC APPLICATION AREAS
VENTURE CAPITAL FUNDING
OPPORTUNITIES
CHAPTER 12 FACTORS INFLUENCING THE GENOME EDITING MARKET
INTRODUCTION
DRIVING FORCES
NEW GENOME EDITING TECHNOLOGIES AND RELATED ADVANCEMENTS
NEW APPLICATIONS OF GENOME EDITING
NEED OF PRECISION MEDICINE
NEED OF IMPROVING DRUG DISCOVERY PROCESS
INCREASING DEMAND FOR SYNTHETIC GENES IN SYNTHETIC BIOLOGY
INVESTMENTS FROM BOTH PUBLIC AND PRIVATE SECTORS
INCREASED R&D EXPENDITURES IN RELATED INDUSTRIAL SECTORS
HIGH PREVALENCE OF GENETIC BIRTH DISORDERS
CONCERNS ON GENETICALLY MODIFIED CROPS
FACTORS LIMITING THE MARKET'S GROWTH
STRINGENT REGULATORY FRAMEWORKS AND TIME-CONSUMING
APPROVAL PROCESSES
RESEARCH FUNDING
PATENT DISPUTE
GOVERNMENTAL POLICIES AND REGULATIONS
REGULATORY UNCERTAINTY ON GENOME EDITED CROPS
ETHICAL ISSUE
CHAPTER 13 COMPANY PROFILES
ADDGENE
AGILENT TECHNOLOGIES INC.
APPLIED STEMCELL INC.
ASTRA ZENECA
CALYXT
CARIBOU BIOSCIENCES
CELLECTA INC.
CELLECTIS S.A.
CIBUS
CLONTECH LABORATORIES
CRISPR THERAPEUTICS
DESKTOP GENETICS
DNA2.0
EDITAS MEDICINE
GE HEALTHCARE DHARMACON
GENECOPOEIA
GENSCRIPT
HORIZON DISCOVERY
INNOVATIVE GENOMICS INITIATIVE
INTELLIA THERAPEUTICS INC.
INTEGRATED DNA TECHNOLOGIES
IXCELLS BIOTECHNOLOGIES
JUNO THERAPEUTICS
LONZA
NEW ENGLAND BIOLABS
NOVA SYNTHETIX
ORIGENE TECHNOLOGIES
PRECISION BIOSCIENCES INC.
RECOMBINETICS
REGENERON PHARMACEUTALS INC.
SANGAMO BIOSCIENCES
SIGMA-ALDRICH CORP.
SYSTEM BIOSCIENCES
THERMO FISHER SCIENTIFIC
TOOLGEN INC.
TRANS GENIC INC.
TRANSOMIC TECHNOLOGIES INC.
TRANSPOSAGEN BIOPHARMACEUTICALS INC.

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