Phospholipids and Sphingolipids of Milk - Competitor and Patent Landscape Report - Key players, innovators and industry analysis

Published by: Dolcera Corporation

Published: Nov. 17, 2011 - 57 Pages


Table of Contents

1. Executive Summary
2. Introduction
2.1. Phospholipids and sphingolipids
2.2. Nutritional aspects/ biological effects
3. Search strategy
4. Sample patent analysis
5. Taxonomy
6. Top citations
6.1. Patent ranking
6.2. Top cited patents
6.3. Key patents
7. Patent to product mapping
8. Key findings
8.1. Major players
8.2. IP activity
8.2.1. IP activity based on publication year
8.2.2. IP activity based on priority year
8.3. Geographical activity
8.3.1. Based on basic patents
8.3.2. Based on basic patents and family members
9. Conclusion
9.1. Scientific information
10. References
11. Appendix A: Control patents
12. Appendix B: Relevant class code definition
12.1. IPC / ECLA class codes
12.2. US class codes
12.3. Japanese F-terms
13. Appendix C: Concept table
13.1. Concept 1: phospholipids and sphingolipids
13.2. Concept 2: milk and milk fat globule membrane
14. Appendix D: Search strategy
14.1. Thomson Innovation search
14.2. Final search query
List of tables
Table 1: Nutritional aspects of phospholipids and sphingolipids
Table 2: Patent ranking
Table 3: Top cited patents
Table 4: Patent to product mapping
Table 5: Control patents
Table 6: IPC/ECLA for milk
Table 7: IPC/ECLA for phospholipids and sphingolipids
Table 8: US class codes for milk
Table 9: US class codes for phospholipids and sphingolipids
Table 10: Japanese F-terms for phospholipids and sphingolipids
Table 11: Japanese F-terms for milk
Table 12: Phospholipid keywords
Table 13: Sphingolipid keywords
Table 14: Milk keywords
Table 15: Milk fat globule membrane keywords
List of Figures
Figure 1: Major players in the technological field
Figure 2: Top cited patents with their assignees
Figure 3: Structure of milk fat globule membrane
Figure 4: Taxonomy based on detailed analysis of patents
Figure 5: Top cited patents with respective assignees
Figure 6: Major players in the technological area
Figure 7: Top assignees in field of product formulations (other than infant feed formulas)
Figure 8: Top assignees in field of extraction
Figure 9: Top assignees in field of infant feed formulations
Figure 10: IP activity based on publication year
Figure 11: IP activity based on priority year
Figure 12: Geographical distribution of patents (one member per family)
Figure 13: Geographical distribution of patent family members

Abstract

Phospholipids and sphingolipids of milk form an integral part of Milk Fat Globule Membrane (MFGM). MFGM is a protein-lipid biopolymer that originates from the apical surface of mammary epithelial cells and surrounds fat globules in milk. The phospholipids and membrane glycoproteins found in MFGM likely interact extensively with the gut epithelia during digestion, both physically and biochemically.

Moreover, MFGM has a relatively high concentration of sphingolipids, which in purified form have been demonstrated to be protective against colon cancer.

Phospholipids represent a major portion of total lipids of buttermilk and skim milk, reflecting presence of proportionately larger amounts of membrane materials in these products.

The phospholipids and sphingolipids in milk are gaining interest due to their nutritional and technological qualities. Sphingolipids and their derivatives are highly bioactive compounds with anti-cancer, bacteriostatic and cholesterol-lowering properties.

Moreover sphingolipids and their metabolites help reduction of the number of aberrant crypt foci (clusters of abnormal tube-like glands in the lining of the colon and rectum), shift in tumor type (malignant ? benign), protect the liver from fat- and cholesterol-induced steatosis (abnormal retention of lipids within a cell), suppress gastrointestinal pathogens, myelination of the developing central nervous system, age-related diseases.

Phosphatidylserine (PS) is observed to have positive effects on Alzheimer’s patients and also helps restore normal memory on a variety of tasks.

Phosphatidylcholine (PC) supports liver recovery from toxic chemical attack or viral damage and protects the human GI mucosa against toxic attack.

Lyso-Phosphatidylcholine (lyso-PC) exhibits bacteriostatic and bactericidal capacity.

Dolcera report focuses on finding the key innovators and the industry ecosystem through relevant patents, clinical trials and university data encompassing the extraction, modification of phospholipids and sphingolipids from milk and their application in variety of products. The relevant keywords used in the search were obtained after an extensive study of relevant scientific articles and patents. The relevant class codes for the search were obtained from the control patents and keyword based searches coupled with manual search of classification index. Dolcera has retrieved around 300 relevant patents related to phospholipids and sphingolipids, covering over 42 worldwide patenting authorities. The report highlights year-wise patent activity (trend line) along with the key industrial players in the field. Patents were categorized on the basis of patent focus- whether extraction or purification, process for improving functionality of phospholipids and sphingolipids, application in food, pharma and cosmetic formulations. The categorized patents were further analyzed to determine the key players under each category. A comprehensible result in the form of Dolcera dashboard has been given. Dashboard links the Companies in each category to their patents, hence making an interactive platform for analysis. Furthermore, patents have been mapped to commercially available products produced by the respective assignees and other licensees.

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