Antibodies for Therapeutic and Diagnostic Imaging Applications, Including Monoclonals and Polyclonal

Published by: BCC Research

Published: Feb. 1, 2000 - 196 Pages

Table of Contents

• Introduction
  
  
  • Objectives And Goals Of Study
    
  • Contribution Of The Study And For Whom
    
  • Study Scope And Format
    
  • Methodology
    
  • Information Sources
    
  • Related BCC Work Credentials, Including Work Done By Other Authors
  
  
• Summary
  
• Overview
  
  
  • Definitions
    
  • The Importance Of Antibody Drugs And Diagnostics
    
  • Major Technical Issues
    
    
    • The HAMA Problem And Its Resolution
      
    • Phage Display And Polysome Display
      
    • Building A Better Mouse
      
    • . . . And Goat
      
    • Using Monoclonal Antibodies As Carriers For Cytotoxic Drugs
    
    
  • New Directions In Antibody Research
    
  • Valuation Of Antibody Product Sales
    
  • Major Business Issues
    
  • Why Do Monoclonal Antibody Products Have So Many Applications And Polyclonal Antibody Products Do Not?
  
  
• Technology
  
  
  • Antibody Classes
    
  • Antibody Forms In Products
    
    
    • Antiserums
      
    • Single-Chain Antibodies
      
    • Abtides
      
    • Chimeric Antibodies
      
    • Humanized Antibodies
      
    • Bispecific Antibodies
      
      
      • The Special Case Of Enbrel
      
      
    • Gene Therapy
  
  
• Products
  
  
  • The Market For Polyclonal And Monoclonal Antibody Drugs
    
  • Therapeutic Polyclonal Antibody Products
    
    
    • Atgam
      
    • Candistat-G
      
    • Civacir
      
    • Crotalidae Polyvalent Antivenin
      
    • Cytogam
      
    • Cytotab
      
    • Diffgam
      
    • Diffstat-G
      
    • Digoxin Immune Fab
      
    • Diphtheria Antitoxin
      
    • Gamma Globulin
      
    • Hepatitis B Immune Globulin
      
    • Lactrodectus Mactans Antivenin
      
    • Micrurus Fulvius Antivenin
      
    • Nabi-Altastaph
      
    • Pylorimune-G
      
    • Rabies Immune Globulin
      
    • Respigam
      
    • Respiratory Syncytial Virus Antiplasma
      
    • RHO(D) Immune Globulin
      
    • Sporidin-G
      
    • Tetanus Immune Globulin
      
    • Thymoglobulin
      
    • Varicella-Zoster Immune Globulin
    
    
  • Therapeutic Monoclonal Antibody Products
    
    
    • The Market For Therapeutic Monoclonal Antibodies
      
    • 2B1
      
    • 2.00E+01
      
    • 31.1
      
    • 323A3
      
    • 3622W94
      
    • 4162W94
      
    • 5G1.1
      
    • 5G1.1-Sc
      
    • A717
      
    • ABX-CBL
      
    • ABX-EGF
      
    • ABX-IL-8
      
    • Adeno-Associated F(AG'G)2
      
    • AJVW2
      
    • AK30 NGF
      
    • AL 901
      
    • Antegren
      
    • Anti-B4-Dc1
      
    • Anti-B7
      
    • Anti-CD2 MAB B-E2
      
    • Anti-CD3
      
    • Anti-CD4 MAB RIB 5-2
      
    • Anti-CD4 Receptor
      
    • Anti-CD5
      
    • Anti-CD11a
      
    • Anti-CD11b
      
    • Anti-CD15 PM81
      
    • Anti-CD18
      
    • Anti-CD19
      
    • Anti-CD23
      
    • Anti-CD33
      
    • Anti-CEA
      
    • Anti-CGH
      
    • Anti-EGFR
      
    • Anti-GP39
      
    • Anti-ICAM-1
      
    • Anti-ICAM-3 ICM3
      
    • Anti-IGE
      
    • Anti-Interleukin-2-Receptor
      
    • Anti-Interleukin-4
      
    • Anti-Interleukin-5
      
    • Anti-Interleukin-6
      
    • Anti-Interleukin-9
      
    • Anti-Interleukin-12
      
    • Anti-LFA-1
      
    • Anti-L-Selectin
      
    • Anti-MIF
      
    • Anti-MRSA/VRSA
      
    • Anti-TNF-Alpha
      
    • Anti-TGF-Beta-2
      
    • Anti-Tissue Factor/Factor VIIa
      
    • Anti-Vcam MAB 2A2
      
    • Anti-VEGF
      
    • Anti-VRE
      
    • Antova
      
    • ATM 027
      
    • B4
      
    • Bexxar
      
    • Brevarex
      
    • BTI-322
      
    • C225
      
    • Campath
      
    • CD40
      
    • CDP 571
      
    • CDP 850
      
    • CDP 860
      
    • CDP 870
      
    • Cea-Cide
      
    • Ceavac
      
    • Centara
      
    • CHH 380
      
    • Clenoliximab
      
    • CMA 676
      
    • CMB 401
      
    • Corsevin M
      
    • Cotara
      
    • Cytolin
      
    • Enlimomab
      
    • Eric-1
      
    • Felvizumab
      
    • G250
      
    • Gliomab-H
      
    • HCTM01
      
    • Herceptin
      
    • HNK20
      
    • HU1124
      
    • HUC242-DMI
      
    • I-125 MAB A33
      
    • IDEC-114
      
    • IDEC-131
      
    • IDEC-151/Sb217969
      
    • IDEC-CE9.1/Sb210396
      
    • Keliximab
      
    • LDP-01
      
    • LDP-02
      
    • Leukarrest
      
    • Leukotac
      
    • LFA 3 TIP
      
    • LMB-7
      
    • Lymphocide
      
    • MA 16N7C2
      
    • Mabthera
      
    • MAK 195F
      
    • MDX-11
      
    • MDX-22
      
    • MDX-33
      
    • MDX-210
      
    • MDX-220
      
    • MDX-240
      
    • MDX-447
      
    • MDX-Cd4
      
    • MDX-Ra
      
    • Medi-500
      
    • Medi-507
      
    • Melimmune
      
    • Melvax
      
    • Monoclonal Antibody Conjugate
      
    • Monopharm C
      
    • MRA
      
    • MRK-16
      
    • Napsagatran
      
    • NM-01
      
    • Novavac-M1
      
    • OKI-1
      
    • Oncolym
      
    • Oncolysin CD6
      
    • Oncolysin S
      
    • Oncopurge
      
    • Orthoclone OKTt3
      
    • Orthoclone OKT4
      
    • Ovarex
      
    • OX52
      
    • Panorex
      
    • Pro 140
      
    • Pro 542
      
    • Protovir
      
    • Regavirumab
      
    • Remicade
      
    • Reopro
      
    • Rhumab-E25
      
    • Rituxan
      
    • SB249417
      
    • SCH 55700
      
    • Simulect
      
    • Smart 1D10
      
    • Smart Anti-CD3 Antibody
      
    • Smart Anti-EP-Selectin
      
    • Smart Anti-Platelet Antibody
      
    • Smart M195/Bismuth 213 Antibody
      
    • Solfib
      
    • Synagis
      
    • TA-650
      
    • Theragyn
      
    • TM 27
      
    • TM 31
      
    • TNT-1
      
    • Triab
      
    • Trigem
      
    • TTMA
      
    • VEGF Receptor 2 MAB
      
    • Vitaxin
      
    • Y1
      
    • Y2B8/In2B8
      
    • ZCR 2060
      
    • ZD 0490
      
    • Zenapax
    
    
  • In Vivo Diagnostic Antibody Products
    
    
    • AFP-Scan
      
    • CEA-Scan
      
    • Diacim
      
    • EBAF Assay
      
    • Leukoscan
      
    • Lymphoscan
      
    • MH-1
      
    • Monopharm C
      
    • Myeloscan
      
    • Oncoscint CR/OV
      
    • PCP-Scan
      
    • Prostascint
      
    • Rigscan
      
    • Solfib
      
    • Tru-Scint AD
      
    • Tru-Scint AG
      
    • Tru-Scint OV
  
  
• Therapeutic And Diagnostic Applications
  
  
  • Leading Therapeutic Indications Of Approved And Pending Antibody Products
    
  • Allergic Rhinitis And Asthma
    
    
    • Antibodies In Development For The Treatment Of Allergic Rhinitis And Asthma
    
    
  • Cancer
    
    
    • Breast Cancer
      
    • Colorectal Cancer
      
    • Liver Cancer
      
    • NonHodgkin's Lymphoma
      
    • Prostate Cancer
      
      
      • Antibodies In Development For The Treatment Of Cancer
    
    
  • Cardiovascular Diseases
    
    
    • Percutaneous Transluminal Coronary Angioplasty
      
    • Atherectomy
      
      
      • Reopro
        
      • Antibodies In Development For The Treatment Of Cardiovascular Diseases
    
    
  • Infectious Diseases
    
    
    • Cytomegalovirus Disease
      
    • Respiratory Syncytial Virus Infection
      
      
      • Antibodies In Development For The Treatment Of Infectious Diseases
    
    
  • Organ Transplant Rejection
    
    
    • Organ Transplant Market Size
      
    • Antibodies In Development For Organ Transplant Rejection
      
    • Bone Marrow Transplant/Graft-Versus-Host Disease
      
      
      • Antibodies In Development For The Treatment Of Graft-Versus-Host Disease
    
    
  • Rheumatoid Arthritis
    
    
    • Antibodies In Development For The Treatment Of Rheumatoid Arthritis
    
    
  • Other Therapeutic Applications
    
    
    • Crohn's Disease
      
    • RH Isoimmunity
      
    • Psoriasis
      
      
      • Antibodies In Development For The Treatment Of Psoriasis
    
    
  • Diagnostic Applications
    
    
    • Selected In Vivo Diagnostic Antibody Products In Development For Specific Indications
  
  
• Industry Structure
  
  
  • Originators
    
  • Commercial Developers
    
  • Vendors
    
  • Manufacturers
    
  • Technology Innovators
    
  • Market Share Of Monoclonal Antibody Product Manufacturers
    
  • Monoclonal Antibody Products Herald The Beginning Of The Genomics Age
    
  • Good Years Ahead For Pharmaceuticals And Pharmacy
    
  • Biotechnology Delivers The Goods
  
  
• Company Profiles
  
  
  • Abgenix, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Product Candidates
    
    
  • Alexion Pharmaceuticals, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Product Candidates
    
    
  • Altarex Corp.
    
    
    • Business Overview
      
    • Leading Product Candidates
    
    
  • Cangene
    
    
    • Corporate Strategy
      
    • Leading Products
    
    
  • Centocor Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • Coulter Pharmaceutical
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Product Candidates
    
    
  • Genentech, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • IDEC Pharmaceuticals Corp.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • Immunomedics, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • Medarex, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Product Candidates
    
    
  • Medimmune, Inc.
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • NABI
    
    
    • Business Overview
      
    • Financial Information
      
    • Corporate Strategy
      
    • Leading Products
    
    
  • Protein Design Labs
    
    
    • Business Overview
      
    • Financial Information
      
    • Leading Products
  
  
• Appendix: Company Names And Addresses
  
• List Of Tables
  
  
  • Summary Table: Worldwide Sales Of Therapeutic And Diagnostic Imaging Antibodies
    
  • 1 - Worldwide Sales Of Polyclonal And Monoclonal Antibodies As Drugs: 1999-2004
    
  • 2 - Selected Polyclonal Antibodies: Worldwide Sales, 1999-2004
    
  • 3 - Selected Therapeutic Monoclonal Antibodies: Worldwide Sales, 1999-2004
    
  • 4 - Selected Diagnostic Imaging Antibodies: Worldwide Sales, 1998, 1999, And 2004
    
  • 5 - Therapeutic Applications Of Selected Antibodies: Worldwide Sales, 1998, 1999, And 2004
    
  • 6 - Therapeutic Antibody Products In Development For The Treatment Of Allergic Rhinitis And/Or Asthma
    
  • 7 - Therapeutic Antibody Products In Development For The Treatment Of Specific Cancers
    
  • 8 - Therapeutic Antibody Products In Development For The Treatment Of Multiple Types Of Cancer
    
  • 9 - Therapeutic Antibody Products In Development For The Treatment Of Cardiovascular Diseases
    
  • 10 - Therapeutic Antibody Products In Development For The Treatment Of Infectious Diseases
    
  • 11 - Number Of Organ Transplants Worldwide: 1998-2004
    
  • 12 - Organ Transplant Rejection Episodes: U.S. And Europe, 1998-2004
    
  • 13 - Therapeutic Antibody Products In Development For The Prevention Of Organ Transplant Rejection
    
  • 14 - Graft-Versus-Host Disease: Worldwide Incidence, 1998-2004
    
  • 15 - Therapeutic Antibody Products In Development For The Prevention Of Graft-Versus-Host Disease
    
  • 16 - Therapeutic Antibody Products In Development For The Treatment Of Rheumatoid Arthritis
    
  • 17 - Therapeutic Antibody Products In Development For The Treatment Of Psoriasis
    
  • 18 - Selected In Vivo Diagnostic Antibody Products In Development For Specific Indications
    
  • 19 - Large Pharmaceutical Firms' Investment In Biotech
    
  • 20 - Abgenix's Product Pipeline
    
  • 21 - Alexion's Product Pipeline
    
  • 22 - Centocor's Product Pipeline
    
  • 23 - Idec's Collaborative Arrangements
    
  • 24 - Idec's Product Pipeline
    
  • 25 - Immunomedics' Product Pipeline
    
  • 26 - Medarex's Product Pipeline
    
  • 27 - Medimmune's Product Pipeline
    
  • 28 - NABI's Pharmaceutical Product Pipeline
  
  
• List Of Figures
  
  
  • Summary Figure: Worldwide Sales Of Therapeutic And Diagnostic Imaging Antibodies
    
  • 1 - Worldwide Sales Of Polyclonal And Monoclonal Antibodies As Drugs: 1999-2004
    
  • 2 - Selected Diagnostic Imaging Antibodies: Worldwide Sales, 1998, 1999 And 2004
    
  • 3 - Therapeutic Applications Of Selected Antibodies: Wowldwide Sales, 1999
    
  • 4 - Market Shares Of Therapeutic Antibodies By Manufacturers, 1998 And 2004
    
  
  

  Abstract

  The market for monoclonal and polyclonal antibodies is just beginning a tremendous growth periods. This report analyzes the worldwide market for monoclonal and polyclonal antibody products utilized in human therapeutic applications and diagnostic imaging. Currently available products as well as those in development are discussed. The report provides market analysis and forecast for 1997 through 2004. Exciting new areas of technology, including production of human antibodies in transgenic animals and development of bispecific antibodies are described. Profiles are provided of leading companies currently active in the marketing of therapeutic and diagnostic antibodies as well as those with products in the pipeline.
  
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