Epigenetics Market Size and Forecast (2021 - 2031), Global and Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Products and Service (Kits and Reagents, Instruments and Accessories, Enzymes, and Services), Application (Oncology,

According to our new research study on “Epigenetics Market Forecast to 2031 -Global Analysis - by Products and Services, Application, Technology, and End User,” the market is anticipated to grow from US$ 11.12 billion in 2024 to US$ 35.84 billion by 2031; the market is expected to register a CAGR of 18.3% from 2025 to 2031. The epigenetics market growth is attributed to the rising global prevalence of cancer, advancements in epigenetic technologies, and the expanding role of personalized medicine. Epigenetics refers to the mechanisms that can be passed down from generation to generation and that regulate gene expression without changing the DNA sequence, usually being affected by factors such as the environment, lifestyle, or the organism's development. The integration of AI and machine learning in epigenetic analysis and advancements in CRISPR-based epigenome editing technologies are expected to be a major epigenetics market trend in the coming years. The epigenetics market in North America is segmented into the US, Canada, and Mexico. The North America epigenetics market is expanding owing to several factors. The US holds the largest market share, followed by Canada. The demand for epigenetics in the region is fueled by the research and therapeutic development, bolstered by extensive academic output and substantial government funding through institutions. The epigenetics market in the US is a strong and front-running sector of the worldwide biotech industry. It is primarily driven by an ambitious and extensive research program, large financial investments, and the introduction of the new and advanced applications in the fields of cancer, nervous system disorders, and personalized medicine among others. A key focus of the US epigenetics market is on the application of epigenetic findings in the development of new drugs. To this end, the US is home to many universities, research programs funded by the government, and private companies that are leading the way in this domain. One such major funder that has been providing support through various initiatives is the National Institutes of Health (NIH). One of the funding initiatives has been the Common Fund Epigenomics Program that kick-started the effort of mapping epigenetic changes at the genome level in a variety of tissues and later expanded the integration of the epigenetic changes across different NIH institutes. The National Cancer Institute (NCI) also helps to advance the field by investing in research that uses epigenomics to diagnose cancer, identify the risk of cancer, and find new treatments, including using DNA methylation biomarkers for primary liver cancer. Some of the statistics illustrate the extent of the field to the following point: PubMed has indexed at least 6,385 scientific papers on epigenetics, all with at least one affiliated author in the US, evidencing intensive work. Regarding money allocated for research, on occasion incentives may be in the range of several millions of dollars; a primary example is a university of Georgia research grant of US$ 1.44 million given by NIH for studies on epigenetics and cancer. Trials are numerous and for-sure, a good number of them, in this case, the epigenetic drugs are involved, as for instance, 110 trials for HDAC inhibitors in solid tumors and 128 in hematologic malignancies, which focus on cancer as the targeted diseases and include the exploration of ethical issues in public communication about epigenetics. Among the innovations, one can mention epigenetic clocks that can unify age-related health outcomes across countries, as in US-led studies that have been published in The Journals of Gerontology and so on. At the same time, America is home to about 57 companies that concentrate on epigenetics, like Chroma Medicine, a startup which sold US$ 125 million worth of shares to fuel its work on rewriting the epigenome for the treatment, and Syros Pharmaceuticals that acquires genomic data to produce better epigenetic drugs. The other three majors EpigenCare which provides personal epigenomics tests via SKINTELLI for DNA methylation analysis, and Fulcrum Therapeutics with the focus on software solutions for drug development, and so on. Places such as the University of Michigan's Epigenomics Core are equipped to offer the services necessary for the research and industrial sectors in the areas of genome-wide and locus-specific analyses. Bibliometric studies also point to the US as a leader with a major contribution of more than 45.9% of the worldwide scientific works in epigenetic fields that have been published by US-based researchers. And the evolution of oncology-related epigenetic therapy research has been steady and upward over the last years. This network nurtures the origin of the ideas, the performing of the experiments and the creation of the sellable diagnostics and treatments, thus making the USA the center of the epigenetic breakthrough during the time of the rise of the non-genetic disease mechanisms theory. Advances in CRISPR-Based Epigenome Editing Technologies Analysis to Provide Market Opportunities in Future The epigenetics market will grow substantially with the help of technologies that use CRISPR to alter the epigenome in a very precise and reversible manner. As a result, without the need to change the DNA sequence, therapeutic applications in cancer, neurodegenerative diseases, and other areas will be possible. Genome editing is made fast and effective through the transient delivery of CRISPR mRNA ribonucleoproteins (RNPs), which also causes minimal immune responses in primary cells, as it is shown in the studies where RNP doses that are going to the target cells achieve up to 90% of alleles edited in vivo. Moreover, the usage of such next-generation tools as CRISPR-dCas9 fused with epigenetic effectors enables the targeted acetylation of histone or demethylation of DNA, thus leading to the reactivation of silenced genes in disease models with an efficiency of 70-80%. Epigenome editing in oncology is one of the ways to defeat the issue of therapy resistance by, for instance, the utilization of base editing strategies that modify both genetic and epigenetic landscapes in up to 60% of resistant tumors while at the same time knocking down EZH2. The most recent development in editing technology - prime editing - works by precisely inserting the gene of interest and thus, for example, the result of muscular dystrophy models can be improved by 40-50%. Besides cancer, CRISPR is capable of modifying epigenetic marks in Alzheimer's Disease and at the same time, achieving the restoration of MECP2 expression in Rett syndrome models, hence, neuronal function normalization occurs in 1 out of 10,000 cases. The upcoming trends feature, among others, the use of mechanosensitive enhancers that can greatly influence cellular responses and thus through CRISPR screening, functional elements can be identified in 80% of the genomes tested. The application of this method goes even further to retina and brain disorders, with the epigenetic editing obtaining correction rates of about 70%. In a nutshell, future improvements of CRISPR will pave the way to the possibility of high-throughput screening and the development of therapies tailored to an individual, thus the whole epigenetics field will be revolutionized for a variety of diseases. The US Food and Drug Administration, World Bank Data, National Health Service (NHS), FDA (Food and Drug Administration), EMA (European Medicines Agency), and WHO (World Health Organization) are among the primary and secondary sources referred to while preparing the epigenetics market report.

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