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Small Nucleic Acid Drug - Global Industry Market Analysis Report 2020-2031

Publisher Paco Research
Published Jul 01, 2025
Length 127 Pages
SKU # PACO20149027

Description

Small Nucleic Acid Drugs are nucleic acid-based drugs, including small interfering RNA (siRNA), antisense oligonucleotides (ASO), microRNA (miRNA) and aptamers. These drugs regulate gene expression by binding to target genes or their mRNAs, with high specificity and design flexibility. They can precisely target specific genes or RNA sequences, thus providing new possibilities in treating many diseases that are considered undruggable, such as genetic diseases, cancer and viral infections. Compared with traditional drugs, small nucleic acid drugs are developed faster because they do not require complex structural matching or a long screening process.

Despite the great potential of small nucleic acid drugs, they also face many challenges in clinical practice, mainly including stability (easily degraded by nucleases), delivery difficulties (cell membranes hinder their entry into cells) and immune responses. However, technological advances in recent years, such as chemical modification, ligand binding and the application of nanotechnology, have significantly improved these problems. Currently, several small nucleic acid drugs have been approved by the FDA for the treatment of diseases such as hereditary transthyretin-mediated amyloidosis, spinal muscular atrophy and acute hepatic porphyria. In the future, small nucleic acid drugs are expected to play a role in the treatment of more diseases, and their efficacy can be further improved by combining them or using them in conjunction with other treatments. Continuing to improve delivery strategies and reduce costs will be the key to promoting their widespread application.

Report Scope

This report aims to deliver a thorough analysis of the global market for Small Nucleic Acid Drug, offering both quantitative and qualitative insights to assist readers in formulating business growth strategies, evaluating the competitive landscape, understanding their current market position, and making well-informed decisions regarding Small Nucleic Acid Drug.

The report is enriched with qualitative evaluations, including market drivers, challenges, Porter’s Five Forces, regulatory frameworks, consumer preferences, and ESG (Environmental, Social, and Governance) factors.

The report provides detailed classification of Small Nucleic Acid Drug, such as type, etc.; detailed examples of Small Nucleic Acid Drug applications, such as application one, etc., and provides comprehensive historical (2020-2025) and forecast (2026-2031) market size data.

The report provides detailed classification of Small Nucleic Acid Drug, such as Antisense Oligonucleotides (ASO), siRNA, Other, etc.; detailed examples of Small Nucleic Acid Drug applications, such as Neuromuscular Diseases, hATTR, Other, etc., and provides comprehensive historical (2020-2025) and forecast (2026-2031) market size data.

The report covers key global regions—North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa—providing granular, country-specific insights for major markets such as the United States, China, Germany, and Brazil.

The report deeply explores the competitive landscape of Small Nucleic Acid Drug products, details the sales, revenue, and regional layout of some of the world's leading manufacturers, and provides in-depth company profiles and contact details.

The report contains a comprehensive industry chain analysis covering raw materials, downstream customers and sales channels.

Core Chapters

Chapter One: Introduces the study scope of this report, market status, market drivers, challenges, porters five forces analysis, regulatory policy, consumer preference, market attractiveness and ESG analysis.
Chapter Two: market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter Three: Small Nucleic Acid Drug market sales and revenue in regional level and country level. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and production of each country in the world.
Chapter Four: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter Five: Detailed analysis of Small Nucleic Acid Drug manufacturers competitive landscape, price, sales, revenue, market share, footprint, merger, and acquisition information, etc.
Chapter Six: Provides profiles of leading manufacturers, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction.
Chapter Seven: Analysis of industrial chain, key raw materials, customers and sales channel.
Chapter Eight: Key Takeaways and Final Conclusions
Chapter Nine: Methodology and Sources.

Table of Contents

127 Pages
1 Small Nucleic Acid Drug Market Overview and Qualitative Analysis
1.1 Small Nucleic Acid Drug Product Definition and Statistical Scope
1.2 Small Nucleic Acid Drug Market Status and Outlook
1.2.1 Small Nucleic Acid Drug Market Revenue Estimates and Forecasts 2020-2031
1.2.2 Small Nucleic Acid Drug Market Sales Estimates and Forecasts 2020-2031
1.3 Small Nucleic Acid Drug Market Driver Analysis
1.4 Small Nucleic Acid Drug Market Challenges Analysis
1.5 Porter's Five Forces Analysis
1.5.1 Bargaining Power of Suppliers
1.5.2 Bargaining Power of Buyers/Consumers
1.5.3 Threat of New Entrants
1.5.4 Threat of Substitute Products
1.5.5 Intensity of Competitive Rivalry
1.6 Regulatory Policy Analysis
1.7 Consumer Preference Analysis
1.8 Market Attractiveness Analysis
1.9 ESG (Environmental, Social and Governance) Analysis
2 Small Nucleic Acid Drug Market Type Estimates & Trend Analysis
2.1 Small Nucleic Acid Drug Type Dashboard
2.2 Small Nucleic Acid Drug Market by Type
2.2.1 Antisense Oligonucleotides (ASO)
2.2.2 siRNA
2.2.3 Other
2.3 Global Small Nucleic Acid Drug Market Size by Type
2.3.1 Historical Analysis of the Global Small Nucleic Acid Drug Market Size by Type (2020-2025)
2.3.2 Projected Analysis of Global Small Nucleic Acid Drug Market Size by Type (2026–2031)
3 Small Nucleic Acid Drug Market Geography Estimates & Trend Analysis
3.1 Small Nucleic Acid Drug Geography Dashboard
3.2 Global Small Nucleic Acid Drug Historic Market Size by Region
3.2.1 Global Small Nucleic Acid Drug Market Sales by Region (2020-2025)
3.2.2 Global Small Nucleic Acid Drug Market Revenue by Region (2020-2025)
3.3 Global Small Nucleic Acid Drug Forecasted Market Size by Region
3.3.1 Global Small Nucleic Acid Drug Market Sales by Region (2026-2031)
3.3.2 Global Small Nucleic Acid Drug Market Revenue by Region (2026-2031)
3.4 North America Small Nucleic Acid Drug Market by Country
3.4.1 North America Small Nucleic Acid Drug Market Sales by Country (2020-2031)
3.4.2 North America Small Nucleic Acid Drug Market Revenue by Country (2020-2031)
3.4.3 United States Small Nucleic Acid Drug Market Sales, Revenue and Growth Rate (2020-2031)
3.4.4 Canada Small Nucleic Acid Drug Market Sales, Revenue and Growth Rate (2020-2031)
3.5 Europe Small Nucleic Acid Drug Market by Country
3.5.1 Europe Small Nucleic Acid Drug Market Sale by Country (2020-2031)
3.5.2 Europe Small Nucleic Acid Drug Market Revenue by Country (2020-2031)
3.5.3 Germany Market Sales, Revenue and Growth Rate (2020-2031)
3.5.4 France Market Sales, Revenue and Growth Rate (2020-2031)
3.5.5 U.K. Market Sales, Revenue and Growth Rate (2020-2031)
3.5.6 Italy Market Sales, Revenue and Growth Rate (2020-2031)
3.5.7 Spain Market Sales, Revenue and Growth Rate (2020-2031)
3.6 Asia-Pacific Small Nucleic Acid Drug Market by Region
3.6.1 Asia-Pacific Small Nucleic Acid Drug Market Sales by Region (2020-2031)
3.6.2 Asia-Pacific Small Nucleic Acid Drug Market Revenue by Region (2020-2031)
3.6.3 China Market Sales, Revenue and Growth Rate (2020-2031)
3.6.4 Japan Market Sales, Revenue and Growth Rate (2020-2031)
3.6.5 South Korea Market Sales, Revenue and Growth Rate (2020-2031)
3.6.6 India Market Sales, Revenue and Growth Rate (2020-2031)
3.6.7 Southeast Asia Market Sales, Revenue and Growth Rate (2020-2031)
3.7 Latin America Small Nucleic Acid Drug Market by Country
3.7.1 Latin America Small Nucleic Acid Drug Market Sales by Country (2020-2031)
3.7.2 Latin America Small Nucleic Acid Drug Market Revenue by Country (2020-2031)
3.7.3 Mexico Market Sales, Revenue and Growth Rate (2020-2031)
3.7.4 Brazil Market Sales, Revenue and Growth Rate (2020-2031)
3.8 Middle East and Africa Small Nucleic Acid Drug Market by Country
3.8.1 Middle East and Africa Small Nucleic Acid Drug Market Sales by Country (2020-2031)
3.8.2 Middle East and Africa Small Nucleic Acid Drug Market Revenue by Country (2020-2031)
3.8.3 Turkey Market Sales, Revenue and Growth Rate (2020-2031)
3.8.4 Saudi Arabia Market Sales, Revenue and Growth Rate (2020-2031)
3.8.5 South Africa Market Sales, Revenue and Growth Rate (2020-2031)
4 Small Nucleic Acid Drug Market Application Estimates & Trend Analysis
4.1 Small Nucleic Acid Drug Market Application Dashboard
4.2 Small Nucleic Acid Drug Market by Application
4.2.1 Neuromuscular Diseases
4.2.2 hATTR
4.2.3 Other
4.3 Global Small Nucleic Acid Drug Market Size by Application
4.3.1 Historical Analysis of Global Small Nucleic Acid Drug Market Size by Application (2020-2025)
4.3.2 Projected Analysis of Global Small Nucleic Acid Drug Market Size by Application (2026-2031)
5 Small Nucleic Acid Drug Market Competitive Landscape Analysis
5.1 Global Small Nucleic Acid Drug Leading Manufacturers’ Market Sales Performance and Share Analysis
5.2 Global Small Nucleic Acid Drug Leading Manufacturers’ Market Revenue Performance and Share Analysis
5.3 Global Small Nucleic Acid Drug Leading Manufacturers’ Average Sales Price (2020-2025)
5.4 Global Small Nucleic Acid Drug Leading Manufacturers’ Regional Footprint (Headquarters, Manufacturing Base and Sales Ares)
5.5 Mergers and Acquisition Analysis
6 Leading Manufacturers’ Company Profiles
6.1 Sarepta Therapeutics
6.1.1 Sarepta Therapeutics Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.1.2 Sarepta Therapeutics Introduction and Business Overview
6.1.3 Sarepta Therapeutics Small Nucleic Acid Drug Product Portfolio
6.1.4 Sarepta Therapeutics Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.2 Ionis Pharmaceuticals
6.2.1 Ionis Pharmaceuticals Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.2.2 Ionis Pharmaceuticals Introduction and Business Overview
6.2.3 Ionis Pharmaceuticals Small Nucleic Acid Drug Product Portfolio
6.2.4 Ionis Pharmaceuticals Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.3 Alnylam
6.3.1 Alnylam Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.3.2 Alnylam Introduction and Business Overview
6.3.3 Alnylam Small Nucleic Acid Drug Product Portfolio
6.3.4 Alnylam Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.4 Biogen
6.4.1 Biogen Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.4.2 Biogen Introduction and Business Overview
6.4.3 Biogen Small Nucleic Acid Drug Product Portfolio
6.4.4 Biogen Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.5 Nippon Shinyaku
6.5.1 Nippon Shinyaku Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.5.2 Nippon Shinyaku Introduction and Business Overview
6.5.3 Nippon Shinyaku Small Nucleic Acid Drug Product Portfolio
6.5.4 Nippon Shinyaku Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.6 Sobi
6.6.1 Sobi Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.6.2 Sobi Introduction and Business Overview
6.6.3 Sobi Small Nucleic Acid Drug Product Portfolio
6.6.4 Sobi Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.7 Novartis
6.7.1 Novartis Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.7.2 Novartis Introduction and Business Overview
6.7.3 Novartis Small Nucleic Acid Drug Product Portfolio
6.7.4 Novartis Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.8 Jazz Pharmaceuticals
6.8.1 Jazz Pharmaceuticals Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.8.2 Jazz Pharmaceuticals Introduction and Business Overview
6.8.3 Jazz Pharmaceuticals Small Nucleic Acid Drug Product Portfolio
6.8.4 Jazz Pharmaceuticals Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.9 AstraZeneca
6.9.1 AstraZeneca Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.9.2 AstraZeneca Introduction and Business Overview
6.9.3 AstraZeneca Small Nucleic Acid Drug Product Portfolio
6.9.4 AstraZeneca Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.10 Novo Nordisk
6.10.1 Novo Nordisk Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.10.2 Novo Nordisk Introduction and Business Overview
6.10.3 Novo Nordisk Small Nucleic Acid Drug Product Portfolio
6.10.4 Novo Nordisk Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.11 Astellas Pharma
6.11.1 Astellas Pharma Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.11.2 Astellas Pharma Introduction and Business Overview
6.11.3 Astellas Pharma Small Nucleic Acid Drug Product Portfolio
6.11.4 Astellas Pharma Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.12 Geron Corporation
6.12.1 Geron Corporation Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.12.2 Geron Corporation Introduction and Business Overview
6.12.3 Geron Corporation Small Nucleic Acid Drug Product Portfolio
6.12.4 Geron Corporation Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.13 CureVac
6.13.1 CureVac Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.13.2 CureVac Introduction and Business Overview
6.13.3 CureVac Small Nucleic Acid Drug Product Portfolio
6.13.4 CureVac Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.14 Regulus Therapeutics
6.14.1 Regulus Therapeutics Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.14.2 Regulus Therapeutics Introduction and Business Overview
6.14.3 Regulus Therapeutics Small Nucleic Acid Drug Product Portfolio
6.14.4 Regulus Therapeutics Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.15 ProQR
6.15.1 ProQR Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.15.2 ProQR Introduction and Business Overview
6.15.3 ProQR Small Nucleic Acid Drug Product Portfolio
6.15.4 ProQR Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.16 Secarna
6.16.1 Secarna Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.16.2 Secarna Introduction and Business Overview
6.16.3 Secarna Small Nucleic Acid Drug Product Portfolio
6.16.4 Secarna Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.17 MiNA Therapeutics
6.17.1 MiNA Therapeutics Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.17.2 MiNA Therapeutics Introduction and Business Overview
6.17.3 MiNA Therapeutics Small Nucleic Acid Drug Product Portfolio
6.17.4 MiNA Therapeutics Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.18 Sylentis
6.18.1 Sylentis Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.18.2 Sylentis Introduction and Business Overview
6.18.3 Sylentis Small Nucleic Acid Drug Product Portfolio
6.18.4 Sylentis Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.19 Arrowhead
6.19.1 Arrowhead Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.19.2 Arrowhead Introduction and Business Overview
6.19.3 Arrowhead Small Nucleic Acid Drug Product Portfolio
6.19.4 Arrowhead Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
6.20 Silence Therapeutics
6.20.1 Silence Therapeutics Overview (Basic Corporate Information, Manufacturing Footprint, Geographic Sales Presence and Key Competitors)
6.20.2 Silence Therapeutics Introduction and Business Overview
6.20.3 Silence Therapeutics Small Nucleic Acid Drug Product Portfolio
6.20.4 Silence Therapeutics Small Nucleic Acid Drug Market Performance Analysis (Revenue, Sales, Price, Gross Margin and Market Share)
7 Industry Chain Analysis
7.1 Upstream Key Raw Materials
7.1.1 Raw Materials A Definition and Suppliers
7.1.2 Raw Materials B Definition and Suppliers
7.1.3 Raw Materials C Definition and Suppliers
7.2 Small Nucleic Acid Drug Typical Downstream Customers
7.3 Small Nucleic Acid Drug Sales Channel Analysis
8 Key Takeaways and Final Conclusions
9 Methodology and Sources
9.1 Research Methodology
9.2 Data Mining
9.2.1 Preliminary Data Sources
9.2.2 Secondary Sources
9.3 Industry Analysis Matrix
9.4 Disclaimer

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