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Global mRNA Raw Enzyme Market Research Report - Market Share Analysis, Industry Trends & Statistics, Growth Forecasts (2025 - 2033)

Published Aug 13, 2025
Length 200 Pages
SKU # LOOK20514510

Description

Definition and Scope:

Already decades in development, the SARS-CoV-2 pandemic first thrust mRNA therapeutics into the limelight. From vaccines and immunotherapies to protein replacement and cell reprogramming, interest in mRNA manufacturing has surged. Today, therapeutic developers have the room and attention to bring innovations to market. Competition is growing. Regulations are crystalizing. Raw enzyme is one of the key raw materials for mRNA production.

mRNA Raw Enzyme are used in mRNA production on a global scale for vaccine and therapeutic development. The process includes DNA linearization, in vitro transcription, mRNA capping and tailing, purification, and analysis. mRNA Raw Enzyme including mRNA polymerase, vaccinia capping enzyme, restriction enzyme, DNASE I, others.

The global mRNA Raw Enzyme market was valued at USD 5761.81 million in 2021 and is expected to reach USD 2207.51 million by the end of 2028, growing at a CAGR of -16.02% between 2022 and 2028.

High demand for mRNA vaccine against coronavirus and coronavirus-modified diseases has become the most important driving force for the development of the mRNA Raw Enzyme market. The COVID-19 pandemic has favorably impacted the growth of the global mRNA Raw Enzyme market owing to an increase in the number of COVID-19 patients globally and substantial external financing for the production of mRNA-based COVID-19 vaccines. Furthermore, when new strains of the SARS-COVID-19 virus appeared in many countries around the world, the demand for mRNA vaccines rose sharply due to their effective protection against these strains.

Referring to the synthesis process of new crown mRNA vaccines such as Moderna and BioNTech, the main raw materials in the production process include plasmid DNA templates, a series of enzymes and substrate nucleotides. According to Frost & Sullivan, the cost of raw materials is the main component of the production cost of mRNA vaccines, accounting for about 58% of the total production cost, of which enzyme raw materials account for about 39.58% of the cost of raw materials. In addition to substrate nucleotides, the preparation of mRNA stock solution currently requires T7 RNA polymerase, inorganic pyrophosphatase, RNase inhibitor, capping enzyme, 2'O-methyltransferase, Poly(A) polymerase and DNase I and other major 7 enzymes.

Considering that the current global new crown epidemic is still in a high incidence period and the risk of virus mutation is high, vaccination is an important measure to control the epidemic, and after vaccination, it has significantly reduced the severe rate and mortality rate. Therefore, we expect global new crown mRNA vaccination volume is expected to remain high in the next three years. Hence, the use of these mRNA-based products is expected to increase during the COVID-19 pandemic and lead to mRNA Raw Enzyme market growth.

However, the duration of the new crown epidemic is uncertain. With the gradual and effective control of the new crown epidemic or the successful development of specific drugs for the treatment of new coronary pneumonia, related companies' new crown diagnostic antibodies, mRNA raw materials enzymes and reagents and other new crown business income will drop significantly.

High demand for mRNA vaccine against coronavirus and coronavirus-modified diseases has become the most important driving force for the development of the mRNA Raw Enzyme market.

Segment by Type, the mRNA Raw Enzyme can be split into mRNA Polymerase, Vaccinia Capping Enzyme, Restriction Enzyme and DNase I. In 2017-2021, mRNA Polymerase and Vaccinia Capping Enzyme are the most important markets for the mRNA Raw Enzyme, occupying the most important market share. In 2021, the market share of the mRNA Polymerase segment has reached 46.34%, and the market share of the Vaccinia Capping Enzyme segment has reached 39.52%.

From the perspective of application scenarios, the mRNA Raw Enzyme can be mainly used in Biopharmaceutical Companies, Academic and Research Institutes and Contract Research Organizations. Among them, Biopharmaceutical Companies has become the most important application scenario of mRNA Raw Enzyme, and has accounted for 97.93% in 2021 market share. Biopharmaceutical Companies use mRNA Raw Enzyme to make mRNA vaccines and related products.

On basis of geography, the mRNA Raw Enzyme market is segmented into North America, Europe, Japan, China, etc. North America and Europe are the most dominant markets, accounting for 48.12% and 48.70% market share respectively in 2021. Availability of substantial research funding, high frequency of RNA-based drugs and clinical trials drive the European and North American markets.

In terms of the competitive landscape, the raw material suppliers of major mRNA vaccine manufacturers in the world are mainly Thermo Fisher (whose products cover transcription modification enzymes, cap analogs and NTP raw materials, etc., with a complete product line), NEB (with a complete transcription capping enzyme system) and NTP) and other companies. Among them, Thermo Fisher is the absolute leading company in the mRNA Raw Enzyme market, and occupies 66.66% of the market share. Overall, key players in the market include Thermo Fisher, Roche Holding AG, New England Biolabs, Novoprotein, Hongene Biotech Corporation, Vazyme, Kactus Biosystems, Aldevron and Yeasen Biotechnology (Shanghai).

This report offers a comprehensive analysis of the global mRNA Raw Enzyme market, examining all key dimensions. It provides both a macro-level overview and micro-level market details, including market size, trends, competitive landscape, niche segments, growth drivers, and key challenges.

Report Framework and Key Highlights:

Market Dynamics: Identification of major market drivers, restraints, opportunities, and challenges.

Trend Analysis: Examination of ongoing and emerging trends impacting the market.

Competitive Landscape: Detailed profiles and market positioning of major players, including market share, operational status, product offerings, and strategic developments.

Strategic Analysis Tools: SWOT Analysis, Porter’s Five Forces Analysis, PEST Analysis, Value Chain Analysis

Market Segmentation: By type, application, region, and end-user industry.

Forecasting and Growth Projections: In-depth revenue forecasts and CAGR analysis through 2033.

This report equips readers with critical insights to navigate competitive dynamics and develop effective strategies. Whether assessing a new market entry or refining existing strategies, the report serves as a valuable tool for:

Industry players

Investors

Researchers

Consultants

Business strategists

And all stakeholders with an interest or investment in the mRNA Raw Enzyme market.

Global mRNA Raw Enzyme Market: Segmentation Analysis and Strategic Insights

This section of the report provides an in-depth segmentation analysis of the global mRNA Raw Enzyme market. The market is segmented based on region (country), manufacturer, product type, and application. Segmentation enables a more precise understanding of market dynamics and facilitates targeted strategies across product development, marketing, and sales.

By breaking the market into meaningful subsets, stakeholders can better tailor their offerings to the specific needs of each segment—enhancing competitiveness and improving return on investment.

Global mRNA Raw Enzyme Market: Market Segmentation Analysis

The research report includes specific segments by region (country), manufacturers, Type, and Application. Market segmentation creates subsets of a market based on product type, end-user or application, Geographic, and other factors. By understanding the market segments, the decision-maker can leverage this targeting in the product, sales, and marketing strategies. Market segments can power your product development cycles by informing how you create product offerings for different segments.

Key Companies Profiled

Thermo Fisher

Roche Holding AG

New England Biolabs

Novoprotein

Hongene Biotech Corporatio

Vazyme

Kactus Biosystems

Aldevron

Yeasen Biotechnology (Shanghai)

Market Segmentation by Type

mRNA Polymerase

Vaccinia Capping Enzyme

Restriction Enzyme

DNase I

Others

Market Segmentation by Application

Biopharmaceutical Companies

Academic and Research Institutes

Contract Research Organizations

Geographic Segmentation

North America: United States, Canada, Mexico

Europe: Germany, France, Italy, U.K., Spain, Sweden, Denmark, Netherlands, Switzerland, Belgium, Russia.

Asia-Pacific: China, Japan, South Korea, India, Australia, Indonesia, Malaysia, Philippines, Singapore, Thailand

South America: Brazil, Argentina, Colombia.

Middle East and Africa (MEA): Saudi Arabia, United Arab Emirates, Egypt, Nigeria, South Africa, Rest of MEA

Report Framework and Chapter Summary

Chapter 1: Report Scope and Market Definition

This chapter outlines the statistical boundaries and scope of the report. It defines the segmentation standards used throughout the study, including criteria for dividing the market by region, product type, application, and other relevant dimensions. It establishes the foundational definitions and classifications that guide the rest of the analysis.

Chapter 2: Executive Summary

This chapter presents a concise summary of the market’s current status and future outlook across different segments—by geography, product type, and application. It includes key metrics such as market size, growth trends, and development potential for each segment. The chapter offers a high-level overview of the mRNA Raw Enzyme Market, highlighting its evolution over the short, medium, and long term.

Chapter 3: Market Dynamics and Policy Environment

This chapter explores the latest developments in the market, identifying key growth drivers, restraints, challenges, and risks faced by industry participants. It also includes an analysis of the policy and regulatory landscape affecting the market, providing insight into how external factors may shape future performance.

Chapter 4: Competitive Landscape

This chapter provides a detailed assessment of the market's competitive environment. It covers market share, production capacity, output, pricing trends, and strategic developments such as mergers, acquisitions, and expansion plans of leading players. This analysis offers a comprehensive view of the positioning and performance of top competitors.

Chapters 5–10: Regional Market Analysis

These chapters offer in-depth, quantitative evaluations of market size and growth potential across major regions and countries. Each chapter assesses regional consumption patterns, market dynamics, development prospects, and available capacity. The analysis helps readers understand geographical differences and opportunities in global markets.

Chapter 11: Market Segmentation by Product Type

This chapter examines the market based on product type, analyzing the size, growth trends, and potential of each segment. It helps stakeholders identify underexplored or high-potential product categories—often referred to as “blue ocean” opportunities.

Chapter 12: Market Segmentation by Application

This chapter analyzes the market based on application fields, providing insights into the scale and future development of each application segment. It supports readers in identifying high-growth areas across downstream markets.

Chapter 13: Company Profiles

This chapter presents comprehensive profiles of leading companies operating in the market. For each company, it details sales revenue, volume, pricing, gross profit margin, market share, product offerings, and recent strategic developments. This section offers valuable insight into corporate performance and strategy.

Chapter 14: Industry Chain and Value Chain Analysis

This chapter explores the full industry chain, from upstream raw material suppliers to downstream application sectors. It includes a value chain analysis that highlights the interconnections and dependencies across various parts of the ecosystem.

Chapter 15: Key Findings and Conclusions

The final chapter summarizes the main takeaways from the report, presenting the core conclusions, strategic recommendations, and implications for stakeholders. It encapsulates the insights drawn from all previous chapters.

Table of Contents

200 Pages
1 Introduction to Research & Analysis Reports
1.1 mRNA Raw Enzyme Market Definition
1.2 mRNA Raw Enzyme Market Segments
1.2.1 Segment by Type
1.2.2 Segment by Application
2 Executive Summary
2.1 Global mRNA Raw Enzyme Market Size
2.2 Market Segmentation – by Type
2.3 Market Segmentation – by Application
2.4 Market Segmentation – by Geography
3 Key Market Trends, Opportunity, Drivers and Restraints
3.1 Key Takeway
3.2 Market Opportunities & Trends
3.3 Market Drivers
3.4 Market Restraints
3.5 Market Major Factor Assessment
4 Global mRNA Raw Enzyme Market Competitive Landscape
4.1 Global mRNA Raw Enzyme Sales by Manufacturers (2020-2025)
4.2 Global mRNA Raw Enzyme Revenue Market Share by Manufacturers (2020-2025)
4.3 mRNA Raw Enzyme Market Share by Company Type (Tier 1, Tier 2, and Tier 3)
4.4 New Entrant and Capacity Expansion Plans
4.5 Mergers & Acquisitions
5 Global mRNA Raw Enzyme Market by Region
5.1 Global mRNA Raw Enzyme Market Size by Region
5.1.1 Global mRNA Raw Enzyme Market Size by Region
5.1.2 Global mRNA Raw Enzyme Market Size Market Share by Region
5.2 Global mRNA Raw Enzyme Sales by Region
5.2.1 Global mRNA Raw Enzyme Sales by Region
5.2.2 Global mRNA Raw Enzyme Sales Market Share by Region
6 North America Market Overview
6.1 North America mRNA Raw Enzyme Market Size by Country
6.1.1 USA Market Overview
6.1.2 Canada Market Overview
6.1.3 Mexico Market Overview
6.2 North America mRNA Raw Enzyme Market Size by Type
6.3 North America mRNA Raw Enzyme Market Size by Application
6.4 Top Players in North America mRNA Raw Enzyme Market
7 Europe Market Overview
7.1 Europe mRNA Raw Enzyme Market Size by Country
7.1.1 Germany Market Overview
7.1.2 France Market Overview
7.1.3 U.K. Market Overview
7.1.4 Italy Market Overview
7.1.5 Spain Market Overview
7.1.6 Sweden Market Overview
7.1.7 Denmark Market Overview
7.1.8 Netherlands Market Overview
7.1.9 Switzerland Market Overview
7.1.10 Belgium Market Overview
7.1.11 Russia Market Overview
7.2 Europe mRNA Raw Enzyme Market Size by Type
7.3 Europe mRNA Raw Enzyme Market Size by Application
7.4 Top Players in Europe mRNA Raw Enzyme Market
8 Asia-Pacific Market Overview
8.1 Asia-Pacific mRNA Raw Enzyme Market Size by Country
8.1.1 China Market Overview
8.1.2 Japan Market Overview
8.1.3 South Korea Market Overview
8.1.4 India Market Overview
8.1.5 Australia Market Overview
8.1.6 Indonesia Market Overview
8.1.7 Malaysia Market Overview
8.1.8 Philippines Market Overview
8.1.9 Singapore Market Overview
8.1.10 Thailand Market Overview
8.1.11 Rest of APAC Market Overview
8.2 Asia-Pacific mRNA Raw Enzyme Market Size by Type
8.3 Asia-Pacific mRNA Raw Enzyme Market Size by Application
8.4 Top Players in Asia-Pacific mRNA Raw Enzyme Market
9 South America Market Overview
9.1 South America mRNA Raw Enzyme Market Size by Country
9.1.1 Brazil Market Overview
9.1.2 Argentina Market Overview
9.1.3 Columbia Market Overview
9.2 South America mRNA Raw Enzyme Market Size by Type
9.3 South America mRNA Raw Enzyme Market Size by Application
9.4 Top Players in South America mRNA Raw Enzyme Market
10 Middle East and Africa Market Overview
10.1 Middle East and Africa mRNA Raw Enzyme Market Size by Country
10.1.1 Saudi Arabia Market Overview
10.1.2 UAE Market Overview
10.1.3 Egypt Market Overview
10.1.4 Nigeria Market Overview
10.1.5 South Africa Market Overview
10.2 Middle East and Africa mRNA Raw Enzyme Market Size by Type
10.3 Middle East and Africa mRNA Raw Enzyme Market Size by Application
10.4 Top Players in Middle East and Africa mRNA Raw Enzyme Market
11 mRNA Raw Enzyme Market Segmentation by Type
11.1 Evaluation Matrix of Segment Market Development Potential (Type)
11.2 Global mRNA Raw Enzyme Sales Market Share by Type (2020-2033)
11.3 Global mRNA Raw Enzyme Market Size Market Share by Type (2020-2033)
11.4 Global mRNA Raw Enzyme Price by Type (2020-2033)
12 mRNA Raw Enzyme Market Segmentation by Application
12.1 Evaluation Matrix of Segment Market Development Potential (Application)
12.2 Global mRNA Raw Enzyme Market Sales by Application (2020-2033)
12.3 Global mRNA Raw Enzyme Market Size (M USD) by Application (2020-2033)
12.4 Global mRNA Raw Enzyme Sales Growth Rate by Application (2020-2033)
13 Company Profiles
13.1 Thermo Fisher
13.1.1 Thermo Fisher Company Overview
13.1.2 Thermo Fisher Business Overview
13.1.3 Thermo Fisher mRNA Raw Enzyme Major Product Offerings
13.1.4 Thermo Fisher mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.1.5 Key News
13.2 Roche Holding AG
13.2.1 Roche Holding AG Company Overview
13.2.2 Roche Holding AG Business Overview
13.2.3 Roche Holding AG mRNA Raw Enzyme Major Product Offerings
13.2.4 Roche Holding AG mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.2.5 Key News
13.3 New England Biolabs
13.3.1 New England Biolabs Company Overview
13.3.2 New England Biolabs Business Overview
13.3.3 New England Biolabs mRNA Raw Enzyme Major Product Offerings
13.3.4 New England Biolabs mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.3.5 Key News
13.4 Novoprotein
13.4.1 Novoprotein Company Overview
13.4.2 Novoprotein Business Overview
13.4.3 Novoprotein mRNA Raw Enzyme Major Product Offerings
13.4.4 Novoprotein mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.4.5 Key News
13.5 Hongene Biotech Corporatio
13.5.1 Hongene Biotech Corporatio Company Overview
13.5.2 Hongene Biotech Corporatio Business Overview
13.5.3 Hongene Biotech Corporatio mRNA Raw Enzyme Major Product Offerings
13.5.4 Hongene Biotech Corporatio mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.5.5 Key News
13.6 Vazyme
13.6.1 Vazyme Company Overview
13.6.2 Vazyme Business Overview
13.6.3 Vazyme mRNA Raw Enzyme Major Product Offerings
13.6.4 Vazyme mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.6.5 Key News
13.7 Kactus Biosystems
13.7.1 Kactus Biosystems Company Overview
13.7.2 Kactus Biosystems Business Overview
13.7.3 Kactus Biosystems mRNA Raw Enzyme Major Product Offerings
13.7.4 Kactus Biosystems mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.7.5 Key News
13.8 Aldevron
13.8.1 Aldevron Company Overview
13.8.2 Aldevron Business Overview
13.8.3 Aldevron mRNA Raw Enzyme Major Product Offerings
13.8.4 Aldevron mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.8.5 Key News
13.9 Yeasen Biotechnology (Shanghai)
13.9.1 Yeasen Biotechnology (Shanghai) Company Overview
13.9.2 Yeasen Biotechnology (Shanghai) Business Overview
13.9.3 Yeasen Biotechnology (Shanghai) mRNA Raw Enzyme Major Product Offerings
13.9.4 Yeasen Biotechnology (Shanghai) mRNA Raw Enzyme Sales and Revenue frommRNA Raw Enzyme (2020-2025)
13.9.5 Key News
14 Key Market Trends, Opportunity, Drivers and Restraints
14.1 Key Takeway
14.2 Market Opportunities & Trends
14.3 Market Drivers
14.4 Market Restraints
14.5 Market Major Factor Assessment
14.6 Porter's Five Forces Analysis of mRNA Raw Enzyme Market
14.7 PEST Analysis of mRNA Raw Enzyme Market
15 Analysis of the mRNA Raw Enzyme Industry Chain
15.1 Overview of the Industry Chain
15.2 Upstream Segment Analysis
15.3 Midstream Segment Analysis
15.3.1 Manufacturing, Processing or Conversion Process Analysis
15.3.2 Key Technology Analysis
15.4 Downstream Segment Analysis
15.4.1 Downstream Customer List and Contact Details
15.4.2 Customer Concerns or Preference Analysis
16 Conclusion
17 Appendix
17.1 Methodology
17.2 Research Process and Data Source
17.3 Disclaimer
17.4 Note
17.5 Examples of Clients
17.6 Disclaimer
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