Calcifediol Market - Forecasts from 2025 to 2030

The Calcifediol Market is expected to grow at a CAGR of 6.24%, reaching a market size of US$2,631.61 million in 2030 from US$1,943.95 million in 2025.
Calcifediol is a form of Vitamin D, also known as 25-hydroxyvitamin D3, produced by the liver by the process of hydroxylation of Vitamin D3 that we get from sunlight or diet. It is further hydroxylated in the kidney to form Calcitriol, an active form of vitamin D3.
Calcifediol in capsule or liquid dosage treats vitamin D deficiency or insufficiency, refractory rickets, familial hypophosphatemia, and secondary hypoparathyroidism. It is used to treat hypocalcemia and renal osteodystrophy in patients suffering from chronic renal failure. It is used with calcium to prevent osteoporosis. It is also used in animal feed to improve its vitamin D level and feed conversation ratio by improving the overall quality of livestock and poultry.
The rising demand for calcifediol is attributed to its more advantageous features than the other forms of vitamin D. Calcifediol is 3 times more potent than cholecalciferol, commonly used to treat vitamin D deficiency. At the same time, its absorption rate is higher than that of other forms of vitamin D. Furthermore, the increasing Vitamin D deficiency worldwide, along with the aging population, is driving the market growth for calcifediol in the form of supplements. Moreover, its use in treating secondary hyperparathyroidism, managing hypocalcemia, and preventing osteoporosis is leading to market expansion.
Calcifediol Market Drivers

Rising Vitamin D deficiency, along with rising health awareness about micronutrient supplementation, will drive the calcifediol market growth
Globally, there is an increase in number of people with Vitamin D deficiency. The number of geriatric populations is also rising worldwide. The rising Vitamin D deficiency among the people, including the aged population, is creating demand for Vitamin D supplements. Calcifediol, a better alternative than other vitamin D, provides an effective solution to meet the demand for vitamin D in calcifediol supplements. Additionally, there is increasing health awareness among youth for their health and wellness. This has led to increased demand for micronutrients, resulting in a significant rise in the need for calcifediol supplements for vitamin D supplementation.
As per a study by the National Center of Biotechnology Information, 76.6% of participants had serum 25-hydroxyvitamin D deficiency below 75 nmol/l, showing a higher prevalence of deficiency of vitamin D. Globally, approx. 30-45% of people have vitamin D deficiency, making it around 1 billion.
Calcifediol Market geographical outlook

North America would be the largest market shareholder for calcifediol in the forecast period.
Region-wise, the global market is segmented into Asia-Pacific, North America, South America, Europe, Middle East and Africa. In the forecast period, North America would hold the largest market share for Calcifediol.
There are increasing trends among people in North America, compared to other regions, for dietary supplements. With the prevalence of advanced healthcare infrastructure and significant innovations and advancement in the health sector, this region is poised for growth in the Calcifediol market. Additionally, North America is experiencing a demographic shift towards the older population. In the United States of America, there would be around 77 million people aged above 65 as per U.S. Census Bureau Project. Hence, North America will dominate this market in the forecast period.

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The Calcifediol market is analyzed into the following segments:

By Application

Pharmaceuticals
Animal Feed
Others

By Geography

North America
United States
Canada
Mexico
South America
Brazil
Argentina
Others
Europe
UK
Germany
France
Italy
Others
Middle East and Africa
Saudi Arabia
Israel
Others
Asia Pacific
Japan
China
India
South Korea
Indonesia
Thailand
Others