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Downstream Bioprocessing Markets (Chromatography Columns and Resins, Membrane Adsorbers, Filtration Systems, Sensors)

Downstream Bioprocessing Markets (Chromatography Columns and Resins, Membrane Adsorbers, Filtration Systems, Sensors)

Downstream processing, or bioprocessing, involves the recovery and purification of biosynthetic products, often pharmaceuticals, from natural sources. These sources may be animal or plant tissue or fermentation broth. It is an essential step in producing pharmaceuticals, such as antibiotics, hormones (insulin and human growth hormone), antibodies, and vaccines. Downstream Bioprocessing Markets analyzes the current and potential world market for components used in downstream processing, including the global downstream bioprocessing market, 2016-2021 ($ billions), in total and by the following market segments: chromatography columns and resins, membrane adsorbers, filtration, and sensors.

The report also provides data in total and by segment for the global downstream bioprocessing markets by geography, 2016-2021 ($ billions; US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW). As well as future markets, this report generally reviews the nature and direction of research.

ESI Ultrapure, GE Healthcare, Millipore, Natrix, Pall, Sartorius, and Thermo Fisher Scientific are among the downstream bioprocessing market companies profiled in the report.


  • Executive Summary
    • Overview
      • Focus on Cost Effectiveness
      • Outsourcing Popular
      • Flexibility and More Research Needed
        • Table World Market for Downstream Bioprocessing Components, 2016-2021 ($ billions)
    • Methodology
  • Introduction
    • Downstream Processing
      • Table The State of Downstream Bioprocessing
      • Important Roles
        • Table Key Roles of Downstream Bioprocessing
      • Safety and Efficacy
    • Stages of Downstream Processing
      • Table Stages of Downstream Bioprocessing
      • Solid-Liquid Separation
      • Intracellular Product Release
      • Product Concentration
      • Chromatography Purification
      • Formulation
    • Changes in Production Nature
      • Table Current Biopharmaceutical Product Mix
      • Innovation Required
      • Globalization Continues
    • The Need for Operational Excellence
    • Competition Generating Cost Efficiencies
      • Downstream Resistance
      • Process Intensification
      • Higher Titers
      • New Technologies
      • Flexibility
      • Integration and Automation
      • Continuous Processing
    • Developing Research Areas
      • Chromatography
      • Resins
      • Alternative Processes for Purification
      • Spectroscopy
    • Filtration Technologies Advance
      • Tangential Flow
      • Automated
      • Gel Filtration Chromatography
      • Precipitation Alternative
      • Slow Adoption of New Technologies
    • Outsourcing
      • Core Competencies
      • Drivers
      • Issues
      • The Future
  • Trends and Drivers
    • Table Key Trends in Downstream Bioprocessing
    • Protein A
    • Molecule Issues
    • Chromatography
      • Table Application of Single Use Technology Downstream (percentage of overall use)
    • Streamlining and Redesigning
      • Streamlining Niches
    • Purification
    • Greater Use of Contract Manufacturers
    • Production Efficiency
    • International
    • Cancer Therapy Push
    • Collaborations and Innovation
  • Challenges
    • Chromatography
    • Continuous Processing
    • Titers and Composition
    • Evolving Clarification and Purification Strategies
    • Capacity Bottlenecks
    • Isolation of Proteins
    • Efficiencies
    • Quality by Design
    • Talent Shortage
  • Market Developments
    • Collaboration to Improve Downstream Bioprocessing
    • Start-up Acquisition
    • Promoting Pre-Packed Columns
    • Next Generation Columns
    • Next Generation Affinity Ligands
    • Immunoglobulin Facility
    • Bioprocessing Services
    • Expansion
    • Acquisition
    • Supply Deal
    • Bioconjugation Process
    • New Structured Substrates
    • New Protein A Chromatography Resin
    • Enterprise Software Increases Throughput and Quality
    • Investing in Protein Expression Platform
  • Market Landscape
    • Overview
    • Drivers
      • Table Key Drivers of Downstream Bioprocessing
      • Expanding Therapies and Markets
    • Market Analysis and Forecasts
      • Biosimilars
      • Growth and Emerging Markets
      • Continuous Processing
    • Global Market for Downstream Bioprocessing Components
      • Table Downstream Components Bioprocessing Market Share by Vendor 2018 (%)
      • Table World Downstream Bioprocessing Markets, 2016-2021 ($ billions)
      • Table World Downstream Bioprocessing Markets by Geography, 2016-2021 ($ billions)
      • Table World Downstream Bioprocessing Markets by Geography, 2017 (%)
      • Chromatography Columns and Resins
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2017 (%)
      • Membrane Adsorbers
        • Table World Downstream Bioprocessing Membrane Adsorber Market, 2016-2021 ($ millions)
        • Table World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2016-2021 ($ millions)
        • Table World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2017 (%)
      • Filtration Systems
        • Table World Downstream Bioprocessing Filtration Market, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Filtration Market by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Filtration Market by Geography, 2017 (%)
      • Sensors
        • Table World Downstream Bioprocessing Sensor Market, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Sensor Market by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Sensor Market by Geography, 2017 (%)
  • Corporate Profiles
    • 3M Company, St. Paul, MN 55144, www.3m.com/3M/en_US/company-us
    • Abec, Bethlehem, PA 18017, www.abec.com
    • Alfa Laval, Lund, Sweden, www.alfalaval.com
    • Avantor Performance Materials, Center Valley, PA 18034, www.avantorinc.com
    • BIA Separations, Ajdovšèina, Slovenia, www.biaseparations.com
    • Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, www.bioxcellence.com
    • Bosch, Stuttgart, Germany, www.bosch.de/en/
    • Dow, Midland, MI, www.dow.com
    • ESI Ultrapure, Cwmbran, Torfaen, NP44 3XS, UK, www.esiultrapure.com
    • Finesse Solutions, Santa Clara, CA 95054, www.finesse.com
    • FujiFilm Diosynth biotechnologies, College Station, TX 77845, www.fujifilmdiosynth.com
    • GE Healthcare Life Sciences, Marlborough, MA 01752, https://www.gelifesciences.com/ solutions/bioprocessing/productsand- solutions/downstream-bioprocessing
    • GEA Germany Düsseldorf, 40468 Düsseldorf, Germany, www.gea.com/en
    • Lonza Group, Basel, Switzerland, www.lonza.com
    • Millipore, Millipore Sigma, Burlington, MA 01803, www.emdmillipore.com
    • Natrix Separations, Burlington, Ontario, L7L 6A8 Canada, www.natrixseparations.com
    • Nordson Medical, Marlborough, MA 01752, www.nordsonmedical.com
    • Pall Biotech, Port Washington, NY 11050, https://biotech.pall.com
    • Parker Hannifin, Cleveland, OH 44124, www.parker.com
    • Repligen, Waltham, MA 02453, www.repligen.com
    • Sartorius AG, Goettingen, Germany, www.sartorius.com
    • Thermo Fisher Scientific, Waltham, MA 02451, https://www.thermofisher.com/us/en/home/lifescience/ bioproduction.html
    • W. L. Gore & Associates, Inc., Newark, DE 19711, www.gore.com
    • Watson-Marlow Fluid Technology Group, Falmouth, TR11 4SZ UK, www.watson-marlow.com

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